Search Result

Targets Recommended:	MMP CRM1 PD-1/PD-L1 Mps1 PAI-1 PDK-1 IRE1 Wee1 URAT1 Ack1 Neprilysin sFRP-1 MALT1 PGC-1α IGF-1R MCHR1 (GPR24) Keap1-Nrf2 E1/E2/E3 Enzyme c-Fms GPR40 EGFR IRAK EAAT2 Adenosine Receptor P-glycoprotein FXR PTEN Oct3/4 PIKfyve

Results for "1 10 phenanthroline mmp Inhibitors" in MCE Product Catalog:

By Targets:	Adenosine Receptor (1) c-Fms (6) E1/E2/E3 Enzyme (3) EGFR (16) IRAK (2) IRE1 (1) Keap1-Nrf2 (1) MCHR1 (GPR24) (1) MMP (75) Mps1 (1) P-glycoprotein (2) PAI-1 (2) PDK-1 (1) PTEN (2) 5 alpha Reductase (1) 5-HT Receptor (10) AChE (3) Acyltransferase (2) ADC Cytotoxin (12) ADC Linker (11) Adenylate Cyclase (1) Adrenergic Receptor (6) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) ALK (2) Aminopeptidase (1) AMPK (2) Amyloid-β (5) Androgen Receptor (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (15) Apoptosis (70) Arenavirus (2) ATM/ATR (2) ATP Synthase (3) Aurora Kinase (3) Autophagy (45) Bacterial (27) Bcl-2 Family (5) Bcr-Abl (4) Beta-secretase (4) BMX Kinase (2) Btk (7) c-Kit (10) c-Met/HGFR (7) c-Myc (1) Calcium Channel (3) CaMK (1) Cannabinoid Receptor (3) Carbonic Anhydrase (1) Casein Kinase (2) Caspase (3) Cathepsin (3) CCR (4) CD73 (1) CDK (24) Chloride Channel (1) Complement System (4) COX (4) CXCR (11) Cytochrome P450 (6) DAPK (1) Deubiquitinase (2) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (2) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (2) DNA/RNA Synthesis (5) Dopamine Receptor (6) Drug Metabolite (4) Drug-Linker Conjugates for ADC (3) DYRK (4) E3 Ligase Ligand-Linker Conjugate (8) Endogenous Metabolite (22) Endothelin Receptor (1) Ephrin Receptor (1) Epigenetic Reader Domain (10) ERK (8) Estrogen Receptor/ERR (3) Eukaryotic Initiation Factor (eIF) (2) FAAH (1) Factor Xa (4) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (8) FGFR (5) Filovirus (2) FLT3 (7) Fungal (4) G-quadruplex (1) GABA Receptor (2) Glucagon Receptor (3) Glucocorticoid Receptor (1) Glucokinase (2) GLUT (1) GSK-3 (5) Haspin Kinase (2) HBV (1) HCV (3) HCV Protease (2) HDAC (16) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (5) Histone Acetyltransferase (2) Histone Demethylase (5) Histone Methyltransferase (3) HIV (16) HSP (2) HSV (2) IFNAR (3) iGluR (6) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (4) Integrin (3) Interleukin Related (13) JAK (15) JNK (5) Ligand for E3 Ligase (1) Ligand for Target Protein for PROTAC (4) Lipoxygenase (3) LPL Receptor (1) LRRK2 (2) mAChR (2) MAP3K (1) MDM-2/p53 (4) MEK (2) Melanocortin Receptor (2) Melatonin Receptor (1) mGluR (3) Microtubule/Tubulin (18) Mitophagy (3) MNK (1) Monoamine Oxidase (3) Monoamine Transporter (1) Monocarboxylate Transporter (1) mTOR (7) Myosin (1) nAChR (1) Nampt (1) Neurokinin Receptor (12) Neuropeptide Y Receptor (2) NF-κB (8) NKCC (1) NO Synthase (2) Notch (1) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (7) P2X Receptor (3) P2Y Receptor (2) p38 MAPK (8) Parasite (7) PARP (5) PDGFR (12) PDHK (1) Phosphatase (6) Phosphodiesterase (PDE) (16) PI3K (15) PI4K (1) Pim (1) PKA (2) PKC (6) Polo-like Kinase (PLK) (2) Potassium Channel (9) PPAR (8) Procollagen C Proteinase (1) Prostaglandin Receptor (8) PROTAC (10) PROTAC Linker (54) Proteasome (1) Raf (1) RAR/RXR (4) Ras (3) Reactive Oxygen Species (8) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) RIP kinase (3) ROCK (2) ROR (1) ROS (2) Salt-inducible Kinase (SIK) (2) SARS-CoV (6) Ser/Thr Protease (1) Serotonin Transporter (1) SGK (1) Sirtuin (4) SNIPER (3) Sodium Channel (4) Somatostatin Receptor (6) Src (6) STAT (3) STING (3) Syk (3) TAM Receptor (5) TGF-beta/Smad (1) TGF-β Receptor (2) Thrombin (6) TNF Receptor (10) Toll-like Receptor (TLR) (7) Topoisomerase (2) Trk Receptor (3) TRP Channel (3) Tyrosinase (1) VEGFR (14) Virus Protease (4) Wnt (3) YAP (1) β-catenin (3) γ-secretase (1)
By Research Areas:	Cancer (475) Cardiovascular Disease (47) Endocrinology (41) Infection (68) Inflammation/Immunology (137) Metabolic Disease (58) Neurological Disease (102)

