Search Result
Results for "
<i>Dalbergia odorifera<_i> T. Chen
" in MedChemExpress (MCE) Product Catalog:
5239
Inhibitors & Agonists
232
Biochemical Assay Reagents
195
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-148761
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PSMA I&T; PNT-2002
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PSMA
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Cancer
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PSMA I&T is an effective inhibitor of prostate-specific membrane antigen (PSMA). PSMA I&T can be used for SPECT/CT imaging and radionuclide studies in triple-negative breast cancer and prostate cancer (PCa) .
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- HY-P10951
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(R)-PSMA I&T; (R)-PNT-2002
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PSMA
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Cancer
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Zadavotide guraxetan (PSMA I&T; PNT-2002) is a prostate-specific membrane antigen (PSMA) inhibitor. Zadavotide guraxetan has antitumor activity and can be used in prostate cancer-targeted research .
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- HY-N12992
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Others
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Others
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(3R)-3′,8-Dihydroxyvestitol (compound DO-9) is an isoflavonoid monomer that can be isolated from Dalbergia odorifera. I .
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- HY-N7969
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Others
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Others
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Odoriflavene is a phenolic compound found in the root heartwood of Dalbergia odorifera T. Chen (Leguminosae) .
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- HY-NP157D
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Biochemical Assay Reagents
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Others
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Type I Collagen, T Cell Grade, from Porcine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Porcine can be used as a stimulating antigen for T-cells in in vitro culture systems .
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- HY-NP157C
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Biochemical Assay Reagents
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Others
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Type I Collagen, T Cell Grade, from Mouse has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Mouse can be used as a stimulating antigen for T-cells in in vitro culture systems .
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- HY-NP157B
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Biochemical Assay Reagents
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Others
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Type I Collagen, T Cell Grade, from Human has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Human, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .
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- HY-NP157A
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Biochemical Assay Reagents
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Others
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Type I Collagen, T Cell Grade, from Chick has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Chick, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .
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- HY-NP157E
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Biochemical Assay Reagents
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Others
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Type I Collagen, T Cell Grade, from Rat has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Rat, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .
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- HY-NP157
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Biochemical Assay Reagents
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Others
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Type I Collagen, T Cell Grade, from Bovine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .
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- HY-P10925
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β-catenin
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Cancer
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I-66 is a potent β-catenin inhibitor with an IC50 of <50 nM. I-66 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-66 shows anticancer effects .
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- HY-P10925A
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β-catenin
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Cancer
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I-67, a structural isomer of I-66 (HY-P10925), is a potent β-catenin inhibitor with an IC50 of <50 nM. I-67 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-67 shows anticancer effects .
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- HY-147986
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Carbonic Anhydrase
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Cancer
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hCA I-IN-2 (Compound 6d) is a selective human carbonic anhydrase I (hCA I) inhibitor with Ki values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .
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- HY-147985
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Carbonic Anhydrase
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Cancer
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hCA I-IN-1 (Compound 6q) is a human carbonic anhydrase I (hCA I) inhibitor with Ki values of 38.3, 716.4, 940.1 and 192.8 nM against hCA I, hCA II, hCAIX and hCAXII, respectively .
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- HY-156969
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Topoisomerase
Btk
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Cancer
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Topoisomerase I inhibitor 11 is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 11 can bind to BTK .
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- HY-162091
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Topoisomerase
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Cancer
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Topoisomerase I inhibitor 13 (Compound G11) is a Topo I inhibitor that inhibits cancer cell proliferation. Topoisomerase I inhibitor 13 significantly inhibits tumor growth in vivo .
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- HY-N1985
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Parasite
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Infection
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Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .
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- HY-N2541
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Taste Receptor
mTOR
Autophagy
Apoptosis
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Metabolic Disease
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Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR .
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- HY-122949
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DGK
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Metabolic Disease
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Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .
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- HY-N12370
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Others
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Others
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Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity .
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- HY-N9736
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Calcineurin
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Infection
Neurological Disease
Inflammation/Immunology
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6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis .
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- HY-N3775
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ERK
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Metabolic Disease
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Dodoviscin I (Dodoviscin A) is an adipogenic agent that increases triglyceride content in 3T3L1 mouse fibroblasts. Dodoviscin I inhibits ERK2 with an IC50 of 10.79 μM.
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- HY-146437
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Topoisomerase
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Cancer
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Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases .
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- HY-P1032F
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Endogenous Metabolite
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Endocrinology
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Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE) .
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- HY-149002
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Topoisomerase
Apoptosis
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Cancer
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Topoisomerase I/II inhibitor 4 (compound F16) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 4 inhibits cell proliferation, invasion and migration and induces apoptosis. Topoisomerase I/II inhibitor 4 can be used for liver cancer research .
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- HY-146497
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Topoisomerase
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Cancer
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Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones .
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- HY-P3006
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Drug Metabolite
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Cardiovascular Disease
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Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell .
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- HY-157282
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PLI
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Others
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Inflammation/Immunology
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Photolumazine I(PLI) is a vitamin B-based hapten.Photolumazine Icanactivates Mucosal-associated Invariant T clones .
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- HY-150685
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- HY-153340
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Keap1-Nrf2
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Metabolic Disease
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I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties .
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- HY-E70040
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Endogenous Metabolite
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Metabolic Disease
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Endoglycoceramidase I (EGCase I) is a glycosidase, is often used in biochemical studies. Endoglycoceramidase I catalyzes a transglycosylation reaction, which transfers the sugar moiety of GSLs to the primary hydroxyl group of several 1-alkanols .
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- HY-170580
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Topoisomerase
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Cancer
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Topo I/II-IN-1 (compound 7t) is a potent Topo I and Topo II dual inhibitor. Topo I/II-IN-1 exhibits significant cytotoxicity against MCF-7 breast cancer cell line with an IC50 of 7.45 μM .
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- HY-100849
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JAK
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Inflammation/Immunology
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JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research .
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- HY-143265
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Topoisomerase
Apoptosis
Caspase
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Cancer
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Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect .
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- HY-P5798
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FAS-I
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Cholinesterase (ChE)
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Neurological Disease
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Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .
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- HY-P2774
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Glo-I
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Biochemical Assay Reagents
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Others
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Glyoxalase I (Glo-I) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-131577A
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Dispase I
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Collagen
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Others
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Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin .
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- HY-NP072
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MAL I
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Fluorescent Dye
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Others
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Maackia Amurensis Lectin I (MAL I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Maackia Amurensis Lectin I (MAL I) is a biological material or organic compound that can be used in life science research .
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- HY-NP079
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RCA I
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Fluorescent Dye
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Others
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Ricinus Communis Agglutinin I (RCA I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ricinus Communis Agglutinin I (RCA I) is a biological material or organic compound that can be used in life science research .
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- HY-NP090
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UEA I
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Fluorescent Dye
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Others
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Ulex Europaeus Agglutinin I (UEA I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) is a biological material or organic compound that can be used in life science research .
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- HY-P5179
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HWTX-I
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Calcium Channel
Sodium Channel
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Neurological Disease
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Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively .
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- HY-N12073
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MFLNH I
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Others
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Others
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Monofucosyllacto-N-hexaose I (MFLNH I) is a composition of human milk oligosaccharide .
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- HY-161529
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Angiotensin Receptor
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Inflammation/Immunology
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Angiotensin I/BSA is an antigen-adjuvant conjugate of Angiotensin I and bovine serum albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
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- HY-136538
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Survivin
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Cancer
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LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors .
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- HY-P3055
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DTX-I
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Potassium Channel
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Neurological Disease
Cancer
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Dendrotoxin-I (DTX-I) is a potent K + channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research .
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- HY-N11172
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Others
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Neurological Disease
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Schibitubin I is a lignin. Schibitubin I has neuroprotective activity. Schibitubin I can be isolated from the fruits of Schisandra bicolor var. tuberculata .
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- HY-W035090
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(Trimethylphosphine)gold(I) chloride
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Biochemical Assay Reagents
Endogenous Metabolite
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Chloro(trimethylphosphine)gold(I) ((Trimethylphosphine)gold(I) chloride) is a metal complex with antitumor activity. Chloro(trimethylphosphine)gold(I) has been studied as a potential chemotherapeutic compound in cancer inhibition. Chloro(trimethylphosphine)gold(I) can also be used in organic synthesis reactions as a catalyst to improve reaction efficiency. The biocompatibility of Chloro(trimethylphosphine)gold(I) makes it promising for application in medicine and materials science.
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- HY-NP068
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GSL I
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Fluorescent Dye
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Others
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Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) is a biological material or organic compound that can be used in life science research .
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- HY-E70280
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rEGCase I
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Biochemical Assay Reagents
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Metabolic Disease
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Recombinant endoglycoceramidase I (rEGCase I) is a glycosidase that catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides. Recombinant endoglycoceramidase I catalyzes a transglycosylation reaction, which transfers the sugar moiety of glycosphingolipids (GSLs) to the primary hydroxyl group of several 1-alkanols .
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- HY-P3446A
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- HY-N12316
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Others
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Others
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Goshuyuamide-I (compound 4) is a kind of alkaloid. Goshuyuamide-I can be isolated from the fruits of Euodia rutaecarpa. Goshuyuamide-I can be used in the research of analgesics .
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- HY-121934
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Drug Derivative
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Cancer
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BH3I-2' is the BH3I-2 analogue. BH3I-2 is a Bcl-2 family inhibitor. BH3I-2' can be used for various studies .
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- HY-107301
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Soyasaponin Be; DHS-I
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Potassium Channel
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Neurological Disease
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Dehydrosoyasaponin I (Soyasaponin Be;DHS-I), a triterpene glycoside, is a potent and reversible calcium-activated potassium (maxi-K) channels activator .
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- HY-161559
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Biochemical Assay Reagents
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Inflammation/Immunology
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Sudan I/OVA is an antigen-adjuvant conjugate formed by coupling Sudan I (HY-D0024) with Ovalbumin (OVA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt the main epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
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- HY-N5196
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Nocathiacine I
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Bacterial
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Infection
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Nocathiacin I (Nocathiacine I) is highly resistant to Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multidrug resistant Enterococcus faecalis (MREF) .
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- HY-P1768
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Uru-TK I
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Bacterial
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Infection
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Urechistachykinin I (Uru-TK I), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .
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- HY-NP0168
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UEA I (Agarose)
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Fluorescent Dye
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Others
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Ulex Europaeus Agglutinin I (UEA I) Agarose is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) Agarose is a biological material or organic compound that can be used in life science research .
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- HY-NP0190
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UEA I (Biotinylated)
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Fluorescent Dye
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Others
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Ulex Europaeus Agglutinin I (UEA I) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) Biotinylated is a biological material or organic compound that can be used in life science research .
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- HY-NP0157
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RCA I (Rhodamine)
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Fluorescent Dye
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Others
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Ricinus Communis Agglutinin I (RCA I) Rhodamine is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ricinus Communis Agglutinin I (RCA I) Rhodamine is a biological material or organic compound that can be used in life science research .
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- HY-NP0172
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RCA I (Agarose)
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Fluorescent Dye
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Others
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Ricinus Communis Agglutinin I (RCA I) Agarose is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ricinus Communis Agglutinin I (RCA I) Agarose is a biological material or organic compound that can be used in life science research .
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- HY-NP0145
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UEA I (Fluorescein)
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Fluorescent Dye
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Others
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Ulex Europaeus Agglutinin I (UEA I) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) Fluorescein is a biological material or organic compound that can be used in life science research .
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- HY-NP0137
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MAL I (Fluorescein)
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Fluorescent Dye
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Others
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Maackia Amurensis Lectin I (MAL I) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Maackia Amurensis Lectin I (MAL I) Fluorescein is a biological material or organic compound that can be used in life science research .
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- HY-NP0186
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RCA I (Biotinylated)
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Fluorescent Dye
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Others
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Ricinus Communis Agglutinin I (RCA I) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ricinus Communis Agglutinin I (RCA I) Biotinylated is a biological material or organic compound that can be used in life science research .
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- HY-NP0141
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RCA I (Fluorescein)
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Fluorescent Dye
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Others
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Ricinus Communis Agglutinin I (RCA I) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ricinus Communis Agglutinin I (RCA I) Fluorescein is a biological material or organic compound that can be used in life science research .
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- HY-NP0158
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UEA I (Rhodamine)
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Fluorescent Dye
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Others
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Ulex Europaeus Agglutinin I (UEA I) Rhodamine is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) Rhodamine is a biological material or organic compound that can be used in life science research .
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- HY-N0407R
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STAT
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Inflammation/Immunology
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Picroside I (Standard) is the analytical standard of Picroside I. This product is intended for research and analytical applications. Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
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- HY-NP090A
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UEA I (peroxidase)
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Biochemical Assay Reagents
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Others
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Ulex Europaeus Agglutinin I (peroxidase) (UEA I (peroxidase)) has anti-H blood group specificity. Ulex Europaeus Agglutinin I (peroxidase) has an affinity for L-fucose .
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- HY-N1628
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1-Hydroxybaccatin I
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Others
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Others
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1β-Hydroxybaccatin I (1-Hydroxybaccatin I) can be extracted from Taxus wallichiana .
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- HY-157034
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Proteasome
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Others
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LU-002i is a subunit-selective human proteasome β2c and β2i inhibitor with an IC50 value of 220 nM for β2i .
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- HY-161545
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Biochemical Assay Reagents
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Inflammation/Immunology
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Sudan I/BSA is the antigen-adjuvant conjugate formed by Sudan I (HY-D0024) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
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- HY-161584
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Biochemical Assay Reagents
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Inflammation/Immunology
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Sudan I/KLH is an antigen-adjuvant conjugate formed by the coupling of Sudan I (HY-D0024) with Keyhole Limpet Hemocyanin (KLH). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
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- HY-N11430
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|
|
HIV
|
Infection
|
|
F1839-I is a compound that can be isolated from Stachybotrys. F1839-I has weak cytotoxicity and anti-HIV activity with an IC50 value of 15.6 μM .
|
-
- HY-N10076
-
-
- HY-117793
-
-
- HY-N14084
-
-
- HY-N11455
-
|
LDFH I
|
Others
|
Metabolic Disease
|
|
Lacto-N-difucohexaose I (LNDFH I), a linker, could be used to combine oligosaccharides containing Lewis b sugar chain to water insoluble polysaccharide .
|
-
- HY-153365
-
|
|
Deubiquitinase
|
Cancer
|
|
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells .
|
-
- HY-N7141R
-
|
|
Antibiotic
Parasite
Bacterial
|
Infection
|
|
Spiramycin I (Standard) is the analytical standard of Spiramycin I. This product is intended for research and analytical applications. Spiramycin I is a macrolide antibiotic and antiparasitic .
|
-
- HY-N3340
-
|
|
Fungal
|
Infection
|
|
Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC50 value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni .
|
-
- HY-162342
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I inhibitor 14 (Compound 4h) is an inhibitor for Topoisomerase I. Topoisomerase I inhibitor 14 inhibits proliferation of A549 and C6 with IC50s of 4.56 μM and 13.17 μM, without significant toxicity in healthy cells NIH3T3 (IC50 is 74.44 μM), which exhibits anticancer potency .
|
-
- HY-N15386
-
|
|
Drug Intermediate
|
Neurological Disease
|
|
Hericenone I (Compound 24) is an aromatic compound, which is found in Hericium erinaceum. Hericenone I can be biosynthetically generated from hericenone A via acid-catalyzed cyclization. Hericenone I is promising for research of neurodegenerative diseases .
|
-
- HY-N8511
-
|
|
Fungal
|
Infection
|
|
Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew .
|
-
- HY-B1411R
-
|
|
Endogenous Metabolite
|
Others
|
|
i-Inositol (Standard) is the analytical standard of i-Inositol. This product is intended for research and analytical applications. i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role .
|
-
- HY-143402
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I/II inhibitor 2 (compound 1a) is a potent Topoisomerase inhibitor (IC50= 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells). Topoisomerase I/II inhibitor 2 has dual inhibition on DNA topoisomerase I/II, also can obviously reduce the growth of xenograft tumor in mice model. Topoisomerase I/II inhibitor 2 has the potential value in researching liver cancer .
|
-
- HY-N0612R
-
|
|
Others
|
Inflammation/Immunology
|
|
Siamenoside I (Standard) is the analytical standard of Siamenoside I. This product is intended for research and analytical applications. Siamenoside I is one of the mogrosides that has several kinds of bioactivities.
|
-
- HY-N8293
-
|
|
Others
|
Cancer
|
|
Eupalinolide I inhibits the viability of breast cancer cells. Eupalinolide I can be isolated from Eupatorium lindleyanum .
|
-
- HY-120860
-
|
|
Others
|
|
|
Sporidesmolide I can be found in Sporidesmium bakeri. Sporidesmolide I is promising for research into diseases such as mammalian facial eczema .
|
-
- HY-148016
-
|
|
Protease Activated Receptor (PAR)
ERK
|
Inflammation/Immunology
|
|
I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research .
|
-
- HY-N0331
-
|
|
MDM-2/p53
Apoptosis
|
Cancer
|
|
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .
|
-
- HY-163106
-
|
|
Ceramidase
|
Cancer
|
|
W000113414_I13 is an acid ceramidase (AC) inhibitor. W000113414_I13 exhibits dose-dependent inhibition of AC with an IC50 value of 6.6?μM. W000113414_I13 can be used for the research of cancer .
|
-
- HY-170883
-
|
|
Photosensitizer
|
Cancer
|
|
Type-I/-II Photosensitizer-1 (compound 8b) is a photosensitizer with anticancer activity. Type-I/-II Photosensitizer-1 exhibits significant phototoxicity against both A549 and 4T1 tumor cells. Type-I/-II Photosensitizer-1 shows a strong oxygen-independent antitumor effect under laser irradiation (IC50=1.50-1.76 μM) .
|
-
- HY-P3053
-
|
|
GCGR
|
Cardiovascular Disease
|
|
Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum .
|
-
- HY-N12127
-
|
|
Others
|
Others
|
|
Gymnoside I (compound 1) is a glycosidoxybenzyl 2-isobutylmalic acid. Gymnoside I shows antiallergic activity in passive cutaneous allergic reaction (PCA) in mice. Gymnoside I can be used in research to treat asthma, neurasthenia and chronic hepatitis .
|
-
- HY-NP0155
-
|
GSL I (Rhodamine)
|
Fluorescent Dye
|
Others
|
|
Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) Rhodamine is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) Rhodamine is a biological material or organic compound that can be used in life science research .
|
-
- HY-NP0131
-
|
GSL I (Fluorescein)
|
Fluorescent Dye
|
Others
|
|
Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Griffonia (Bandeiraea) Simplicifolia Lectin I (GSL I) Fluorescein is a biological material or organic compound that can be used in life science research .
|
-
- HY-N0331R
-
|
|
MDM-2/p53
Apoptosis
|
Cancer
|
|
Ziyuglycoside I (Standard) is the analytical standard of Ziyuglycoside I. This product is intended for research and analytical applications. Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .
|
-
- HY-145840
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC50 0.21 µM for the Pol I large catalytic subunit RPA194 .
|
-
- HY-110078
-
|
|
p97
Apoptosis
|
Cancer
|
|
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
|
-
- HY-W019806
-
|
LNFP I
|
Endogenous Metabolite
CDK
Reactive Oxygen Species (ROS)
Apoptosis
Enterovirus
Bacterial
|
Infection
Inflammation/Immunology
|
|
Lacto-N-fucopentaose I (LNFPI) is a human milk oligosaccharide (HMO), possessing antiviral and antibacterial activity. Lacto-N-fucopentaose I can reduce capsid protein VP1 to block virus adsorption, promote CDK2 and reduce cyclin E to recover cell cycle S phase block. Lacto-N-fucopentaose I inhibits ROS production and apoptosis in virus-infected cells. Lacto-N-fucopentaose I can also regulate intestinal microbiota to affect immune system development .
|
-
- HY-N8614
-
|
|
Others
|
Others
|
|
Peucedanocoumarin I (compound 1) is a kind of dihydropyranocoumarin. Peucedanocoumarin I can be isolated from the root of f Peucedanum praeruptorum .
|
-
- HY-N12718
-
|
|
Others
|
Others
|
|
Campneoside I is a bitter phenyl propanoid glycoside. Campneoside I can be isolated from the roots of Incarvillea compacta .
|
-
- HY-N7218
-
-
- HY-P3055A
-
|
DTX-I TFA
|
Potassium Channel
|
Cancer
|
|
Dendrotoxin-I (DTX-I) TFA is a potent K + channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6. Dendrotoxin-I TFA, a neurotoxin, has the potential for cancer research .
|
-
- HY-148092
-
|
|
STAT
|
Inflammation/Immunology
Cancer
|
|
PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research [1].
|
-
- HY-P1777
-
|
Insulin-like Growth Factor I (24-41)
|
IGF-1R
|
Metabolic Disease
Inflammation/Immunology
|
|
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development .
|
-
- HY-112134A
-
|
|
AP-1
|
Cancer
|
|
(R)-CSN5i-3 is the (R)-enantiomer of CSN5i-3. CSN5i-3 is a potent, selective and orally available inhibitor of CSN5 .
|
-
- HY-N0432R
-
|
|
Wnt
β-catenin
|
Metabolic Disease
|
Astragaloside I (Standard) is the analytical standard of Astragaloside I. This product is intended for research and analytical applications. Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .
|
-
- HY-N7022R
-
|
|
Others
|
Cancer
|
|
Eclalbasaponin I (Standard) is the analytical standard of Eclalbasaponin I. This product is intended for research and analytical applications. Eclalbasaponin I is isolated from Eclipta prostrata L with antitumor activity. Eclalbasaponin I inhibits the proliferation of hepatoma cell smmc-7721 with an IC50 value of 111.1703 μg/ml .
|
-
- HY-N15368
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Pradimicinone I (Compound 10), a Pradimicin A (HY-132191) analog, is an antibiotic. Pradimicinone I is promising for research of antibacterial agents .
|
-
- HY-170994
-
|
|
Imidazoline Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
I2-IRs ligand-1 (Compound 12d) is an orally active and BBB-penetrable compound. I2-IRs ligand-1 has a high affinity for imidazoline I2 receptors (I2-IRs) (pKi: 9.98). I2-IRs ligand-1 can improve cognitive impairment in senescent mice and exhibits analgesic, anti-inflammatory, and neuroprotective activities. I2-IRs ligand-1 can be used for the research of Alzheimer's disease and related pain disorders .
|
-
- HY-N2013
-
|
Aristololactam; Aristolactam
|
Drug Metabolite
Aquaporin
Cadherin
TGF-beta/Smad
|
Endocrinology
Cancer
|
|
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis .
|
-
- HY-162433
-
-
- HY-122530
-
|
|
Insecticide
|
Endocrinology
|
|
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .
|
-
- HY-162434
-
-
- HY-N0360R
-
|
|
SARS-CoV
|
Cardiovascular Disease
|
|
Dihydrotanshinone I (Standard) is the analytical standard of Dihydrotanshinone I. This product is intended for research and analytical applications. Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.
|
-
- HY-120723
-
-
- HY-157034A
-
|
|
Proteasome
|
Others
|
|
LU-002i TFA is a subunit-selective human proteasome β2c and β2i inhibitor with an IC50 value of 220 nM for β2i .
|
-
- HY-N10414R
-
|
|
Insecticide
|
Others
|
|
Primulic acid I (Standard) is the analytical standard of Primulic acid I. This product is intended for research and analytical applications. Primulic acid I (Primulasaponin 1) is a plant-derived triterpenoid saponin with one sugar chain (monodesmoid) .
|
-
- HY-111237
-
|
Olomoucin
|
CDK
NF-κB
PERK
Bcl-2 Family
Reactive Oxygen Species (ROS)
Apoptosis
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Butyrolactone I is an orally active and ATP-competitive inhibitor of CDK1. Butyrolactone I inhibits NF-κB, cdc2 kinase, Bax, ROS production, modulates the PERK/CHOP. Butyrolactone I mitigates heat-stress-induced Apoptosis. Butyrolactone I shows anti-inflammatory and intestinal protective activity. Butyrolactone I has antitumor effects against non-small cell lung, small cell lung, prostate cancer and leukemia. Butyrolactone I can be used in NASH research .
|
-
- HY-115735
-
|
|
SphK
Apoptosis
|
Cancer
|
|
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines .
|
-
- HY-126476
-
|
|
Others
|
Others
|
|
Justicisaponin I can be used as an anti-fertility agent. Justicisaponin I stabilizes the acrosome membrane of sperm, and inhibits the release of acid hydrolase and sperm proteins .
|
-
- HY-N15545
-
|
|
Drug Derivative
|
Neurological Disease
|
|
Thaigranatumin I is a limonoid compound found in the seeds of the Thai mangrove (Xylocarpus granatum). Thaigranatumin I is promising for research of neurodegenerative diseases such as Parkinson's diseases .
|
-
- HY-148093
-
|
|
STAT
|
Inflammation/Immunology
Cancer
|
|
PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer [1].
|
-
- HY-148732
-
-
- HY-N1939R
-
|
|
Others
|
Others
|
|
Icariside I (Standard) is the analytical standard of Icariside I. This product is intended for research and analytical applications. Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.
|
-
- HY-162041
-
|
|
Survivin
|
Cancer
|
|
AQIM-I is an inhibitor of survivin via inhibits survivin expression and colony formation. AQIM-I induces ROS production, apoptosis, cell cycle arrest, DNA damage, and autophagy. AQIM-I inhibits nonsmall cell lung cancer cells A549 with an IC50 value of 9 nM .
|
-
- HY-107588
-
TC-I 15
1 Publications Verification
|
Integrin
|
Cardiovascular Disease
|
|
TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .
|
-
- HY-P2632
-
|
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
RAD16-I, a soft nanofibrous self-assembling peptide, is a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes . RAD16-I is a well-studied ionic complementary peptide was used as a model to check potential amyloid-like staining properties of SAPNFs .
|
-
- HY-N8355
-
|
|
Endogenous Metabolite
|
Infection
|
|
Beauveriolide I is the metabolite of Entomopathogenic Fungi Beauveria sp.. Beauveriolide I (1) exhibits moderate insecticidal activities against Spodoptera litura and Callosobruchus chinensis .
|
-
- HY-N0047R
-
|
|
JNK
mTOR
Akt
PDK-1
Autophagy
Apoptosis
|
Cancer
|
|
Polyphyllin I (Standard) is the analytical standard of Polyphyllin I. This product is intended for research and analytical applications. Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
|
-
- HY-161909
-
-
- HY-P1773
-
|
Insulin-like Growth Factor I (30-41)
|
Insulin Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions) .
|
-
- HY-N0407
-
|
6'-Cinnamoylcatalpol
|
STAT
|
Inflammation/Immunology
|
|
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
|
-
- HY-N7052
-
|
|
ADC Cytotoxin
Microtubule/Tubulin
|
Cancer
|
|
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .
|
-
- HY-164512
-
|
|
Drug Intermediate
|
Neurological Disease
|
|
NRMA-I is the amide produrg of the small molecule nuclear receptor modulator. NRMA-I exhibits a higher exposure in the brain, indicating that a good blood-brain barrier (BBB) penetration. NRMA-I can be used for research of central nervous system diseases related to nuclear receptors, such as Alzheimer's disease and Parkinson's disease .
|
-
- HY-W013508
-
|
|
Biochemical Assay Reagents
|
Others
|
|
I2959 is widely used as a photoinitiator for photochemical cross-linking of hydrogels, and the combination of I2959 and CMA hydrogel has been used as a bio-ink for biological 3D printing applications. In addition, I2959 has a high free radical generation efficiency and is cytotoxic to rapidly dividing cell lines .
|
-
- HY-P3545
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone .
|
-
- HY-135137
-
|
|
Others
|
Cancer
|
|
Leptosin I is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin I inhibits Leukemia lymphocyte P388 in culture with an ED50 of 1.13 μg/mL .
|
-
- HY-W194810
-
|
|
Mitochondrial Metabolism
Calcium Channel
|
Neurological Disease
Cancer
|
|
MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca 2+ uptake. MCU-i11 impairs muscle cell growth. MCU-i11 can be used to study breast cancer, cervical cancer and neurological diseases .
|
-
- HY-116431
-
|
|
Prostaglandin Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle . I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons .
|
-
- HY-100838A
-
|
|
mGluR
|
Metabolic Disease
|
|
L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for mGluR2 with an EC50 value of 0.3 nM. L-CCG-I can be used for the research of mGluR family .
|
-
- HY-N0887
-
|
Isoastragaloside-I
|
Others
|
Metabolic Disease
|
|
Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.
|
-
- HY-N1939
-
|
Icarisid I
|
Others
|
Others
|
|
Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.
|
-
- HY-N12719
-
|
|
Others
|
Others
|
|
Isocampneoside I is an acylated phenethyl oligosaccharide that can be isolated from Cistanche deserticola (Orobanchaceae). Isocampneoside I inhibits D-galactose-induced cytotoxicity and protects primary hepatocytes in mice .
|
-
- HY-N7022
-
|
|
Others
|
Cancer
|
|
Eclalbasaponin I is isolated from Eclipta prostrata L with antitumor activity. Eclalbasaponin I inhibits the proliferation of hepatoma cell smmc-7721 with an IC50 value of 111.1703 μg/ml .
|
-
- HY-N4246R
-
|
|
Others
|
Neurological Disease
|
|
Bacopaside I (Standard) is the analytical standard of Bacopaside I. This product is intended for research and analytical applications. Bacopaside I, a saponin isolated from Bacopa monnieri, exbibits antioxidant properties and free radical scavenging capacity and exerts antidepressant-like effect .
|
-
- HY-P10282
-
|
|
CaMK
|
Neurological Disease
|
|
Synapsin I-(3-13), a substrate for CaMK1, is a glycoprotein. Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals .
|
-
- HY-P5156
-
|
|
Potassium Channel
|
Neurological Disease
|
|
BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death .
|
-
- HY-N13615
-
-
- HY-N7299
-
-
- HY-129475
-
-
- HY-N9669
-
-
- HY-N7580
-
-
- HY-N9581
-
-
- HY-N13601
-
-
- HY-113791
-
-
- HY-N13587
-
-
- HY-N13651
-
-
- HY-N6592
-
-
- HY-N3071
-
|
|
Apoptosis
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1 .
|
-
- HY-N0047
-
|
|
JNK
mTOR
Akt
PDK-1
Autophagy
Apoptosis
|
Cancer
|
|
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
|
-
- HY-P1777A
-
|
Insulin-like Growth Factor I (24-41) (TFA)
|
IGF-1R
|
Metabolic Disease
Inflammation/Immunology
|
|
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) TFA is amino acids 24 to 41 fragment of IGF-I. IGF-I TFA, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I TFA is partly responsible for systemic growth hormone (GH) activities. IGF-I TFA has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) TFA regulates somatic growth and behavioral development .
|
-
- HY-15167
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research .
|
-
- HY-172675
-
-
- HY-129738
-
|
|
Ras
|
Cardiovascular Disease
|
|
I942 is a first in class, selective non-cyclic nucleotide (NCN) EPAC1 agonist. I942 can attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases .
|
-
- HY-145859
-
-
- HY-156112
-
|
|
Ser/Thr Protease
|
Cancer
|
|
LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway .
|
-
- HY-N1235
-
|
Panicolin
|
Elastase
MicroRNA
|
Cancer
|
|
Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a .
|
-
- HY-125930A
-
|
|
Topoisomerase
DNA/RNA Synthesis
|
Cancer
|
|
T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .
|
-
- HY-125930
-
|
|
Topoisomerase
DNA/RNA Synthesis
|
Cancer
|
|
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .
|
-
- HY-N0360
-
|
|
SARS-CoV
|
Cardiovascular Disease
|
|
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.
|
-
- HY-N0011R
-
|
|
CXCR
Apoptosis
|
Inflammation/Immunology
Endocrinology
Cancer
|
|
Baohuoside I (Standard) is the analytical standard of Baohuoside I. This product is intended for research and analytical applications. Baohuoside I, a flavonoid isolated from Epimedium koreanum Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 expression, induces apoptosis and shows anti-tumor activity.
|
-
- HY-N0201R
-
|
|
TNF Receptor
Toll-like Receptor (TLR)
JAK
STAT
|
Cancer
|
|
Atractylenolide I (Standard) is the analytical standard of Atractylenolide I. This product is intended for research and analytical applications. Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
|
-
- HY-N7141
-
-
- HY-N0134R
-
|
|
Phospholipase
|
Cardiovascular Disease
Cancer
|
|
Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
|
-
- HY-118044
-
|
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC) .
|
-
- HY-N12336
-
|
|
Others
|
Metabolic Disease
|
|
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC50=2.63 μM) .
|
-
- HY-N3921
-
|
|
Carboxylesterase (CES)
|
Cancer
|
|
Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC50 of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .
|
-
- HY-N1085
-
|
|
Others
|
Others
|
|
Viscidulin I is found in Scutellaria baicalensis Georgi .
|
-
- HY-N2999
-
|
|
Others
|
Others
|
|
Ganoderic acid I is a triterpenoid found in ganoderma lucidum .
|
-
- HY-158372
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
hCA I-IN-3 (compound 24), an aryl ether derivative, is a potent carbonic anhydrase inhibitor. hCA I-IN-3 can inhibit carbonic anhydrase hCA I and hCA II isoenzymes, with IC50 values of 4.77 and 9.66 nM, respectively. hCA I-IN-3 can be used for cancer research .
|
-
- HY-158991
-
|
|
CFTR
|
Inflammation/Immunology
|
|
I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency, with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor (HY-111772) to enhance CFTR currents .
|
-
- HY-147649
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor 7 (Compound 6) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 3.65 μM. Glyoxalase I inhibitor 7 can be used as anticancer agent .
|
-
- HY-P1773A
-
|
Insulin-like Growth Factor I (30-41) (TFA)
|
IGF-1R
|
Metabolic Disease
Inflammation/Immunology
|
|
IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions) .
|
-
- HY-119016
-
SK1-I
1 Publications Verification
BML-258
|
SphK
|
Cancer
|
|
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 μM . SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity .
|
-
- HY-164410
-
|
|
Notch
|
Cancer
|
|
MO-I-1100 is an inhibitor of ASPH (Aspartyl-(Asparaginyl)-β-hydroxylase) enzymatic activity. MO-I-1100 suppresses HCC cell migration, invasion and anchorage independent growth. MO-I-1100 shows antitumor effects through inhibiting Notch signaling cascade in HCC .
|
-
- HY-147647
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor 5 (Compound 9h) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.28 μM. Glyoxalase I inhibitor 5 can be used as anticancer agent .
|
-
- HY-138237
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
25I-NBMD hydrochloride is a derivative of the phenethylamine 2C-I that increases the affinity and activity at the 5-HT2A receptor .
|
-
- HY-N11475
-
|
|
Others
|
Others
|
|
Selaginellin I can be isolated from Selaginella tamariscina (Beauv.) . Selaginellin I is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-B0175
-
-
- HY-N11461
-
|
Lacto-N-neo-difucohexaose I
|
Others
|
Others
|
|
LNnDFH I is a natural product that can be isolated from human urine .
|
-
- HY-107202A
-
|
|
Toll-like Receptor (TLR)
PKD
HSP
Bcl-2 Family
Interleukin Related
|
Infection
Inflammation/Immunology
Cancer
|
|
Poly(I:C):Kanamycin (1:1) is a mixture of Poly(I:C) (HY-107202) and Kanamycin (HY-16566). Poly(I:C) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Poly(I:C) can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Poly(I:C) can directly trigger cancer cells to undergo apoptosis. Kanamycin stabilizes Poly(I:C) .
|
-
- HY-N8183
-
|
|
Others
|
Others
|
|
Shancigusin I is a natural compound found in Cremastra appendiculata .
|
-
- HY-107284
-
|
|
Others
|
Others
|
|
Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.
|
-
- HY-N0612
-
-
- HY-N3030
-
-
- HY-158246
-
|
|
Acetyl-CoA Carboxylase
|
Others
|
|
QPP-I-6 is an inhibitor for acetyl-coenzyme A carboxylase (ACCase). QPP-I-6 exhibits herbicidal activity through induction of cell membrane permeability .
|
-
- HY-P1032
-
-
- HY-W890109S
-
-
- HY-E70282
-
|
rEGCase I assisted by activator II
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Recombinant endoglycoceramidase I assisted by activator II (rEGCase I assisted by Activator II) is a mixture-form of EGCase I and Activator II. EGCase I is a glycolipid-specific hydrolase that well-suited to a comprehensive analysis of glycosphingolipids (GSLs). Activator II is capable of inducing activity of EGCase without any detergent reagents .
|
-
- HY-147648
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor 6 (Compound 9j) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.13 μM. Glyoxalase I inhibitor 6 can be used as anticancer agent with low toxicity .
|
-
- HY-141881
-
|
|
PROTACs
Apoptosis
SF3B1
|
Cancer
|
|
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells .
|
-
- HY-P1632
-
|
|
Bacterial
|
Infection
Cancer
|
|
Tachyplesin I is a β-hairpin antimicrobial peptide that contains 17 amino acid residues. Tachyplesin I exhibits cytotoxic properties against various human tumor cell lines acting primarily by impairing the integrity of the outer cell membrane .
|
-
- HY-P1631
-
|
|
Bacterial
|
Infection
|
|
Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges .
|
-
- HY-144061
-
|
|
SARS-CoV
|
Infection
|
|
INSCoV-601I(1) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-601I(1) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
|
-
- HY-N2466A
-
|
MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate
|
Melanocortin Receptor
|
Cancer
|
|
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research .
|
-
- HY-110199
-
|
|
TRP Channel
|
Neurological Disease
|
|
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models .
|
-
- HY-118009
-
-
- HY-NP150
-
|
MAL I (Biotinylated)
|
Fluorescent Dye
|
Others
|
|
Maackia Amurensis Lectin I Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.). Maackia Amurensis Lectin I Biotinylated is a biological material or organic compound that can be used in life science research .
|
-
- HY-NP151
-
|
GSL I (Biotinylated)
|
Fluorescent Dye
|
Others
|
|
Griffonia Simplicifolia Lectin I Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.). Griffonia Simplicifolia Lectin I Biotinylated is a biological material or organic compound that can be used in life science research .
|
-
- HY-P1806
-
-
- HY-N6579
-
|
|
Others
|
Cancer
|
|
Arvenin I is a natural cucurbitacin glucoside with moderate anticancer effects .
|
-
- HY-N9847
-
-
- HY-N12712
-
|
|
Others
|
Others
|
|
Heteroclitin I is an active product that can be isolated Kadsura heteroclita .
|
-
- HY-76293
-
I2906
1 Publications Verification
|
Bacterial
|
Infection
|
|
I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.
|
-
- HY-116931
-
|
|
Others
|
Others
|
|
Kelletinin I is a coumarin compound with anti-HIV-1 activity.
|
-
- HY-N8694
-
|
|
Others
|
Others
|
|
Obtusafuran methyl ether is a Lignans product that can be isolated from the herbs of Dalbergia odorifera .
|
-
- HY-P3199
-
|
|
PKC
|
Inflammation/Immunology
|
|
PKCβII Peptide Inhibitor I is a PKCβII inhibitor. PKCβII Peptide Inhibitor I shows cardioprotective effects in rat cardiac Ischemia/reperfusion injury model. PKCβII Peptide Inhibitor I also prevents vascular endothelial dysfunction .
|
-
- HY-D1148
-
|
|
Fluorescent Dye
|
Others
|
|
HKGreen-4I is a highly sensitive green fluorescent probe for the specific detection of ONOO - in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .
|
-
- HY-N12200
-
|
|
Others
|
Cancer
|
|
Mollicellin I (compound 1) is a depsidone. The growth inhibitory activity of Mollicellin I on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines is not significant, with GI50s >10 μg/mL .
|
-
- HY-N2013R
-
|
Aristololactam (Standard); Aristolactam (Standard)
|
Caspase
Apoptosis
|
Inflammation/Immunology
|
|
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis .
|
-
- HY-155528
-
|
|
Others
|
Others
|
|
O4I4 (compound 23) is a OCT4-inducing compound with metabolical stability. O4I4 extends lifespan in Caenorhabditis elegans and Drosophila. O4I4 can be used for regenerative medicine and rejuvenation research .
|
-
- HY-135680
-
|
I-OMe-AG 538
|
IGF-1R
|
Metabolic Disease
Cancer
|
|
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM .
|
-
- HY-N2466
-
|
MT-I; [Nle4,D-Phe7]-α-MSH
|
Melanocortin Receptor
|
Neurological Disease
Cancer
|
|
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction .
|
-
- HY-115431
-
|
|
Aminopeptidase
|
Neurological Disease
|
|
Antho-rwamide I is a neuropeptide that can be isolated from the sea anemone Anthopleura elegantissima. Antho-rwamide I is resistant to nonspecific aminopeptidases, which increases the stability of the peptide after neuronal release .
|
-
- HY-D1116
-
|
|
Fluorescent Dye
|
Others
|
|
MitoMark Red I is a fluorescent mitochondrial marker. MitoMark Red I is a red fluorescent dye which accumulates in mitochondria in viable cells and has an excitation wavelength of 578 nm and emission of 599 nm .
|
-
- HY-165065
-
-
- HY-N12570
-
|
|
NO Synthase
|
Others
|
|
Isoarundinin I is a stilbene compound that can be isolated from Arundinu bambusifolia .
|
-
- HY-N2286
-
-
- HY-N4224
-
|
|
Others
|
Others
|
|
Neoastragaloside I (Compound 20) is a compound that can be isolated from Radix Astragali.
|
-
- HY-N8042
-
|
|
Others
|
Others
|
|
Erigeside I is a free radical scavenger isolated from Erigeron breviscapus .
|
-
- HY-125684
-
-
- HY-N8998
-
|
|
Others
|
Others
|
|
Sophoraflavanone I the seeds of Sophora moorcroftiana BENTH. ex. BAKER (Leguminosae) .
|
-
- HY-N12148
-
|
|
Others
|
Others
|
|
Macrostemonoside I is a furostanol saponin that can be isolated from Allium macrostemon .
|
-
- HY-N5082
-
|
|
Others
|
Others
|
|
Homodihydrocapsaicin I is a kind of capsaicinoid from the fruits of Capsicum annuum .
|
-
- HY-172006
-
-
- HY-N11974
-
|
|
Others
|
Others
|
|
Isobatatasin I is a phenanthrene derivative that can be isolated from the rhizome of safflower .
|
-
- HY-N5095
-
|
|
Others
|
Metabolic Disease
|
|
Eupteleasaponin I is a component of Euptelea polyandra, may has gastroprotective activity .
|
-
- HY-N11450
-
|
|
Others
|
Others
|
|
Complanatin I is a natural product that can be isolated from Astragalus complanatus .
|
-
- HY-44157
-
|
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
ALS-I, an acid-Liable surfactant, is adopted for in-solution enzymatic digestions, can help to solubilize hydrophobic proteins. ALS-I is significantly enhanced peptide recovery for mass spectrometry (MS) mapping in the study of the proteomes of regenerating rat retina and mouse brain .
|
-
- HY-W653982
-
-
- HY-168091
-
|
|
NOD-like Receptor (NLR)
Interleukin Related
|
Inflammation/Immunology
|
|
YM-I-26 is a selective NLRP3 inflammasome inhibitor. YM-I-26 enhances the phagocytosis of β-amyloid protein by mouse microglial BV2 cells and inhibits the production of IL-1β and IL-10. YM-I-26 can be used to study the immunomodulatory activity associated with inflammation .
|
-
- HY-151894
-
|
|
Epigenetic Reader Domain
|
Cancer
|
|
I-BET432 is a BET inhibitor. I-BET432 inhibits BRD4 N-terminal bromodomain (BD1) and the C-terminal bromodomain (BD2) with pIC50 values of 7.5 and 7.2, respectively. I-BET432 can be used as an oral candidate quality molecule for the research of multiple oncology and inflammatory diseases .
|
-
- HY-168428
-
|
|
Histone Acetyltransferase
Apoptosis
|
Cancer
|
|
CHI-KAT8i5 is a selective and orally active KAT8 inhibitor with a KD value of 19.72 μM. CHI-KAT8i5 does not bind to other proteins in HAT family (KAT2A, KAT2B, KAT5, and KAT7). CHI-KAT8i5 induces cancer cell apoptosis. CHI-KAT8i5 suppresses esophageal squamous cell carcinoma (ESCC) growth through targeting KAT8/c-Myc signaling pathway .
|
-
- HY-P3934
-
|
|
HIV Protease
|
Infection
|
|
HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease .
|
-
- HY-148058
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells .
|
-
- HY-163200
-
|
|
Cuproptosis
|
Neurological Disease
|
|
Cu(I) chelator 1 (Compound LH2) is a chelator which targets the Cu(I) redox state. Cu(I) chelator 1 prevents ROS production .
|
-
- HY-119195
-
-
- HY-131318
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609) .
|
-
- HY-NP0178
-
|
GSL I-B4 (Biotinylated)
|
Fluorescent Dye
|
Others
|
|
Griffonia Simplicifolia Lectin I Isolectin B4 (GSL I-B4) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Griffonia Simplicifolia Lectin I Isolectin B4 (GSL I-B4) Biotinylated is a biological material or organic compound that can be used in life science research .
|
-
- HY-P2200
-
|
BMY-29304
|
HIV
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .
|
-
- HY-146180
-
|
|
FAP
|
Cancer
|
|
FSDD0I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD0I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging .
|
-
- HY-146181
-
|
|
FAP
|
Cancer
|
|
FSDD1I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD1I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging .
|
-
- HY-146182
-
|
|
FAP
|
Cancer
|
|
FSDD3I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD3I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging .
|
-
- HY-N7304
-
|
|
Others
|
Others
|
|
Jatrophane I is a Diterpenoids product that can be isolated from the herbs of Euphorbia peplus .
|
-
- HY-N4213
-
|
|
Others
|
Cardiovascular Disease
|
|
Anemarrhenasaponin I, a traditional Chinese medicine, shows remarkable inhibiting effect on platelet aggregation.
|
-
- HY-N3790
-
|
|
Others
|
Others
|
|
Durantoside I is a natural product, that can be isolated from the stems of Duranta erecta .
|
-
- HY-N3689
-
|
|
Others
|
Others
|
|
Daturametelin I is a Steroids product that can be isolated from the herbs of Datura tatura. .
|
-
- HY-N3983
-
|
|
Others
|
Others
|
|
Gynosaponin I (compound 1) is a natural product that can be found in Gynostemma pentaphyllum .
|
-
- HY-N3109
-
|
|
Others
|
Others
|
|
Paniculoside I is a Diterpenoids product that can be isolated from the herbs of Stevia rebaudiana .
|
-
- HY-162783
-
|
|
Histone Methyltransferase
|
Cancer
|
|
AZ-PRMT5i-1 (Compound 28) is an effective and orally active MTAP-selective PRMT5 inhibitor. AZ-PRMT5i-1 also demonstrates MTA cooperativity and exhibits both in vitro and in vivo antitumor activities, and can be used to study MTAP-deficient cancers .
|
-
- HY-P1542
-
|
Catostomus urotensin I
|
CRFR
|
Cardiovascular Disease
Endocrinology
|
|
Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively .
|
-
- HY-149780
-
|
DiNap
|
HSP
|
Cancer
|
|
Flavokawain 1i (DiNap) is an Hsp90 inhibitor. Flavokawain 1i (DiNap) has anti-cell proliferation activity and can be used in cancer research .
|
-
- HY-N0890
-
|
Tubeimoside-1; Lobatoside-H
|
HSP
NF-κB
p38 MAPK
Akt
Autophagy
Interleukin Related
VEGFR
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Tubeimoside I is an orally active HSPD1 inhibitor. Tubeimoside I inhibits NF-κB, MAPK, as well as regulates eNOS-VEGF. Tubeimoside I induces cytoprotective Autophagy via an Akt-mediated pathway. Tubeimoside I inhibits proinflammatory cytokine (IL-6 and IL-1β) production. Tubeimoside I exhibits anti-inflammatory activities. Tubeimoside I promotes angiogenesis and improves sepsis symptoms. Tubeimoside I is used in the research of inflammatory diseases, various cancers, sepsis and ischemic diseases .
|
-
- HY-143266
-
|
|
Topoisomerase
Apoptosis
|
Cancer
|
|
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .
|
-
- HY-128206
-
I3MT-3
5 Publications Verification
HMPSNE
|
Hippo (MST)
|
Metabolic Disease
|
|
I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes.?I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST .
|
-
- HY-P1912
-
|
|
MMP
|
Endocrinology
|
|
Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.
|
-
- HY-D0140
-
|
ETH 5294
|
Fluorescent Dye
|
Others
|
|
Chromoionophore I (ETH 5294) is a hydrophobic pH indicator. Chromoionophore I is used as a transmissive or fluorescent probe molecule in many types of hydrophobic sensor membranes. Chromoionophore I is oil-soluble .
|
-
- HY-N7026
-
|
|
Others
|
Metabolic Disease
|
|
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .
|
-
- HY-148170
-
|
|
EBV
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
|
Infection
|
|
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .
|
-
- HY-169962
-
|
|
Carbonic Anhydrase
Cholinesterase (ChE)
|
Neurological Disease
Cancer
|
|
hCA I-IN-4 (Compound 14) is the inhibitor for carbonic anhydrase and cholinesterase, that inhibits hCA I, hCA II, AChE, and BChE with Ki of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nMrespectively. hCA I-IN-4 exhibits cytotoxicity in BT-549 with IC50 of 16.59 μM .
|
-
- HY-N10048
-
|
|
Others
|
Others
|
|
Agroastragaloside I is a astragaloside, and can be isolated from the hairy root cultures of Astragalus
membranaceus .
|
-
- HY-N12961
-
|
|
Others
|
Others
|
|
Vulgaxanthin I is a yellow phytochrome isolated from the beautiful Japanese Raphanus japonica flower .
|
-
- HY-N6889
-
|
|
Others
|
Others
|
|
Rebaudioside I is a natural non-claoric sweetener isolated from S. rebaudiana Morita .
|
-
- HY-N3645
-
|
|
Others
|
Others
|
|
Cucumegastigmane I is a Sesquiterpenoids product that can be isolated from the fruits of Trichosanthes kirilowii Maxim .
|
-
- HY-N8343
-
-
- HY-N11986
-
|
|
Others
|
Others
|
|
Regaloside I (compound 15) is a phenylpropanoid glycerol glucosides that can be isolated from L. tenuifolium .
|
-
- HY-144774
-
|
|
Topoisomerase
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
Topoisomerase I inhibitor 5 is an effective topoisomerase inhibitor with IC50 value of. Topoisomerase I inhibitor 5 can interfere with DNA and significantly inhibit the activity of Topoisomerase I. Topoisomerase I inhibitor 5 can arrest cell cycle at the G1 phase and induce MCF-7 cells apoptosis. Topoisomerase I inhibitor 5 has potency in reversing P-gp-mediated resistance to Adriamycin .
|
-
- HY-124211S
-
-
- HY-146656
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor 4 (compound 14) is a potent glyoxalase I inhibitor with an Ki of 10 nM .
|
-
- HY-143623S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Neo Spiramycin I-d3 is the deuterium labeled Neo Spiramycin I (HY-143623) . Neo Spiramycin I (NSPI) is the active metabolite of Spiramycin (SPI) with antimicrobial activity. Neo Spiramycin is widely used in veterinary medicine .
|
-
- HY-168603
-
-
- HY-162341
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I inhibitor 15 (compound 4b) is an inhibitor of topoisomerase I with anticancer activity. Topoisomerase I inhibitor 15 inhibits A549 cells with an IC50 of 7.34 μM .
|
-
- HY-161082
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity .
|
-
- HY-N0201
-
|
|
TNF Receptor
Toll-like Receptor (TLR)
JAK
STAT
|
Cancer
|
|
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
|
-
- HY-107300
-
|
Soyasaponin Be methyl ester; DHS-I methyl ester
|
Others
|
Others
|
|
Dehydrosoyasaponin I methyl ester (Soyasaponin Be methyl ester) is a saponin found in Trifolium alexandrinum .
|
-
- HY-P1839
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Angiotensin I/II 1-5 is a peptide that contains the amino acids 1-5, which is converted from Angiotensin I/II. Angiotensin I is formed by the action of renin on angiotensinogen. Angiotensin II is produced from angiotensin I. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy .
|
-
- HY-P2492
-
|
|
Angiotensin Receptor
|
Metabolic Disease
|
|
Renin FRET Substrate I is a substrate of human renin. Renin FRET Substrate I is designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen .
|
-
- HY-P1396
-
-
- HY-NP0132
-
|
GSL I Isolectin B4 (Fluorescein)
|
Fluorescent Dye
|
Others
|
|
Griffonia Simplicifolia Lectin I Isolectin B4 (GSL I Isolectin B4) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Griffonia Simplicifolia Lectin I Isolectin B4 (GSL I Isolectin B4) Fluorescein is a biological material or organic compound that can be used in life science research .
|
-
- HY-NP101
-
|
Bovine Type I collagen, immunization grade
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .
|
-
- HY-146654
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor 2 (compound 26) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.5 µM. Glyoxalase I inhibitor 2 has the potential for the research of depression and anxiety .
|
-
- HY-P1806A
-
-
- HY-N12585
-
|
|
Others
|
Others
|
|
Picfeltarraegenin I (Compound 2) is a cucurbitacin that can be isolated from Picria fel-terrae Lour .
|
-
- HY-N7471
-
|
|
Others
|
Others
|
|
Daphnicyclidin I is a Alkaloids product that can be isolated from the dried stems and leaves of Daphniphyllum longeracemosum. .
|
-
- HY-116189
-
|
|
Others
|
Others
|
|
Julibrine I is a pyridoxine derivative found in the fresh stem bark of Albizzia julibrissin DURAzz, IV .
|
-
- HY-N10414
-
|
Primulasaponin 1; Primula acid I
|
Bacterial
|
Others
|
|
Primulic acid I (Primulasaponin 1) is a plant-derived triterpenoid saponin with one sugar chain (monodesmoid) .
|
-
- HY-146655
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety .
|
-
- HY-N0745
-
|
|
Caspase
|
Inflammation/Immunology
|
|
Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3 .
|
-
- HY-129831
-
-
- HY-19541A
-
|
|
Epigenetic Reader Domain
|
Cancer
|
|
I-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains (Kds = 142 and 625 nM, respectively). I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin .
|
-
- HY-15167A
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor free base (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research .
|
-
- HY-108882A
-
|
|
Endonuclease
|
Others
|
|
Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis .
|
-
- HY-170912
-
|
|
Topoisomerase
Apoptosis
ROS Kinase
Cytochrome P450
Caspase
Bcl-2 Family
PI3K
Akt
mTOR
|
Cancer
|
Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. .
|
-
- HY-P1632A
-
|
|
Bacterial
|
Infection
Cancer
|
|
Tachyplesin I TFA is a β-hairpin antimicrobial peptide that contains 17 amino acid residues. Tachyplesin I TFA exhibits cytotoxic properties against various human tumor cell lines acting primarily by impairing the integrity of the outer cell membrane .
|
-
- HY-NP085
-
|
GSL I Isolectin B4
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
Griffonia Simplicifolia Lectin I Isolectin B4 (GSL I Isolectin B4) is a lectin, that can be isolated from the seeds of Griffonia simplicifolia. Griffonia Simplicifolia Lectin I Isolectin B4 recognizes and binds to carbohydrate structures with the sequence Galα1-4Gal, and can be used in biochemical and immunological .
|
-
- HY-W587414
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Neospiramycin I is a macrolide antibiotic and a derivative of Spiramycin I (HY-N7141). Neospiramycin I is effective against the macrolide-sensitive KB210 strain of S. aureus, but ineffective against the macrolide-resistant KB224 strain, with minimum inhibitory concentrations (MIC) of 3.12 and greater than 100 µg/mL, respectively; it is also effective against B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae, with respective MIC values of 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/mL. Neospiramycin I binds to the ribosomes of E. coli, with an inhibitory concentration 50 (IC50) of 1.2 µM. It protects mice from death in a type III S. pneumoniae infection model, with an effective dose 50 (ED50) of 399.8 mg/kg .
|
-
- HY-N7532
-
|
|
TMV
|
Infection
|
|
Yadanzioside I is a potent anti-tobacco mosaic virus (TMV) quassinoid with an IC50 of 4.22 μM .
|
-
- HY-W073080
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Coproporphyrin I dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127800
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Etioporphyrin I is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-117637
-
|
|
Oxytocin Receptor
|
Neurological Disease
|
|
ALS-I-41 is a novel, potent and selective oxytocin receptor antagonist with the potential to modulate biological activities related to social behavior and mental disorders. ALS-I-41 is being evaluated for behavioral pharmacology experiments in non-human primates and can be administered via intranasal or intramuscular injection. The central nervous system penetration and metabolic rate of ALS-I-41 were studied by mass spectrometry analysis in cerebrospinal fluid and plasma of macaque monkeys .
|
-
- HY-19915
-
|
MRX-I
|
Bacterial
Antibiotic
Monoamine Oxidase
|
Infection
Inflammation/Immunology
|
|
Contezolid (MRX-I), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid (MRX-I) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI) .
|
-
- HY-N15146
-
|
|
Bacterial
|
Infection
|
|
Aralia-saponin I is a saponin that can be isolated from Aralia elata, possessing high binding affinity for aerolysin and capable of binding to amino acids critical for aerolysin function. Aralia-saponin I can be utilized in research on infections caused by Aeromonas hydrophila .
|
-
- HY-P1194
-
|
|
Neurokinin Receptor
|
Inflammation/Immunology
|
|
Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .
|
-
- HY-125733
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively .
|
-
- HY-126618
-
|
|
Tyrosinase
|
Cancer
|
|
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent .
|
-
- HY-112476
-
|
|
Phosphatase
|
Cancer
|
|
PRL-3 Inhibitor I is a potent PRL-3 inhibitor with an IC50 of 0.9 μM. PRL-3 Inhibitor I shows a reduced invasion in cell-based assay .
|
-
- HY-P5282
-
|
|
Acyltransferase
|
Others
|
|
ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) has good lecithin:cholesterol acyl transferase (LCAT) activation potency. ApoA-I mimetic peptide can be used for synthesis of peptide/lipid complex .
|
-
- HY-107400
-
B I09
1 Publications Verification
|
IRE1
|
Cancer
|
|
B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
|
-
- HY-N3249
-
|
|
Others
|
Others
|
|
Momor-cerebroside I is a cerebroside compound isolated from Momordica charantia .
|
-
- HY-124813
-
|
113B7
|
FAK
EGFR
MMP
|
Cancer
|
|
PDZ1i is a potent, BBB-penetrated and specific MDA-9/Syntenin inhibitor. PDZ1i inhibits crucial GBM (glioblastoma multiforme) signaling involving FAK and EGFRvIII. PDZ1i reduces MMP secretion. PDZ1i can improve survival of brain tumor-bearing mice and reduce tumor invasion .
|
-
- HY-135748
-
|
Poly(I:C) sodium
|
Toll-like Receptor (TLR)
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis .
|
-
- HY-107202
-
|
Poly(I:C)
|
Toll-like Receptor (TLR)
PKD
HSP
Bcl-2 Family
Interleukin Related
|
Infection
Inflammation/Immunology
Cancer
|
|
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .
|
-
- HY-134958
-
|
Poly(I:C) potassium
|
Toll-like Receptor (TLR)
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid potassium can directly trigger cancer cells to undergoApoptosis .
|
-
- HY-P1829
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy .
|
-
- HY-B1411
-
|
myo-Inositol; meso-Inositol
|
Endogenous Metabolite
|
Others
|
|
i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role .
|
-
- HY-N15046
-
|
|
Others
|
Cancer
|
|
Barminomycin I shows a strong inhibition of P388 leukemia cells with IC50 of about 0.00001 g/mL .
|
-
- HY-168739
-
|
|
Topoisomerase
Reactive Oxygen Species (ROS)
Apoptosis
Survivin
Bcl-2 Family
IAP
DNA/RNA Synthesis
|
Cancer
|
|
Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, γH2AX). Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice .
|
-
- HY-100341
-
|
|
Checkpoint Kinase (Chk)
|
Others
|
|
M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC) .
|
-
- HY-49457
-
-
- HY-143301
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer .
|
-
- HY-P10599
-
|
|
Neurokinin Receptor
|
Neurological Disease
|
|
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a Ki value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .
|
-
- HY-W127805
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Pentacarboxylporphyrin I dihydrochloride is an organic compound belonging to the family of porphyrin derivatives. It is commonly used in biochemical research as a reference standard for the quantification of porphyrins and related compounds in biological samples. Pentacarboxylporphyrin I dihydrochloride has several applications in the diagnosis and monitoring of porphyrias, a group of inherited disorders characterized by abnormalities in heme metabolism. In addition, it can be used as a photosensitizer in photodynamic therapy for the improvement of cancer and other diseases.
|
-
- HY-P10551
-
|
|
Transmembrane Glycoprotein
NF-κB
TNF Receptor
|
Cardiovascular Disease
|
|
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). Apo A-I mimetic 5A peptide can promote the efflux of cholesterol from cells and help reduce the accumulation of cholesterol in cells. Apo A-I mimetic 5A peptide also shows anti-inflammatory activity and can reduce inflammatory markers in blood and tissues. Apo A-I mimetic 5A peptide can be used in the study of cardiovascular diseases .
|
-
- HY-I0454
-
|
|
Factor Xa
|
Cardiovascular Disease
|
|
Rivaroxaban EP Impurity I is an impurity of Rivaroxaban (HY-50903). Rivaroxaban EP Impurity I can be used to ensure the purity of Rivaroxaban. Rivaroxaban is a highly potent, selective and direct Factor Xa (FXa) inhibitor .
|
-
- HY-W787537
-
|
LBB
|
Biochemical Assay Reagents
|
Others
|
|
Leucoberbelin blue I (LBB) is a leuco base that is oxidized by manganese through a hydrogen atom transfer reaction forming a colored complex. Leucoberbelin blue I can be used to quantify or confirm the Mn (II) oxides formation .
