2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. PM-43I

PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research[1].

For research use only. We do not sell to patients.

PM-43I Chemical Structure

PM-43I Chemical Structure

CAS No. : 1637532-77-4

Size Price Stock Quantity
5 mg USD 826 In-stock
10 mg USD 1405 In-stock
25 mg USD 2950 In-stock
50 mg USD 5000 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

PM-43I Related Antibodies

Top Publications Citing Use of Products

View All STAT Isoform Specific Products:

View All Isoforms
STAT3 STAT5 STAT6 STAT1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research[1].

In Vitro

PM-43I (0.05-5 μM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Beas-2B immortalized human airway cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PM-43I Related Antibodies

Western Blot Analysis[1]

Cell Line: Beas-2B immortalized human airway cells
Concentration: 0.05, 0.1, 0.5, 1, 2.5, 5 µM
Incubation Time: 2 h
Result: Inhibited STAT6 phosphorylation level to 18%, 21% at 2.5 and 5 µM, respectively.
In Vivo

PM-43I (intranasal administration; 5 μg per mouse; every other day; 18 d) activity is restricted to the lung by intranasal administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice injected with Ovalhumin/Alum[1]
Dosage: 5 μg per mouse
Administration: Intranasal administration; 5 μg per mouse; every other day; 18 days
Result: Showed no effect on the sensisization of peripheral spleenocytes to ovalbumin.
Molecular Weight

777.79

Formula

C38H50F2N3O10P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C)C(OCOP(C(F)(C1=CC=C(C=C1)/C(C)=C/C(N[C@@H]2C(N(CCCC2)CC(N(C3=CC=CC=C3)C)=O)=O)=O)F)(OCOC(C(C)(C)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (45.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2857 mL 6.4285 mL 12.8569 mL
5 mM 0.2571 mL 1.2857 mL 2.5714 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2857 mL 6.4285 mL 12.8569 mL 32.1424 mL
5 mM 0.2571 mL 1.2857 mL 2.5714 mL 6.4285 mL
10 mM 0.1286 mL 0.6428 mL 1.2857 mL 3.2142 mL
15 mM 0.0857 mL 0.4286 mL 0.8571 mL 2.1428 mL
20 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6071 mL
25 mM 0.0514 mL 0.2571 mL 0.5143 mL 1.2857 mL
30 mM 0.0429 mL 0.2143 mL 0.4286 mL 1.0714 mL
40 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8036 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PM-43I Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PM-43I1637532-77-4STATallergic lung diseaseallergic rhinitiscancerchronic pulmonary obstructive diseaseBeas-2B immortalized human airway cellInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PM-43I
Cat. No.:
HY-148092
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.