By Targets:

Adenosine Receptor (1)

c-Fms (6)

E1/E2/E3 Enzyme (3)

EGFR (16)

IRAK (2)

IRE1 (1)

Keap1-Nrf2 (1)

MCHR1 (GPR24) (1)

MMP (75)

Mps1 (1)

P-glycoprotein (2)

PAI-1 (2)

PDK-1 (1)

PTEN (2)

5 alpha Reductase (1)

5-HT Receptor (10)

AChE (3)

Acyltransferase (2)

ADC Cytotoxin (12)

ADC Linker (11)

Adenylate Cyclase (1)

Adrenergic Receptor (6)

Akt (4)

Aldehyde Dehydrogenase (ALDH) (1)

Aldose Reductase (1)

ALK (2)

Aminopeptidase (1)

AMPK (2)

Amyloid-β (5)

Androgen Receptor (1)

Angiotensin Receptor (2)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (15)

Apoptosis (70)

Arenavirus (2)

ATM/ATR (2)

ATP Synthase (3)

Aurora Kinase (3)

Autophagy (45)

Bacterial (27)

Bcl-2 Family (5)

Bcr-Abl (4)

Beta-secretase (4)

BMX Kinase (2)

Btk (7)

c-Kit (10)

c-Met/HGFR (7)

c-Myc (1)

Calcium Channel (3)

CaMK (1)

Cannabinoid Receptor (3)

Carbonic Anhydrase (1)

Casein Kinase (2)

Caspase (3)

Cathepsin (3)

CCR (4)

CD73 (1)

CDK (24)

Chloride Channel (1)

Complement System (4)

COX (4)

CXCR (11)

Cytochrome P450 (6)

DAPK (1)

Deubiquitinase (2)

Dihydroorotate Dehydrogenase (1)

Dipeptidyl Peptidase (2)

Discoidin Domain Receptor (2)

DNA Alkylator/Crosslinker (2)

DNA Methyltransferase (2)

DNA/RNA Synthesis (5)

Dopamine Receptor (6)

Drug Metabolite (4)

Drug-Linker Conjugates for ADC (3)

DYRK (4)

E3 Ligase Ligand-Linker Conjugate (8)

Endogenous Metabolite (22)

Endothelin Receptor (1)

Ephrin Receptor (1)

Epigenetic Reader Domain (10)

ERK (8)

Estrogen Receptor/ERR (3)

Eukaryotic Initiation Factor (eIF) (2)

FAAH (1)

Factor Xa (4)

Farnesyl Transferase (1)

Fatty Acid Synthase (FASN) (2)

Ferroptosis (8)

FGFR (5)

Filovirus (2)

FLT3 (7)

Fungal (4)

G-quadruplex (1)

GABA Receptor (2)

