1. One-stop Drug Screening
  2. Screening Libraries
  3. Structurally Diverse Fragment Library
Structurally Diverse Fragment Library

Cat. No.: HY-L187

Fragment-based drug development (FBDD) is a strategy for drug discovery that can be applied both academically and commercially to enhance the identification of some non-drug targets. Fragment-based drug development has identified low molecular weight molecules (<300 Da) capable of binding to related macromolecules. These fragments can cover a wide chemical space and are easy to optimize later. Currently, several fragment-based drugs have entered clinical trials, of which two drugs, Vemurafenib and Venetoclax, have been approved for marketing.

Based on Tanimoto coefficient, MCE uses similarity algorithm to carefully select 2,309 high-structurally diverse 'RO3' compliant fragment molecules from large-scale fragment molecules, which can be applied to fragment based drug development.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
- +

Compound Screening Libraries

Top Publications Citing Use of MedChemExpress (MCE) Products

Publications Citing Use of MedChemExpress (MCE) Products

  • Biological Activity
  • Product Details
  • Composition

Description & Advantages

•   A unique collection of 2,309 high diversity fragments for high throughput screening (HTS) and high content screening (HCS).

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 2,309 fragments as pre-dissolved solutions or solid.
Solution: 2,309 compounds supplied in 10 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Related Service
Recommendation
Compound Customization
  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
  •  YES
Contact Us for Customization

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Container *

    Remarks

    Inquiry Information

    Product Name:
    Structurally Diverse Fragment Library
    Cat. No.:
    HY-L187
    Quantity:
    MCE Japan Authorized Agent:

    Request SDF File

    Please enter your email address. We will send your requested SDF file to you as soon as possible.

    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack