1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Calcium Channel
    Mitochondrial Metabolism
  3. Ru360

Ru360 

Cat. No.: HY-122898 Purity: >99.0%
Handling Instructions

Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects.

For research use only. We do not sell to patients.

Ru360 Chemical Structure

Ru360 Chemical Structure

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Description

Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2].

IC50 & Target

IC50: 0.184 nM (Ca2+ uptake into mitochondria)[2]
Kd: 0.34 nM (Mitochondria)[2]

In Vitro

Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial cells and accumulated in the cytosol in a biphasic manner[1].
During pelleting hypoxia, Ru360 (10 µM) significantly improves cell viability in wild type cardiomyocytes[3].

In Vivo

Ru360 (15-50 nmol/kg) treatment abolishes the incidence of arrhythmias and haemodynamic dysfunction elicited by reperfusion in a whole rat model. Ru360 administration partially inhibits calcium uptake, preventing mitochondria from depolarization by the opening of the mitochondrial permeability transition pore (mPTP)[1].

Molecular Weight

550.78

Formula

C₂H₂₆Cl₃N₈O₅Ru₂ ₃-

SMILES

[NH3][Ru]([NH3])([NH3])([NH3])(O[Ru]([NH3])([NH3])([NH3])([NH3])OC=O)OC=O.[Cl-].[Cl-].[Cl-].[3+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 0.5 mg/mL (0.91 mM; Need ultrasonic and warming)

References

Purity: >99.0%

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Keywords:

Ru360Ru 360Ru-360Calcium ChannelMitochondrial MetabolismCa2+ channelsCa channelsMitochondrialcalciumuptakerutheniumredantiarrhythmiccardioprotectiveoxygen-bridgeddinuclearInhibitorinhibitorinhibit

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Ru360
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HY-122898
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