Glucagon Receptor (3)

Glucocorticoid Receptor (1)

Glucokinase (2)

GLUT (1)

GSK-3 (5)

Haspin Kinase (2)

HBV (1)

HCV (3)

HCV Protease (2)

HDAC (16)

Hedgehog (1)

HIF/HIF Prolyl-Hydroxylase (2)

Histamine Receptor (5)

Histone Acetyltransferase (2)

Histone Demethylase (5)

Histone Methyltransferase (3)

HIV (16)

HSP (2)

HSV (2)

IFNAR (3)

iGluR (6)

Indoleamine 2,3-Dioxygenase (IDO) (3)

Influenza Virus (4)

Integrin (3)

Interleukin Related (13)

JAK (15)

JNK (5)

Ligand for E3 Ligase (1)

Ligand for Target Protein for PROTAC (4)

Lipoxygenase (3)

LPL Receptor (1)

LRRK2 (2)

mAChR (2)

MAP3K (1)

MDM-2/p53 (4)

MEK (2)

Melanocortin Receptor (2)

Melatonin Receptor (1)

mGluR (3)

Microtubule/Tubulin (18)

Mitophagy (3)

MNK (1)

Monoamine Oxidase (3)

Monoamine Transporter (1)

Monocarboxylate Transporter (1)

mTOR (7)

Myosin (1)

nAChR (1)

Nampt (1)

Neurokinin Receptor (12)

Neuropeptide Y Receptor (2)

NF-κB (8)

NKCC (1)

NO Synthase (2)

Notch (1)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (7)

P2X Receptor (3)

P2Y Receptor (2)

p38 MAPK (8)

Parasite (7)

PARP (5)

PDGFR (12)

PDHK (1)

Phosphatase (6)

Phosphodiesterase (PDE) (16)

PI3K (15)

PI4K (1)

Pim (1)

PKA (2)

PKC (6)

Polo-like Kinase (PLK) (2)

Potassium Channel (9)

PPAR (8)

Procollagen C Proteinase (1)

Prostaglandin Receptor (8)

PROTAC (10)

PROTAC Linker (54)

Proteasome (1)

Raf (1)

RAR/RXR (4)

Ras (3)

Reactive Oxygen Species (8)

Reverse Transcriptase (1)

Ribosomal S6 Kinase (RSK) (1)

RIP kinase (3)

ROCK (2)

ROR (1)

ROS (2)

Salt-inducible Kinase (SIK) (2)

SARS-CoV (6)

Ser/Thr Protease (1)

Serotonin Transporter (1)

SGK (1)

Sirtuin (4)

SNIPER (3)

Sodium Channel (4)

Somatostatin Receptor (6)

Src (6)

STAT (3)

STING (3)

Syk (3)

TAM Receptor (5)

TGF-beta/Smad (1)

TGF-β Receptor (2)

Thrombin (6)

TNF Receptor (10)

Toll-like Receptor (TLR) (7)

Topoisomerase (2)

Trk Receptor (3)

TRP Channel (3)

Tyrosinase (1)

VEGFR (14)

Virus Protease (4)

Wnt (3)

YAP (1)

β-catenin (3)

γ-secretase (1)

By Research Areas:

Cancer (475)

Cardiovascular Disease (47)

Endocrinology (41)

Infection (68)

Inflammation/Immunology (137)

Metabolic Disease (58)

Neurological Disease (102)

816

Inhibitors & Agonists

Screening Libraries

Dye Reagents

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

101

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas

HY-135232

MMP-9-IN-1
MMP Cancer

MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs.

MMP-9-IN-1	MMP	Cancer
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs.

HY-124029

MMP13-IN-3	MMP	Inflammation/Immunology
MMP13-IN-3 is a potent, selective, and orally active *MMP-13* inhibitor (IC₅₀=1 nM) for the potential treatment of osteoarthritis. MMP13-IN-3 is >1000 selective over other MMPs.

HY-114418

MMP3 inhibitor 1
MMP Cancer

MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC₅₀ of 1 nM.

MMP3 inhibitor 1	MMP	Cancer
MMP3 inhibitor 1 is a potent and highly selective *MMP-3* inhibitor with an IC₅₀ of 1 nM.

HY-108672

NF157	P2Y Receptor	Inflammation/Immunology
NF157 is a highly selective nanomolar P2Y11 antagonist with a pK_i of 7.35. The IC₅₀s are 463 nM, 1811 µM, 170 µM for P2Y11 (K_i=44.3 nM), P2Y1 (K_i=187 µM), P2Y2 (K_i=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA).

HY-117970

MMPI-1154	MMP	Cardiovascular Disease
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) *MMP-2* inhibitor(IC₅₀=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC₅₀s of 1.8 μM,10 μM, and 13 μM, respectively.

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Microtubule/Tubulin	Cancer
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines.

HY-19485

XL-784	MMP	Cardiovascular Disease
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively.

HY-112160

XL-784 free base	MMP	Cardiovascular Disease
XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively.

HY-N0095

(S)-10-Hydroxycamptothecin 10-HCPT; 10-Hydroxycamptothecin	Topoisomerase Apoptosis	Cancer
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.

HY-115467

MitoBloCK-10	Others	Metabolic Disease
MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70.

HY-U00439

Protein kinase inhibitors 1
DYRK Cancer

Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.
HY-14550

TP-10
Phosphodiesterase (PDE) Cardiovascular Disease

TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM.

*Protein kinase inhibitors* 1**	DYRK	Cancer
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC₅₀ of 74 nM and K_d of 9.5 nM.

TP-10	Phosphodiesterase (PDE)	Cardiovascular Disease
TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM.

HY-N0275

(±)-10-Hydroxycamptothecin (±)-10-HCPT	Topoisomerase	Cancer
(±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-N0446

10-Methoxycamptothecin	Others	Cancer
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines.

HY-15580

Dolastatin 10 DLS 10; NSC 376128	Microtubule/Tubulin ADC Cytotoxin	Cancer
Dolastatin 10 (DLS 10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.

HY-N2434

[10]-Shogaol	COX	Cancer
[10]-Shogaol is an antioxidant from Zingiber officinale for human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC₅₀ of 7.5 μM and has antiproliferation activity.

HY-114320

BuChE-IN-TM-10 TM-10	AChE	Neurological Disease
BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC₅₀ of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer’s disease.

HY-N0448

10-Gingerol	Others	Cancer Inflammation/Immunology
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC₅₀ of 12.1 μM.

HY-101865

KKL-10
Bacterial Infection

KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

KKL-10	Bacterial	Infection
KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

HY-103258

TC ASK 10	MAP3K Apoptosis	Cancer
TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC₅₀ of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC₅₀ of 0.51 μM).

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	Others	Cancer
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM.

HY-B1720

Ubiquinol Ubiquinol-10; CoQH2-10	Endogenous Metabolite	Metabolic Disease Cancer
Ubiquinol (Ubiquinol-10) is a reduced form of coenzyme Q10 (CoQ10). Ubiquinol is a potent antioxidant that has the capacity to protect Vitamin E, and also helps to regenerate depleted vitamin E and Vitamin C. Ubiquinol is both lipophilic and hydrophilic and acts as transmembrane factor preventing lipid peroxidation and propagation by transferring electrons to ROS.

HY-125997

BTK inhibitor 10	Btk	Inflammation/Immunology
BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment.

HY-16565

10-Deacetylbaccatin III
Others Cancer

10-Deacetylbaccatin-III is an intermediate for taxol analog preparations.

10-Deacetylbaccatin III	Others	Cancer
10-Deacetylbaccatin-III is an intermediate for taxol analog preparations.

HY-P1116

PBP10	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects.

HY-N0111

Coenzyme Q10 CoQ10; Ubiquinone-10	Endogenous Metabolite Reactive Oxygen Species Ferroptosis	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective *MMP12* inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

HY-U00277

JAK-IN-10
JAK Others

JAK-IN-10 is a useful composition for treating and/or preventing dry eye disorders.
HY-12813

PDE10-IN-1
Phosphodiesterase (PDE) Neurological Disease

PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.
HY-130850

CDK9-IN-10
CDK Ligand for Target Protein for PROTAC Cancer

CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811).

