STAT6 Protein, Human (sf9, His)

STAT6 is a versatile protein that executes a dual function encompassing both signal transduction and transcriptional activation. It plays a crucial role in mediating signaling cascades induced by IL4/interleukin-4 and IL3/interleukin-3. The protein exhibits the ability to form homodimers or heterodimers with related family members, contributing to its diverse functional roles in cellular responses. Additionally, STAT6 engages in specific protein-protein interactions, such as binding to NCOA1 through its C-terminal LXXLL motif, further highlighting its involvement in intricate cellular signaling networks. STAT6 Protein, Human (sf9, His) is the recombinant human-derived STAT6 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of STAT6 Protein, Human (sf9, His) is 846 a.a., with molecular weight of ~100 kDa.

STAT6 is a versatile protein that executes a dual function encompassing both signal transduction and transcriptional activation. It plays a crucial role in mediating signaling cascades induced by IL4/interleukin-4 and IL3/interleukin-3. The protein exhibits the ability to form homodimers or heterodimers with related family members, contributing to its diverse functional roles in cellular responses. Additionally, STAT6 engages in specific protein-protein interactions, such as binding to NCOA1 through its C-terminal LXXLL motif, further highlighting its involvement in intricate cellular signaling networks.

Human

Sf9 insect cells

C-His

P42226 (S2-W847)

6778  [NCBI]

SLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW

Approximately 100 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 20% Glycerol, 0.3 mM DTT. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.