ROR2 Protein, Human (HEK293, C-His)

The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, C-His) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ROR2 Protein, Human (HEK293, C-His) is 370 a.a., with molecular weight of ~55 kDa.

ROR2 protein, a tyrosine-protein kinase receptor, emerges as a key player in the early stages of chondrocyte formation and is deemed essential for cartilage and growth plate development. Its phosphorylation of YWHAB not only induces osteogenesis but also promotes bone formation. Despite exhibiting minimal tyrosine kinase activity in vitro, ROR2's intricate role extends to potentially acting as a receptor for the Wnt ligand WNT5A. This interaction may lead to the intriguing outcome of inhibiting WNT3A-mediated signaling. The multifaceted functions of ROR2 highlight its significance in orchestrating complex processes such as chondrogenesis, osteogenesis, and the intricate regulation of Wnt signaling pathways.

Human

HEK293

C-10*His

Q01974 (E34-G403)

4920  [NCBI]

EVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMG

Approximately 55 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.