JAK-IN-10	JAK	Others
JAK-IN-10 is a useful composition for treating and/or preventing dry eye disorders.

PDE10-IN-1	Phosphodiesterase (PDE)	Neurological Disease
PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.

CDK9-IN-10	CDK Ligand for Target Protein for PROTAC	Cancer
CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811).

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Microtubule/Tubulin ADC Cytotoxin	Cancer
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-133295

Thiol-PEG10-alcohol
HS-PEG10-OH
PROTAC Linker Cancer

Thiol-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-130889

(+)-Biotin-PEG10-OH
(+)-Biotin-PEG10-alcohol
PROTAC Linker Cancer

(+)-Biotin-PEG10-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-P2246

JTP10-△-TATi TFA
JNK Cancer

JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor, with an IC₅₀ of 92 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

Thiol-PEG10-alcohol HS-PEG10-OH	PROTAC Linker	Cancer
Thiol-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

(+)-Biotin-PEG10-OH (+)-Biotin-PEG10-alcohol	PROTAC Linker	Cancer
(+)-Biotin-PEG10-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

JTP10-△-TATi TFA	JNK	Cancer
JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor, with an IC₅₀ of 92 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

HY-P1978

CysHHC10	Bacterial	Infection
CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 against *E. coli, P. aeruginosa, S. aureus* and *S. epidermidis* are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively.

HY-140500

m-PEG10-acid	ADC Linker PROTAC Linker	Cancer
m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140333

Diethyl 10-bromodecylphosphonate
PROTAC Linker Cancer

Diethyl 10-bromodecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Diethyl 10-bromodecylphosphonate	PROTAC Linker	Cancer
Diethyl 10-bromodecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140226

m-PEG10-amine	ADC Linker PROTAC Linker	Cancer
m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-135841

CM10	Aldehyde Dehydrogenase (ALDH)	Cancer Metabolic Disease
CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC₅₀s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.

HY-W019939

Hydroxy-PEG10-Boc	ADC Linker	Cancer
Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024). Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011).

HY-N4303

5-Ethoxy-10-Gingerol
Others Others

5-Ethoxy-10-Gingerol is a derivate of gingerol.

5-Ethoxy-10-Gingerol	Others	Others
5-Ethoxy-10-Gingerol is a derivate of gingerol.

HY-N6679A

10,11-Dehydrocurvularin	HSP TGF-beta/Smad	Cancer Infection
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.

HY-P1116A

PBP10 TFA	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects.

HY-128553A

(Rac)-Antineoplaston A10	Ras Apoptosis	Cancer
(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10. Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

HY-P1279

[Lys5,MeLeu9,Nle10]-NKA(4-10)
Neurokinin Receptor Inflammation/Immunology

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.
HY-120761

Amino-PEG10-OH
ADC Linker Cancer

Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-113450

10Z-Nonadecenoic acid
Endogenous Metabolite Metabolic Disease Cancer

10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity.

[Lys5,MeLeu9,Nle10]-NKA(4-10)	Neurokinin Receptor	Inflammation/Immunology
[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.

Amino-PEG10-OH	ADC Linker	Cancer
Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

10Z-Nonadecenoic acid	Endogenous Metabolite	Metabolic Disease Cancer
10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity.

HY-107024

Osteogenic Growth Peptide (10-14) OGP(10-14); Historphin	Src	Others
Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor.

HY-129554

cis-9,10-Epoxystearic acid cis-9,10-Epoxyoctadecanoic acid	Endogenous Metabolite	Others
cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) is an endogenous constituent in human blood and urine. cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) can be produced from oleic acid by enzymic and non-enzymic epoxidation.

HY-126297

c-Fms-IN-10	c-Fms	Cancer Inflammation/Immunology
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC₅₀ of 2 nM. c-Fms-IN-10 has anti-tumor activity.

HY-109502S

10-OH-NBP D4	Others	Neurological Disease
10-OH-NBP D4 is deuterium labeled 10-OH-NBP. 10-OH-NBP is a Butylphthalide (3-n-Butylphthalide; NBP) hydroxylated metabolite and can penetrates the blood-brain barrier (BBB). Butylphthalide exerts neuroprotective effects and has potential for cerebral ischemia research.

HY-121744

PS10	PDHK	Inflammation/Immunology
PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC₅₀ of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (K_d= 239 nM) than for Hsp90 (K_d= 47 μM). PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy.PDK: pyruvate dehydrogenase kinase

HY-19956

GI254023X
GI4023; SRI028594
MMP Cancer

GI254023X is a potent MMP9 and ADAM10 inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.
HY-133230

Propargyl-PEG10-amine
PROTAC Linker Cancer

Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-130424

m-PEG10-azide
PROTAC Linker Cancer

m-PEG10-azide a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-P1279A

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.

HY-P2247

JTP10-△-R9 TFA
JNK Cancer

JTP10-△-R9 TFA is a selective JNK2 peptide inhibitor, with an IC₅₀ of 89 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.
HY-140455

Azido-PEG10-acid
PROTAC Linker Cancer

Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140020

Propargyl-PEG10-acid
PROTAC Linker Cancer

Propargyl-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140176

Amino-PEG10-acid
PROTAC Linker Cancer

Amino-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140330

(10-BRomodecyl)phosphonic acid
PROTAC Linker Cancer

(10-BRomodecyl)phosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133231

Bis-PEG10-acid
PROTAC Linker Cancer

Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-125835

CP-10	PROTAC CDK	Cancer
CP-10 is a PROTAC with highly selective, specific, and remarkable CDK6 degradation (DC₅₀=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6.

HY-128807

E3 ligase Ligand 10	Ligand for E3 Ligase	Cancer
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

HY-13564A

Batimastat sodium salt BB-94 sodium salt	MMP	Cancer
Batimastat sodium salt is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-13564

Batimastat
BB94
MMP Cancer

Batimastat is a potent broad spectrum MMP inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.

HY-126492

Vat-Cit-PAB-Monomethyl Dolastatin 10	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
Vat-Cit-PAB-Monomethyl Dolastatin 10 is a drug-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.

HY-141399

m-PEG10-Boc
PROTAC Linker Cancer

m-PEG10-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-140029

Propargyl-PEG10-Boc
PROTAC Linker Cancer

Propargyl-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133278

m-PEG10-Br
PROTAC Linker Cancer

m-PEG10-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140861

Trityl-PEG10-azide
PROTAC Linker Cancer

Trityl-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140360

m-PEG10-Tos
PROTAC Linker Cancer

m-PEG10-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-140217

Azido-PEG10-amine
PROTAC Linker Cancer

Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140196

Amino-PEG10-Boc
PROTAC Linker Cancer

Amino-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133270

m-PEG10-SH
PROTAC Linker Cancer

m-PEG10-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140304

DBCO-PEG10-DBCO
PROTAC Linker Cancer

DBCO-PEG10-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140781

Azido-PEG10-Boc
PROTAC Linker Cancer

Azido-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140801

Azido-PEG10-alcohol
PROTAC Linker Cancer

Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-U00050S

(E)-10-Hydroxy Nortriptyline D3	Others	Neurological Disease
(E)-10-Hydroxy Nortriptyline D3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.

HY-107394

UK 356618	MMP	Cancer Inflammation/Immunology
UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC₅₀ of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with *MMP-3*.

HY-P1978A

CysHHC10 TFA	Bacterial	Infection
CysHHC10 TFA is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 TFA against *E. coli, P. aeruginosa, S. aureus* and *S. epidermidis* are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively.

HY-13102

UK-383367	Procollagen C Proteinase	Others
UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).

HY-B0914

10-Undecenoic acid
Undecylenic acid
Fungal Endogenous Metabolite Antibiotic Others

10-Undecenoic acid was used as a starting reagent in the syntheses of Pheromone (11Z)-hexadecenal.

HY-N0181A

Lumisterol 9β,10α-Ergosterol	Endogenous Metabolite	Metabolic Disease
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities.

HY-15615

TIC10 isomer
ONC201 isomer
Others Others

TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression.

HY-15768

Ilomastat GM6001; Galardin	MMP	Cancer
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-19408

Pyr10	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.

HY-104047

LM22B-10
Trk Receptor Akt ERK Neurological Disease

LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.

HY-111518

JH-XI-10-02	PROTAC CDK	Cancer
JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC₅₀ of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.

HY-107639

UK-370106	MMP	Inflammation/Immunology
UK-370106 is a potent and highly selective *MMP-3* (IC₅₀ of 23 nM) and *MMP-12* (IC₅₀ of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [³H]-fibronectin by *MMP-3* (IC₅₀ of 320 nM) and has little effect on keratinocyte migration in vitro.

HY-133307

Hydroxy-PEG10-acid
HO-PEG10-CH2CH2COOH
PROTAC Linker Cancer

Hydroxy-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-100198

PI4KIIIbeta-IN-10
PI4K Infection

PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC₅₀ of 3.6 nM.

HY-100646A

(Z)-10-Hydroxy Nortriptyline	Drug Metabolite	Neurological Disease
(Z)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.

HY-N1463

Luteolin 7-O-glucuronide Luteolin 7-glucuronide	MMP	Others
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-106992

S 3304
MMP Cancer

S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

HY-130641

Br-C10-methyl ester	PROTAC Linker	Cancer
Br-C10-methyl ester is a PROTAC linker, which refers to the alkyl/ether composition. Br-C10-methyl ester is used in the synthesis of a series of PROTACs (MS432). PROTACs contain two different ligands connected by a linker; one is the VHL ligand portion and the other is for the target protein.

HY-101384A

Ro 10-5824 dihydrochloride
Dopamine Receptor Others

Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with K_i of 5.2 nM.
HY-U00427

PDE2/PDE10-IN-1
Phosphodiesterase (PDE) Neurological Disease

PDE2/PDE10-IN-1 is a phosphodiesterase 2 (PDE2) and PDE10 inhibitor with IC₅₀s of 29 and 480 nM, respectively.
HY-140973

Mal-amido-PEG10-acid
PROTAC Linker Cancer

Mal-amido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140461

Fmoc-NH-PEG10-acid
PROTAC Linker Cancer

Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140490

Cbz-N-PEG10-acid
PROTAC Linker Cancer

Cbz-N-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-141104

m-PEG10-NHS ester
PROTAC Linker Cancer

m-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140759

Azido-PEG10-NHS ester
PROTAC Linker Cancer

Azido-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-Y0148

10-Hydroxydecanoic acid NSC 15139	Others	Inflammation/Immunology
10-Hydroxydecanoic acid (NSC 15139) is a saturated fatty acid of 10-hydroxy-trans-2-decenoic acid from royal jelly, with anti-inflammatory activity.

HY-P1594

Dynorphin A 1-10	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-112718

PROTAC BET Degrader-10	PROTAC Epigenetic Reader Domain	Cancer
PROTAC BET Degrader-10 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, with a DC₅₀ of 49 nM.

HY-135920

Biotin-C10-NHS Ester
PROTAC Linker Cancer

Biotin-C10-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-W009037

Maleimide-C10-NHS ester
PROTAC Linker Cancer

Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-130824

Bis-PEG10-NHS ester
ADC Linker Cancer

Bis-PEG10-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-N1454

Apigenin-7-glucuronide Apigenin 7-O-glucuronide	MMP	Cancer
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-P0236

Neurokinin A(4-10)
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

HY-12170

Prinomastat AG3340; KB-R9896	MMP	Cancer
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3* and *MMP-9* with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity.

HY-12170A

Prinomastat hydrochloride AG3340 hydrochloride; KB-R9896 hydrochloride	MMP	Cancer
Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat hydrochloride inhibits MMP-2, MMP-3* and *MMP-9* with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity.

HY-P1789

CTTHWGFTLC, CYCLIC
MMP Cancer Inflammation/Immunology

CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM.
HY-133312

Hydroxy-PEG10-CH2-Boc
HO-PEG10-CH2COOtBu
PROTAC Linker Cancer

Hydroxy-PEG10-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Cancer Inflammation/Immunology
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM.

HY-135122

DC10SMe	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
DC10SMe is a DNA alkylator, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC10SMe exhibits IC₅₀s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively.

