1. Metabolic Enzyme/Protease
    Autophagy
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
  3. (rel)-Atorvastatin

(rel)-Atorvastatin 

Cat. No.: HY-B0589A
Handling Instructions

(rel)-Atorvastatin, a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.

For research use only. We do not sell to patients.

(rel)-Atorvastatin Chemical Structure

(rel)-Atorvastatin Chemical Structure

CAS No. : 110862-48-1

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Description

(rel)-Atorvastatin, a relative configuration of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

Molecular Weight

558.64

Formula

C₃₃H₃₅FN₂O₅

CAS No.

110862-48-1

SMILES

O=C(C(C(C1=CC=CC=C1)=C(C2=CC=C(F)C=C2)N3CC[[email protected]](O)C[[email protected]](O)CC(O)=O)=C3C(C)C)NC4=CC=CC=C4.[Relative stereochemistry]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (223.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7901 mL 8.9503 mL 17.9006 mL
5 mM 0.3580 mL 1.7901 mL 3.5801 mL
10 mM 0.1790 mL 0.8950 mL 1.7901 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (11.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (11.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
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Keywords:

(rel)-AtorvastatinHMG-CoA Reductase (HMGCR)AutophagyRelativeconfigurationanti-proliferationinvasionInhibitorinhibitorinhibit

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(rel)-Atorvastatin
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