1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Serine/Threonine Kinase Proteins
  4. TLK2
  5. TLK2 Protein, Human (sf9)

TLK2 Protein, Human (sf9)

Cat. No.: HY-P76106
Handling Instructions

TLK2 is an important serine/threonine protein kinase with complex effects on chromatin assembly, DNA replication, transcription, repair, and chromosome segregation. It plays multiple roles by phosphorylating and stabilizing chromatin assembly factors such as ASF1A and ASF1B, preventing proteasome-mediated degradation. TLK2 Protein, Human (sf9) is the recombinant human-derived TLK2 protein, expressed by Sf9 insect cells , with tag free. The total length of TLK2 Protein, Human (sf9) is 376 a.a., with molecular weight of ~44 kDa.

For research use only. We do not sell to patients.

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Description

TLK2 is an important serine/threonine protein kinase with complex effects on chromatin assembly, DNA replication, transcription, repair, and chromosome segregation. It plays multiple roles by phosphorylating and stabilizing chromatin assembly factors such as ASF1A and ASF1B, preventing proteasome-mediated degradation. TLK2 Protein, Human (sf9) is the recombinant human-derived TLK2 protein, expressed by Sf9 insect cells , with tag free. The total length of TLK2 Protein, Human (sf9) is 376 a.a., with molecular weight of ~44 kDa.

Background

TLK2, a serine/threonine-protein kinase, plays a crucial role in the intricate processes of chromatin assembly, potentially extending its influence to DNA replication, transcription, repair, and chromosome segregation. This kinase exhibits a multifaceted role by phosphorylating chromatin assembly factors, including ASF1A and ASF1B, and contributing to their stabilization, particularly through the prevention of proteasome-mediated degradation. By enhancing chromatin assembly, TLK2 actively participates in the maintenance of genomic integrity. Additionally, TLK2 functions as a negative regulator of amino acid starvation-induced autophagy, showcasing its involvement in cellular responses to nutritional cues. This versatile kinase, with its impact on fundamental cellular processes, emerges as a key player in the intricate orchestration of various aspects of nuclear and cellular dynamics.

Species

Human

Source

Sf9 insect cells

Tag

Tag Free

Accession

Q86UE8 (L397-N772)

Gene ID
Molecular Construction
N-term
TLK2 (L397-N772)
Accession # Q86UE8
C-term
Synonyms
Serine/threonine-protein kinase tousled-like 2; HsHPK; PKU-alpha; Tousled-like kinase 2; TLK2
Molecular Weight

Approximately 44 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

TLK2 Protein, Human (sf9) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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TLK2 Protein, Human (sf9)
Cat. No.:
HY-P76106
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