|
-
- HY-18772
-
|
|
Oct3/4
|
Others
|
|
O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1 .
|
-
- HY-18975
-
I-BRD9
5 Publications Verification
|
Epigenetic Reader Domain
|
Inflammation/Immunology
Cancer
|
|
I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways .
|
-
- HY-P1194B
-
-
![[D-Pro2] Spantide I TFA](//file.medchemexpress.com/product_pic/hy-p1194b.gif)
- HY-146504
-
|
|
Topoisomerase
PI3K
Apoptosis
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Topoisomerase I/II inhibitor 3 (compound 7) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 3 can inhibit cell proliferation, invasion and migration, and induce apoptosis by inhibiting PI3K/Akt/mTOR signaling pathway. Topoisomerase I/II inhibitor 3 can be used for liver cancer research .
|
-
- HY-117426
-
|
|
Fat Mass and Obesity-associated Protein (FTO)
|
Cancer
|
|
MO-I-500 is a pharmacological of FTO inhibitor with an IC50 of 8.7 μM for the inhibition of purified FTO demethylase catalyzing demethylation of an artificial small methylated substrate. MO-I-500 can be used for the research of rare panresistant triple-negative inflammatory breast cancer .
|
-
- HY-163729
-
-
- HY-N8331
-
-
- HY-P1839A
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Angiotensin I/II 1-5 TFA is a peptide that contains the amino acids 1-5, which is converted from Angiotensin I/II. Angiotensin I is formed by the action of renin on angiotensinogen. Angiotensin II is produced from angiotensin I. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy .
|
-
- HY-100383
-
|
BHI1
|
Bcl-2 Family
MDM-2/p53
E1/E2/E3 Enzyme
|
Cancer
|
|
BH3I-1 is a Bcl-2 family antagonist, which inhibits the binding of the Bak BH3 peptide to Bcl-xL with a Ki of 2.4±0.2 μM in FP assay. BH3I-1 has a Kd of 5.3 μM against the p53/MDM2 pair.
|
-
- HY-169628
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I/II inhibitor 7 (Compound 5h) is a Topoisomerase I/II inhibitor .
|
-
- HY-152086
-
|
|
Dynamin
|
Cardiovascular Disease
|
|
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .
|
-
- HY-152086A
-
|
|
Dynamin
|
Cardiovascular Disease
|
|
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .
|
-
- HY-161385
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM .
|
-
- HY-138181
-
|
MRX-I phosphoramidic acid
|
Drug Intermediate
|
Others
|
|
Contezolid phosphoramidic acid is an intermediate in the synthesis of proagents of antibacterial oxazolidinone agent MRX-I. Contezolid phosphoramidic acid is extracted from patent WO2015127316A1, Intermediate 3, Method I .
|
-
- HY-119576
-
-
- HY-139865
-
|
|
Apoptosis
|
Cancer
|
|
142I5 is a potent ML-IAP Lys-covalent inhibitor with an IC50 value of 11 nM.
|
-
- HY-N8308
-
|
|
Others
|
Others
|
|
Momordicoside I aglycone is a Triterpenoids product that can be isolated from the herbs of Mormodica charantia L. .
|
-
- HY-148152
-
|
|
PSMA
|
Others
|
|
PSMA I&S is a precursor of the 99mTc-labeled PSMA-targeting ligand .
|
-
- HY-W008867
-
-
- HY-P1396A
-
|
|
G Protein-coupled Receptor Kinase (GRK)
|
Others
|
|
GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist .
|
-
- HY-112134
-
|
|
Others
|
Cancer
|
|
CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM .
|
-
- HY-N2102
-
|
|
Others
|
Cancer
|
|
Tenacissoside I is a C21 steroid from the Marsdenia tenacissima, which is detected at relatively high level in M. tenacissima .
|
-
- HY-N0940
-
-
- HY-113318
-
-
- HY-142520
-
|
|
Epigenetic Reader Domain
|
Inflammation/Immunology
Cancer
|
|
I-BET567 is a potent and orally active inhibitor of pan-BET candidate with pIC50s of 6.9 and 7.2 for BRD4 BD1 and BD2, respectively. I-BET567 has been demonstrated efficacy in mouse models of oncology and inflammation .
|
-
- HY-162407
-
|
|
Btk
|
Cancer
|
|
I-As-1 is a potent inhibitor of Bruton’s tyrosine kinase (BTK), with the IC50 of 2.35 nM. I-As-1 shows antiproliferative activities among Ramos cells and OCI-LY10 cells with IC50s of 0.52 μM and 0.11 μM, respectively .
|
-
- HY-R00852
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-378i mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
hsa-miR-378i mimic
hsa-miR-378i mimic
- HY-R03472
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-669i mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
mmu-miR-669i mimic
mmu-miR-669i mimic
- HY-R01687
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-548i mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
hsa-miR-548i mimic
hsa-miR-548i mimic
- HY-R03056
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-344i mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
mmu-miR-344i mimic
mmu-miR-344i mimic
- HY-R04367
-
|
|
MicroRNA
|
Cancer
|
|
rno-miR-344i mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
rno-miR-344i mimic
rno-miR-344i mimic
- HY-124691
-
D-I03
3 Publications Verification
|
DNA/RNA Synthesis
|
Cancer
|
|
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 μM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 μM and 8 μM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin .
|
-
- HY-P1073
-
|
|
Calcium Channel
Sodium Channel
Potassium Channel
|
Cancer
|
|
ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na + channels and inhibits KV 2.1 channels .
|
-
- HY-112405
-
|
PD 159121
|
EGFR
|
Cancer
|
|
BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively .
|
-
- HY-P1542B
-
|
Catostomus urotensin I TFA
|
CRFR
|
Cardiovascular Disease
Endocrinology
|
|
Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively .
|
-
- HY-N4217
-
|
|
Others
|
Others
|
|
Saikosaponin I is a triterpene saponin extracted from Bupleurum falcatum L. Saikosaponin can be used to treat fever, inflammation, liver disease, and nephritis .
|
-
- HY-117180
-
|
30-Hydroxy-naphthomycin C
|
Antibiotic
|
Infection
Cancer
|
|
Diastovaricin I (30-Hydroxy-naphthomycin C) is an antibiotic without exhibiting antimicrobial activity. Diastovaricin I induces differentation of mouse Friend cell .
|
-
- HY-N0890R
-
|
Tubeimoside-1 (Standard); Lobatoside-H (Standard)
|
Apoptosis
|
Cancer
|
|
Tubeimoside I (Standard) is the analytical standard of Tubeimoside I. This product is intended for research and analytical applications. Tubeimoside I is an orally active HSPD1 inhibitor. Tubeimoside I inhibits NF-κB, MAPK, as well as regulates eNOS-VEGF. Tubeimoside I induces cytoprotective Autophagy via an Akt-mediated pathway. Tubeimoside I inhibits proinflammatory cytokine (IL-6 and IL-1β) production. Tubeimoside I exhibits anti-inflammatory activities. Tubeimoside I promotes angiogenesis and improves sepsis symptoms. Tubeimoside I is used in the research of inflammatory diseases, various cancers, sepsis and ischemic diseases .
|
-
- HY-146653
-
|
|
Glyoxalase (GLO)
|
Cancer
|
|
Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 26 nM . Glyoxalase I inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-P5525
-
|
Autocamtide-3 Derived Inhibitory Peptide
|
CaMK
|
Others
|
|
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)
|
-
- HY-P1829A
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Angiotensin I/II (1-6) TFA contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy .
|
-
- HY-156297
-
|
|
Proteasome
|
Inflammation/Immunology
|
|
β5i-IN-1 is a potent and selective inhibitor of β5i with a IC50 of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of NF-κB. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis .
|
-
- HY-P2218
-
|
|
Radionuclide-Drug Conjugates (RDCs)
CXCR
|
Cancer
|
|
Anditixafortide (Pentixather) is an endoradiotherapeutic vector. Anditixafortide is a CXCR4-targeting peptide derivative . Anditixafortide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
|
-
- HY-170560
-
-
- HY-124012
-
|
|
DNA/RNA Synthesis
Apoptosis
|
Cancer
|
|
PCNA-I1 is a selective small molecule inhibitor targeting proliferating cell nuclear antigen (PCNA) with anticancer activity. PCNA-I1 can stabilize the PCNA trimer structure (Kd=0.14-0.41μM), reduce its binding to chromatin, induce tumor cell cycle arrest, inhibit DNA replication and repair, and enhance the anti-tumor effect of DNA damaging agents. PCNA-I1 can be used in the study of targeted therapy for prostate cancer, lung cancer and other tumors .
|
-
- HY-N5042
-
|
|
Others
|
Inflammation/Immunology
|
|
Forsythoside I, a caffeoyl phenylethanoid glycoside (CPG) isolated from the fruits of Forsythia suspense (Thunb.) Vahl, may possesses anti-inflammatory activities .
|
-
- HY-N9317
-
|
|
Glycosidase
|
Metabolic Disease
|
|
Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC50 of 1.4 mM .
|
-
- HY-P0324
-
|
|
Bacterial
|
Infection
|
|
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.
|
-
- HY-N4246
-
|
|
Others
|
Neurological Disease
|
|
Bacopaside I, a saponin isolated from Bacopa monnieri, exbibits antioxidant properties and free radical scavenging capacity and exerts antidepressant-like effect .
|
-
- HY-124259
-
-
- HY-18771
-
-
- HY-N8798
-
|
Qinghaosu I
|
Others
|
Others
|
|
Arteannuin A (Qinghaosu I) is a product that can be isolated from Alpinia officinarum .
|
-
- HY-N5032
-
|
|
Others
|
Others
|
|
7Z-Trifostigmanoside I is found in Polygala hongkongensis Hemsl .
|
-
- HY-W344938R
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Acid yellow 3 (Standard) is the analytical standard of C.I. Acid yellow 3. This product is intended for research and analytical applications. C.I. Acid yellow 3 is an anionic quinolinone dye that is commonly used as a food additive, but also in the cosmetic and pharmaceutical industries .
|
-
- HY-114527
-
|
|
Apoptosis
Stearoyl-CoA Desaturase (SCD)
|
Cancer
|
|
TPMP-I-2 is an anticancer agent that induces cancer cell lines Apoptosis and decreases protein levels of stearoyl-CoA desaturase. TPMP-I-2 prolongs the survival time of nude rats in a simulated micrometastatic cervical cancer model and reduces tumor growth in a breast cancer model in nude mice combined with immunotoxins .
|
-
- HY-121820
-
|
|
HIV
|
Infection
|
|
DMJ-I-228 is a CD4-mimetic. DMJ-I-228 binds to HIV-1 gp120 within the conserved Phe 43 cavity near the CD4-binding site, thereby blocking CD4 binding and inhibiting HIV-1 infection .
|
-
- HY-173554
-
|
|
HSV
|
Infection
|
|
MPXV I7L protease-IN-1 (compound 11) is a Monkeypox virus I7L protease inhibitor with the IC50 of 69 nM .
|
-
- HY-P3572
-
|
Lom-AKH-I
|
Endogenous Metabolite
|
Endocrinology
|
|
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .
|
-
- HY-168632
-
|
|
Topoisomerase
Apoptosis
|
Cancer
|
|
Topoisomerase I/II inhibitor 6 (compound 3i) is a potent inhibitor of topoisomerase I and II with IC50s of 4.77 and 15 µM, respectively. Topoisomerase I/II inhibitor 6 shows antiproliferative activities against human melanoma LOX IMVI cancer cell line with IC50 values of 26.7 and 25.4 µM, respectively. Topoisomerase I/II inhibitor 6 provokes substantial levels of early, late apoptosis and increases the expression level of active caspase-3 .
|
-
- HY-128044
-
|
B581
|
Farnesyl Transferase
|
Cancer
|
|
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras) .
|
-
- HY-N5178
-
|
|
HIV
|
Infection
|
|
Chloropeptin I inhibits the binding of gp120 to CD4 with IC50 of 2.0 μM, with the activity of selective anti-human immunodeficiency virus (HIV) .
|
-
- HY-W073069
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Coproporphyrin I tetramethyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P2960
-
|
Acylase I
|
Biochemical Assay Reagents
|
Others
|
|
Aminoacylase (Acylase I) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P3174
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Pyroglutamate aminopeptidase I is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N12100
-
-
- HY-P3967
-
-
- HY-N0432
-
|
Astrasieversianin IV; Cyclosieversioside B
|
Wnt
β-catenin
|
Metabolic Disease
|
Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .
|
-
- HY-P1194A
-
|
|
Neurokinin Receptor
|
Inflammation/Immunology
|
|
Spantide I TFA, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .
|
-
- HY-150755
-
-
- HY-D0929
-
|
α-Naphthol Orange
|
Fluorescent Dye
|
Others
|
|
Orange I (α-Naphthol Orange) is an azo dye that can form a complex with Methylene blue (HY-14536) and cause fluorescence quenching. The equilibrium constant of the complex of Orange I and Methylene blue is 79900 mol -1·dm 3. Orange I can change the absorption spectrum of itself and Methylene blue .
|
-
- HY-169212
-
|
|
PI3K
Annexin A
ERK
VEGFR
STAT
Raf
FAK
Akt
Ras
|
Cancer
|
|
I194496 is a potent cystathionine γ-lyase (CSE) inhibitor, with an IC50 of 0.79 mM. I194496 can inhibit the growth of human TNBC cells via the dual targeting PI3K/Akt and Ras/Raf/ERK pathway and suppress the metastasis of human TNBC cells via down-regulating Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways .
|
-
- HY-123420
-
|
Dinordrin I
|
Steroid Sulfatase
|
Metabolic Disease
|
|
Dinordrin (Dinordrin I) is a steroid with a luteolytic effect. Dinordrin can cause depression of both plasma estrogen and progesterone levels .
|
-
- HY-N12203
-
|
|
Others
|
Others
|
|
5-Deoxypulchelloside I is a magnoside glycoside that can be isolated from the aerial parts of the Lamiaceae plant Eremostachys laciniata .
|
-
- HY-P1097
-
-
- HY-W008452
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .
|
-
- HY-P1336
-
-
- HY-165014
-
-
- HY-D0497R
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Disperse orange 37 (Standard) is the analytical standard of C.I. Disperse orange 37. This product is intended for research and analytical applications. C.I. Disperse orange 37 is an orange-orange dye commonly used for fiber dyeing.
|
-
- HY-W779640
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
25I-NBOMe 4-methoxy isomer hydrochloride is an isomer of 25I-NBOMe. 25I-NBOMe is an agonist for 5-HT2A, that binds to rat 5-HT2A and human 5-HT2A with Ki of 0.087 nM and 0.044 nM .
|
-
- HY-156464
-
|
|
Topoisomerase
|
Infection
|
|
Topoisomerase I inhibitor 10 (compound 13) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 10 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 27.91 μM .
|
-
- HY-D0024R
-
|
Solvent Yellow 14 (Standard)
|
Reference Standards
Bacterial
|
Others
|
|
Sudan I (Standard) is the analytical standard of Sudan I. This product is intended for research and analytical applications. Sudan I (Solvent Yellow 14) is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus .
|
-
- HY-N11529
-
|
|
Others
|
Others
|
|
9-Methoxyaristolactam I is a natural product that can be isolated from the roots of Asarum sieboldii Miq. var. Seoulense Nakai .
|
-
- HY-P5765
-
|
|
Neuropeptide Y Receptor
|
Neurological Disease
|
|
Galanin (1-13)-spantide I is a chimeric peptide composed of the N-terminal fragment of galanin (amino acids 1-13) and spantide, a known substance P receptor antagonist. Galanin (1-13)-spantide I has a high affinity for spinal galanin receptor (Kd=1.16 nM). Galanin (1-13)-spantide I can be used to study the effects of galanin on feeding behavior .
|
-
- HY-103078
-
|
|
HIV
|
Infection
|
|
I-XW-053 is an inhibitor of HIV-1 capsid protein that can suppress the replication of HIV-189BZ167 with an IC50 value of 164.2 μM. I-XW-053 exhibits antiviral activity and can block the interface between capsid protein (CA) N-terminal domains (NTD-NTD interface) with micromolar affinity .
|
-
- HY-103078A
-
|
|
HIV
|
Infection
|
|
I-XW-053 is an inhibitor of HIV-1 capsid protein that can suppress the replication of HIV-189BZ167 with an IC50 value of 164.2 μM. I-XW-053 exhibits antiviral activity and can block the interface between capsid protein (CA) N-terminal domains (NTD-NTD interface) with micromolar affinity .
|
-
- HY-P1882
-
|
|
Insecticide
|
Inflammation/Immunology
|
|
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .
|
-
- HY-W006103
-
-
- HY-148152A
-
|
|
PSMA
|
Others
|
|
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand .
|
-
- HY-129269
-
|
A-68567
|
Antibiotic
Bacterial
|
Infection
|
|
Pacidamycin I (A-68567) is a nucleoside peptide antibiotic that is highly specific for Pseudomonas aeruginosa .
|
-
- HY-N1228
-
|
|
Others
|
Others
|
|
Soyacerebroside I is a glycosphingolipid, together with Soyacerebroside II, which can be isolated from the seeds of Glycine max Merrill (Leguminosae). Soyacerebroside II shows ionophoretic activity for Ca 2+ .
|
-
- HY-15146
-
|
S3I-201
|
STAT
|
Cancer
|
|
NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM .
|
-
- HY-P2671
-
|
|
Cholecystokinin Receptor
|
Cancer
|
|
[Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer .
|
-
![[Leu15]-Gastrin I (human)](//file.medchemexpress.com/product_pic/hy-p2671.gif)
- HY-108905
-
|
Human IGF-I; FK 780
|
IGF-1R
|
Metabolic Disease
|
|
Mecasermin (Human IGF-I; FK 780) is a recombinant human insulin-like growth factor I (IGF-I). Mecasermin has the potential for the study of the growth failure of growth hormone (GH) insensitivity caused by GH receptor defects or GH-inhibiting antibodies .
|
-
- HY-156462
-
|
|
Topoisomerase
|
Infection
|
|
Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 34.81μM .
|
-
- HY-P2839
-
|
Heparinase I
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Heparinase (Heparinase I) degrades heparin to oligosaccharide or unsaturated disaccharide. Heparinase can be used in the preparation of low molecular weight heparin (LMWH) .
|
-
- HY-W013714
-
-
- HY-W007615
-
-
- HY-N10159
-
|
|
Others
|
Cancer
|
|
1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .
|
-
- HY-W008452S
-
-
- HY-N9201
-
|
|
Others
|
Others
|
|
8beta-Methoxyatractylenolide I is a Sesquiterpenoids product that can be isolated from the rhizomes of Atractylodes macrocephala. .
|
-
- HY-136807
-
|
|
MAP3K
|
Cancer
|
|
Tpl2-IN-I functions as an inhibitor of the Tpl2 (tumour progression locus 2) kinase.
|
-
- HY-P2973
-
|
Aspergillus acid protease
|
Others
|
Others
|
|
Aspergillopepsin I (Aspergillus acid protease) is an aspartic endopeptidase that catalyses the hydrolysis of peptide bonds in proteins, with broad specificity .
|
-
- HY-135748A
-
|
|
Toll-like Receptor (TLR)
Apoptosis
|
Infection
Cancer
|
|
Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and b>MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .
|
-
- HY-W019776
-
|
Solvent Yellow 14-d5
|
Bacterial
|
Infection
|
|
Sudan I-d5 is a the deuterated Sudan I. Sudan I is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus .
|
-
- HY-N6724
-
|
Dihydroalterperylenol
|
Others
|
Metabolic Disease
|
|
Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi, which is mutagenic and cytotoxic, and can weakly disrupts metabolic communication .
|
-
- HY-126746
-
|
|
Antibiotic
|
Infection
|
|
Corynecin I is an antibiotic produced by Corynebacterium hydrocarboclastus, and its precursor (D-(-) threo-p-amino phenyl serinol-N-acetylamine) has a minimal inhibitory effect on the synthesis of Corynecin from mevalonic acid .
|
-
- HY-P2878
-
|
PDE
|
Phosphodiesterase (PDE)
|
Neurological Disease
Cancer
|
|
Phosphodiesterase I (PDE) is an enzyme that can catalyze the hydrolysis of the 3' ring phosphate bond of cyclic nucleotides, and is often used in biochemical research. Phosphodiesterase I acts as an important regulator of signal transduction mediated by the second messenger molecules cAMP and cGMP. According to their specificity to cyclic nucleotides, they can also be divided into different types, such as PDE1-PDE11, which also have certain potential in various diseases .
|
-
- HY-141627
-
-
- HY-19261
-
|
|
Cholecystokinin Receptor
|
Metabolic Disease
|
|
T-0632 is a CCK A receptor antagonist that exhibits significant pharmacological properties in in vitro studies. T-0632 competitively inhibits the binding of [125I]CCK-8 to rat pancreatic CCK A receptors with a K_i value of 0.24 nM, which is significantly lower than the K_i value for guinea pig CCK B receptors. T-0632 has higher selectivity in inhibiting CCK-8-stimulated pancreatic enzyme release, with an IC_50 value of 5.0 nM, which is more advantageous than L-364,718 and loxiglumide. In rabbit gallbladder smooth muscle, the antagonistic effects of T-0632 and loxiglumide are reversible, while L-364,718 shows a persistent inhibitory effect. These results indicate that T-0632 is a highly potent, reversible and more selective CCK A receptor antagonist.
|
-
- HY-P1593
-
-
- HY-W096157
-
|
|
PROTAC Linkers
|
Cancer
|
|
I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-112546
-
|
|
MMP
|
Cancer
|
|
MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor with a Ki of 1.7 μM .
|
-
- HY-124211
-
-
- HY-W096156
-
|
|
PROTAC Linkers
|
Cancer
|
|
I-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-N10206
-
|
|
Endogenous Metabolite
|
Cancer
|
|
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .
|
-
- HY-N9256
-
|
|
Others
|
Others
|
|
5,7-Dihydroxy-3',4',5'-trimethoxyflavanone is a Flavonoids product that can be isolated from the heartwoods of Dalbergia odorifera .
|
-
- HY-W127440
-
|
|
Biochemical Assay Reagents
|
Others
|
|
i-Cholesteryl methyl ether is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P10248
-
|
|
Androgen Receptor
|
Endocrinology
|
|
Atriopeptin I rat, mouse is an atrial natriuretic peptide, which stimulates the testosterone production with half-maximum stimulation of 38 nM .
|
-
- HY-D0024
-
|
Solvent Yellow 14
|
Bacterial
|
Others
|
|
Sudan I (Solvent Yellow 14) is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus .
|
-
- HY-138620
-
-
- HY-P0324A
-
|
|
Bacterial
|
Infection
|
|
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity .
|
-
- HY-101387
-
|
|
mGluR
|
Neurological Disease
|
|
rel-ACPT-I is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects .
|
-
- HY-161564
-
-
- HY-A0126A
-
|
Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan
|
Endogenous Metabolite
Apoptosis
|
Cardiovascular Disease
|
|
Epoprostenol sodium (Prostaglandin I2) sodium salt, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation .
|
-
- HY-W033813
-
|
|
Caspase
Apoptosis
|
Cancer
|
|
Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes .
|
-
- HY-NP127
-
|
Canine Type I collagen, immunization grade
|
MMP
|
Inflammation/Immunology
|
|
Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
|
-
- HY-NP122
-
|
Porcine Type I collagen, immunization grade
|
MMP
|
Inflammation/Immunology
|
|
Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
|
-
- HY-NP128
-
|
Rabbit Type I collagen, immunization grade
|
MMP
|
Inflammation/Immunology
|
|
Highly purified Type I collagen, from rabbit skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from rabbit skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
|
-
- HY-NP107
-
|
Rat Type I collagen, immunization grade
|
MMP
|
Inflammation/Immunology
|
|
Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
|
-
- HY-NP109
-
|
Mouse Type I collagen, immunization grade
|
MMP
|
Inflammation/Immunology
|
|
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
|
-
- HY-NP112
-
|
Chick type I collagen, immunization grade
|
MMP
|
Inflammation/Immunology
|
|
Highly purified Type I collagen, from chick skin (Chick type I collagen, immunization grade) is an immune grade collagen derived from chick skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
|
-
- HY-E70107
-
|
Cbh1
|
Others
|
Others
|
|
Cellobiohydrolase I (Cbh1) belongs to glycoside hydrolase family 7 (GH7) that catalyzes the processive hydrolysis of cellulose into cellobiose .
|
-
- HY-D0496
-
-
- HY-D0409
-
-
- HY-D0475
-
-
- HY-D0439
-
-
- HY-D0319
-
-
- HY-D0597
-
-
- HY-P2474
-
|
|
PD-1/PD-L1
|
Cancer
|
|
Human PD-L1 inhibitor I is a hPD-1 peptide ligand, with a KD of 3.39 μM. Human PD-L1 inhibitor I may disturb the binding of hPD-L1 to hPD-1 .
|
-
- HY-13032B
-
|
GSK 525762C; I-BET 762 besylate
|
Epigenetic Reader Domain
|
Cancer
|
|
Molibresib besylate (GSK 525762C; I-BET 762 besylate) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
|
-
- HY-RI04367
-
|
|
MicroRNA
|
Cancer
|
|
rno-miR-344i inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
rno-miR-344i inhibitor
rno-miR-344i inhibitor
- HY-RI03056
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-344i inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
mmu-miR-344i inhibitor
mmu-miR-344i inhibitor
- HY-RI00852
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-378i inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
hsa-miR-378i inhibitor
hsa-miR-378i inhibitor
- HY-RI03472
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-669i inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
mmu-miR-669i inhibitor
mmu-miR-669i inhibitor
- HY-RI01687
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-548i inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
hsa-miR-548i inhibitor
hsa-miR-548i inhibitor
- HY-N6020A
-
|
|
Others
|
Others
|
|
(+)-Butin is the R enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities .
|
-
- HY-R00014
-
|
|
MicroRNA
|
Cancer
|
|
hsa-let-7i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
hsa-let-7i-5p mimic
hsa-let-7i-5p mimic
- HY-R04616
-
|
|
MicroRNA
|
Others
|
|
mmu-let-7i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
mmu-let-7i-5p mimic
mmu-let-7i-5p mimic
- HY-R00013
-
|
|
MicroRNA
|
Cancer
|
|
hsa-let-7i-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
hsa-let-7i-3p mimic
hsa-let-7i-3p mimic
- HY-R03181
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
mmu-miR-466i-3p mimic
mmu-miR-466i-3p mimic
- HY-R04623
-
|
|
MicroRNA
|
Others
|
|
rno-let-7i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
rno-let-7i-5p mimic
rno-let-7i-5p mimic
- HY-R03182
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
mmu-miR-466i-5p mimic
mmu-miR-466i-5p mimic
- HY-P990832
-
|
|
MHC
|
Others
|
|
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a, κ chimeric antibody, targeting to human MHC Class I. The recommend isotype control of Anti-MHC Class I Antibody (W6/32): Mouse IgG2a kappa, Isotype Control (HY-P99978).
|
-
- HY-P1032S2
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensin II and is cleaved into angiotensin II by angiotensin converting enzyme (ACE) .
|
-
- HY-19760
-
|
|
Epigenetic Reader Domain
|
Inflammation/Immunology
|
|
I-BET282 is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282 shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD) .
|
-
- HY-14988
-
|
|
Bacterial
|
Infection
|
|
I-A09 and its derivatives, specifically 1,2,3-triazole-adamantylacetamide hybrids (5a–u), exhibit significant antitubercular activity. These hybrids were synthesized using copper-catalyzed click chemistry, combining bioactive fragments from antitubercular I-A09 and substituted adamantyl urea. The compound N-(1-adamantyl)-2-azido acetamide was reacted with various alkyl/aryl acetylenes to produce new analogues. Among them, N-(1-adamantan-1-yl)-2-(4-(phenanthren-2-yl)-1H-1,2,3-triazol-1-yl)acetamide (5t) showed the most promise with a minimum inhibitory concentration (MIC) of 3.12 μg/mL against Mycobacterium tuberculosis H37Rv, and a selectivity index greater than 15 .
|
-
- HY-P10440
-
|
|
CDK
|
Neurological Disease
|
|
Cdk5i peptide is a CDK5 inhibitory peptide with high binding affinity for Cdk5/p25 (Kd of 0.17 μM), which can block the interaction between CDK5 and p25 and reduce the kinase activity of CDK5/p25. Cdk5i peptide can be used in the stud y of neurodegenerative diseases .
|
-
- HY-167556
-
-
- HY-N14758
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
6"'-Deamino-6"'-hydroxyparomomycin I is an amino glycosyl antibiotic that can be produced by Streptomyces rimosus forma paromomycinus A67 15. It is active against both Gram-positive and Gram-negative bacteria. 6"'-Deamino-6"'-hydroxyparomomycin I can be used as an intermediate in the biosynthesis of paromomycin .
|
-
- HY-D0420
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 151 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0422
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 183 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0412
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid yellow 48 is an acidic yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-D0438
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 114 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0480
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid black 60 is an acidic black dye that can be adsorbed and removed by bentone.
|
-
- HY-D0423
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid green 27 is an acidic green dye that can be adsorbed and removed by bentone.
|
-
- HY-D0447
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 374 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0490
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid yellow 49 is an acidic yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-W016028
-
-
- HY-D0494
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid yellow 151 is an acidic yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-D0434
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid blue 40 sodium salt is an acidic blue dye that can be adsorbed and removed by bentone.
|
-
- HY-D0508
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 138 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0413
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 37 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0509
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid yellow 172 is an acidic yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-D0536
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid black 132 is an acidic black dye that can be adsorbed and removed by bentone.
|
-
- HY-D0418
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid yellow 42 is an acidic yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-W011472
-
-
- HY-D0477
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 57 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-W009284
-
-
- HY-D0448
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 154 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0424
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid blue 25 is an acidic blue dye that can be adsorbed and removed by bentone.
|
-
- HY-D0410
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid yellow 200 is an acidic yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-D0458
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid red 106 is an acid red dye that can be adsorbed and removed by bentone clay.
|
-
- HY-E70005A
-
|
EC 3.4.24.3
|
MMP
|
Others
|
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .
|
-
- HY-135241
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
25I-NBF hydrochloride is a highly potent partial agonist for the 5-HT2A receptors receptor with a Ki value of 0.26 nM and an EC50 value of 1.6 nM .
|
-
- HY-I0512
-
|
|
HCV
|
Infection
|
|
Sofosbuvir impurity I, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
|
-
- HY-N6854
-
|
|
Others
|
Metabolic Disease
Cancer
|
|
Mogroside I A1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .
|
-
- HY-N6853
-
|
|
DNA/RNA Synthesis
AMPK
|
Metabolic Disease
Cancer
|
|
Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .
|
-
- HY-126548
-
-
- HY-P2643
-
-
- HY-E70443
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chondroitinase ABC I is a hydrolase with high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries .
|
-
- HY-19541
-
-
- HY-D0417
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid orange 3 is an acidic orange-yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-D0435
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid brown 120 is an acidic brown dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0446
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid orange 33 is an acidic orange-yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-D0481
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid orange 67 is an acidic orange-yellow dye that can be adsorbed and removed by bentone.
