1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. RNA polymerase II-IN-1

RNA polymerase II-IN-1 

Cat. No.: HY-147916
Handling Instructions

RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin.

For research use only. We do not sell to patients.

RNA polymerase II-IN-1 Chemical Structure

RNA polymerase II-IN-1 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin[1].

IC50 & Target

IC50: 36.66 nM (Pol II)[1]

In Vitro

RNA polymerase II-IN-1 (compound 19iv) has cytotoxicity against CHO, HEK293 and HeLa with IC50s of 0.19 μM, 0.20 μM and 3.32 μM, respectively; exhibits 2.7-fold less toxicity than α-Amanitin in HepG2 with an IC50 of 5.6 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

887.96

Formula

C38H53N11O12S

SMILES

O=C([[email protected]@H](NC(CNC1=O)=O)[[email protected]](CC)C)NNC(N[[email protected]@H]2C(N[[email protected]](C(N3C[[email protected]@H](C[[email protected]]3C(N[[email protected]](C(N[[email protected]@H]1CC4=C(SC2)NC5=C4C=CC=C5)=O)[[email protected]]([[email protected]](CO)O)C)=O)O)=O)CC(N)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
RNA polymerase II-IN-1
Cat. No.:
HY-147916
Quantity:
MCE Japan Authorized Agent: