1. Metabolic Enzyme/Protease
  2. FABP
  3. SBFI-26

SBFI-26 

Cat. No.: HY-117506B Purity: 98.62%
Handling Instructions

SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects.

For research use only. We do not sell to patients.

SBFI-26 Chemical Structure

SBFI-26 Chemical Structure

CAS No. : 1541207-06-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects[1][2].

IC50 & Target

Ki: 0.9 μM (FABP5), 0.4 µM (FABP7)[1][2]

In Vitro

SBFI-26 binds to the canonical ligand-binding pocket of FABP5[1].
SBFI-26 significantly inhibits cellular AEA accumulation[2].

In Vivo

SBFI-26 (20 mg/kg, i.p.) significantly reduces carrageenan-induced thermal hyperalgesia and paw edema[2].
SBFI-26 produces antinociceptive and anti-inflammatory effects in mice[2].

Animal Model: Mice[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection
Result: Significantly reduced carrageenan-induced thermal hyperalgesia and paw edema.
Molecular Weight

422.47

Formula

C₂₈H₂₂O₄

CAS No.

1541207-06-0

SMILES

O=C([[email protected]]1[[email protected]@H](C2=CC=CC=C2)[[email protected]](C(O)=O)[[email protected]@H]1C3=CC=CC=C3)OC4=CC=CC5=C4C=CC=C5.[Relative stereochemistry]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (236.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3670 mL 11.8352 mL 23.6703 mL
5 mM 0.4734 mL 2.3670 mL 4.7341 mL
10 mM 0.2367 mL 1.1835 mL 2.3670 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SBFI-26SBFI26SBFI 26FABPFatty acid-binding proteinFABP5FABP7anti-nociceptiveAnandamidetransportersInhibitorinhibitorinhibit

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Product name:
SBFI-26
Cat. No.:
HY-117506B
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