1. Recombinant Proteins
  2. Recombinant Rat Granulocyte Colony-Stimulating Factor (HEK293-expressed)

Recombinant Rat Granulocyte Colony-Stimulating Factor (HEK293-expressed)

Cat. No.: HY-P7093A
Handling Instructions

Recombinant Rat Granulocyte Colony-Stimulating Factor (HEK293-expressed) is a glycoprotein, acting to stimulate granulopoiesis, the innate immunity, and the differentiation of neural progenitor cells.

For research use only. We do not sell to patients.

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10 μg $190 Ask For Quote & Lead Time
50 μg $590 Ask For Quote & Lead Time
100 μg $990 Ask For Quote & Lead Time

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  • Technical Parameters

  • Properties

  • Description

Synonyms
rRtG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim
Species

Rat

Source

HEK 293

Accession

P97712

Gene ID

25610

Molecular Weight

25-28 kDa

AA Sequence

IPLLTVSSLP PSLPLPRSFL LKSLEQVRKI QARNTELLEQ LCATYKLCHP EELVLFGHSL GIPKASLSSC SSQALQQTKC LSQLHSGLFL YQGLLQALAG ISSELAPTLD MLHLDVDNFA TTIWQQMESL GVAPTVQPTQ STMPIFTSAF QRRAGGVLVT SYLQSFLETA HHALHHLPRP AQKHFPESLF ISI

Biological Activity
The ED50 is <5 pg/mL as measured by NFS-60 cells.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<0.2 EU/μg, determined by LAL method.

Reconstitution

Reconstitute the lyophilized recombinant Rat Granulocyte Colony-Stimulating Factor (HEK293-expressed) (rRtG-CSF) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability

Lyophilized recombinant Rat Granulocyte Colony-Stimulating Factor (HEK293-expressed) (rRtG-CSF) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

G-CSF is a glycoprotein, secreted by the cells of the immune system, fibroblasts, and endothelium and functions to stimulate granulopoiesis, the innate immunity, and the differentiation of neural progenitor cells. G-CSF conveys neuroprotection to central neurons upon increases in phosphorylation of PI3K/Akt pathway, and regulates epithelial to mesenchymal transition in cancer[1]. G-CSF acts via a specific cognate receptor (G-CSFR) that belongs to the class I cytokine receptor superfamily. G-CSF is well known as a hematopoietic cytokine that stimulates the proliferation, differentiation, and function of myeloid progenitors and mobilization of hematopoietic stem and progenitor cells[2]. G-CSF has the potential to inhibit the progression of atherosclerosis in animal models[3].

Documentation
References
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Product Name:
Recombinant Rat Granulocyte Colony-Stimulating Factor (HEK293-expressed)
Cat. No.:
HY-P7093A
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