|
-
- HY-D0495
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid brown 83 is an acidic brown dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0444
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid brown 121 is an acidic brown dye that can be adsorbed and removed by bentone clay.
|
-
- HY-D0452
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid brown 75 is an acidic brown dye that can be adsorbed and removed by bentone clay.
|
-
- HY-157035
-
|
|
Proteasome
|
Others
|
|
Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective human proteasome β2c and β2i inhibitor
.
|
-
- HY-P1593A
-
-
- HY-130594
-
|
6α-PGI1
|
Prostaglandin Receptor
|
Others
|
|
6α-Prostaglandin I1 (6α-PGI1) is an analogue of prostacycline I2 (PGI2) and is resistant to hydrolysis in aqueous solution .
|
-
- HY-149012
-
-
- HY-P3673
-
|
|
GnRH Receptor
|
Endocrinology
|
|
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models .
|
-
- HY-D0437
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct blue 75 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0482
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct blue 80 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0436
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct black 32 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0465
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct black 80 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0440
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct green 28 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0443
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct black 22 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0419
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct green 26 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0451
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct orange 102 is a good dyeing agent for cotton fabrics.
|
-
- HY-D0425
-
|
|
Fluorescent Dye
|
|
|
C.I. Direct red 84 is a good dyeing agent for cotton fabrics.
|
-
- HY-Y0961
-
|
Copper(I) iodide
|
Biochemical Assay Reagents
|
Others
|
|
Cuprous iodide (Copper(I) iodide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N1405R
-
|
Elatericin B (Standard); JSI-124 (Standard); NSC-521777 (Standard)
|
STAT
JAK
|
Cancer
|
|
Cucurbitacin I (Standard) is the analytical standard of Cucurbitacin I. This product is intended for research and analytical applications. Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
|
-
- HY-D0391
-
|
|
Fluorescent Dye
|
|
|
C.I Acid orange 8 is an acidic orange dye that photochemically decolorizes during a UV/hydrogen peroxide process.
|
-
- HY-D0400
-
|
|
Fluorescent Dye
|
|
|
C.I. Disperse yellow 23 is a yellow dye commonly used for fiber dyeing.
|
-
- HY-D0454
-
|
|
Fluorescent Dye
|
|
|
C.I. Disperse red 54 is a red dye commonly used for fiber dyeing.
|
-
- HY-D0491
-
|
|
Fluorescent Dye
|
|
|
C.I. Disperse blue 79 is a blue dye commonly used for fiber dyeing.
|
-
- HY-D0484
-
|
|
Fluorescent Dye
|
|
|
C.I. Disperse yellow 70 is a yellow dye commonly used for fiber dyeing.
|
-
- HY-13329
-
|
IRAK-1/4 Inhibitor I
|
IRAK
|
Inflammation/Immunology
|
|
IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively.
|
-
- HY-169509
-
|
|
PARP
Necroptosis
Topoisomerase
RIP kinase
Mixed Lineage Kinase
|
Cancer
|
|
Topoisomerase I/II Inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II, capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer treatment .
|
-
- HY-RS01799
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
CACNA1I Human Pre-designed siRNA Set A contains three designed siRNAs for CACNA1I gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
CACNA1I Human Pre-designed siRNA Set A
CACNA1I Human Pre-designed siRNA Set A
- HY-RS18848
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Ube2i Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ube2i gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Ube2i Mouse Pre-designed siRNA Set A
Ube2i Mouse Pre-designed siRNA Set A
- HY-RS04265
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
EIF3I Human Pre-designed siRNA Set A contains three designed siRNAs for EIF3I gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
EIF3I Human Pre-designed siRNA Set A
EIF3I Human Pre-designed siRNA Set A
- HY-RS25340
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Ube2i Rat Pre-designed siRNA Set A contains three designed siRNAs for Ube2i gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Ube2i Rat Pre-designed siRNA Set A
Ube2i Rat Pre-designed siRNA Set A
- HY-RS20626
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Cacna1i Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cacna1i gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Cacna1i Mouse Pre-designed siRNA Set A
Cacna1i Mouse Pre-designed siRNA Set A
- HY-RS27135
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Cacna1i Rat Pre-designed siRNA Set A contains three designed siRNAs for Cacna1i gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Cacna1i Rat Pre-designed siRNA Set A
Cacna1i Rat Pre-designed siRNA Set A
- HY-RS05903
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
GTF2I Human Pre-designed siRNA Set A contains three designed siRNAs for GTF2I gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
GTF2I Human Pre-designed siRNA Set A
GTF2I Human Pre-designed siRNA Set A
- HY-RS27467
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Gtf2i Rat Pre-designed siRNA Set A contains three designed siRNAs for Gtf2i gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Gtf2i Rat Pre-designed siRNA Set A
Gtf2i Rat Pre-designed siRNA Set A
- HY-RS20950
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Gtf2i Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gtf2i gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Gtf2i Mouse Pre-designed siRNA Set A
Gtf2i Mouse Pre-designed siRNA Set A
- HY-RS10850
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
POLR2I Human Pre-designed siRNA Set A contains three designed siRNAs for POLR2I gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
POLR2I Human Pre-designed siRNA Set A
POLR2I Human Pre-designed siRNA Set A
- HY-RS15349
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UBE2I Human Pre-designed siRNA Set A contains three designed siRNAs for UBE2I gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UBE2I Human Pre-designed siRNA Set A
UBE2I Human Pre-designed siRNA Set A
- HY-130522
-
|
6β-PGI1
|
Prostaglandin Receptor
|
Others
|
|
6β-Prostaglandin I1 (6β-PGI1) is an analog of prostaglandin I2 (PGI2) that is resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1 can reduce gastric acid secretion with an ID50 (dose causing 50% inhibition) of approximately 3.0 μg/kg/min (intravenous injection) .
|
-
- HY-N0134
-
-
- HY-103351
-
|
|
Cathepsin
|
Inflammation/Immunology
|
|
Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC50=53 nM; Ki=63 nM) .
|
-
- HY-P2416
-
-
- HY-P5518
-
-
![[Des-Arg10]-HOE I40](//file.medchemexpress.com/product_pic/hy-p5518.gif)
- HY-D0476
-
|
|
Fluorescent Dye
|
|
|
C.I. Acid yellow 99 is an acidic yellow dye that combines with coconut shell pith through electrostatic and complexing reactions.
|
-
- HY-D0497
-
|
|
Fluorescent Dye
|
|
|
C.I. Disperse orange 37 is an orange-orange dye commonly used for fiber dyeing.
|
-
- HY-D0643
-
|
|
Fluorescent Dye
|
|
|
C.I. Disperse orange 33 is an orange-orange dye commonly used for fiber dyeing.
|
-
- HY-D0555
-
-
- HY-P3064
-
|
Leiurotoxin I
|
Potassium Channel
|
Neurological Disease
|
|
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .
|
-
- HY-B1411S1
-
-
- HY-R03056A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-344i agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-344i agomir
mmu-miR-344i agomir
- HY-R00852A
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-378i agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-miR-378i agomir
hsa-miR-378i agomir
- HY-R04367A
-
|
|
MicroRNA
|
Cancer
|
|
rno-miR-344i agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
rno-miR-344i agomir
rno-miR-344i agomir
- HY-R01687A
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-548i agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-miR-548i agomir
hsa-miR-548i agomir
- HY-R03472A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-669i agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-669i agomir
mmu-miR-669i agomir
- HY-W674112
-
|
ETH 1117
|
Endogenous Metabolite
|
Others
|
|
Magnesium ionophore I (ETH 1117) serves as the primary component for the development of calcium-magnesium selective electrodes.
|
-
- HY-19760B
-
|
|
Epigenetic Reader Domain
|
Inflammation/Immunology
|
|
I-BET282E is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282E shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD) .
|
-
- HY-P990251
-
|
|
MMP
|
Others
|
|
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I.
|
-
- HY-N0697
-
-
- HY-P99619
-
|
SCT-I10A
|
PD-1/PD-L1
|
Cancer
|
|
Finotonlimab (SCT-I10A) is a recombinant humanised IgG PD-1 antibody. Finotonlimab has the potential for solid tumors or lymphomas research .
|
-
- HY-P5411
-
|
SIITFEKL, OVA (257-264) Variant
|
MHC
|
Others
|
|
OVA-T4 Peptide (SIITFEKL, OVA (257-264) Variant) is a biological active peptide. (T4 peptide (SIITFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)
|
-
- HY-D0376
-
|
C.I. 48160
|
Fluorescent Dye
|
Others
|
|
Solvent Yellow 93 (C.I. 48160) is an azomethine dye. Solvent Yellow 93 is used as a colorant of toner. Solvent Yellow 93 is used for the coloring of polyester fiber pulp and is also used to make polyester masterbatch .
|
-
- HY-N10418
-
|
|
Fungal
|
Infection
|
|
Isorhapontin is an antifungal agent. Isorhapontin inhibits the hydrolytic activity of Trichoderma cellobiohydrolase I (CBH I) with a Ki of 57.2 μM. Isorhapontin also inhibits the activity of Trichoderma endoglucanase I .
|
-
- HY-128026
-
|
|
MMP
|
Inflammation/Immunology
|
|
MMP-9/MMP-13 Inhibitor I is a potent MMP-9 and MMP-13 inhibitor with IC50s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs .
|
-
- HY-124254
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Vat Yellow 2 is an agent of yellow dye and can also be used for the paper dyeing .
|
-
- HY-136460
-
|
ETH 1001
|
Calcium Channel
|
Others
|
|
Calcium ionophore I (ETH 1001) is a selective Ca 2+ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .
|
-
- HY-N7761
-
|
Tetrahydro tanshinone I
|
Others
|
Cancer
|
|
Trijuganone B (Tetrahydro tanshinone I) can be extracted from from the roots of Salvia miltiorrhiza f. alba. Trijuganone B inhibits the proliferation of leukemia cells .
|
-
- HY-D0314R
-
|
Sudan R (Standard)
|
Fluorescent Dye
|
Others
|
|
Solvent Red 1 (C.I.) (Standard) is the analytical standard of Solvent Red 1 (C.I.). This product is intended for research and analytical applications. Solvent Red 1 (C.I.) is a red dye. Its series of products, such as Solvent orange 60 (HY-D1177), has been used in dyeing applications of plastic materials.
|
-
- HY-RS19057
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Cox4i2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cox4i2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Cox4i2 Mouse Pre-designed siRNA Set A
Cox4i2 Mouse Pre-designed siRNA Set A
- HY-RS25547
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Cox4i2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cox4i2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Cox4i2 Rat Pre-designed siRNA Set A
Cox4i2 Rat Pre-designed siRNA Set A
- HY-RS03065
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
COX4I2 Human Pre-designed siRNA Set A contains three designed siRNAs for COX4I2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
COX4I2 Human Pre-designed siRNA Set A
COX4I2 Human Pre-designed siRNA Set A
- HY-RS14438
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TGFB1I1 Human Pre-designed siRNA Set A contains three designed siRNAs for TGFB1I1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TGFB1I1 Human Pre-designed siRNA Set A
TGFB1I1 Human Pre-designed siRNA Set A
- HY-RS09535
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
NR1I3 Human Pre-designed siRNA Set A contains three designed siRNAs for NR1I3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
NR1I3 Human Pre-designed siRNA Set A
NR1I3 Human Pre-designed siRNA Set A
- HY-RS20068
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Nr1i3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nr1i3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Nr1i3 Mouse Pre-designed siRNA Set A
Nr1i3 Mouse Pre-designed siRNA Set A
- HY-RS04083
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
DYNC1I1 Human Pre-designed siRNA Set A contains three designed siRNAs for DYNC1I1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
DYNC1I1 Human Pre-designed siRNA Set A
DYNC1I1 Human Pre-designed siRNA Set A
- HY-RS09534
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
NR1I2 Human Pre-designed siRNA Set A contains three designed siRNAs for NR1I2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
NR1I2 Human Pre-designed siRNA Set A
NR1I2 Human Pre-designed siRNA Set A
- HY-RS25740
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Cox4i1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cox4i1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Cox4i1 Rat Pre-designed siRNA Set A
Cox4i1 Rat Pre-designed siRNA Set A
- HY-RS26028
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Tp53i3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp53i3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Tp53i3 Rat Pre-designed siRNA Set A
Tp53i3 Rat Pre-designed siRNA Set A
- HY-RS26572
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Nr1i3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nr1i3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Nr1i3 Rat Pre-designed siRNA Set A
Nr1i3 Rat Pre-designed siRNA Set A
- HY-RS14917
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TP53I11 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TP53I11 Human Pre-designed siRNA Set A
TP53I11 Human Pre-designed siRNA Set A
- HY-RS17465
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Il4i1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il4i1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Il4i1 Mouse Pre-designed siRNA Set A
Il4i1 Mouse Pre-designed siRNA Set A
- HY-RS19251
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Cox4i1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cox4i1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Cox4i1 Mouse Pre-designed siRNA Set A
Cox4i1 Mouse Pre-designed siRNA Set A
- HY-RS06768
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
IL4I1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL4I1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
IL4I1 Human Pre-designed siRNA Set A
IL4I1 Human Pre-designed siRNA Set A
- HY-RS23923
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Il4i1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il4i1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Il4i1 Rat Pre-designed siRNA Set A
Il4i1 Rat Pre-designed siRNA Set A
- HY-RS29199
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Nr1i2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nr1i2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Nr1i2 Rat Pre-designed siRNA Set A
Nr1i2 Rat Pre-designed siRNA Set A
- HY-RS14918
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TP53I13 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TP53I13 Human Pre-designed siRNA Set A
TP53I13 Human Pre-designed siRNA Set A
- HY-RS04084
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
DYNC1I2 Human Pre-designed siRNA Set A contains three designed siRNAs for DYNC1I2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
DYNC1I2 Human Pre-designed siRNA Set A
DYNC1I2 Human Pre-designed siRNA Set A
- HY-RS03064
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
COX4I1 Human Pre-designed siRNA Set A contains three designed siRNAs for COX4I1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
COX4I1 Human Pre-designed siRNA Set A
COX4I1 Human Pre-designed siRNA Set A
- HY-RS14919
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
TP53I3 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
TP53I3 Human Pre-designed siRNA Set A
TP53I3 Human Pre-designed siRNA Set A
- HY-RS22685
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Nr1i2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nr1i2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Nr1i2 Mouse Pre-designed siRNA Set A
Nr1i2 Mouse Pre-designed siRNA Set A
- HY-B1411S
-
|
myo-Inositol-d6; meso-Inositol-d6
|
Endogenous Metabolite
|
Others
|
|
i-Inositol-d6 is the deuterium labeled i-Inositol. i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges.
|
-
- HY-NP160
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Recombinant Humanized Type I Collagen is a recombinant humanized collagen protein with has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc .
|
-
- HY-50713
-
|
|
CaSR
|
Others
|
|
Calcium-Sensing receptor antagonist I is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-RI03181
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
mmu-miR-466i-3p inhibitor
mmu-miR-466i-3p inhibitor
- HY-RI00014
-
|
|
MicroRNA
|
Cancer
|
|
hsa-let-7i-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
hsa-let-7i-5p inhibitor
hsa-let-7i-5p inhibitor
- HY-RI03182
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
mmu-miR-466i-5p inhibitor
mmu-miR-466i-5p inhibitor
- HY-RI00013
-
|
|
MicroRNA
|
Cancer
|
|
hsa-let-7i-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
hsa-let-7i-3p inhibitor
hsa-let-7i-3p inhibitor
- HY-13867A
-
|
GF109203X hydrochloride; Go 6850 hydrochloride
|
PKC
GSK-3
|
Metabolic Disease
Cancer
|
|
Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor .
|
-
- HY-13867
-
|
GF109203X; Go 6850
|
PKC
GSK-3
|
Metabolic Disease
Cancer
|
|
Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor .
|
-
- HY-D0396
-
|
DR16
|
Fluorescent Dye
|
|
|
C.I. Direct red 16 is a good dyeing agent for cotton fabrics.
|
-
- HY-A0104D
-
|
Hypromellose (Type I,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:4000mPa.s); Celacol HPM 5000 (Type I,Viscosity:4000mPa.s)
|
Biochemical Assay Reagents
|
Others
|
|
Hydroxypropylmethylcellulose (Type I,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-A0104C
-
|
Hypromellose (Type I,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:400mPa.s); Celacol HPM 5000 (Type I,Viscosity:400mPa.s)
|
Biochemical Assay Reagents
|
Others
|
|
Hydroxypropylmethylcellulose (Type I,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-A0104B
-
|
Hypromellose (Type I,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:100mPa.s); Celacol HPM 5000 (Type I,Viscosity:100mPa.s)
|
Biochemical Assay Reagents
|
Others
|
|
Hypromellose (Type I,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-A0104A
-
|
Hypromellose (Type I,Viscosity:30mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:30mPa.s); Celacol HPM 5000 (Type I,Viscosity:30mPa.s)
|
Biochemical Assay Reagents
|
Others
|
|
Hydroxypropylmethylcellulose (Type I,Viscosity:30mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N8086
-
|
Epimedin I
|
Others
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Korepimedoside C (Epimedin I), a flavonol glycoside, is isolated from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a famous Chinese herbal medicine for the research of impotence, osteoporosis, immune suppression and cardiovascular diseases .
|
-
- HY-NP156
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .
|
-
- HY-NP156A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type I Collagen, for cell culture, from Porcine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Porcine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .
|
-
- HY-D0502
-
|
|
Fluorescent Dye
|
Others
|
|
C.I.Pigment red 88 is a red pigment that can be used in plasticised Poly(viny1 chloride) (PVC) .
|
-
- HY-P5518A
-
-
![[Des-Arg10]-HOE I40 TFA](//file.medchemexpress.com/product_pic/hy-p5518a.gif)
- HY-W874904
-
-
- HY-103002
-
SU5408
4 Publications Verification
VEGFR2 Kinase Inhibitor I
|
VEGFR
|
Cardiovascular Disease
|
|
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70 nM.
|
-
- HY-N3068
-
|
Nigakilactone I; Simalikalactone B
|
Others
|
Others
|
|
Picrasin B (Nigakilactone I) can be isolated from the bark of Picrasma quassioides. Picrasin B shows antifeedant and insecticidal activity against Diamondback Moth .
|
-
- HY-163962
-
|
|
PROTACs
Btk
|
Inflammation/Immunology
|
|
L18I is a PROTAC targeting Btk that can reduce inflammation in autoimmune diseases such as lupus erythematosus induced by BM12 splenocytes. L18I is composed of PROTAC target protein ligand IBT6A (HY-13036A) (red part), PROTAC Linker Propargyl-PEG3-alcohol (HY-41921) (balck part) and E3 ubiquitin ligase ligand Lenalidomide-Br (HY-43722) (blue part), of which the active control of the target protein ligand is IBT6A-CO-ethyne (HY-163963), and the conjugate of E3 ubiquitin ligase ligand + Linker is Lenalidomide-C3-PEG3-N3 (HY-163964) [1] .
|
-
- HY-O0004
-
|
|
MMP
|
Metabolic Disease
|
|
Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation.
|
-
- HY-108882C
-
|
|
DNA/RNA Synthesis
|
Others
|
|
DNase I (filtered) (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer . Filtered through a 0.22 μM filter, not tested for pyrogenicity.
|
-
- HY-N6020
-
-
- HY-168150
-
|
|
Topoisomerase
|
Cancer
|
|
Topoisomerase I/II inhibitor 5 (compund 1) simultaneously inhibits activities of TopoI and II by binding to and stabilizing the G4 structure .
|
-
- HY-N0011
-
-
- HY-P2525
-
|
|
MHC
|
Inflammation/Immunology
|
|
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .
|
-
- HY-N2795
-
|
Xanthone I
|
Parasite
Bacterial
|
Infection
|
|
9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM) .
|
-
- HY-RI03472A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-669i antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-669i antagomir
mmu-miR-669i antagomir
- HY-RI04367A
-
|
|
MicroRNA
|
Cancer
|
|
rno-miR-344i antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
rno-miR-344i antagomir
rno-miR-344i antagomir
- HY-RI01687A
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-548i antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-miR-548i antagomir
hsa-miR-548i antagomir
- HY-RI00852A
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-378i antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-miR-378i antagomir
hsa-miR-378i antagomir
- HY-RI03056A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-344i antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-344i antagomir
mmu-miR-344i antagomir
- HY-W110910
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Eriochrome black T indicator (C.I. 14645), 1% solid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D0492
-
|
|
Fluorescent Dye
|
|
|
C.I. Basic blue 41 is an alkaline dye that can be removed from aqueous solutions in intermittent adsorption systems using tree ferns as biosorbents.
|
-
- HY-D0551
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Basic red 24 is an alkaline dye that can be removed from aqueous solutions in intermittent adsorption systems using tree ferns as biosorbents.
|
-
- HY-W110884
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Eriochrome cyanine R indicator (C.I. 43820) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-D0406
-
|
|
Fluorescent Dye
|
|
|
C.I. Basic yellow 37 is an alkaline dye that can be removed from aqueous solutions in intermittent adsorption systems using tree ferns as biosorbents.
|
-
- HY-D0478
-
|
|
Fluorescent Dye
|
|
|
C.I. Basic red 14 is an alkaline dye that can be removed from aqueous solutions in intermittent adsorption systems using tree ferns as biosorbents.
|
-
- HY-P3730
-
|
|
CDK
|
Cancer
|
|
Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner .
|
-
- HY-W344938
-
|
Quinoline yellow
|
Fluorescent Dye
|
Others
|
|
C.I. Acid yellow 3 is an anionic quinolinone dye that is commonly used as a food additive, but also in the cosmetic and pharmaceutical industries .
|
-
- HY-N1405
-
|
Elatericin B; JSI-124; NSC-521777
|
STAT
JAK
|
Cancer
|
|
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
|
-
- HY-136926
-
|
FR-008I
|
Fungal
|
Infection
|
|
Candicidin A3 (FR-008I) is an antifungal antibiotic with significant biological activity. Candicidin A3 can effectively inhibit the growth of fungi through its unique three-dimensional structure and seven-membered ring geometry. The absolute configuration of Candicidin A3 is a specific arrangement of multiple chiral centers, which may affect its biological activity and interaction with targets. Candicidin A3 can be used as a potential drug to inhibit fungal infections .
|
-
- HY-N10917
-
|
|
Cholinesterase (ChE)
|
Infection
Cancer
|
|
Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC50s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC50s of 51.25 μM and 63.07 μM .
|
-
- HY-158122
-
|
|
DNA-PK
|
Cancer
|
|
Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the pharmacokinetic properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu can increase the residence time of PSMA ligand in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-O-tBu also reduces salivary gland absorption, possibly extending the half-life of the active compound .
|
-
- HY-107613A
-
|
DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride
|
PKC
5-HT Receptor
|
Infection
Inflammation/Immunology
Cancer
|
|
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils .
|
-
- HY-107613
-
|
DKGI-I; Diacylglycerol kinase inhibitor I
|
PKC
5-HT Receptor
|
Inflammation/Immunology
|
|
R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils .
|
-
- HY-P5795
-
|
|
Sodium Channel
Potassium Channel
|
Neurological Disease
|
|
GsAF-I is a potent Nav and hERG1 channels blocker with IC50s of 0.36, 0.6, 1.28, 0.33, 1.2, 0.04 and 4.8 μM against Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, Nav1.7 and hERG1, respectively .
|
-
- HY-P2969
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .
|
-
- HY-108882
-
|
DNase
|
Others
|
Inflammation/Immunology
Cancer
|
|
DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer .
|
-
- HY-R00013A
-
|
|
MicroRNA
|
|
|
hsa-let-7i-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-let-7i-3p agomir
hsa-let-7i-3p agomir
- HY-R03182A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-466i-5p agomir
mmu-miR-466i-5p agomir
- HY-158225
-
|
Col1MA
|
MMP
|
Others
|
Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen . Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.
|
-
- HY-R00014A
-
|
|
MicroRNA
|
|
|
hsa-let-7i-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-let-7i-5p agomir
hsa-let-7i-5p agomir
- HY-R03181A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-466i-3p agomir
mmu-miR-466i-3p agomir
- HY-13032
-
|
I-BET762; GSK525762; GSK525762A
|
Epigenetic Reader Domain
|
Cancer
|
|
Molibresib (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
|
-
- HY-123572
-
-
- HY-P991452
-
|
|
Orexin Receptor (OX Receptor)
|
Cancer
|
|
Anti-CD200R1/OX2R Antibody (I-4P) is a human monoclonal antibody (mAb) targeting CD200R1/OX2R. Anti-CD200R1/OX2R Antibody (I-4P) can be used in solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
- HY-A0126AR
-
|
Prostaglandin I2 sodium salt (Standard); Prostacyclin sodium salt (Standard); Flolan (Standard)
|
Reference Standards
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Epoprostenol (sodium) (Standard) is the analytical standard of Epoprostenol (sodium). This product is intended for research and analytical applications. Epoprostenol sodium (Prostaglandin I2 (sodium salt)), the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH) . Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation .
|
-
- HY-P0269
-
|
Magainin I
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .
|
-
- HY-163970
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Heparin disaccharide I-A (sodium)is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-110106
-
|
GSK1210151A dihydrochloride
|
Epigenetic Reader Domain
|
Cancer
|
|
I-BET151 dihydrochloride (GSK1210151A dihydrochloride) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively .
|
-
- HY-13235
-
|
GSK1210151A
|
Epigenetic Reader Domain
|
Cancer
|
|
I-BET151 (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively .
|
-
- HY-P2738
-
|
|
MMP
|
Inflammation/Immunology
|
|
Collagen, Type I, from bovine achilles tendon are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. This product is enzymatically hydrolyzed collagen peptide .
|
-
- HY-107443A
-
|
(R)-Molibresib carboxylic acid; (R)-GSK525762A carboxylic acid; (R)-PROTAC BRD4-binding moiety 2
|
Ligands for Target Protein for PROTAC
Epigenetic Reader Domain
|
Cancer
|
|
(R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1 .
|
-
- HY-P990195
-
|
|
LAG-3
|
Others
|
|
Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse MHC Class I.
|
-
- HY-N9583
-
|
|
Others
|
Inflammation/Immunology
|
|
(S)-4-Methoxydalbergione can be isolated from Dalbergia odorifera. (S)-4-Methoxydalbergione has anti-allergic and anti-inflammatory activity. (S)-4-Methoxydalbergione inhibits superoxide formation .
|
-
- HY-107443
-
|
Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2
|
Ligands for Target Protein for PROTAC
Epigenetic Reader Domain
|
Cancer
|
|
I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1 .
|
-
- HY-N1239
-
|
Longiside B; Sitoindoside; Daucosterol 6'-O-palmitate
|
Others
|
Others
|
|
Sitoindoside I (Longiside B; Sitoindoside; Daucosterol 6'-O-palmitate) is a compound that can be isolated from Gyn'nops walla Gaertn .
|
-
- HY-108882D
-
|
|
DNA/RNA Synthesis
|
Others
|
|
Recombinant DNase I (Protease & RNase free, animal free) (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer . This product is recombinant bovine pancreatic DNase I, purified by chromatography, free of animal-derived components, RNase and protease, and contains glycine as a stabilizer.
|
-
- HY-N8292
-
|
|
Others
|
Others
|
|
7-(2'-Deoxyadenosin-N6-yl)aristolactam I is a Alkaloids product that can be isolated from the herbs of Aristolochia debilis Sieb. et Zucc .
|
-
- HY-B0175S
-
|
BAY-i 9142-d3
|
Isotope-Labeled Compounds
|
Infection
|
|
Toltrazuril-d3 is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.
|
-
- HY-153118
-
|
ctDNA sodium, Type I, fibers; DNA sodium, from calf thymus, Type I, fibers; Thymonucleic acid sodium, Type I, fibers
|
Biochemical Assay Reagents
|
Others
Cancer
|
|
Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc .
|
-
- HY-RI00013A
-
|
|
MicroRNA
|
Cancer
|
|
hsa-let-7i-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-let-7i-3p antagomir
hsa-let-7i-3p antagomir
- HY-RI00014A
-
|
|
MicroRNA
|
Cancer
|
|
hsa-let-7i-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-let-7i-5p antagomir
hsa-let-7i-5p antagomir
- HY-RI03182A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-466i-5p antagomir
mmu-miR-466i-5p antagomir
- HY-RI03181A
-
|
|
MicroRNA
|
Cancer
|
|
mmu-miR-466i-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
mmu-miR-466i-3p antagomir
mmu-miR-466i-3p antagomir
- HY-D0519
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 52:1 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D1191
-
|
|
Fluorescent Dye
|
Others
|
|
SYBR green I (chloride) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0314
-
|
Sudan R
|
Fluorescent Dye
|
|
|
Solvent Red 1 (C.I.) is a red dye. Its series of products, such as Solvent orange 60 (HY-D1177), has been used in dyeing applications of plastic materials.
|
-
- HY-P5903
-
|
aFGF (102-111)
|
FGFR
|
Neurological Disease
|
|
FGF acidic I (102-111) (bovine brain) (aFGF (102-111)) is the 102-111 fragment of acidic FGF that can be used as a potential neurotrophic agent .
|
-
- HY-D0293
-
|
Xylene Blue; C.I. Acid Blue 1
|
Biochemical Assay Reagents
|
Others
|
|
C.I. Acid Blue 1 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-158118
-
|
|
DNA-PK
|
Cancer
|
|
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-141488
-
|
Galβ1-3GlcNAc
|
Endogenous Metabolite
|
Endocrinology
|
|
Lacto-N-biose I (Galβ1-3GlcNAc), as an endogenous metabolite, is an acceptor for the α1,2-fucosyltransferase enzyme from Helicobacter pylori .
|
-
- HY-D0428
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 9 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0427
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 12 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0459
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment brown 25 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0405
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment yellow 74 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0488
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment orange 36 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0960
-
|
|
Fluorescent Dye
|
|
|
C.I. Solvent Blue 43 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0489
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment orange 38 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0493
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment yellow 62 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0408
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 38 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0686
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 221 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0531
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 123 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0450
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 112 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0392
-
|
|
Fluorescent Dye
|
|
|
C. I. Pigment yellow 16 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0486
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment violet 32 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0442
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 14 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0431
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment blue 56 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0510
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment orange 34 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0429
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 5 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0421
-
|
|
Fluorescent Dye
|
|
|
C.I. Solvent yellow 18 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0415
-
|
|
Fluorescent Dye
|
|
|
C.I. Vat blue 22 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0441
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 23 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0725
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment yellow 180 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0445
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment orange 16 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0426
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 8 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0457
-
|
|
Fluorescent Dye
|
|
|
C.I. Solvent red 179 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0394
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment red 2 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D1137
-
|
|
Fluorescent Dye
|
|
|
C.I. Pigment yellow 110 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-P0269A
-
|
Magainin I TFA
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .
