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  3. RORγt inverse agonist 13

RORγt inverse agonist 13 

Cat. No.: HY-131338 Purity: 99.22%
Handling Instructions

RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM.

For research use only. We do not sell to patients.

RORγt inverse agonist 13 Chemical Structure

RORγt inverse agonist 13 Chemical Structure

CAS No. : 2170477-75-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 339 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM[1].

IC50 & Target[1]

ROR-γ

63.8 nM (IC50)

In Vitro

RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 µM in Th17 cell differentiation assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Imiquimod (IMQ)-induced psoriasis mice model[1].
Dosage: 25 mg/kg.
Administration: Orally, twice daily.
Result: Brought in a significant reduction in clinical severity of psoriasis as measured through the ear erythema, back skin erythema and scaliness scales.
Animal Model: Male CD-1 Mice[1].
Dosage: 1 mg/kg (i.v.) and 5 mg/kg (p.o.)(Pharmacokinetic Analysis).
Administration: IV or PO, single dose.
Result: Cmax: 609.67 ng/mL (PO), 1550 ng/mL (IV).
T1/2: 3.63 h (PO), 3.04 h (IV).
Molecular Weight

513.29

Formula

C₂₃H₁₇Cl₂F₃N₂O₄

CAS No.
SMILES

O=C(O)CC1=CC=C(CNC(NC2=CC(Cl)=C(C3=CC=CC=C3OC(F)(F)F)C(Cl)=C2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (194.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9482 mL 9.7411 mL 19.4822 mL
5 mM 0.3896 mL 1.9482 mL 3.8964 mL
10 mM 0.1948 mL 0.9741 mL 1.9482 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RORγt inverse agonist 13RORγt inverse agonist13RORγt inverse agonist-13RORRAR-related orphan receptorInhibitorinhibitorinhibit

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Product Name:
RORγt inverse agonist 13
Cat. No.:
HY-131338
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