1. TGF-beta/Smad
  2. TGF-β Receptor

SB 525334 

Cat. No.: HY-12043 Purity: 99.45%
Handling Instructions

SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM.

For research use only. We do not sell to patients.

SB 525334 Chemical Structure

SB 525334 Chemical Structure

CAS No. : 356559-20-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 372 In-stock
Estimated Time of Arrival: December 31
100 mg USD 612 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

    SB 525334 purchased from MCE. Usage Cited in: Biochim Biophys Acta. 2017 Dec 18;1864(3):721-734.

    Microglial cells are incubated with or without TGF-β1 (5 ng/mL) and/or SB525334 (10 μM) for 24 h, followed by incubation with or without LPS for 24 h and subsequent NO determination.

    SB 525334 purchased from MCE. Usage Cited in: Cell Commun Signal. 2018 Dec 7;16(1):97.

    Immunofluorescence staining of LC3B and MHC in gastrocnemius in different groups (TGF-β1, TGF-β1+SB525334, SB525334, TGF-β1+CQ, TGF-β1+si-HMGB1) and HMGB1 staining of gastrocnemius.

    SB 525334 purchased from MCE. Usage Cited in: Cell Commun Signal. 2018 Dec 7;16(1):97.

    Western blot analysis of LC3B, p62, HMGB1 and MHC protein expression in gastrocnemius muscles with the treatment of groups (TGF-β1, TGF-β1+SB525334, SB525334, TGF-β1+CQ, TGF-β1+si-HMGB1).
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM.

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46 mg/mL (133.95 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9119 mL 14.5594 mL 29.1189 mL
    5 mM 0.5824 mL 2.9119 mL 5.8238 mL
    10 mM 0.2912 mL 1.4559 mL 2.9119 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    343.42

    Formula

    C₂₁H₂₁N₅

    CAS No.

    356559-20-1

    SMILES

    CC(C)(C1=NC(C2=CC=CC(C)=N2)=C(C3=CC=C4N=CC=NC4=C3)N1)C

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.45%

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    SB 525334
    Cat. No.:
    HY-12043
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    SB 525334

    Cat. No.: HY-12043