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  2. Antibiotic
  3. Safracin B

Safracin B 

Cat. No.: HY-126804
Handling Instructions

Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities.

For research use only. We do not sell to patients.

Safracin B Chemical Structure

Safracin B Chemical Structure

CAS No. : 87578-99-2

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Description

Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities[1].

In Vivo

Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F1 (CD2F1) mice weighing 19-24 g[2].
The LD50 is 7.3 mg/kg with safracin B in normal CD2F1 mice by ip administration[2].

Molecular Weight

540.61

Formula

C₂₈H₃₆N₄O₇

CAS No.

87578-99-2

SMILES

C[[email protected]](N)C(NC[[email protected]]1C2=C(C(C(C)=C(OC)C2=O)=O)C[[email protected]@]3([H])[[email protected]@]4([H])C5=C(O)C(OC)=C(C)C=C5C[[email protected]@](N4C)([H])[[email protected]](O)N31)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Safracin BAntibiotictetrahydroisoquinolineTHIQalkaloidantimicrobialantitumorInhibitorinhibitorinhibit

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