TrkB Protein, Mouse (429a.a, HEK293, His)

TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (429a.a, HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Mouse (429a.a, HEK293, His) is 429 a.a., with molecular weight of 75-85 kDa.

TrkB protein, also known as tropomyosin receptor kinase B, is composed of a non-catalytic isoform. Unlike its catalytic isoform, the non-catalytic isoform of TrkB lacks intrinsic kinase activity. The catalytic isoform of TrkB is responsible for initiating signaling cascades upon activation by its ligands, such as brain-derived neurotrophic factor (BDNF). However, the non-catalytic isoform of TrkB is believed to modulate the activity of the catalytic isoform and regulate its signaling pathways. While the precise role of the non-catalytic isoform of TrkB is still being investigated, it is thought to play a regulatory role in various cellular processes, particularly in neuronal development and synaptic plasticity. Further research is needed to fully elucidate the functional significance of the non-catalytic isoform of TrkB and its contribution to neuronal function.

Mouse

HEK293

C-His

P15209-2 (M1-H429)

18212  [NCBI]

75-85 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.