1. Apoptosis
  2. MDM-2/p53
  3. MDM2/4-p53-IN-3

MDM2/4-p53-IN-3 is a MDM2/4-p53 protein-protein interactions (PPIs) inhibitor (IC50s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer.

For research use only. We do not sell to patients.

MDM2/4-p53-IN-3 Chemical Structure

MDM2/4-p53-IN-3 Chemical Structure

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Description

MDM2/4-p53-IN-3 is a MDM2/4-p53 protein-protein interactions (PPIs) inhibitor (IC50s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer[1].

IC50 & Target

MDM2/4-p53 protein-protein interactions (PPIs)[1]

In Vitro

MDM2/4-p53-IN-3 (Compound 2a, 1-100 μM, 48 h) inhibits cell proliferation[1].
MDM2/4-p53-IN-3 dissociates p53-MDMs complexes (immunoenzymatic assays) with IC50 values of 18.5 nM (MDM2-p53) and 14.8 nM (MDM4-p53)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HCT116, SJSA-1, LNCaP, MCF-7
Concentration: 1-100 μM
Incubation Time: 48 h (HCT116), 72 h (MCF-7), 96 h (SJSA-1, LNCaP)
Result: Inhibited cell proliferation with IC50 values of 23.6 μM (HCT116), 12.6 μM (SJSA-1), 13.1 μM (LNCaP), 14.3 μM (MCF-7).
Molecular Weight

504.38

Formula

C25H24Cl2FN3O3

SMILES

O=C(C([C@@H]1C2=CC=CC(Cl)=C2F)=NN(C3CCCCC3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)OCC.[Relative stereochemistry]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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MDM2/4-p53-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MDM2/4-p53-IN-3
Cat. No.:
HY-151171
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