1. Recombinant Proteins
  2. Recombinant Mouse Interleukin-1 alpha

Recombinant Mouse Interleukin-1 alpha

Cat. No.: HY-P7072
Handling Instructions

Recombinant Murine Interleukin-1 alpha, a potent immuno-modulator that mediates a wide range of immune and inflammatory responses.

For research use only. We do not sell to patients.

Recombinant Proteins

Recombinant Proteins-MedChemExpress
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10 μg $220 Ask For Quote & Lead Time
50 μg $560 Ask For Quote & Lead Time

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  • Technical Parameters

  • Properties

  • Description

Synonyms
rMuIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha
Species

Mouse

Source

E. coli

Accession

P01582

Gene ID

16175

Molecular Weight

Approximately 17.9 kDa

AA Sequence

SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS

Biological Activity
The ED50 is <2 pg/mL as measured by murine D10S cells, corresponding to a specific activity of >5.0 × 108 units/mg.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

Reconstitute the lyophilized recombinant Murine Interleukin-1 alpha (rMuIL-1α) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA.

Storage & Stability

Lyophilized recombinant Murine Interleukin-1 alpha (rMuIL-1α) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

Interleukin-1 (IL-1) is a family of related peptides that are produced by mononuclear phagocytes and other cell types that have been stimulated by microbes or various microbial products. IL-1 has been shown to initiate or augment a number of biological responses that are proinflammatory in nature. Recombinant Murine Interleukin-1 alpha is a non-glycosylated polypeptide chain containing 156 amino acids and having a molecular mass of 17.9 kDa. Treatment with recombinant murine interleukin-1 alpha (rIL-1 alpha) significantly enhances the resistance of mice to infection by the facultative intracellular pathogen Listeria monocytogenes[1]. Members of the IL-1 family such as IL-1α and IL-1β are pro-inflammatory cytokines. Increased IL-1α and IL-1β levels have been detected separately in cigarette smoke (CS)-treated animals and inhibition of the respective signaling pathways result in anti-inflammatory activity[2].

Documentation
References
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Product Name:
Recombinant Mouse Interleukin-1 alpha
Cat. No.:
HY-P7072
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