|
-
- HY-P5976
-
|
Renin Substrate I
|
Renin
|
Others
|
|
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate
|
-
- HY-P4569
-
|
|
Dipeptidyl Peptidase
|
Others
|
|
H-Ser-Pro-OH is a dipeptide containing serine and proline, which can serve as a substrate for prolinase I (PD I) and PD II. H-Ser-Pro-OH can also be used for the synthesis of polypeptide .
|
-
- HY-W035155
-
|
|
Drug Intermediate
Endogenous Metabolite
|
|
|
(1,5-Cyclooctadiene)bis(methyldiphenylphosphine)iridium(I) hexafluorophosphate is a highly efficient catalyst with excellent hydrogenation activity. It can catalyze the reaction of hydrogen and organic substrates in various chemical reactions. This compound is often used to synthesize important chemical intermediates and compounds.
|
-
- HY-100738
-
|
NSC144303
|
Apoptosis
|
Cancer
|
|
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
|
-
- HY-162587
-
|
|
Topoisomerase
|
Cancer
|
|
Fagopyrine is a DNA topoisomerase I (Topo I) inhibitor. Fagopyrine is a photosensitizer that can be used in the study of tumors .
|
-
- HY-N6020B
-
|
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat .
|
-
- HY-108882B
-
|
|
DNA/RNA Synthesis
|
Others
|
|
DNase I (RNase & Protease free) (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer . Molecular biology grade, chromatographically purified to remove RNases and proteases. Supplied as a solution containing 50% glycerol and 1 mM Calcium chloride.
|
-
- HY-160129
-
|
ML-970; AS-I-145; NSC 716970
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening .
|
-
- HY-16229A
-
|
|
Apoptosis
GGTase
|
Cancer
|
|
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer .
|
-
- HY-16229
-
|
|
Apoptosis
|
Cancer
|
|
GGTI-2154 is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 can be used for the research of cancer .
|
-
- HY-154408
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2’-O-Me-5-I-U-3’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-160478
-
|
|
Bcr-Abl
|
Cancer
|
|
GNF-6 (Compound 14) inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50s of 0.25 μM, 0.09 μM and 0.590 μM for c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants, respectively. GNF-6, an ATP competitive inhibitor, disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), thereby locking the kinase in an inactive ‘DFG-out’ conformation .
|
-
- HY-N0510
-
|
Aristolochic acid I; TR 1736
|
NF-κB
|
Cancer
|
|
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .
|
-
- HY-18964
-
|
Calpain inhibitor I; Ac-LLnL-CHO; ALLN
|
Proteasome
Apoptosis
|
Cancer
|
|
MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer .
|
-
- HY-P1032S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Angiotensin I- 13C19, 15N3 (human, mouse, rat) is the 13C and 15N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
|
-
- HY-D0433
-
|
Navy Blue G
|
Fluorescent Dye
|
|
|
C.I. Vat Blue 16 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-D0407
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Acid black 94 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0414
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Acid blue 158 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0399
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Acid blue 40 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0472
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Acid red 97 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-W020887
-
|
Chlorobis(cyclooctene)iridium(I)dimer
|
Biochemical Assay Reagents
Endogenous Metabolite
|
|
|
[IrCl(COE)2]2 (Chlorobis(cyclooctene)iridium(I)dimer) is a transition metal catalyst with remarkable catalytic activity. It is widely used in catalyzing a variety of organic reactions, especially in the synthesis of unsaturated compounds. In addition, [IrCl(COE)2]2 has shown potential anti-tumor properties in biochemical research.
|
-
![[IrCl(COE)2]2](//file.medchemexpress.com/product_pic/hy-w020887.gif)
- HY-163292
-
|
|
Bacterial
Parasite
|
Infection
|
|
Antibacterial agent 180 (15g), an appropriate substrate for the type I nitro reductases (TcNTR I), is a promising antitrypanosomatid agent. Antibacterial agent 180 (15g) shows nonmutagenic potential against Salmonella typhimurium strains (TA98, TA100, and TA102) .
|
-
- HY-N15138
-
|
|
Glycosidase
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent α-glucosidase inhibitor, with an EC50 of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .
|
-
- HY-P3884
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Arylomycin A2, an antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects .
|
-
- HY-172103
-
|
|
Carbonic Anhydrase
|
Others
|
|
hCAI/II-IN-10 (Compound 5d) is a human carbonic anhydrase I and II (hCA I and hCA II) inhibitor with IC50 values are 4.32 and 3.89 nM respectively .
|
-
- HY-P1368
-
|
Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)
|
CRFR
|
Endocrinology
|
|
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats .
|
-
- HY-106700
-
|
CM 7857; Penticainide; Propisomide
|
Sodium Channel
|
Cardiovascular Disease
|
|
Pentisomide (CM 7857), a is an orally active antiarrhythmic agent that blocks sodium channels. Pentisomide processes Vaughan-Williams class I (class I) antiarrhythmic actions .
|
-
- HY-113681
-
-
- HY-D0523
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Food Blue 5:2 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-N5112B
-
|
Isoarnebin I
|
HIF/HIF Prolyl-Hydroxylase
Apoptosis
Notch
NO Synthase
Bcl-2 Family
|
Cancer
|
|
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .
|
-
- HY-P1368A
-
|
Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA
|
CRFR
|
Endocrinology
|
|
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats .
|
-
- HY-D0456
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Direct violet 66 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0395
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Mordant Orange 29 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0559
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Disperse blue 284 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0473
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Direct yellow 27 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0397
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Direct Violet 9 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0678
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Reactive yellow 86 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0487
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Pigment yellow 97 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0590
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Pigment red 187 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0560
-
|
|
Fluorescent Dye
|
Others
|
|
C.I. Pigment red 247 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-D0460
-
|
Pigment red 48 calcium salt
|
Fluorescent Dye
|
|
|
C.I. Pigment red 48 is the most important colorant used to add color or change the color of something and is chemically essentially unaffected by the carrier or medium into which it is incorporated. It can be widely used in textile, medicine, food, cosmetics, plastics, paint, ink, photography and paper industries.
|
-
- HY-P5333
-
|
UB311 immunogen I
|
Amyloid-β
|
Others
|
|
Aβ1-14-εK-KKK-MvF5 Th (UB311 immunogen I) is a biological active peptide. (one of UB-311's Aβ1–14–targeting peptides (B-cell epitope))
|
-
- HY-118581
-
|
|
Topoisomerase
|
Cancer
|
|
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .
|
-
- HY-P99530
-
|
AGT-181; HIRMAb-IDUA
|
Insulin Receptor
|
Metabolic Disease
|
|
Valanafusp alfa (AGT-181) is a chimeric monoclonal antibody that fuses human α-L-iduronidase (IDUA) and targets the human insulin receptor (HIR). Valanafusp alfa has brain penetrating properties, making it useful for research on mucopolysaccharidosis type I (MPS I) .
|
-
- HY-145707
-
|
|
Mitochondrial Metabolism
|
Cancer
|
|
BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor. BAY-179 shows IC50 values of 79 nM, 38 nM, 27 nM, and 47 nM for human, mouse, rat, and dog complex I, respectively .
|
-
- HY-P10582A
-
|
|
MHC
|
Inflammation/Immunology
|
|
SIYNFEKL TFA is a variant of major MHC class I-restricted epitope SIINFEKL. SIYNFEKL TFA is an antigenic peptide, that can stimulate specific T cells in experimental settings to study the competitive interaction between T cell. SIYNFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR), and can be used for detection of CD8+ T cells .
|
-
- HY-P10581A
-
|
|
MHC
|
Inflammation/Immunology
|
|
SIIVFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. SIIVFEKL TFA is an antigenic peptide, that can stimulate specific T cells in experimental settings to study the competitive interaction between T cells. SIIVFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR), and can be used for detection of CD8+ T cells .
|
-
- HY-W010685
-
|
[Rh(dppb)(COD)]BF4
|
Biochemical Assay Reagents
Endogenous Metabolite
|
Others
|
|
[1,4-Bis(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate ([Rh(dppb)(COD)]BF4) serves as a rhodium-based catalyst that facilitates regioselective hydrogenation and enantioselective reductive amination reactions.
|
-
rhodium(I) tetrafluoroborate](//file.medchemexpress.com/product_pic/hy-w010685.gif)
- HY-12484
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .
|
-
- HY-P990185
-
|
|
MHC
|
Others
|
|
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse/rat MHC Class II.
|
-
- HY-B1359
-
|
C.I. Basic Blue 9 trihydrate
|
Guanylate Cyclase
Monoamine Oxidase
NO Synthase
Parasite
|
Infection
Neurological Disease
Cancer
|
|
Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment .
|
-
- HY-P2972
-
|
|
Endogenous Metabolite
|
Others
|
|
Sulfatase, Helix pomatia is a type I enzyme of prokaryotes and eukaryotes. Sulfatase, Helix pomatia is a sulfatase enzyme, is often used in biochemical studies .
|
-
- HY-156723
-
|
|
Topoisomerase
|
Cancer
|
|
9-Chloromethyl-10-hydroxy-11-F-Camptothecin is a novel camptothecin derivatives. 9-Chloromethyl-10-hydroxy-11-F-Camptothecin is a DNA topoisomerase I (Topo I) inhibitor, can be used in anticancer research .
|
-
- HY-147708
-
|
|
Calcium Channel
|
Cancer
|
|
T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively .
|
-
- HY-153008
-
|
|
Bcr-Abl
|
Cancer
|
|
BCR-ABL-IN-7 (compound 4) is a WT and T315I mutant ABL kinases inhibitor. BCR-ABL-IN-7 effectively inhibits activities of WT and T315I mutant ABL kinases. BCR-ABL-IN-7 can be used for the research of chronic myeloid leukemia (CML) research .
|
-
- HY-103559
-
|
|
mGluR
|
Neurological Disease
|
|
HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat .
|
-
- HY-B1102
-
|
Direct Blue 53; T-1824; C.I. 23860
|
EAAT
iGluR
|
Cardiovascular Disease
Neurological Disease
|
|
Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .
|
-
- HY-113066C
-
|
GDP (sodium), Type I, 96% (HPLC)
|
Endogenous Metabolite
Potassium Channel
|
Inflammation/Immunology
Cancer
|
|
Guanosine 5'-diphosphate (sodium), 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate sodium, Type I, 96% (HPLC) is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate (sodium), 96% (HPLC) can be used in the research of inflammation, such as anemia of inflammation (AI) .
|
-
- HY-13622B
-
|
BN 80927 TFA
|
Topoisomerase
|
Cancer
|
|
Elomotecan TFA is a potent inhibitor of topoisomerases I and II. Elomotecan TFA is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan TFA reduces the proliferation of different tumor cells with higher potency than other anticancer agents of reference targeting topoisomerases I and II .
|
-
- HY-13622A
-
|
BN 80927 free base
|
Topoisomerase
|
Cancer
|
|
Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II. Elomotecan is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan reduces the proliferation of different tumor cells with higher potency than other anticancer agents of reference targeting topoisomerases I and II .
|
-
- HY-N3488
-
|
|
Topoisomerase
Bacterial
Fungal
|
Infection
Cancer
|
|
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .
|
-
- HY-170911
-
|
|
PDGFR
|
Cancer
|
|
KIT/PDGFRA-IN-1 (compound 19) is a stem cell growth factor receptor (KIT) and platelet-derived growth factor receptor alpha (PDGFRA) inhibitor. KIT/PDGFRA-IN-1 inhibits KIT-wt, KIT-D816H, KIT-T670I, PDGFRA-wt, PDGFRA-D842V, PDGFRA-T674I and PDGFRA-G680R with IC50s of 2.3, 12, 492, 0.8, 99.9, 42.3, and 4.3 μM, respectively. KIT/PDGFRA-IN-1 inhibits GIST-T1, T1-a-D842V and GIST-48B cells (PDGFR- and KIT-Mutant GIST cell Lines) with GR50s of 12, 8900, ≥10 000 nM, respectively .
|
-
- HY-13218
-
|
WP-871
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Acitazanolast is an orally active antiallergic agent, can inhibit histamine release. Acitazanolast can be used in study of type I anaphylaxis (immediate) caused by IgE antibodies .
|
-
- HY-159118
-
|
|
Bacterial
|
Infection
|
|
PC-Qz1 is a mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor with an IC50 of 470 nM. PC-Qz1 has antibacterial activity .
|
-
- HY-139015
-
|
5-Aza-T-dCyd; NTX-301
|
DNA Methyltransferase
|
Cancer
|
|
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects .
|
-
- HY-13622
-
|
BN 80927
|
Topoisomerase
|
Cancer
|
|
Elomotecan hydrochloride (BN 80927) is a potent inhibitor of topoisomerases I and II. Elomotecan hydrochloride (BN 80927) is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan hydrochloride (BN 80927) reduces the proliferation of different tumor cells with higher potency than other anticancer agents of reference targeting topoisomerases I and II .
|
-
- HY-100777
-
|
|
Topoisomerase
|
Cancer
|
|
DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells .
|
-
- HY-112624K
-
|
Dextran 5; Dextran D5; Dextran T5(MW 4500-5500)
|
Apoptosis
Autophagy
|
Others
|
|
Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
-
- HY-108991
-
|
(-)-T-0509
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
T-0509 ((-)-T-0509) is a selective full agonist of the β1 receptor. T-0509 activates the cAMP signaling pathway through the β1 receptor and enhances myocardial contractility .
|
-
- HY-123159
-
|
|
Aurora Kinase
|
Cancer
|
|
AKI603 is an inhibitor of Aurora kinase A (AurA), with an IC50 of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells .
|
-
- HY-152157
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M .
|
-
- HY-W010452
-
|
β-Hydroxybutyric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
|
-
- HY-113378
-
|
β-Hydroxybutyric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids .
|
-
- HY-N15319
-
|
Canangine
|
Topoisomerase
Fungal
|
Infection
|
|
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases .
|
-
- HY-12083
-
|
|
Bcr-Abl
|
Cancer
|
|
PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba?F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML) .
|
-
- HY-P10316
-
|
Calmodulin-Dependent Protein Kinase I (299-320) Binding Domain
|
CaMK
|
Others
|
|
CaMKI (299-320) refers to a peptide consisting of residues 299-320 of Calcium/calmodulin-dependent protein kinase I (CaMKI). CaMKI (299-320), as a protein kinase, has a high affinity interaction with Ca 2+-CAM (Kd≤1 nM≤1 nM), which can phosphorylate specific substrate proteins, thereby regulating their activity. CaMKI (299-320) contains the CAM-binding domain and the self-inhibition domain, and CaMKI (299-320) can be used to study cell physiological processes, including cell proliferation, differentiation, and apoptosis .
|
-
- HY-17020
-
-
- HY-N3642
-
|
Erythrabyssin I; Erythrabissin I
|
Others
|
Cancer
|
|
Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence .
|
-
- HY-17020A
-
-
- HY-101489
-
|
|
PDGFR
Bcr-Abl
Apoptosis
|
Cancer
|
|
GZD856 formic is a potent and orally active PDGFRα/β inhibitor, with IC50s of 68.6 and 136.6 nM, respectively. GZD856 formic is also a Bcr-Abl T315I inhibitor, with IC50s of 19.9 and 15.4 nM for native Bcr-Abl and the T315I mutant. GZD856 formic has antitumor activity .
|
-
- HY-12071
-
|
DM-3189
|
Organoid
TGF-β Receptor
|
Cancer
|
|
LDN193189 is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
|
-
- HY-148161
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity .
|
-
- HY-158423
-
|
|
Mitochondrial Metabolism
Parasite
|
Infection
|
|
NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths .
|
-
- HY-163003
-
|
|
Parasite
|
Infection
|
|
Antitrypanosomal agent 19 (compound 10) is an orally available antitrypanosomal agent. Antitrypanosomal agent 19 effectively inhibits the growth of trypanosomatids T. b. brucei, T. b. gambiense and T. b. rhodesiense, mitigating the Human trypanosomiasis (HAT)-induced acute infectious toxicity in mice .
|
-
- HY-N2373
-
-
- HY-127167
-
|
|
Histamine Receptor
|
Inflammation/Immunology
|
|
3',4'-Dihydroxyflavone is a flavonoid. 3',4'-Dihydroxyflavone has antiallergic activity with an IC50 value of 30 μM. 3',4'-Dihydroxyflavone can be used for the research of type I allergy .
|
-
- HY-171837A
-
|
|
TNF Receptor
Interleukin Related
SOD
|
Inflammation/Immunology
|
|
t9,t11,c15-CLNA is a conjugated linolenic acid (CLNA) isomer produced by Lactobacillus plantarum ZS2058. t9,t11,c15-CLNA has the main activities of anti-inflammatory, antioxidant and improving intestinal barrier function. The regulatory mechanism of t9,t11,c15-CLNA includes upregulation of tight junction proteins, inhibition of pro-inflammatory cytokines (such as TNF-α, IL-6) and activation of antioxidant enzymes (such as SOD, CAT). t9,t11,c15-CLNA can be used in the study of inflammatory bowel diseases (such as colitis) .
|
-
- HY-P5305A
-
|
|
GABA Receptor
|
Metabolic Disease
|
|
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .
|
-
- HY-W015764
-
T-1105
1 Publications Verification
|
Flavivirus
|
Infection
|
|
T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase .
|
-
- HY-172972
-
-
- HY-100777R
-
|
|
Topoisomerase
Reference Standards
|
Cancer
|
|
DACA (Standard) is the analytical standard of DACA. This product is intended for research and analytical applications. DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells .
|
-
- HY-118723
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types .
|
-
- HY-161307
-
|
|
HDAC
Microtubule/Tubulin
|
Neurological Disease
|
|
T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy .
|
-
- HY-162515
-
|
|
Mitochondrial Metabolism
|
Cancer
|
|
8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines .
|
-
- HY-16560
-
|
Campathecin; (S)-(+)-Camptothecin; CPT
|
Topoisomerase
ADC Cytotoxin
MicroRNA
Influenza Virus
Apoptosis
Fungal
Antibiotic
|
Infection
Cancer
|
|
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .
|
-
- HY-163763
-
|
|
G2A (GPR132)
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
T-10418 is a potent and highly selective G2A/GPR132 agonist. T-10418 has an EC50 of 0.82 μM for human G2A activation. T-10418 has good water solubility, metabolic stability, and pharmacokinetic properties. T-10418 can be used for the research of various diseases such as neuropathic pain, acute myeloid leukemia, and inflammation .
|
-
- HY-W142313
-
|
Dimethyldodecylethylammonium bromide, 98%(T)
|
Biochemical Assay Reagents
|
Others
|
|
Dodecylethyldimethylammonium bromide (EDDAB), 98%(T) (Dimethyldodecylethylammonium bromide, 98%(T)) is a cationic surfactant .
|
-
- HY-Y1184B
-
|
Potassium hydrogen carbonate, 99.5%(T)
|
Biochemical Assay Reagents
|
Others
|
|
Potassium bicarbonate, 99.5%(T) (Potassium hydrogen carbonate, 99.5%(T)) is a biologically active chemical .
|
-
- HY-N8039
-
|
Ganodermic acid T-Q
|
Microtubule/Tubulin
|
Cancer
|
|
Ganoderic acid T-Q (Ganodermic acid T-Q) (compound 1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid T-Q stimulates tubulin polymerization .
|
-
- HY-139070
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glyceric acid is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .
|
-
- HY-128589
-
|
|
c-Kit
|
Cancer
|
|
CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC50 of 0.045 μM .
|
-
- HY-W248726
-
|
|
Biochemical Assay Reagents
|
Others
|
|
tert-Butyl (6-iodohexyl)carbamate is a six carbon linker containing an iodine group and a t-butyl ester. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions. The t-butyl ester groups can be deprotected under acidic conditions.
|
-
- HY-168484
-
-
- HY-N6720
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t1/2λz), Peak plasma concentrations (Cmax) and Tmax values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .
|
-
- HY-100682
-
|
|
IAP
|
Cancer
|
|
T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC50s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity .
|
-
- HY-105349
-
|
|
Phosphodiesterase (PDE)
|
Neurological Disease
|
|
T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway .
|
-
- HY-125594
-
-
- HY-146693
-
|
|
TGF-β Receptor
|
Cancer
|
|
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex .
|
-
- HY-W010452S1
-
-
- HY-W010452S2
-
-
- HY-123450
-
|
|
Bcr-Abl
Apoptosis
PDGFR
|
Cancer
|
|
S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-145304
-
-
- HY-147414
-
|
PF-114
|
Bcr-Abl
|
Cancer
|
|
Vamotinib (PF-114) is a potent, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces apoptosis. Vamotinib shows anti-proliferative and anti-tumor activity. Vamotinib has the potential for the research of resistant philadelphia chromosome-positive (Ph+) leukemia. Vamotinib inhibits ABL series kinases with IC50s of 0.49 nM (ABL), 0.78 nM (ABL T315I), 9.5 nM (ABL E255K), 2.0 nM (ABL F317I), 7.4 nM (ABL G250E), 1.0 nM (ABL H396P), 2.8 nM (ABL M351T), 12 nM (ABL Q252H), and 4.1 nM (ABL Y253F), respectively . Vamotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151412
-
-
- HY-19352
-
|
T5601640
|
LIM Kinase (LIMK)
|
Cancer
|
|
T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM.
|
-
- HY-161142
-
-
- HY-139202
-
|
|
Integrin
|
Inflammation/Immunology
|
|
XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo .
|
-
- HY-13611
-
|
BN 80915
|
Topoisomerase
|
Cancer
|
|
Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds .
|
-
- HY-116933
-
|
|
Topoisomerase
Bacterial
|
Infection
Inflammation/Immunology
|
|
Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and topoisomerase II (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial .
|
-
- HY-120356A
-
|
TAI-95 tosylate
|
NEKs
Apoptosis
|
Cancer
|
|
T-1101 tosylate (TAI-95 tosylate) is the tosylate salt form of T-1101 (HY-120356). T-1101 tosylate is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 tosylate blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 tosylate induces apoptosis in Huh-7. T-1101 tosylate exhibits antitumor efficacy in mouse models .
|
-
- HY-117938
-
|
|
Aminoacyl-tRNA Synthetase
|
Cancer
|
|
T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight .
|
-
- HY-152218
-
|
|
Dynamin
|
Neurological Disease
|
|
Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM .
|
-
- HY-136498A
-
|
|
Drug Metabolite
|
Infection
|
|
T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .
|
-
- HY-106158
-
|
|
SGLT
|
Metabolic Disease
|
|
T-1095 is a selective and orally active Na +-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research .
|
-
- HY-D0983
-
-
- HY-122635A
-
|
|
Histone Demethylase
|
Neurological Disease
|
|
T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons .
|
-
- HY-155281
-
|
|
Parasite
|
Infection
|
|
Antiparasitic agent-18 (compound 3a) is active and selective against the T. brucei (EC50=0.4 μM), T. cruzi (EC50=0.21 μM), and L. donovani (EC50=0.26 μM). Antiparasitic agent-18 has potent antiprotozoal activity .
|
-
- HY-11085
-
|
|
MCHR1 (GPR24)
|
Metabolic Disease
|
|
T-226296 is an oral active and selective melanin-concentrating hormone receptor antagonist with the IC50 values of 5.5 nM and 8.6 nM for human SLC-1 and rat SLC-1, respectively. T-226296 can be used for study of obesity and insulin resistance .
|
-
- HY-136498
-
|
|
Drug Metabolite
|
Infection
|
|
T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM .
|
-
- HY-145303
-
-
- HY-161045
-
|
|
EGFR
Apoptosis
|
Cancer
|
|
T-1-DOCA ia a EGFR inhibitor, with the IC50 of 56.94 and 269.01?nM for EGFR WT and EGFR T790M, respectively. T-1-DOCA can induces cell apoptosis of HCT-116 cells .
|
-
- HY-B0724B
-
-
- HY-B0959
-
|
|
Bacterial
|
Infection
|
|
Chloramine-T is a titrimetric reagent, and an oxidizing agent. Chloramine-T is an oxidizing biocide .
|
-
- HY-134315
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-164143
-
|
|
Topoisomerase
|
Cancer
|
|
T638 is a topoisomerase II (TOP2) inhibitor. T638 inhibits TOP2A activity with a IC50 of 0.7 uM. T638 strongly inhibits cancer cell growth .
|
-
- HY-18819
-
|
|
Bcr-Abl
|
Cancer
|
|
BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1 native and ABL1 T315I, respectively.
|
-
- HY-10339
-
-
- HY-12270R
-
|
|
AP-1
MMP
|
Others
|
|
T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
|
-
- HY-N10375
-
|
|
COX
|
Others
|
|
Kuwanon T is an isoprenylated flavonoid compound isolated from the root bark of Morus alba. Kuwanon T shows protective effects on t-BHP-induced oxidative stress with a EC50 of 30.32 μM .
|
-
- HY-P10356
-
|
|
TRP Channel
|
Others
|
|
T100-Mut is a cell-permeable peptide whose N-terminus is conjugated with a myristoylated group to enable T100-Mut to penetrate and localize to the inner side of the plasma membrane, thus mimicking the topology of Tmem100-3Q. T100-Mut can alleviate TRPA1-mediated pain .
|
-
- HY-142102
-
|
(+)-T988C
|
Others
|
Cancer
|
|
T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .
|
-
- HY-W111144
-
|
|
Hedgehog
|
Cancer
|
|
T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression .
|
-
- HY-102045
-
-
- HY-152430
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154332
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
8-(Phenylmethoxy)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152610
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
3′-C-Methylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152517
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
8-(Methylthio)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-148820
-
|
|
Drug-Linker Conjugates for ADC
Topoisomerase
|
Cancer
|
|
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make an antibody agent conjugate (ADC), ABBV-969 .
|
-
![Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT](//file.medchemexpress.com/product_pic/hy-148820.gif)
- HY-110251
-
|
|
DNA Stain
|
Others
|
|
DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells .
|
-
- HY-162064
-
|
|
VEGFR
|
Cancer
|
|
T-1-MBHEPA is a potent inhibitor of VEGFR-2, with the IC50 value of 0.121±0.051 μM. T-1-MBHEPA has anti-tumor and anti-angiogenic effect .
|
-
- HY-158149
-
|
|
EGFR
Apoptosis
|
Cancer
|
|
T-1-PMPA is a potent EGFR inhibitor with apoptotic properties. T-1-PMPA effectively inhibits EGFR WT and EGFR 790m, with IC50 values of 86 nM and 561.73 nM, respectively .
|
-
- HY-W190966
-
|
|
PROTAC Linkers
|
Others
|
|
t-Boc-Aminooxy-PEG4-t-butyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-13202R
-
|
|
PPAR
|
Cancer
|
|
T0070907 (Standard) is the analytical standard of T0070907. This product is intended for research and analytical applications. T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
|
-
- HY-122083
-
|
|
PPAR
|
Metabolic Disease
|
|
T2384 is a peroxisome proliferator-activated receptor γ (PPARγ) ligand. T2384 also is an orally active antidiabetic agent. T2384 reduces the fasting plasma glucose levels and plasma insulin levels .
|
-
- HY-156452
-
|
|
VEGFR
|
Cancer
|
|
T-1-MCPAB is a VEGFR-2 inhibitor (IC50=0.135 µM) that effectively inhibits MCF7 migration. T-1-MCPAB can be used in cancer research .
|
-
- HY-120356
-
|
TAI-95
|
Apoptosis
NEKs
|
Cancer
|
|
T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models .
|
-
- HY-113378R
-
|
β-Hydroxybutyric acid (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid (Standard) is the analytical standard of 3-Hydroxybutyric acid. This product is intended for research and analytical applications. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].
|
-
- HY-13202S
-
-
- HY-110251A
-
|
|
DNA Stain
|
Others
|
|
DFHBI-2T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=500 nm/523 nm). DFHBI-2T is used to image RNA in live cells .
|
-
- HY-103085
-
|
|
Histone Demethylase
|
Cancer
|
|
T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM.
|
-
- HY-154111
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
8-(N-Boc-aminomethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152673
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154506
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-Phenoxyacetylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152742
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
8-(N,N-Dimethylaminomethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-137406
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
1,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152652
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-P5745
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
TYVPANASL is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL can be used to prepare J-LEAPS vaccine .
|
-
- HY-123390
-
|
|
Bcr-Abl
Akt
|
Cancer
|
|
DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM .
|
-
- HY-169203
-
|
|
Fungal
|
Cancer
|
|
Antifungal agent 119 (compund T23) is an antifungal agent that targets type I reduced NADH oxidoreductase. Antifungal agent 119 carries an azide group and can be used for click chemistry reactions. .
|
-
- HY-163028
-
|
|
Tim3
|
Cancer
|
|
ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1.
ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research .
|
-
- HY-P1630
-
|
|
Bacterial
|
Infection
|
|
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria .
|
-
- HY-122210
-
-
- HY-162516
-
|
|
AMPK
Mitochondrial Metabolism
|
Cancer
|
|
DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells .
|
-
- HY-13418
-
|
Compound C dihydrochloride; BML-275 dihydrochloride
|
Organoid
AMPK
TGF-β Receptor
Autophagy
|
Cancer
|
|
Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).
|
-
- HY-152216
-
|
|
Dynamin
|
Neurological Disease
|
|
Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM .
|
-
- HY-114909
-
|
|
Parasite
|
Infection
|
|
TachypleginA can inhibit the motility of T. gondii by binding directly and covalently to C58 of TgMLC1，thereby causing a decrease in the activity of the parasite's myosin motor .
|
-
- HY-172030
-
-
- HY-114220
-
|
|
Fungal
|
Infection
|
|
T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
|
-
- HY-10626R
-
|
|
Reference Standards
LXR
FXR
ROR
Apoptosis
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
T0901317 (Standard) is the analytical standard of T0901317. This product is intended for research and analytical applications. T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα . T0901317 activates FXR with an EC50 of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .
|
-
- HY-N12728
-
|
|
Others
|
Others
|
|
Heteroclitin G is a lignan which can be extracted from Dian-Jixueteng. Heteroclitin G (2.0 mg/kg, i.v.) exerts an C5min of 665.97 ± 29.89 ng/mL and T1/2z of 5.04 ± 1.84 h .
|
-
- HY-N11648
-
|
|
Apoptosis
Caspase
|
Inflammation/Immunology
Cancer
|
|
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .
|
-
- HY-155107
-
|
|
Mitochondrial Metabolism
Bacterial
|
Infection
|
|
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study .
|
-
- HY-152493
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-13418A
-
Dorsomorphin
Maximum Cited Publications
565 Publications Verification
Compound C; BML-275
|
Organoid
AMPK
TGF-β Receptor
Autophagy
|
Cancer
|
|
Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .
|
-
- HY-162045
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
Ru-4T is a phototherapy agent. Ru-4T has phototherapeutic efficacy (PI = 114,000) against melanoma cells (SK-MEL-28) under broad-band visible light (400-700 nm) with EC50 values of 740 pM .
|
-
- HY-118490
-
-
- HY-P0229
-
|
Rnase T1
|
DNA/RNA Synthesis
|
Others
|
|
Ribonulease T1, Aspergillus oryzae (Rnase T1), is commonly used in biochemical research. Ribonuclease T1 is an endonuclease that can specifically degrade single stranded RNA. Ribonuclease T1 can form nucleoside 2 ', 3 '-cyclic phosphoric acid intermediates to cut the phosphodiester bond between 3' -guanosine residues and adjacent nucleoside 5 '-OH groups to produce 3' -GMP terminal oligonucleotides .
|
-
- HY-P1115
-
|
|
Akt
|
Others
|
|
AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .
|
-
- HY-114271A
-
-
- HY-114272A
-
-
- HY-137460
-
|
K0706
|
Bcr-Abl
|
Cancer
|
|
Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic myeloid leukemia (CML) research . Vodobatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-129765
-
|
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells .
|
-
- HY-139070A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glyceric acid sodium is the sodium form of D-Glyceric acid (HY-139070A). D-Glyceric acid is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .
|
-
- HY-146404
-
-
- HY-148185
-
|
|
ADC Cytotoxin
|
Cancer
|
|
T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity .
|
-
- HY-P5981
-
-
- HY-P2251
-
|
|
HIV
Microtubule/Tubulin
|
Infection
Inflammation/Immunology
Cancer
|
|
T-peptide, a Tuftsin analog, can be used for the research of human immunodeficiency virus (HIV) infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection .
|
-
- HY-162406
-
|
|
TAM Receptor
|
Cancer
|
|
UNC8969 (compound 43) is a MERTK/AXL dual inhibitor with IC50s of 1.1±0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. UNC8969 also exerts a T1/2 of 7.3 h with 5 mg/kg i.v. in mice .
|
-
- HY-125961
-
|
|
Others
|
Cancer
|
|
T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream) .
|
-
- HY-164685
-
|
|
Phosphodiesterase (PDE)
|
Neurological Disease
|
|
T-0156 free base is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 free base specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 free base inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 free base enhances the nitric oxide (NO)/cGMP pathway .
|
-
- HY-119690
-
|
|
HDAC
HIV
|
Infection
Cancer
|
|
T326 is a potent and selective HDAC3 inhibitor, with an IC50 of 0.26 μM. T326 can be used for the research of cancer and HIV infection .
|
-
- HY-12270
-
|
|
AP-1
MMP
|
Others
|
|
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
|
-
- HY-160068
-
|
|
EGFR
|
Cancer
|
|
2-2(t) aptamer sodium is a 42-nucleotide trimeric complex of aptamer (2-2) targeting ErbB-2. 2-2(t) aptamer sodium inhibits the growth of gastric cancer cells in vitro and in vivo .
|
-
- HY-W012954B
-
|
Tetramethylammonium chloride, for molecular biology, 99%(T)
|
Biochemical Assay Reagents
|
Others
|
|
TMA chloride, for molecular biology, 99%(T) (Tetramethylammonium chloride, for molecular biology, 99%(T)) can increase the specificity of hybridization and raise the DNA denaturation temperature in PCR.
|
-
- HY-128139
-
|
2'-C-beta-Methylguanosine
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154336
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
![N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine](//file.medchemexpress.com/product_pic/hy-154336.gif)
- HY-152991
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154549
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154484
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3’-O-Me-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152993
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-18600A
-
|
NE-10064 dihydrochloride
|
Potassium Channel
|
Cardiovascular Disease
|
|
Azimilide (NE-10064) dihydrochloride is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
|
-
- HY-18600
-
|
NE-10064
|
Potassium Channel
|
Cardiovascular Disease
|
|
Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
|
-
- HY-110111A
-
|
|
DNA/RNA Synthesis
|
Others
|
|
T2AA hydrochloride is a non-peptide small molecule PCNA inhibitor T2 amino alcohol (T2AA) that lacks thyroid hormone activity. T2AA hydrochloride inhibits the interaction of PCNA/PIP-box peptide (IC50=~1 μM) and the interaction of PCNA with full-length p21 protein .
|
-
- HY-164395
-
|
|
Phosphatase
|
Inflammation/Immunology
Cancer
|
|
Sipuleucel-T is a cancer vaccine. Sipuleucel-T recognizes prostatic acid phosphatase (PAP), present PAP antigens, and stimulates the immune response against prostate cancer cells .
|
-
- HY-155230
-
|
|
Bacterial
|
Infection
|
|
T3SS-IN-2 (Compound 2h) is a type three secretion system (T3SS) inhibitor. T3SS-IN-2 can be used for bacterial infection research .
|
-
- HY-172724
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .
|
-
- HY-172723A
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .
|
-
- HY-172723
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG2000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG2000-T7 can be used for drug delivery .
|
-
- HY-158320
-
|
|
Bacterial
|
Infection
|
|
T3SS-IN-5 (Compound F9) is a specific inhibitor of the type III secretion system (T3SS). T3SS-IN-5 reduces bacterial pathogenicity without affecting bacterial viability by inhibiting the expression of genes associated with T3SS .
|
-
- HY-172722
-
|
|
Liposome
|
Cancer
|
|
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .
|
-
- HY-P5745A
-
|
|
MHC
EGFR
|
Cancer
|
|
TYVPANASL TFA is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL TFA can be used to prepare J-LEAPS vaccine .
|
-
- HY-162063
-
-
- HY-144641
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .
|
-
- HY-144640
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of human carbonic anhydrase (hCA), with Kis of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I, respectively .
|
-
- HY-103660
-
-
- HY-107533
-
|
|
GnRH Receptor
|
Endocrinology
|
|
T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM .
|
-
- HY-161528
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
T3/OVA is an antigen-adjuvant conjugate formed by conjugating T3 (thyroxine) with ovalbumin (OVA). By conjugating the antigen with protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
|
-
- HY-161552
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
T3/BSA is an antigen-adjuvant conjugate of T3 (thyroid hormone) and bovine serum albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
|
-
- HY-101380A
-
|
|
Imidazoline Receptor
|
Neurological Disease
|
|
BU226 hydrochloride is a selective imidazoline 2 (I2) receptors ligand with an Ki of 1.4 nM for I2 and an IC50 of 534.5 nM for I1. BU226 hydrochloride can be used for researching antidepressant .
|
-
- HY-162266
-
|
|
Ser/Thr Protease
|
Cancer
|
|
C3TD879 is a Type I kinase inhibitor that potently inhibits CITK catalytic activity (IC50 = 12 nM). C3TD879 binds directly to full-length human CITK in cells (NanoBRET Kd < 10 nM). C3TD879 is a chemical probe suitable for interrogating the complex biology of CITK .
|
-
- HY-120858
-
-
- HY-124332
-
-
- HY-N14437
-
|
|
Antibiotic
Fungal
|
Infection
|
|
Pradimicin T2 is an antibiotic. Pradimicin T2 has activity against filamentous fungi and yeast-like fungi .
|
-
- HY-162376
-
|
|
Bacterial
|
Infection
|
|
T3SS-IN-4 (Compound Z-8) is a T3SS inhibitor that can inhibit the expression of Xanthomonas oryzae pv oryzae (Xoo) T3SS-related genes without affecting bacterial growth. T3SS-IN-4 can effectively reduce the hypersensitive response (HR) induced by Xoo in tobacco and lower the pathogenicity of Xoo in rice .
|
-
- HY-161526
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
T3/KLH is an antigen-adjuvant conjugate formed by the coupling of T3 (thyroid hormone) with keyhole limpet hemocyanin (KLH). By coupling the antigen with the protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
|
-
- HY-N7300
-
-
- HY-P1287
-
|
|
iGluR
|
Neurological Disease
|
|
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa .
|
-
- HY-139308
-
T0467
2 Publications Verification
|
PINK1/Parkin
Mitochondrial Metabolism
|
Neurological Disease
|
|
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research .
|
-
- HY-116456
-
-
- HY-D0971
-
|
Pyronine G; C.I. 45005
|
DNA Stain
|
Others
|
|
Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells .
|
-
- HY-154482
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-iso-Butyroyl-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154448
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3,5-Bis-O-(2,4-dichlorobenzyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152988
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152992
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152797
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
N4-Desmethyl-N5-Methyl wyosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154547
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-157130
-
|
|
Bacterial
|
Infection
|
T3SS-IN-3 (compound F-24) is an inhibitor of type III secretion system (T3SS). T3SS-IN-3 inhibits the transcription of hrpY gene significantly without inhibiting bacterial growth .
|
-
- HY-P0272
-
|
|
HIV
|
Infection
|
|
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.
|
-
- HY-P10800
-
|
|
Deubiquitinase
|
Cancer
|
|
T20-M is a lead peptide that shows good potential for binding affinity towards UBE2C .
|
-
- HY-139801
-
|
CI-907
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
Metabolic Disease
|
|
Indolapril hydrochloride (CI-907) is an orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor. Indolapril hydrochloride is highly specific in suppressing the contractile or pressor responses to Angiotensin I. Indolapril hydrochloride is a potent antihypertensive agent .
|
-
- HY-144106
-
|
|
HCV
|
Infection
|
|
HCV-IN-33 (Compound (S)-3i) is an HCV entry inhibitor .
|
-
- HY-119370
-
|
|
Bcr-Abl
Apoptosis
|
Cancer
|
|
CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively .
|
-
- HY-W129509
-
-
- HY-135780
-
-
- HY-161029
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (Ki=22 nM, IC50=6 nM). T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile .
|
-
- HY-158269
-
-
- HY-118441
-
-
- HY-U00028
-
-
- HY-101489A
-
|
|
PDGFR
Bcr-Abl
Apoptosis
|
Cancer
|
|
GZD856 formic is a potent and orally active PDGFRα/β inhibitor, with IC50s of 68.6 and 136.6 nM, respectively. GZD856 formic is also a Bcr-Abl T315I inhibitor, with IC50s of 19.9 and 15.4 nM for native Bcr-Abl and the T315I mutant. GZD856 formic has antitumor activity . GZD856 (formic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-161269
-
|
|
EGFR
|
Cancer
|
|
EGFR-IN-101 (I-10) is a 2-phenylamino pyrimidine derivative. EGFR-IN-101 is a EGFR inhibitor. The IC50 values for EGFR L858R/T790M/C797S and Ba/F3-EGFR L858R/T790M/C797S are 33.26 and 106.4 nM, respectively. EGFR-IN-101 can be used IN the study of non-small cell lung cancer (NSCLC) .
|
-
- HY-W015590R
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Polyphyllin I (Standard) is the analytical standard of Polyphyllin I. This product is intended for research and analytical applications. Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
|
-
- HY-122635
-
|
|
Histone Demethylase
|
Neurological Disease
|
|
T-448 free base is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons .
|
-
- HY-171836
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
c9,t11-CLA is an active isomer of conjugated linoleic acid (CLA). c9,t11-CLA has multiple physiological activities such as anti-cancer, anti-atherosclerosis, anti-obesity, anti-diabetes and anti-hypertension. The main regulatory mechanism of c9,t11-CLA is related to the regulation of cell signaling pathways and metabolic processes. c9,t11-CLA can be used in functional foods, drug development and health-related research .
|
-
- HY-173598
-
|
|
Bacterial
|
Infection
|
|
T3SS-1-IN-1 (Compound C26) is a T3SS-1 inhibitor. T3SS-1-IN-1 inhibits the secretion of SipA and the activity of HilD (IC50 values are 29.2 and 16.9 μM, respectively). T3SS-1-IN-1 can be used for the study of anti-virulence of Salmonella .
|
-
- HY-135956
-
-
- HY-32219
-
|
|
Acyltransferase
|
Metabolic Disease
|
|
T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC50 of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells .
|
-
- HY-105049
-
|
PPI-0903M
|
Bacterial
|
Infection
|
|
T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria .
|
-
- HY-W010696R
-
|
|
Thyroid Hormone Receptor
|
Cardiovascular Disease
|
|
Reverse T3 (Standard) is the analytical standard of Reverse T3. This product is intended for research and analytical applications. Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine . Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes .
|
-
- HY-P1115A
-
|
|
Akt
|
Others
|
|
AKTide-2T TFA is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T TFA mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position .
|
-
- HY-154350
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152545
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N1,N2-Dimethyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154606
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-149875
-
|
|
Bacterial
|
Infection
|
|
T3SS-IN-1 (compound B9) is a potent inhibitor of type III secretion system (T3SS) inhibitor. T3SS-IN-1 can also inhibits hpa1 promoter activity and harpin protein expression without affecting bacterial growth .
|
-
- HY-160053
-
|
|
PDGFR
|
Cancer
|
|
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .
|
-
- HY-112296
-
T025
2 Publications Verification
|
CDK
Apoptosis
DYRK
|
Cancer
|
|
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research .
|
-
- HY-N6581
-
|
|
Others
|
Cardiovascular Disease
Cancer
|
|
Notoginsenoside T5 is a dammarane 61 glycoside. Notoginsenoside T5 is isolated from the acidic deglycosylation of saponins from the roots of P. 62 notoginseng .
|
-
- HY-13202
-
|
|
PPAR
|
Cancer
|
|
T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
|
-
- HY-160774
-
|
|
Drug-Linker Conjugates for ADC
Topoisomerase
|
Cancer
|
|
Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC .
|
-
- HY-N12788
-
|
|
Parasite
|
Infection
|
|
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC50 values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .
|
-
- HY-W053842
-
|
|
Biochemical Assay Reagents
|
Others
|
|
tert-Butyl 3-iodopropylcarbamate is a compound with a t-butyl and a terminal iodine. The iodine (I) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-16906
-
|
|
Src
|
Cancer
|
|
T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.
|
-
- HY-E70090
-
|
|
DNA/RNA Synthesis
|
Others
|
|
T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg 2+, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .
|
-
- HY-111595
-
-
- HY-137823
-
|
|
Endogenous Metabolite
|
Cancer
|
|
4-Nitrophenyl-N-acetyl-β-D-galactosaminide has inhibitory activity against GlcNAc and GalNAc with Kis of 1.15 mM and 0.51 mM, respectively. 4-Nitrophenyl-N-acetyl-β-D-galactosaminide is extracted from Trichomonas foetus (T. foetus)
|
-
- HY-163719
-
|
|
PARP
|
Cancer
|
|
PARP7-IN-22 (XLY-1) is a PARP7 inhibitor with an IC50 of 0.6 nM. PARP7-IN-22 (XLY-1) is orally active, enhances type I interferon signaling in vitro, restores type I interferon signaling, promotes T cell infiltration into tumor tissues, and significantly inhibits tumor growth. PARP7-IN-22 shows promise for research in the field of cancer immunotherapy .
|
-
- HY-P2455
-
|
Listeriolysin O (91-99)
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
LLO (91-99) (Listeriolysin O (91-99)) is an exotoxin and class I MHC-restricted T-cell epitope of listeriolysin (LLO). LLO (91-99) is processed by antigen-presenting cells, binds to MHC class I molecules and is presented to the cell surface. LLO (91-99) induces CTL responses and effectively eliminates Listeria from infected cells. LLO (91-99) can be used in the research of Listeria infections (e.g., listeriosis) .
|
-
- HY-D0070
-
|
Diaminofluorescein 2T
|
Fluorescent Dye
|
Others
|
|
DAF-2T (Diaminofluorescein 2T) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-122649
-
|
|
β-catenin
|
Cancer
|
|
UU-T01 is a selective inhibitor for β-Catenin/T-cell factor 4 protein-protein interaction (β-catenin/Tcf PPI) with an Ki value of 3.14 µM. UU-T01 is directly combined with β-catenin, and the KD value is 0.531 µM .
|
-
- HY-156595
-
-
- HY-16562
-
|
(+)-Irinotecan; CPT-11; VAL-413(free base)
|
Topoisomerase
Autophagy
|
Cancer
|
|
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
|
-
- HY-101374A
-
-
- HY-W073825
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-162539
-
-
- HY-117233
-
UU-T02
1 Publications Verification
|
β-catenin
Wnt
|
Metabolic Disease
Cancer
|
|
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM . UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells .
|
-
- HY-E70400
-
|
|
DNA/RNA Synthesis
|
Others
|
|
Thermostable T7 RNA Polymerase is a thermostable version of T7 RNA Polymerase (HY-E70090). Compared with T7 RNA Polymerase, it has high temperature resistance and stable activity. T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg 2+, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .
|
-
- HY-146775S
-
-
- HY-P0327
-
|
|
Biochemical Assay Reagents
|
Others
|
|
T7 Tag Peptide is a protein tag derived from the N-terminal 11 residues of the major T7 capsid protein, gp 10. T7 Tag Peptide can be used in different immunoassays as well as affinity purification .
|
-
- HY-N10842
-
|
|
Others
|
Others
|
|
6-Formyllimetin is a natural product isolated from the root bark of T. asiatica LAM .
|
-
- HY-N0822
-
|
C.I. 75535; Isoarnebin 4
|
Chloride Channel
Pyruvate Kinase
NF-κB
TNF Receptor
HIV
AIM2
|
Cancer
|
|
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .
|
-
- HY-14925
-
-
- HY-P1569
-
|
|
Arenavirus
|
Inflammation/Immunology
|
|
LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .
|
-
- HY-147696
-
|
|
HSP
AMPK
Reactive Oxygen Species (ROS)
|
Cancer
|
|
SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells .
|
-
- HY-125529
-
|
Chol-T
|
Liposome
|
Others
|
|
DMPAC-Chol (Chol-T) is used for liposome formation. DMPAC-Chol (Chol-T) liposomes exhibits great transfection effciencies .
|
-
- HY-134302
-
|
8-Hexylamino-cAMP
|
PKA
|
Others
|
|
8-HA-cAMP is a membrane-permeable cAMP analogue and an activator of cAMP-dependent protein kinase and PKA I. 8-HA-cAMP exerts metabolic stability towards mammalian cyclic nucleotide-responsive phosphodiesterases .
|
-
- HY-124346
-
|
|
Stearoyl-CoA Desaturase (SCD)
|
Metabolic Disease
|
|
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay .
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-
- HY-N11591
-
|
|
Others
|
Others
|
|
Ganoderic acid T is a natural product that can be found in ganoderma lucidum .
|
-
- HY-117841
-
-
- HY-132893
-
|
|
TAM Receptor
|
Cancer
|
|
AZ14145845 is a highly selective type I1/2 dual Mer/Axl kinase inhibitor with in vivo efficacy.
|
-
- HY-162998
-
-
- HY-159783
-
-
- HY-18600AS
-
|
NE-10064-dd8 dihydrochloride
|
Isotope-Labeled Compounds
Potassium Channel
|
Cardiovascular Disease
|
|
Azimilide-d8 (dihydrochloride) is the deuterium labeled Azimilide dihydrochloride. Azimilide Dihydrochloride (NE-10064 Dihydrochloride) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
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-
- HY-146385
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor with IC50 values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively .
|
-
- HY-N11537
-
|
|
Others
|
Others
|
|
2-Methoxy-6-pentadecyl-1,4-benzoquinone (1c) is a pentadecyl derivative that can be isolated from seed oils of different iris plants such as I. pseudacorus, I. missouriensis and I. sibirica .
|
-
- HY-13418R
-
|
|
Organoid
AMPK
TGF-β Receptor
Autophagy
|
Cancer
|
|
Dorsomorphin (dihydrochloride) (Standard) is the analytical standard of Dorsomorphin (dihydrochloride). This product is intended for research and analytical applications. Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).
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-
- HY-154548
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154507
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
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-
- HY-18341
-
-
- HY-141121
-
|
|
Drug Intermediate
|
Others
|
|
T-Butoxycarbonyl-PEG1-NHS ester contains a t-boc protecting group and an NHS ester moiety. T-Butoxycarbonyl-PEG1-NHS ester can be used for the modification and labeling of biomolecules.
|
-
- HY-120661
-
|
|
c-Met/HGFR
VEGFR
|
Cancer
|
|
T-1840383 is a potent, ATP-competitive inhibitor of c-Met/VEGFR-2, with the IC50s of 1.9 nM, 7.7 nM, 2.2 nM and 5.5 nM for c-Met, VEGFR1, VEGFR2 and VEGFR3, respectively .
|
-
- HY-100518A
-
|
|
MMP
|
Inflammation/Immunology
|
|
T26c sodium is a potent and selective MMP13 inhibitor with IC50 value of 6.9 pM. T26c sodium can inhibit the degradation of bovine nasal septal cartilage explants .
|
-
- HY-P0272A
-
|
|
HIV
|
Infection
|
|
Peptide T (TFA) is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.
|
-
- HY-123789
-
|
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
|
-
- HY-N10495
-
|
|
Antibiotic
Bacterial
Topoisomerase
|
Infection
|
|
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics .
|
-
- HY-164792
-
-
- HY-173591
-
-
- HY-125618
-
|
T-2636 D
|
Antibiotic
Bacterial
|
Infection
|
|
Lankacidinol A (T-2636 D) is an antibiotic, and shows antibacterial activity against Gram-positive bacteria .
|
-
- HY-N15120
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Polymyxin T1 is an antibiotic found in Bacillus polymyxa E-12. Polymyxin T1 has an effect against Gram-negative bacteria and a weak effect against Gram-positive bacteria .
|
-
- HY-161237
-
|
|
Parasite
|
Infection
|
|
Antitrypanosomal agent 20 (Compd 27) is an anti-trypanosomal, with an IC50 of 0.75 μM for T. b. brucei .
|
-
- HY-101184R
-
|
AV-1451 (Standard)
|
Reference Standards
Tau Protein
|
Neurological Disease
|
|
T807 (Standard) is the analytical standard of T807. This product is intended for research and analytical applications. T807 a novel tau positron emission tomography (PET) tracer.
|
-
- HY-P1569A
-
|
|
Arenavirus
|
Inflammation/Immunology
|
|
LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .
|
-
- HY-15481
-
-
- HY-N14936
-
|
|
Fungal
|
Infection
|
|
AK-toxin I is a host-specific phytotoxic metabolite. AK-toxin I causes black spot disease of pear trees .
|
-
- HY-160846
-
-
- HY-160845
-
-
- HY-18600B
-
-
- HY-145107
-
-
- HY-157476
-
|
|
iGluR
|
Neurological Disease
|
|
AChE-IN-53 (Compound I-52) is a potent NMDAR inhibitor, which is a compound with favorable behavioral and neuroprotective effects .
|
-
- HY-16905
-
|
|
Src
|
Cancer
|
|
T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase).
|
-
- HY-B0724A
-
|
T-3762; Pazufloxacin methanesulfonate; Pazufloxacin mesilate
|
Bacterial
Antibiotic
|
Infection
|
|
Pazufloxacin (T-3761) mesylate is a fluoroquinolone antibiotic.
|
-
- HY-P1089
-
|
PCC 88-104
|
Cytochrome P450
|
Inflammation/Immunology
|
|
Cytochrome c-pigeon (88-104) (PCC 88-104) has full stimulatory activity for pigeon cytochrome c-primed T cells from B10.A mice. The I-E k-restricted T cell response to Cytochrome c pigeon (pcyt c) is specific for the COOH-terminal sequence 88-104 .
|
-
- HY-108313
-
|
|
PI4K
|
Infection
|
|
T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta (PI4KB) inhibitor with an IC50 of 60 nM.
|
-
- HY-101185
-
|
|
Tau Protein
|
Neurological Disease
|
|
T808 is a tau-selective Alzheimer’s PET ligand. T808 is a type of imaging agent used in positron emission tomography (PET) scans. It is a radiotracer that is used to help visualize certain areas of the body, such as the brain, in order to diagnose and monitor various medical conditions .
|
-
- HY-159097
-
|
|
Parasite
|
Infection
|
|
T.cruzi-IN-4 (Compound 21) is an anti-parasitic agent. T.cruzi-IN-4 inhibits the trypomastigote and amastigote form of Trypanosoma cruzi with IC50 of 0.033 μM (120 h), T.cruzi-IN-4 inhibits the promastigote and amastigote form of Leishmania infantum with IC50 of 28.74 and 61.82 μM. T.cruzi-IN-4 inhibits Leishmania amazonensis promastigote form with IC50 of 18.38 μM .
|
-
- HY-122918
-
|
|
Bacterial
|
Infection
|
|
Moracin T can be isolated from the bark of mulberry trees and has antibacterial activity.
|
-
- HY-N12787
-
|
|
Others
|
Others
|
|
T-Muurolol is a sesquiterpene and can be isolated from Streptomyces sp. M491 .
|
-
- HY-P0052
-
|
T20; DP178
|
HIV
|
Infection
|
|
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.
|
-
- HY-154464
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-iso-Butyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154351
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-154483
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-3’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
- HY-152547
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .
|
-
![N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine](//file.medchemexpress.com/product_pic/hy-152547.gif)
- HY-105840
-
|
p-Toluenesulfondichloramide
|
Bacterial
|
Infection
|
|
Dichloramine-T is a strong oxidizer and disinfectant, with strong oxidation and sterilization. Dichloramine-T is also widely used in the medical and health field for disinfection and sterilization operations .
|
-
- HY-118170
-
|
|
Chloride Channel
|
Others
|
|
T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling .
|
-
- HY-W190921
-
|
|
Biochemical Assay Reagents
|
Others
|
|
t-Butyl 3-(hydroxypropoxyl)-propanoate contains reactive hydroxyl and t-butyl protected carboxyl moieties. The hydroxyl group can react to further derivatize the compound. The t-butyl carbonyl group can be deprotected under acidic conditions.
|
-
- HY-P991410
-
|
MEDI0641 antibody
|
Wnt
|
Cancer
|
|
5T4_0108 (MEDI0641 antibody) is a human monoclonal antibody (mAb) targeting TPBG. 5T4_0108 can be used in breast and prostate cancer research .
|
-
- HY-P3543
-
-
- HY-122014
-
|
|
Topoisomerase
|
Others
|
|
39625 is a camptothecin ketone analogue, a stable, potent and selective topoisomerase I inhibitor, active against purified topoisomerase I and cytotoxic to cancer cells.
|
-
- HY-144468
-
-
- HY-112275
-
-
- HY-153585
-
IK-930
1 Publications Verification
|
YAP
|
Cancer
|
|
IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 µM .
|
-
- HY-153553
-
-
- HY-N7089
-
|
quinazolinedione
|
Bacterial
|
Infection
|
|
Benzoyleneurea possesses anti-bacterial activity. Benzoyleneurea scaffold can be used in the synthesis of novel protein geranylgeranyltransferase-I (PGGTase-I) inhibitors .
|
-
- HY-106761
-
|
|
Calcium Channel
|
Cardiovascular Disease
Others
|
|
Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC50 of 0.24 μM, and against T-type Ca currents (I) with an IC50 of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs .
|
-
- HY-12598
-
|
|
mGluR
|
Neurological Disease
|
|
(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively . (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia .
|
-
- HY-P99694
-
|
JR-171
|
Transferrin Receptor
|
Neurological Disease
|
|
Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase). Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS). Lepunafusp alfa can be used for research of mucopolysaccharidosis type I .
|
-
- HY-16707
-
|
Z-Ile-Glu-Pro-Phe-Ome
|
Proteasome
|
Inflammation/Immunology
|
|
CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 µM .
|
-
- HY-106668
-
|
Sch 21420
|
Antibiotic
Bacterial
|
Infection
|
|
Isepamicin (Sch 21420) is an aminoglycoside antibacterial. Isepamicin has better activity against strains producing type I 6'-acetyltransferase. Isepamicin’s antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Isepamicin exhibits a strong concentration-dependent bactericidal effect, a long post-antibiotic effect (several hours) and induces adaptive resistance .
|
-
- HY-139170
-
|
|
ROCK
|
Metabolic Disease
|
|
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR) .
|
-
- HY-116448
-
-
- HY-N10340
-
|
Clauszoline I
|
Others
|
Cancer
|
|
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.
|
-
- HY-B2171A
-
|
Carminomycin hydrochloride; Carminomicin I hydrochloride
|
Apoptosis
|
Infection
Cancer
|
|
Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases .
|
-
- HY-N6798
-
|
Thermozymocidin; ISP-I
|
HCV
Antibiotic
|
Infection
|
|
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection .
|
-
- HY-N1166
-
|
Deguelinol I; Hydroxydeguelin
|
EGFR
|
Cancer
|
|
Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors .
|
-
- HY-126559
-
|
Mycotrienin I
|
Fungal
Antibiotic
|
Infection
|
|
Ansatrienin A is an antifungal antibiotic that can be isolated from Streptomyces collinus .
|
-
- HY-N0864
-
|
Macranthoiside I
|
Others
|
Cancer
|
|
Macranthoidin B is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.
|
-
- HY-N6790
-
-
- HY-B2171
-
|
Carminomycin; Carminomicin I
|
Apoptosis
|
Infection
Cancer
|
|
Carubicin (Carminomycin) is a microbially-derived compound. Carubicin is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin has the potential for the research of cancer diseases .
|
-
- HY-108938
-
|
|
Cytochrome P450
Fungal
Parasite
|
Infection
|
|
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .
|
-
- HY-N7326
-
-
- HY-N9064
-
|
|
Others
|
Others
|
|
Parvifuran is a Phenols product that can be isolated from the heartwoods of Dalbergia parviflora. .
|
-
- HY-W127828
-
|
T-BOC-AC-NTA
|
Biochemical Assay Reagents
|
Others
|
|
t-Boc-aminocaproicnitrilotriacetic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-161917
-
-
- HY-144466
-
-
- HY-100518
-
T-26c
2 Publications Verification
|
MMP
|
Inflammation/Immunology
|
|
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes .
|
-
- HY-120356S1
-
-
- HY-158230
-
|
|
Topoisomerase
|
Cancer
|
|
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells .
|
-
- HY-151212
-
|
|
Ferroptosis
Glutathione Peroxidase
|
Cancer
|
|
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4 . BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W104819
-
|
4-Hydroxyphenylglyoxylic acid; 4-HPGA
|
Acyltransferase
|
Metabolic Disease
|
|
4-Hydroxyphenylglyoxylate (4-Hydroxyphenylglyoxylic acid) is an inhibitor of carnitine palmitoyltransferase I (CPT I). 4-Hydroxyphenylglyoxylate can be used to study sensitivity changes in CPT I of liver mitochondria and fatty acid oxidation by isolated hepatocytes. 4-Hydroxyphenylglyoxylate can inhibits fatty acid oxidation .
|
-
- HY-149332
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-26 (Compound 7i) is an α-glucosidase inhibitor (IC50=4.63 µM). α-Glucosidase-IN-26 can be used in the study of type 2 diabetes mellitus (T2DM) .
|
-
- HY-P5453
-
|
|
CD3
|
Others
|
|
CFP10 (71–85) is a biological active peptide. (CFP1071–85, that elicited IFN-γ production and CTL activity by both CD4+ and CD8+ T cells from persons expressing multiple MHC class II and class I molecules)
|
-
- HY-110353
-
|
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
Cancer
|
|
CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS .
|
-
- HY-129115
-
|
|
Reactive Oxygen Species (ROS)
Caspase
|
Others
|
|
S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC50 of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress .
|
-
- HY-P0229A
-
|
Rnase T1 (animal free)
|
DNA/RNA Synthesis
|
Others
|
|
Ribonuclease T1 (animal free) (Rnase T1 (animal free)) (EC 4.6.1.24) is an endonuclease that specifically degrades single-stranded RNA. Ribonuclease T1 forms a nucleoside 2′, 3′-cyclic phosphate intermediate to cleave the phosphodiester bond between the 3′-guanosine residue and the 5′-OH group of the adjacent nucleoside to produce a 3′-GMP-terminated oligonucleotide. This product does not contain ingredients of animal origin .
|
-
- HY-138746
-
|
|
EGFR
|
Cancer
|
|
EGFR-IN-15 (compound I-005) is a EGFR inhibitor with an IC50 of 4 nM. EGFR-IN-15 can be used for oncological diseases research .
|
-
- HY-170502
-
-
- HY-D0277
-
|
|
Fluorescent Dye
|
|
|
Eriochrome black T is a complex indicator used in complex titrations, e.g.
|
-
- HY-N14521
-
|
|
Others
|
Infection
|
|
Pacidamycin 5T is found in the strain of Streptomyces coeruleorubidus NRRL 18370 .
|
-
- HY-E70094
-
|
|
DNA/RNA Synthesis
|
Others
|
|
T4 UvsX Recombinase helps initiate DNA replication on a double-stranded DNA template by catalyzing synapsis between the template and a homologous DNA single strand that serves as primer. T4 UvsX Recombinase greatly amplifies the snap-back (hairpin-primed) DNA synthesis that is catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded DNA templates .
|
-
- HY-136498AR
-
|
|
Reference Standards
Drug Metabolite
|
Infection
|
|
Rilmenidine (phosphate) (Standard) is the analytical standard of Rilmenidine (phosphate). This product is intended for research and analytical applications. Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .
|
-
- HY-13456
-
|
|
iGluR
|
Neurological Disease
|
|
LY-404187 is a potent, selective and centrally active positive allosteric modulator of AMPA receptors, with the EC50s of 5.65, 0.15, 1.44, 1.66 and 0.21 µM for GluR1i, GluR2i, GluR2o, GluR3i and GluR4i, respectively. LY-404187 has therapeutic potential in a number of psychiatric disorders and neurodegenerative diseases .
|
-
- HY-P35433
-
|
T-1249
|
HIV
|
Inflammation/Immunology
|
|
Tifuvirtide (T-1249) is a peptide human immunodeficiency virus type-1 (HIV-1) fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection .
|
-
- HY-125832
-
-
- HY-19744
-
|
|
MyD88
|
Inflammation/Immunology
|
|
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively .
|
-
- HY-N1569
-
|
(3S)-Pteroside D
|
Others
|
Others
|
|
Pteroside D ((3S)-Pteroside D) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .
|
-
- HY-130676
-
|
|
CDK
|
Cancer
|
|
CLK-IN-T3N, the negative control of CLK-IN-T3 (HY-115470), is a chemical probe for CDC-like kinase (CLK).
|
-
- HY-111028
-
|
T 5979345
|
HDAC
|
Infection
|
|
J1038 (T 5979345) is a selective HDAC8 inhibitor. J1038 binds the catalytic zinc ion of Schistosoma mansoni HDAC8 (smHDAC8) .
|
-
- HY-22296
-
-
- HY-14768
-
|
T-705
|
DNA/RNA Synthesis
Influenza Virus
SARS-CoV
Bacterial
|
Infection
|
|
Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
|
-
- HY-171837
-
|
|
Caspase
|
Cancer
|
|
c9,t11,c15-CLNA is a conjugated linolenic acid (CLNA) isomer produced by Lactobacillus plantarum ZS2058. c9,t11,c15-CLNA has significant anti-proliferation activity against colon cancer cells (IC50: 18.26 μM). c9,t11,c15-CLNA induces pyroptosis by activating the canonical pyroptosis pathway mediated by caspase-1. c9,t11,c15-CLNA can be used in the study of colon cancer .
|
-
- HY-100530B
-
-
- HY-100530C
-
|
|
PKA
Phosphodiesterase (PDE)
|
Neurological Disease
Metabolic Disease
|
|
Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM .
|
-
- HY-B0817
-
|
|
Parasite
|
Infection
|
|
Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .
|
-
- HY-154361
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-152478
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W008719
-
|
|
Mitochondrial Metabolism
|
Neurological Disease
|
|
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .
|
-
- HY-103033
-
|
|
Parasite
|
Infection
|
|
T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .
|
-
- HY-168344
-
|
|
Adrenergic Receptor
|
Inflammation/Immunology
|
|
CACPD2011a-0001278239 is a β2AR mixed agonist that shows a wide range of high-affinity binding to both wild-type and T164I β2AR variants, with no cytotoxicity or mutagenicity, making it suitable for asthma research .
|
-
- HY-P10245
-
|
|
RSV
|
Inflammation/Immunology
|
|
Fusion glycoprotein 92-106 is a polypeptide from fusion protein of respiratory syncytial virus (RSV). Fusion glycoprotein 92-106 acts as MHC class I-restricted CTL epitope, that all 15 amino acids are required for efficient recognition by cytotoxic T lymphocyte (CTL) .
|
-
- HY-N13981
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Arylomycin B2, an antibiotic, is a potent signal peptidase I (SPase I) inhibitor. Arylomycin B2 has anti-Gram-positive bacteria activities .
|
-
- HY-162740
-
-
- HY-145587
-
|
PBI-200; PPI-5278
|
Tyrosinase
Trk Receptor
|
Inflammation/Immunology
Cancer
|
|
Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases .
|
-
- HY-123052
-
-
- HY-19990
-
-
- HY-P4545
-
|
|
Angiotensin Receptor
|
Others
|
|
Abz-Gly-p-nitro-Phe-Pro-OH is the fluorescent substrate angiotensin I converting enzyme (ACE-I) with 355 nm excitation and 405 nm emission wavelengths .
|
-
- HY-P10425
-
|
|
Histone Methyltransferase
|
Cancer
|
|
T2857W is a mutant peptide that has inhibitory effect on KIX-MLL interaction (IC50=5.67 μM). T2857W can be used for protein-protein interaction (PPI) and for the study of diseases related to KIX-MLL interaction, such as leukemia, cancer, etc .
|
-
- HY-130159
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Hydroxy-PEG12-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
|
-
- HY-W190808
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tos-PEG11-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
|
-
- HY-P99837
-
|
SPV-T3a
|
CD3
|
Infection
|
|
Dafsolimab (SPV-T3a) is an IgG2a murine monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD) .
|
-
- HY-D0932
-
|
Solvent Red 24; C.I. 26105
|
Biochemical Assay Reagents
Aryl Hydrocarbon Receptor
Cytochrome P450
|
Metabolic Disease
|
|
Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .
|
-
- HY-N7572
-
|
|
Parasite
|
Infection
|
|
Eupatoriopicrin is an antitrypanosomic agent with an IC50 value of 1.2 μM (T. b. rhodesiense). Eupatoriopicrin is cytotoxic to L6 cells with an IC50 value of 1.6 μM .
|
-
- HY-14768A
-
|
T-705 sodium
|
DNA/RNA Synthesis
Influenza Virus
SARS-CoV
Bacterial
|
Infection
|
|
Favipiravir (T-705) sodium is an inhibitor of viral RNA polymerase (RNA polymerase), which is converted into its active form Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the activity of influenza virus RNA-dependent RNA polymerase (RdRP) with an IC50 of 341 nM .
|
-
- HY-NP158H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type II Collagen, T Cell Grade, from Rat is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Rat, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .
|
-
- HY-NP158E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type II Collagen, T Cell Grade, from Porcine is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Porcine can be used as a stimulating antigen for T-cells in in vitro culture systems .
|
-
- HY-NP158A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type II Collagen, T Cell Grade, from Chick is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Chick, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .
|
-
- HY-NP158
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type II Collagen, T Cell Grade, from Bovine is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .
|
-
- HY-NP158D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type II Collagen, T Cell Grade, from Mouse is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Mouse can be used as a stimulating antigen for T-cells in in vitro culture systems .
|
-
- HY-NP158B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type II Collagen, T Cell Grade, from Human is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Human, from Human can be used as a stimulating antigen for T-cells in in vitro culture systems .
|
-
- HY-NP158C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Type II Collagen, T Cell Grade, from Monkey is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Chick, from Monkey can be used as a stimulating antigen for T-cells in in vitro culture systems .
|
-
- HY-W074541
-
|
Trimethylacetohydrazideammonium chloride
|
Biochemical Assay Reagents
|
Others
|
|
Girard's reagent T is often used in analytical chemistry as a derivatizing agent for carbonyl compounds. Girard's reagent T reacts with ketones and aldehydes to form stable hydrazones that can be readily analyzed by various techniques including chromatography and spectrophotometry. In addition, Girard's Reagent T has been used in the synthesis of a variety of organic compounds, including pharmaceuticals and agrochemicals.
|
-
- HY-N3357
-
|
|
Others
|
Cancer
|
|
Caffeoxylupeol is a natural compound with anticancer activity that can be isolated from the Leaves of Dalbergia velutina .
|
-
- HY-139316
-
|
|
IRAK
PROTACs
|
Cancer
|
|
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171 .
|
-
- HY-N6621
-
|
|
Topoisomerase
|
Cancer
|
|
Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities .
|
-
- HY-P0142A
-
|
|
PKG
|
Cardiovascular Disease
|
|
DT-3 acetate is a membrane-permeable protein kinase G Iα (PKG Iα) inhibitory peptide and shows pharmacological blockade of the cGMP-PKG signalling .
|
-
- HY-P0142
-
|
|
PKG
|
Cardiovascular Disease
|
|
DT-3 is a membrane-permeable protein kinase G Iα (PKG Iα) inhibitory peptide and shows pharmacological blockade of the cGMP-PKG signalling .
|
-
- HY-162739
-
|
|
Epigenetic Reader Domain
|
Cancer
|
|
SMARCA2-IN-1 (Compound I-19) is an inhibitor for SWI/SNF chromatin remodeling complexe SMARCA2 with IC50 >1000 nM in H1299 .
|
-
- HY-126826
-
-
- HY-10257
-
|
BAY 11-7083
|
NF-κB
Ferroptosis
Apoptosis
|
Cancer
|
|
BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM .
|
-
- HY-N2063
-
|
|
Topoisomerase
|
Others
|
|
12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM .
|
-
- HY-18341B
-
-
- HY-N9404
-
|
|
Sodium Channel
|
Neurological Disease
|
|
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na +]i, [Ca 2+]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge .
|
-
- HY-112037A
-
|
IACS-10759 hydrochloride
|
Oxidative Phosphorylation
Mitochondrial Metabolism
Apoptosis
|
Cancer
|
|
IACS-010759 hydrochlorideis an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research .
|
-
- HY-112037
-
|
IACS-10759
|
Oxidative Phosphorylation
Mitochondrial Metabolism
Apoptosis
|
Cancer
|
|
IACS-010759 is an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 has the potential for relapsed/refractory AML and solid tumors research .
|
-
- HY-172505
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG12-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
|
-
- HY-W190761
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Amino-PEG11-t-butyl ester is a click chemistry linker containing an amine and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
|
-
- HY-163268
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
Carbonic anhydrase inhibitor 18 (Compound 9) is a human carbonic anhydrase (hCA) isoform inhibitor, with Kis of 604.8, 333.6, 1.9 and 6.7 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 18 can be used for the research of cancer .
|
-
- HY-156169
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
hCAIX/XII-IN-7 (compound 3e) is a potent hCA IX and XII inhibitor with Kis of 3.2 nM, 9.2 nM, 503.7 nM and 59 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. hCAIX/XII-IN-7 has the potential for hypoxic tumors research .
|
-
- HY-101184
-
-
- HY-142537S
-
-
- HY-137449
-
|
G1T48
|
Estrogen Receptor/ERR
CDK
|
Cancer
|
|
Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor .
|
-
- HY-W096990A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sodium 1-octanesulfonate monohydrate, 97%(T) is an ion-pairing agent with anionic surfactant properties, which interacts with a Tobramycin (HY-B0441) molecule whose amino group is protonated .
|
-
- HY-158177
-
|
|
EGFR
|
Cancer
|
|
EGFR T790M/L858R-IN-6 (compound 53), a pyrimidine compound, is a potent EGFR T790M/L858R inhibitor. EGFR T790M/L858R-IN-6 shows 90.88% enzyme activity inhibition with 0.05 μM .
|
-
- HY-158175
-
|
|
EGFR
|
Cancer
|
|
EGFR T790M/L858R-IN-4 (Example 14) is a potent EGFR T790M/L858R inhibitor with anticancer effects .
|
-
- HY-123295
-
|
|
HDAC
|
Infection
Cancer
|
|
HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells .
|
-
- HY-129152
-
|
|
Influenza Virus
|
Infection
|
|
Ganoderic acid T-N, a triterpenoid, is a H5N1 and H1N1 influenza neuraminidase (NA) inhibitor with IC50s of 2.7 μM and 42 μM, respectively. Ganoderic acid T-Q shows cytotoxicity against MCF7 cells (CC50=24.4 μM) .
|
-
- HY-N2954
-
|
|
Others
|
Others
|
|
Borapetoside F is a furanoditerpene which can be extracted from T. crispa and has been suggested to have edible toxicity .
|
-
- HY-16562S1
-
|
|
Isotope-Labeled Compounds
Topoisomerase
Autophagy
|
Cancer
|
|
Irinotecan-d10 (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
|
-
- HY-142518
-
|
|
VEGFR
|
Cancer
|
|
EGFR-IN-26 is a EGFR inhibitor extracted from patent WO2019162323A1 compound I-028. EGFR-IN-26 can be used for the research of cancer .
|
-
- HY-16562S
-
|
(+)-Irinotecan-d10; CPT-11-d10; VAL-413-d10
|
Topoisomerase
Autophagy
|
Cancer
|
|
Irinotecan-d10 is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
|
-
- HY-148099
-
|
|
Deubiquitinase
|
Cancer
|
|
USP1-IN-2 (Compound I-193) is a potent ubiquitin-specific protease 1 (USP1) inhibitor with an IC50 of less than about 50 nM .
|
-
- HY-159805
-
|
|
CDK
|
Cancer
|
|
CDK2-IN-31 (compound I-125A) is a CDK2 inhibitor. CDK2-IN-31 can be used in cancer research .
|
-
- HY-157994
-
|
|
EGFR
Apoptosis
|
Cancer
|
|
EGFR WT/T790M-IN-2 (Compound 7c) is a EGFR T790M/WT inhibitor with IC50 values of 0.08 and 0.13 μM, respectively. EGFR WT/T790M-IN-2 induces apoptosis by blocking the G0-G1 phase (apoptosis). EGFR WT/T790M-IN-2 has antitumor activity .
|
-
- HY-156403
-
|
|
Topoisomerase
|
Cancer
|
|
AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC50 value of 1.2 μM .
|
-
- HY-165657S
-
-
- HY-110005
-
|
|
PKA
Phosphodiesterase (PDE)
|
Neurological Disease
Metabolic Disease
|
|
Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC50 of 40 μM .
|
-
- HY-W008343
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with Ki of 316.2 μM and 166.4 μM, respectively .
|
-
- HY-19834
-
|
GDC-0853
|
Btk
|
Cancer
|
|
Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with Kis of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research .
|
-
- HY-P3715
-
|
|
MHC
|
Inflammation/Immunology
|
|
OVA peptide mainly exists in egg white, it is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC). OVA peptide has been widely studied in allergy research .
|
-
- HY-10432
-
|
|
Organoid
TGF-β Receptor
|
Cancer
|
|
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
|
-
- HY-P991364
-
|
BSI-060T
|
Transmembrane Glycoprotein
|
Cancer
|
|
PYX-106 (BSI-060T) is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. PYX-106 reverses Siglec-15-mediated immunosuppression and enhances T-cell proliferation. PYX-106 induces significantly increased levels of IFNγ and TNFα in T cells. PYX-106 can be used in cancer immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-W539893
-
|
NODAG
|
Biochemical Assay Reagents
|
Cancer
|
|
NODAGA-tris(t-Bu ester) (NODAG) is a NODAGA derivative. NODAGA-tris(t-Bu ester) can be used to label peptides, antibodies, etc., and subsequently radiolabeled for PET imaging .
|
-
- HY-P1404
-
|
|
Pim
|
Cancer
|
|
R8-T198wt is a cell-permeable carboxyl-terminal p27 Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase .
|
-
- HY-157135
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
hCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (KI ) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117) .
|
-
- HY-121866
-
|
|
Topoisomerase
|
Cancer
|
|
Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC50 of 7.25 μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities.
|
-
- HY-137665
-
|
|
PKG
|
Cardiovascular Disease
|
|
PET-cGMP is a cyclic guanosine monophosphate analog and an effective selective agonist of PKG I, the EC50 of PET-cGMP for PKG Iβ is 3.8 nM, while for PKG II, it's 193 nM .
|
-
- HY-15871
-
|
|
Apoptosis
|
Cancer
|
|
GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.
|
-
- HY-124855
-
STD1T
1 Publications Verification
|
Deubiquitinase
|
Cancer
|
|
STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay .
|
-
- HY-118618
-
|
Hiyodorilactone A; Schkuhrin I
|
STAT
|
Cancer
|
|
Eucannabinolide is a STAT3 inhibitor. Eucannabinolide suppresses STAT3 activation at tyrosine 705, inhibiteds its translocation to nucleus, and decreases its DNA binding capacity. Eucannabinolide can be used for triple negative breast cancer (TNBC) diseases research .
|
-
- HY-W020955
-
|
Chloro(triphenylphosphine)gold(I)
|
Biochemical Assay Reagents
|
Others
|
|
Triphenylphosphinechlorogold is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-13217
-
|
GBR-12909 dihydrochloride; I893 dihydrochloride
|
Dopamine Transporter
|
Neurological Disease
|
|
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT) .
|
-
- HY-N10181
-
|
Simplifusidic acid I
|
Bacterial
|
Infection
|
|
11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL.
|
-
- HY-18676
-
|
|
Integrin
Autophagy
Apoptosis
|
Cancer
|
|
OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain) . OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner . OSU-T315 causes cell death through apoptosis and autophagy .
|
-
- HY-W425093
-
-
- HY-172717
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG4-t-butyl ester is a TAMRA red-fluorescent dye linker, with excitation/emission maximum 553/575 nm, containing a t-butyl protected carboxyl group which can be deprotected under acidic conditions.
|
-
- HY-E70095
-
|
|
Others
|
Others
|
|
T4 UvsY Protein is an accessory protein for in vitro catalysis of strand exchange. T4 UvsY Protein enhances strand exchange by UvsX protein by interacting specifically with UvsX protein. UvsY protein enhances the rate of single-stranded-DNA-dependent ATP hydrolysis by UvsX protein .
|
-
- HY-158176
-
|
|
EGFR
|
Cancer
|
|
EGFR T790M/L858R-IN-5 (example 52) is a potent inhibitor of EGFR T790M/L858R with the inhibition percentage of 92.9% in the concerntration of 0.05 μM .
|
-
- HY-164056
-
|
|
EGFR
|
Cancer
|
|
EGFR T790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, targeting mutant EGFR T790M/L858R with IC50 of 56.8 μM. The anti-proliferative effect of EGFR T790M/L858R-IN-8 on cancer cell lines A549, A431, and NHI-H1975 is not significant .
|
-
- HY-146071
-
|
|
Parasite
|
Infection
|
|
Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC50s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively .
|
-
- HY-152158
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-22 (compound 7i), a benzimidazole, is a potent α-glucosidase inhibitor with an IC50 of 0.64 μM. α-Glucosidase-IN-22 is a potent anti-diabetic agent and has the potential for type 2 diabetes mellitus (T2DM) research .
|
-
- HY-148029
-
|
TAK-676
|
STING
|
Cancer
|
|
Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity .
|
-
- HY-W190920
-
|
|
Biochemical Assay Reagents
|
Others
|
|
t-Butoxycarbonyl-PEG2-NHS ester has a t-Boc protecting group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
|
-
- HY-16562R
-
|
(+)-Irinotecan (Standard); CPT-11 (Standard); VAL-413(free base) (Standard)
|
Reference Standards
Topoisomerase
Autophagy
|
Cancer
|
|
Irinotecan (Standard) is the analytical standard of Irinotecan. This product is intended for research and analytical applications. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
|
-
- HY-158421
-
-
- HY-169271
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2 degrader-20 (Compound I-40) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-20 has the potential for the research of cancer .
|
-
- HY-150545
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro .
|
-
- HY-113970A
-
|
WEB 1881 FU hydrochloride
|
mAChR
|
Neurological Disease
|
|
Nebracetam hydrochloride, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca 2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca 2+]i .
|
-
- HY-115470
-
|
|
CDK
DYRK
|
Cancer
|
|
CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity .
|
-
- HY-157398
-
|
|
EGFR
|
Cancer
|
|
EGFR T790M/L858R-IN-3 (compound B1) is a EGFR L858R/T790M inhibitor with IC50 value of 13?nM. EGFR T790M/L858R-IN-3 shows anti-tumour activity in H1975 cells with an IC50 value of 0.087 μΜ. EGFR T790M/L858R-IN-3 inhibits cell migration in A549 cells and induces apoptosis in H1975 cells .
|
-
- HY-124153
-
|
|
Btk
|
Cardiovascular Disease
Inflammation/Immunology
|
|
GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases .
|
-
- HY-131334
-
|
|
AMPK
|
Metabolic Disease
|
|
AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .
|
-
- HY-163371
-
|
|
EGFR
Apoptosis
|
Cancer
|
|
EGFR WT/T790M-IN-1 (Compound 16h) is a dual EGFR WT and EGFR T790 inhibitor. EGFR WT/T790M-IN-1 can arrest the cell cycle in G2/M phase and induce apoptosis. EGFR WT/T790M-IN-1 has anti-cancer activity .
|
-
- HY-W127622
-
|
3-(4-(tert-Butyl)pyridinio)-1-propanesulfonate
|
Biochemical Assay Reagents
|
Others
|
|
NDSB 256-4T is a non-washing sulfabetaine compound. NDSB-256-4T prevents protein aggregation and promotes protein folding by interacting with early folding intermediates .
|
-
- HY-146911S
-
-
- HY-P2297
-
-
- HY-152906
-
-
- HY-W062216
-
|
|
Bacterial
Arginase
|
Infection
|
|
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM .
|
-
- HY-106084
-
|
T-2525; RO 19-5247; Cefterame
|
Bacterial
|
Infection
|
|
Cefteram (T-2525) is the free acid of Cefteram pivoxil (HY-106571), which is an orally active cephalosporin ester. Cefteram potently targets to the enteropathogenic Enterobacteriaceae and Vibrionaceae .
|
-
- HY-W881216
-
-
- HY-162435
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
GLP-1R agonist 20 (Compound I-132) is an agonist for glucagon-like peptide-1 receptor (GLP-1 receptor), with EC50 of 0.0162 nM .
|
-
- HY-162436
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
GLP-1R agonist 21 (Compound I-134) is an agonist for glucagon-like peptide-1 receptor (GLP-1 receptor), with EC50 of 0.0104 nM .
|
-
- HY-P99168
-
|
|
IFNAR
|
Inflammation/Immunology
|
|
Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research .
|
-
- HY-162437
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
GLP-1R agonist 22 (Compound I-135) is an agonist for glucagon-like peptide-1 receptor (GLP-1 receptor), with EC50 of 0.0165 nM .
|
-
- HY-B0374R
-
|
|
Imidazoline Receptor
|
Neurological Disease
|
|
Moxonidine (Standard) is the analytical standard of Moxonidine. This product is intended for research and analytical applications. Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
|
-
- HY-E70008
-
|
|
Sirtuin
|
Inflammation/Immunology
|
|
Lumbokinase attenuates myocardial ischemia-reperfusion (I-R) injury through the activation of Sirt1 signaling, and thus enhances autophagic flux and reduces I-R-induced oxidative damage, inflammation and apoptosis .
|
-
- HY-169670
-
|
|
Pim
CDK
GSK-3
Src
|
Cancer
|
|
Protein kinase inhibitor 13 (Compound I-90) is the inhibitor for protein kinase that exhibits inhibitory effects on kinases such as PIM-1, CDK-2, GSK-3 and SRC .
|
-
- HY-N6621A
-
|
|
Topoisomerase
|
Cancer
|
|
Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC50 of 7.25?μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities .
|
-
- HY-W007599S
-
-
- HY-117183
-
|
T-2636 F
|
Antibiotic
|
Cancer
|
|
Lankacidinol (T-2636 F) is an antibiotic. Lankacidinol and its related metabolites 2,18-seco-lankacidinol A (1) and 2,18-seco-lankacidinol B (2) have significant biological activities and potential medicinal value. In addition, 2,18-seco-lankacidinol A exhibits potent antitumor activity.
|
-
- HY-P10030
-
|
|
Proteasome
NF-κB
|
Inflammation/Immunology
|
|
DPLG3 is a specific chymotryptic-like β5i subunits inhibitor, with an IC50 of 4.5 nM. DPLG3 inhibits mouse i-20S with IC50 of 9.4 nM. DPLG3 downregulates the protein levels of NF-κB p50 and p65. DPLG3 can be used for immune disease research .
|
-
- HY-16231
-
|
|
Apoptosis
|
Cancer
|
|
GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors .
|
-
- HY-W034551
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Others
Cancer
|
|
DOTA-tri(t-butyl ester) belongs to the DOTA class of chelating agents. DOTA-tri(t-butyl ester) is a key raw material for synthesizing nanospherical magnetic resonance imaging (MRI) contrast agents, which are used in MR angiography and tumor angiogenesis imaging .
|
-
- HY-149824
-
|
|
EGFR
Apoptosis
|
Cancer
|
|
EGFR T790M/L858R-IN-2 is a potent and selective EGFRT790M/L858R inhibitor with IC50 values of 3.5, 1290 nM for EGFRT790M/L858R, EGFR WT, respectively. EGFR T790M/L858R-IN-2 decreases the expression of p-EGFR, P-AKT, P-ERK1/2. EGFR T790M/L858R-IN-2 induces Apoptosis and cell cycle arrest in the G1 phase. EGFR T790M/L858R-IN-2 shows anti-cancer activity .
|
-
- HY-W009412S
-
-
- HY-112624E
-
|
Dextran 0.8; Dextran D0.8; Dextran T0.8(MW 640-960)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T0.8 (Dextran 0.8; Dextran T0.8(MW 640-960)) is a food additive with a porous network structure that exhibits strong hydration capacity and low browning activity. Dextran T0.8 (MW 800) can improve the coagulation of dairy products and is used as a prebiotic in baked goods. Dextran T0.8 (MW 800) is non-toxic to HeLa cells at a concentration of ~500 μg/mL and has a low relative browning rate in the Maillard reaction. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
|
-
- HY-113924
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tri(t-butoxycarbonylethoxymethyl) ethanol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-158178
-
|
|
EGFR
|
Cancer
|
|
EGFR T790M/L858R-IN-7 (Compound 72) is a novel pyrimidine compound that inhibits the EGFR T790M and L858R mutation with a high efficacy (93% inhibition rate at 0.05 μM). EGFR T790M/L858R-IN-7 functions by specifically binding to the kinase domain of EGFR, thereby inhibiting its phosphorylation activity .
|
-
- HY-W451440
-
-
- HY-126539
-
|
|
E1/E2/E3 Enzyme
|
Cancer
|
|
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin .
|
-
- HY-101458A
-
-
- HY-101458
-
-
- HY-B0374S1
-
-
- HY-147107
-
|
|
Insecticide
|
Others
|
|
OfHex1-IN-2 (compound I-79) is a potent β-N-acetylhexosaminidase OfHex1 inhibitor. OfHex1-IN-2 can be used in control of insect .
|
-
- HY-156970
-
|
|
Phosphatase
|
Cancer
|
|
Phosphatase Binder-1 (comppund i-196) provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Phosphatase Binder-1 plays an important role in cancer .
|
-
- HY-172973
-
|
|
Tau Protein
|
Neurological Disease
|
|
TAU-IN-4 (compound I1.21) is a potent Tau aggregation inhibitor with a KD of 1.58 μM. TAU-IN-4 can be used in the study of Alzheimer’s disease .
|
-
- HY-15466
-
|
CH5132799
|
PI3K
|
Cancer
|
|
Izorlisib (CH5132799) is a selective class I PI3K inhibitor. Izorlisib inhibits class I PI3Ks, particularly PI3Kα, with an IC50 of 14 nM.
|
-
- HY-148974
-
|
|
Polo-like Kinase (PLK)
|
Cancer
|
|
PLK1-IN-5 is a potent PLK1 inhibitor with an IC50 of < 500 nM. PLK1-IN-5 shows anticancer effects (WO2008113711A1; compound I-4) .
|
-
- HY-143545
-
|
|
RET
|
Cancer
|
|
RET-IN-8 is a rearranged during transfection (RET) kinase inhibitor extracted from patent WO2021093720A1 compound I-1. RET-IN-8 can be used for the research of cancer .
|
-
- HY-19825
-
|
|
Topoisomerase
ADC Cytotoxin
Antibiotic
|
Cancer
|
|
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .
|
-
- HY-152684
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-154349
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N2-iso-Butyroyl-2’-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) . N2-iso-Butyroyl-2’-O-propargylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N8347
-
|
|
Apoptosis
|
Others
|
|
Dalbergin is a composition of the extract from the Dalbergia Sissoo Linn. knot wood. Dalbergin demonstrats notable antioxidant ability .
|
-
- HY-W584517
-
|
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584522
-
|
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-4-NH-PEG1-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG1-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584524
-
|
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-W584516
-
|
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
|
-
- HY-N10583
-
|
|
Others
|
Others
|
|
Motuporin is a cyclic peptide. Motuporin was initially isolated from T. swinhoei .
|
-
- HY-14821
-
|
ST-1968
|
Topoisomerase
|
Cancer
|
|
Namitecan is a potent topoisomerase I inhibitor, with antitumor property.
|
-
- HY-U00232
-
-
- HY-112624L
-
|
Dextran 10; Dextran D10; Dextran T10(MW 8000-12000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T10 MW 10,000 (Dextran D10; Dextran T10 MW 8000-12000) is a polymer of anhydroglucose with the average molecular weight of 10000. Dextran T10 MW 10,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-112624O
-
|
Dextran 100; Dextran D100; Dextran T100(MW 90000-110000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T200 MW 200,000 (Dextran D200; Dextran T200 MW 180000-220000) is a polymer of anhydroglucose with the average molecular weight of 1000. Dextran T1 MW 1,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-112624M
-
|
Dextran 150; Dextran D150; Dextran T150(MW 130000-170000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T150 MW 150,000 (Dextran D150; Dextran T150 MW 130000-170000) is a polymer of anhydroglucose with the average molecular weight of 150000. Dextran T150 MW 150,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-12071B
-
|
DM-3189 dihydrochloride
|
TGF-β Receptor
Organoid
|
Cancer
|
|
LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
|
-
- HY-P5410
-
|
|
MHC
|
Others
|
|
OVA-Q4 Peptide is a biological active peptide. (Q4 Peptide (SIIQFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)
|
-
- HY-10057
-
|
|
Aurora Kinase
|
Cancer
|
|
AT9283 hydrochloride is a multi-targeted kinase inhibitor with anti-tumor activity. AT9283 hydrochloride has been found to effectively inhibit Aurora A and Aurora B kinases, thereby affecting cell proliferation and survival. AT9283 hydrochloride can also inhibit several other kinases, including JAK2 and Abl (T315I) .
