TLR3 Protein, Mouse (705a.a, HEK293, His)

TLR3 protein is an important component of innate and adaptive immunity and can recognize pathogen-associated molecular patterns and activate NF-κ-B, IRF3 and cytokine secretion. Ligand binding induces TLR3 dimerization, and efficient signal transduction requires clustering of signaling units along the ligand. TLR3 Protein, Mouse (705a.a, HEK293, His) is the recombinant mouse-derived TLR3 protein, expressed by HEK293 , with C-His labeled tag. The total length of TLR3 Protein, Mouse (705a.a, HEK293, His) is 705 a.a., with molecular weight of 100-110 kDa.

TLR3 protein serves as a key component in both innate and adaptive immunity, playing a pivotal role in the host immune response against pathogens by recognizing specific molecular patterns associated with microorganisms. Activated by double-stranded RNA, a characteristic feature of viral infection, TLR3 functions through the adapter TRIF/TICAM1, leading to NF-kappa-B activation, nuclear translocation of IRF3, cytokine secretion, and initiation of the inflammatory response. TLR3 exists as a monomer and homodimer, with ligand-binding triggering dimerization. The signaling unit comprises one approximately 40 bp ds-RNA and two TLR3 molecules, requiring lateral clustering of signaling units along the ds-RNA ligand for effective signal transduction. Interaction with UNC93B1, SRC, and TICAM1, particularly in response to poly(I:C), contributes to its regulatory functions, highlighting the intricate molecular mechanisms involved in TLR3-mediated immune responses.

Mouse

HEK293

C-His

Q99MB1 (M1-L705)

142980  [NCBI]

100-110 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.