|
-
- HY-50514
-
|
|
JAK
Aurora Kinase
Bcr-Abl
FLT3
Apoptosis
Autophagy
|
Cancer
|
|
AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo .
|
-
- HY-155555
-
|
|
Oxidative Phosphorylation
Mitochondrial Metabolism
|
Cancer
|
|
SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. SCAL-266 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-266 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .
|
-
- HY-W717833
-
-
- HY-148859
-
-
- HY-112624T
-
|
Dextran 7; Dextran D7; Dextran T7(MW 5600-8400)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T7 MW 7,000 (Dextran 7; Dextran D7; Dextran T7 MW 5600-8400) is a polymer of anhydroglucose with the average molecular weight of 7000. Dextran T7 MW 7,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-112624A
-
|
Dextran 1; Dextran D1; Dextran T1(MW 800-1200)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T1 MW 1,000 (Dextran 1; Dextran D1; Dextran T1 MW 800-1200) is a polymer of anhydroglucose with the average molecular weight of 1000. Dextran T1 MW 1,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-170665
-
|
|
EGFR
|
Cancer
|
|
EGFR T790M/L858R-IN-9 (Compound 8) is an EGFR-L858R/T790M inhibitor that demonstrates potent inhibitory phosphorylation effects against the EGFR-L858R/T790M mutant kinase, with an IC50 value of 0.0064µM. EGFR T790M/L858R-IN-9 also inhibits the proliferation of non-small cell lung cancer (NSCLC) cells and can be utilized in cancer research .
|
-
- HY-118942
-
|
ARC 111
|
Topoisomerase
|
Cancer
|
|
Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells .
|
-
- HY-100876
-
|
|
Apoptosis
|
Cancer
|
|
GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
|
-
- HY-112197
-
|
|
PKG
|
Cardiovascular Disease
|
|
PKG agent G1 targets C42 of PKG Iα. PKG agent G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
|
-
- HY-159611
-
|
|
Ras
|
Cancer
|
|
KRAS G12C inhibitor 68 (compound I-063) is a KRAS G12C inhibitor with an IC50 of 7 nM. KRAS G12C inhibitor 68 has anti-tumor activity .
|
-
- HY-P1489
-
|
|
MHC
|
Inflammation/Immunology
|
|
OVA Peptide(257-264) is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.
|
-
- HY-101692
-
-
- HY-19332
-
|
FR-900494
|
Glycosidase
|
Inflammation/Immunology
|
|
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .
|
-
- HY-173599
-
|
|
Lipase
|
Cancer
|
|
NUV-244 is a PNPLA3 I148M degrader. NUV-244 reduces PNPLA3 I148M levels on lipid droplets via BFAR-mediated ubiquitin-proteasome degradation .
|
-
- HY-156296
-
|
|
CDK
Apoptosis
|
Cancer
|
|
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective CDK9-Cyclin T1 protein-protein interaction (PPI) inhibitor. CDK9-Cyclin T1 PPI-IN-1 inhibits cell proliferation in TNBC MDA-MB-231 cells (IC50: 0.044 μM), and induces apoptosis. CDK9-Cyclin T1 PPI-IN-1 inhibits CDK9 transcription activity, reduces the phosphorylation of RNA Pol II CTD ser2. CDK9-Cyclin T1 PPI-IN-1 inhibits tumor growth in a TNBC 4T1 mouse model .
|
-
- HY-P0052A
-
|
T20 acetate; DP178 acetate
|
HIV
|
Infection
|
|
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.
|
-
- HY-154034
-
|
|
DNA/RNA Synthesis
|
Others
|
|
5'-DMTr-T-Methyl phosphonamidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-18341R
-
|
Levothyroxine (Standard); T4 (Standard)
|
Reference Standards
Thyroid Hormone Receptor
Endogenous Metabolite
|
Endocrinology
Cancer
|
|
L-Thyroxine (Standard) is the analytical standard of L-Thyroxine. This product is intended for research and analytical applications. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
- HY-155024
-
|
|
Parasite
|
Infection
|
|
HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC50: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .
|
-
- HY-164152
-
|
|
Antibody-Drug Conjugates (ADCs)
Topoisomerase
|
Cancer
|
|
ADC Control Human IgG1-Deruxtecan (DAR 4) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .
|
-
- HY-B0817R
-
|
|
Parasite
|
Infection
|
|
Pyridaben (Standard) is the analytical standard of Pyridaben. This product is intended for research and analytical applications. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .
|
-
- HY-164152A
-
|
|
Antibody-Drug Conjugates (ADCs)
Topoisomerase
|
Cancer
|
|
ADC Control Human IgG1-Deruxtecan (DAR 8) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .
|
-
- HY-100612
-
|
|
Chloride Channel
|
Others
|
|
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC) .
|
-
- HY-W010696
-
|
3′,5′,3-Triiodothyronine
|
Thyroid Hormone Receptor
|
Cardiovascular Disease
|
|
Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine . Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes .
|
-
- HY-112624P
-
|
Dextran 500; Dextran D500; Dextran T500(MW 440000-560000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T500 MW 500,000 (Dextran 500; Dextran D500; Dextran T500 MW 440000-560000) is a polymer of anhydroglucose with the average molecular weight of 500,000. Dextran T500 MW 500,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-112624Q
-
|
Dextran 800; Dextran D800; Dextran T800(MW 750000-850000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T800 MW 800,000 (Dextran 800; Dextran D800; Dextran T800 MW 750000-850000) is a polymer of anhydroglucose with the average molecular weight of 800,000. Dextran T800 MW 800,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-112624U
-
|
Dextran 20; Dextran D20; Dextran T20(MW 16000-24000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T20 MW 20,000 (Dextran 20; Dextran D20; Dextran T20 MW 16000-24000) is a polymer of anhydroglucose with the average molecular weight of 20,000. Dextran T20 MW 20,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-112624D
-
|
Dextran 60; Dextran D60; Dextran T60(MW 54000-66000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T60 MW 60,000 (Dextran 60; Dextran D60; Dextran T60 MW 54000-66000) is a polymer of anhydroglucose with the average molecular weight of 60,000. Dextran T60 MW 60,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-113687
-
|
|
Bacterial
|
Infection
|
|
T145 is an oxazolidinone with antibacterial activity that inhibits growth of gram negatives (K. pneumoniae, A. baumannii, P. aeruginosa and E. cloacae), gram positives (E. faecalis and S. aureus) and acid fast pathogens (Mab, Mav and Mtb) .
|
-
- HY-15320
-
|
|
CXCR
|
Inflammation/Immunology
Endocrinology
|
|
NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of ( 125I)CXCL10 and ( 125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
|
-
- HY-P1489A
-
|
|
MHC
|
Inflammation/Immunology
|
|
OVA Peptide(257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.
|
-
- HY-P1489B
-
|
|
MHC
|
Inflammation/Immunology
|
|
OVA Peptide(257-264) acetate salt is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb .
|
-
- HY-N10791
-
|
|
Others
|
Infection
|
|
Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1 .
|
-
- HY-157751
-
-
- HY-107593
-
|
|
IKK
|
Inflammation/Immunology
|
|
PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats .
|
-
- HY-P2983
-
|
Kininase II; CD143
|
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
|
Angiotensin-converting enzyme (Kininase II) is a dicarboxypeptidase, it converts inactive Angiotensin I (Ang I) to active Ang II and degrades active bradykinin (BK). Angiotensin-converting enzyme is a potent vasoconstrictor, is often used in biochemical studies .
|
-
- HY-128829
-
|
|
Potassium Channel
|
Inflammation/Immunology
|
|
Kv3 modulator 2 (formula (I)) is a potent Kv3 channels modulator extracted from patent WO2018109484A1, compound formula (I) , has analgesic activity and is used in the prophylaxis or treatment of related disorders .
|
-
- HY-N5028
-
-
- HY-115708S
-
-
- HY-42771
-
|
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
|
-
- HY-173703
-
|
|
Topoisomerase
Drug Intermediate
|
Cancer
|
|
β-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. β-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. β-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by β-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. β-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-β -Glu-Pab-Exatecan. β-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers .
|
-
- HY-R01698
-
|
|
MicroRNA
|
Cancer
|
|
hsa-miR-548t-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
hsa-miR-548t-5p mimic
hsa-miR-548t-5p mimic
- HY-113133
-
|
|
Glycosidase
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo .
|
-
- HY-13960
-
|
I-BET726
|
Epigenetic Reader Domain
Apoptosis
|
Cancer
|
|
GSK1324726A is a novel, potent, and selective inhibitor of BET proteins with high affinity to BRD2 (IC50=41 nM), BRD3 (IC50=31 nM), and BRD4 (IC50=22 nM).
|
-
- HY-N3710
-
|
Kumujian G; O-Methylpicrasidine I
|
JAK
Apoptosis
|
Neurological Disease
Cancer
|
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain .
|
-
- HY-10324
-
|
Casein Kinase I Inhibitor
|
Casein Kinase
Autophagy
Apoptosis
|
Cancer
|
|
D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC50 value of 0.3 μM in vitro.
|
-
- HY-116448R
-
|
BAS-320I (Standard)
|
Reference Standards
Sodium Channel
Parasite
|
Infection
|
|
Metaflumizone (Standard) is the analytical standard of Metaflumizone. This product is intended for research and analytical applications. Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker .
|
-
- HY-P2297A
-
-
- HY-P990061
-
|
JTX 8064
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
Cancer
|
|
Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor .
|
-
- HY-159884
-
|
|
Tim3
TNF Receptor
IFNAR
|
Cancer
|
|
MG-T-19 is an effective TIM-3 inhibitor that can suppress the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9. MG-T-19 can increase the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood mononuclear cells (PBMCs) from healthy donors, and enhance the ability of PBMCs to inhibit the proliferation of Kasumi-1 cells (an acute myelogenous leukemia cell line) .
|
-
- HY-D0932R
-
|
Solvent Red 24 (Standard); C.I. 26105 (Standard)
|
Biochemical Assay Reagents
Aryl Hydrocarbon Receptor
Cytochrome P450
|
Metabolic Disease
|
|
Sudan IV (Standard) (Solvent Red 24 (Standard)) is the analytical standard of Sudan IV (HY-D0932). This product is intended for research and analytical applications. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
|
-
- HY-129721
-
|
Ponceau MX; Xylidine ponceau 2R; C.I. 16150
|
Biochemical Assay Reagents
|
Others
|
|
Acid Red 26 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-132088
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-Boc-PEG-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-139315
-
|
|
PROTACs
IRAK
|
Cancer
|
|
PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127 .
|
-
- HY-168465
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-83 (compound I-1) is a potent inhibitor of α-Glucosidase, with the IC50 of 1.49 μg/mL. α-Glucosidase-IN-83 shows reduction in blood glucose levels in vivo .
|
-
- HY-W590664
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
C2 Dihydroceramide is a derivative of C2 Ceramide (HY-101180). C2 Dihydroceramide enhances the ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I) without causing cytotoxicity .
|
-
- HY-146115
-
|
|
Trk Receptor
|
Cancer
|
|
TRK-IN-19 (Compound I-10 ) is a potent inhibitor of TRK (TRKA IC50 = 1.1 nM, TRKA G595R IC50 = 5.3 nM). TRK-IN-19 has the potential for the research of cancer diseases .
|
-
- HY-147093
-
|
|
ADC Linker
|
Cancer
|
|
vc-PAB-DMEA-PNU159682 (compound I.47) can be used to synthesize the ADC molecule based on Sulfomaleimide-based Linker. vc-PAB-DMEA-PNU159682 has good serum stability .
|
-
- HY-137629
-
|
|
PKG
|
Cardiovascular Disease
|
|
Sp-8-pCPT-PET-cGMPS is an activator for PKG-I. Sp-8-pCPT-PET-cGMPS can be used for research of NO/NOS/sGC/PKG-I signaling pathway in cardiac differentiation .
|
-
- HY-139317
-
|
|
PROTACs
IRAK
|
Cancer
|
|
PROTAC IRAK4 degrader-6 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172 .
|
-
- HY-75161
-
|
|
TRP Channel
Endogenous Metabolite
|
Cancer
|
|
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca 2+-permeable nonselective cation channel, to increase [Ca 2+]i . Antitumor activity .
|
-
- HY-B0374S2
-
-
- HY-13821
-
|
BU-4061T
|
Proteasome
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity .
|
-
- HY-116045
-
|
|
Parasite
|
Cancer
|
|
PDEB1-IN-1 (Compound 12b) is the derivative of Cilomilast (HY-10790), and serves as an inhibitor for TryPanosoma Brucei PDEB1 (TbrPDEB1) with an IC50 of 0.95 μM. PDEB1-IN-1 inhibits the proliferation of T. Brucei with an EC50 of 26 μM .
|
-
- HY-142922
-
|
|
Bcr-Abl
|
Cancer
|
|
BCR-ABL-IN-4 is a BCR-ABL inhibitor with anticancer effects. BCR-ABL-IN-4 inhibits the cancer cell growth with IC50 values of 0.67 nM and 16 nM for K562 cells and BCR-ABL T315I transfected Ba/F3 cells, respectively (WO2021143927A1; compound 11) .
|
-
- HY-10058
-
|
|
JAK
Aurora Kinase
Bcr-Abl
FLT3
Apoptosis
Autophagy
|
Cancer
|
|
AT9283 lactic acid is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 lactic acid inhibits growth and survival of multiple solid tumors in vitro and in vivo .
|
-
- HY-162958
-
|
|
Apoptosis
TrxR
|
Cancer
|
|
Photosensitizer-6 (Compound 4) is a gold (I) complex and exhibits inhibitory activity against TrxR. Photosensitizer-6 induces apoptosis in 4T1 cell, targets and eradicates tumors through chemo-phototherapy and immunogenic cell death under light exposure. Photosensitizer-6 can be used for tumor imaging .
|
-
- HY-146780
-
|
|
TGF-β Receptor
|
Cancer
|
|
TGFβRI-IN-4 is a highly potent and orally active TGFβ receptor type I (TGFβRI) inhibitor, with IC50s of 44 nM and 42.5 nM for ALK5 and NIH3T3. TGFβRI-IN-4 can suppress tumor growth and tumor weight in tumor xenograft model .
|
-
- HY-W755222
-
|
(S)-NODAG
|
Biochemical Assay Reagents
|
Cancer
|
|
(S)-NODAGA-tris(t-Bu ester) ((S)-NODAG) is a NODAGA derivative. (S)-NODAGA-tris(t-Bu ester) can be used to label peptides, antibodies, etc., and subsequently radiolabeled for PET imaging .
|
-
- HY-W591317
-
|
(R)-NODAG
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
(R)-NODAGA-tris(t-Bu ester) ((R)-NODAG) is a NODAGA derivative. (R)-NODAGA-tris(t-Bu ester) can be used to label peptides, antibodies, etc., and subsequently radiolabeled for PET imaging .
|
-
- HY-108163A
-
|
|
Calcium Channel
Potassium Channel
|
Neurological Disease
|
|
SB-237376 is a blocker of potassium and calcium channels. SB-237376 inhibits the rapidly activating delayed rectifier potassium current I(Kr) (IC50: 0.42 μM) and blocks the L-type calcium current I(Ca,L) at high concentrations .
|
-
- HY-145046
-
|
|
SOS1
Ras
|
Cancer
|
|
SOS1-IN-3 is a potent SOS1 (son of sevenless homolog 1) inhibitor with an IC50 of 5 nM. SOS1-IN-3 has anticancer effects (WO2019122129A1; compound I-1) .
|
-
- HY-14768R
-
|
T-705 (Standard)
|
Reference Standards
DNA/RNA Synthesis
Influenza Virus
SARS-CoV
Bacterial
|
Infection
|
|
Favipiravir (Standard) is the analytical standard of Favipiravir. This product is intended for research and analytical applications. Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
|
-
- HY-A0074
-
|
tetra-tBu-DTPA
|
Biochemical Assay Reagents
|
Others
|
|
DTPA-tetra (t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. DTPA-tetra (t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-161111
-
|
|
Ser/Thr Kinase
|
Cancer
|
|
KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases .
|
-
- HY-18350A
-
|
LMP776 hydrochloride
|
Topoisomerase
|
Cancer
|
|
Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities .
|
-
- HY-108228
-
-
- HY-W783421
-
-
- HY-U00159
-
-
- HY-45826
-
-
- HY-13768A
-
|
SKF 104864A hydrochloride; NSC 609669 hydrochloride
|
Topoisomerase
Autophagy
Apoptosis
|
Cancer
|
|
Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
|
-
- HY-14812
-
|
Cositecan; BNP 1350
|
Topoisomerase
|
Cancer
|
|
Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity.
|
-
- HY-N10115
-
-
- HY-105661
-
|
|
IKK
|
Cancer
|
|
IMD-0560 is a novel IκB kinase β inhibitor.
|
-
- HY-W210476
-
-
- HY-P0030
-
-
- HY-W684904
-
|
|
TGF-β Receptor
|
Cancer
|
|
LY550410 is a small-molecule ATP-competitive inhibitor against type I TGF-β receptor kinase, which contains heteroaryl rings for potent binding to the kinase-domain active site. LY550410 modulates TGF-β signalling, thereby regulates gene expression and ultimately cell growth. LY550410 is promising for research of cancers .
|
-
- HY-12071G
-
|
DM-3189
|
TGF-β Receptor
|
Cancer
|
|
LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective BMP type I receptor inhibitor .
|
-
- HY-W460274
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Aminobutyl-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-143835
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG9-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132084
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromoacetamido-PEG8-t-butyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143837
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG12-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132117
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG12-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132067
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132022
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143836
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132066
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132109
-
|
|
PROTAC Linkers
|
Cancer
|
|
MS-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132056
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG14-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096076
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG6-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132118
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132057
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132034
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG6-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-144076
-
|
|
PROTAC Linkers
|
Cancer
|
|
t-Boc-amido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132081
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132044
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG8-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132071
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methylamino-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132073
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG14-t-butyl-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190816
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143838
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG14-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132100
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140386
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132054
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG17-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140384
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132079
-
|
|
PROTAC Linkers
|
Cancer
|
|
FmocNH-PEG4-t-butyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132080
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG8-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132064
-
|
|
PROTAC Linkers
|
Cancer
|
|
FmocNH-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132101
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140414
-
|
|
PROTAC Linkers
|
Cancer
|
|
t-Boc-Aminooxy-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132025
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-154698
-
|
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
Homouridine, is an uridine analogue. Homouridine serves as an intermediate to prepare MMP-2 inhibitor (compund I, IC50=150 μM). Homouridine derivate (compund I) also inhibits TNF-α binding to TNF-αR1 .
|
-
- HY-B0374AS
-
-
- HY-169152
-
-
- HY-112624N
-
|
Dextran 200; Dextran D200; Dextran T200(MW 180000-220000)
|
Biochemical Assay Reagents
|
Others
|
|
Dextran T200 (MW 200,000) is a polymer of anhydroglucose with the average molecular weight of 200000. Dextran T200 (MW 200,000) exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .
|
-
- HY-N10846
-
|
|
Others
|
Others
|
|
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC50 values of 65.80, 35.45 and 64.80 µM respectively .
|
-
- HY-P10685
-
|
[Tyr5,12,Lys7]-Polyphemusin II
|
HIV
CMV
|
Infection
|
|
T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an EC50 of 0.008 μg/mL and a CC50 of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV .
|
-
- HY-E70091
-
|
|
DNA/RNA Synthesis
|
Others
|
|
T4 RNA ligase is an ATP-dependent RNA ligase that can catalyze the formation of phosphodiester bonds between the 5'-P end and the 3'-OH end of single-stranded RNA, single-stranded DNA or single nucleotides between molecules or within molecules. T4 RNA ligase is used for enzymatic low ribonucleotide synthesis and 3′ end labeling of RNA. It is mainly used for RNA and RNA, but can also be used for RNA and single nucleotides .
|
-
- HY-N4287
-
|
|
Others
|
Cancer
|
|
Nordalbergin, a coumarin isolated from the wood bark of Dalbergia sissoo. Nordalbergin shows strong activity in the induction of differentiation of HL-60 .
|
-
- HY-131699
-
|
|
Biochemical Assay Reagents
|
Others
|
|
t-Butyl ester-PEG4-CH2COOH is a PEG linker containing a t-butyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl group can be deprotected under acidic conditions.
|
-
- HY-149986
-
|
|
Parasite
|
Infection
|
|
Antitrypanosomal agent 13 (compound 4b) is a potent antitrypanosomal agent. Antitrypanosomal agent 13 has trypanocidal and cytotoxic activity with GI50 values of 0.18 and 8.4 μM for T. brucei and HL-60, respectively .
|
-
- HY-D0256
-
|
Chlorazol Black E; Ferristatin II disodium; C.I. 30235
|
Biochemical Assay Reagents
|
Others
|
|
Direct Black 38 (Chlorazol Black E) is a benzidine-based azo dye, a substrate of Enterococcus gallinarum, and is mainly used for textile dyeing. Direct Black 38 is biodegradable after being reduced by microbial enzymes (such as Enterococcus gallinarum azoreductase), breaking the azo bonds and releasing benzidine and 4-aminobiphenyl. Direct Black 38 can be used in environmental toxicology, wastewater treatment and carcinogenicity studies, but its metabolite benzidine is listed as a human carcinogen .
|
-
- HY-13686
-
PQ401
2 Publications Verification
|
IGF-1R
Apoptosis
|
Cancer
|
|
PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis .
|
-
- HY-10432R
-
|
|
Reference Standards
TGF-β Receptor
|
Cancer
|
|
A 83-01 (Standard) is the analytical standard of A 83-01 (HY-10432). This product is intended for research and analytical applications. A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
|
-
- HY-N10443
-
|
|
Parasite
Apoptosis
Autophagy
Reactive Oxygen Species (ROS)
|
Infection
|
|
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .
|
-
- HY-163147
-
|
|
Influenza Virus
|
Infection
|
|
PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target .
|
-
- HY-13024
-
|
DCC-2036
|
Bcr-Abl
FLT3
Src
Apoptosis
|
Cancer
|
|
Rebastinib (DCC-2036) is an orally active, non-ATP-competitive Bcr-Abl inhibitor for Abl1 WT and Abl1 T315I with IC50s of 0.8 nM and 4 nM, respectively. Rebastinib also inhibits SRC, KDR, FLT3, and Tie-2, and has low activity to seen towards c-Kit.
|
-
- HY-P6312
-
|
|
Bacterial
|
Infection
|
|
ESAT6 Epitope is a known CD4+ T cell epitope in early secretory antigen target gene 6 (ESAT6) that binds to major histocompatibility complex MHC class I with nanometer affinity (IC50=180 nM). ESAT6 Epitope can be used to enhance BCG-induced anti-Mycobacterium tuberculosis cellular immunity .
|
-
- HY-156871
-
|
|
CaMK
|
Cancer
|
|
CAMK1D-IN-1 (compound I) is an inhibitor of CAMK1D, targeting cytotoxic T lymphocyte (CTL)-resistant tumor cells. CAMK1D impairs CTL-induced death receptor signaling and apoptosis by inhibiting caspases, making it a key and effective target for PD-L1-refractory tumors .
|
-
- HY-110111
-
T2AA
1 Publications Verification
|
DNA/RNA Synthesis
|
Cancer
|
|
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .
|
-
- HY-B1416A
-
-
- HY-100904
-
|
2 BFI
|
Imidazoline Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI) .
|
-
- HY-169933
-
|
|
NEKs
|
Inflammation/Immunology
Cancer
|
|
NEK7-IN-1 (Compound I-15) is the inhibitor for NIMA-related kinase 7 NEK7 with IC50 <100 nM. NEK7-IN-1 inhibits the IL-1β release with IC50 <50 nM .
|
-
- HY-168879
-
|
|
Glutathione Peroxidase
|
Cancer
|
|
GPX4-IN-16 ((R)-9i) is a potent GPX4 inhibitor with an Kd value of 20.4 nM. GPX4-IN-16 shows cytotoxicity. GPX4-IN-16 shows anticancer activity .
|
-
- HY-N12808
-
|
|
Fungal
|
Infection
|
|
(E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent and can be extracted from Dracaena cochinchinensis (Lour.) S. C. Chen .
|
-
- HY-P3994
-
-
![[3,5 Diiodo-Tyr7] Peptide T](//file.medchemexpress.com/product_pic/hy-p3994.gif)
- HY-W728110
-
|
5-Methoxy pyrrolidinyltryptamine
|
5-HT Receptor
|
Neurological Disease
|
|
5-MeO-pyr-T (5-Methoxy pyrrolidinyltryptamine) is a 5-HT1AR agonist, with Kis of 0.577 and 373 μM for 5-HT1AR and 5-HT2AR respectively. 5-MeO-pyr-T inhibits 5-HT uptake and elicits 5-HT release. 5-MeO-pyr-T induces hypolocomotion .
|
-
- HY-136969
-
-
- HY-119509
-
-
- HY-13566A
-
|
CKD-602
|
Topoisomerase
|
Cancer
|
|
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.
|
-
- HY-U00432
-
-
- HY-N1068
-
|
|
Others
|
Others
|
|
Xanthinin is a plant growth-regulating compound from Xanthium pennsylvanicum. I .
|
-
- HY-16568
-
|
(+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate
|
Topoisomerase
Autophagy
|
Cancer
|
|
Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity .
|
-
- HY-18008
-
-
- HY-140054
-
|
|
PROTAC Linkers
|
Cancer
|
|
t-Boc-aminooxy-PEG6-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . t-Boc-aminooxy-PEG6-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-149778
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 87(10) acts as a highly potent PDT antimycotic photosensitizer (PDT-IC50 = 1 nM for T. rubrum) .
|
-
- HY-129974
-
-
- HY-RS17062
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Ube2t Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ube2t gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Ube2t Mouse Pre-designed siRNA Set A
Ube2t Mouse Pre-designed siRNA Set A
- HY-RS23506
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
Ube2t Rat Pre-designed siRNA Set A contains three designed siRNAs for Ube2t gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
Ube2t Rat Pre-designed siRNA Set A
Ube2t Rat Pre-designed siRNA Set A
- HY-RS15362
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
UBE2T Human Pre-designed siRNA Set A contains three designed siRNAs for UBE2T gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
UBE2T Human Pre-designed siRNA Set A
UBE2T Human Pre-designed siRNA Set A
- HY-RS03275
-
|
|
Small Interfering RNA (siRNA)
|
Others
|
|
CSTF2T Human Pre-designed siRNA Set A contains three designed siRNAs for CSTF2T gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
CSTF2T Human Pre-designed siRNA Set A
CSTF2T Human Pre-designed siRNA Set A
- HY-N11173
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Others
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Metabolic Disease
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cis-Melilotoside, an o-Coumaric acid derivative, shows potent antioxidant activity. cis-Melilotoside has antiprotozoal activity moderately against T. cruzi with an IC50 of 78.2 ug/mL .
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- HY-163865
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PROTACs
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Cancer
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SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-114147
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Bacterial
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Infection
Inflammation/Immunology
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Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against agent-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability .
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- HY-163874
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PROTACs
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Cancer
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SMARCA2 degrader-13 (compound I-406) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-163866
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PROTACs
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Cancer
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SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-147829
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Carbonic Anhydrase
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Cancer
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hCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with Ki values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II .
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- HY-136546
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STAT
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Cancer
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Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members .
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- HY-163867
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PROTACs
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Cancer
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SMARCA2 degrader-4 (compound I-332) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-79404A
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Amino Acid Derivatives
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Others
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Boc-beta-t-butyl-d-alanine is an intermediate, can be used in the synthesis of peptides and other amino acids .
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- HY-106199
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Adenosine Receptor
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Neurological Disease
Inflammation/Immunology
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Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain .
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- HY-134243
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6-Thioguanosine 5'-diphosphate
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Endogenous Metabolite
Ras
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Inflammation/Immunology
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6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation .
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- HY-167993
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Biochemical Assay Reagents
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Others
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(R)-GNA-T phosphoramiditec (compound 7a) is a monophosphate nucleoside similar to DNA or RNA but differing in the composition of its sugar-phosphodiester backbone, using propylene glycol in place of ribose or deoxyribose .
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- HY-110243
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Carbonic Anhydrase
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Cancer
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CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .
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- HY-W250929
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Biochemical Assay Reagents
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Others
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Maleimido-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
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- HY-13833
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Parasite
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Infection
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Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis .
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- HY-152657
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Nucleoside Antimetabolite/Analog
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Others
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N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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![N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine](//file.medchemexpress.com/product_pic/hy-152657.gif)
- HY-168527
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Histone Demethylase
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Cancer
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Acaricide agent 1 (Compound 7l) is a potent LSD1 inhibitor. LSD1 exhibits excellent acaricidal activity against egg of T. cinnabarinus with a LC50 of 0.0035 mg/L .
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- HY-135103
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T-βMCA sodium
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FXR
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Cancer
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Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM .
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- HY-164151
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ERK
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Cancer
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ERK-IN-8 (compound I-1) is an aniline pyrimidine derivative that acts as an ERK inhibitor. ERK-IN-8 has a strong inhibitory effect on ERK2 in vitro (IC50≤50 nM). ERK-IN-8 can be used in cancer research .
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- HY-148827A
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HYBO-165 sodium
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PKA
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Cancer
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GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
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- HY-162747
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-17 (compound I-290) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-162742
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-143766
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Influenza Virus
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Infection
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Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-13 has the potential for the research of influenza virus infection (only influenza A) (extracted from patent WO2021180147A1, compound I-1) .
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- HY-172555
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CFTR
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Endocrinology
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CFTR corrector 18 (Compound I-99) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 18 facilitates the processing and trafficking of CFTR, increasing the number of CFTR on the cell surface. CFTR corrector 18 is promising for research of cystic fibrosis (CF) .
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![[D-Pro2] Spantide I TFA](http://file.medchemexpress.com/product_pic/hy-p1194b.gif)
![[Leu15]-Gastrin I (human)](http://file.medchemexpress.com/product_pic/hy-p2671.gif)
![[Des-Arg10]-HOE I40](http://file.medchemexpress.com/product_pic/hy-p5518.gif)
![[Des-Arg10]-HOE I40 TFA](http://file.medchemexpress.com/product_pic/hy-p5518a.gif)
![[IrCl(COE)2]2](http://file.medchemexpress.com/product_pic/hy-w020887.gif)
rhodium(I) tetrafluoroborate](http://file.medchemexpress.com/product_pic/hy-w010685.gif)
![Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT](http://file.medchemexpress.com/product_pic/hy-148820.gif)
![N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine](http://file.medchemexpress.com/product_pic/hy-154336.gif)
![N2-[(N,N-Dimethyl amino]methylene-N1-methyl-2’-O-methylguanosine](http://file.medchemexpress.com/product_pic/hy-152547.gif)
![[3,5 Diiodo-Tyr7] Peptide T](http://file.medchemexpress.com/product_pic/hy-p3994.gif)
![N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine](http://file.medchemexpress.com/product_pic/hy-152657.gif)