HY-103575A

MFZ 10-7 hydrochloride	mGluR	Neurological Disease
MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a K_i of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats.

HY-114091

PF-00356231 hydrochloride	MMP	Inflammation/Immunology
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase *MMP-12* (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.

HY-P1567

β-Amyloid (10-35), amide	Amyloid-β	Neurological Disease
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

HY-117491

BRD4 Inhibitor-10
Epigenetic Reader Domain Cancer

BRD4 Inhibitor-10 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC₅₀ of 8 nM.

HY-15827

NSC 405020	MMP	Cancer
NSC 405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2.

HY-128894

MC-Sq-Cit-PAB-Dolastatin10	Drug-Linker Conjugates for ADC	Cancer
MC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.

HY-N6834

Fructo-oligosaccharide DP10/GF9	Others	Others
Fructo-oligosaccharide DP10/GF9 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=10). Fructo-oligosaccharides (FOS) are composed of 9 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end.

HY-100646

(E)-10-Hydroxy Nortriptyline maleate	Drug Metabolite	Neurological Disease
(E)-10-Hydroxy Nortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.

HY-117889

PARP14 inhibitor H10	PARP Apoptosis	Cancer
PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC₅₀=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis.

HY-19740

BIA 10-2474
FAAH Autophagy Neurological Disease

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC₅₀ values of 50 to 70mg/kg in various rat brain regions.

HY-129941

(S,R,S)-AHPC-C10-NH2 VH032-C10-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.

HY-129941A

(S,R,S)-AHPC-C10-NH2 dihydrochloride VH032-C10-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.

HY-15801

HG-14-10-04
ALK Cancer

HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.

HY-10255AS

Sunitinib D10 SU 11248 D10	VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis	Cancer
Sunitinib D10 (SU 11248 D10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation.

HY-103444

ARP-100	MMP	Cancer
ARP-100 is a potent and selective matrix metalloproteinase *MMP-2* inhibitor (IC₅₀=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).

HY-140386

Ms-PEG10-t-butyl ester
PROTAC Linker Cancer

Ms-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-141120

Boc-NH-PEG10-NHS ester
PROTAC Linker Cancer

Boc-NH-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140327

[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid	PROTAC Linker	Cancer
[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-141130

LG-PEG10-click-DBCO-Oleic
PROTAC Linker Cancer

LG-PEG10-click-DBCO-Oleic is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-12168

Tanomastat BAY 12-9566	MMP	Cancer
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The K_i values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models.

HY-128553

Antineoplaston A10	Ras Endogenous Metabolite	Cancer
Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

HY-W040270

Amino-PEG10-amine	PROTAC Linker	Cancer
Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.

HY-N6679

(R)-10,11-Dehydrocurvularin	Others	Cancer
(R)-10,11-Dehydrocurvularin is a secondary metabolite isolated from Curvularia sp.. (R)-10,11-Dehydrocurvularin displays concentration-dependent cytotoxicity towards human tumor cell lines with a mean IC₅₀ value of 1.25 µM.

HY-114396

BR351
MMP Cancer

BR351 is a brain penetrant MMP inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.
HY-B0797

Etretinate
Ro 10-9359
Apoptosis Others

Etretinate(Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis treatment.

HY-P1594A

Dynorphin A (1-10) (TFA)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-112191

PI3K-IN-10
PI3K Cancer

PI3K-IN-10 is a potent pan-PI3K inhibitor as a benzimidazole derivative, compound 332, extracted from patent WO2018057808A1.

HY-15615A

TIC10 ONC-201	TNF Receptor Apoptosis	Cancer
TIC10 is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. TIC10 can cross the blood-brain barrier.

HY-130876

HS-PEG10-CH2CH2COOH
Thiol-PEG10-propionic acid
PROTAC Linker Cancer

HS-PEG10-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-141218

m-PEG10-alcohol Decaethylene glycol monomethyl ether	ADC Linker PROTAC Linker	Cancer
m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-133304

HO-PEG10-CH2COOH
PROTAC Linker Cancer

HO-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133335

Amino-PEG10-CH2-Boc
PROTAC Linker Cancer

Amino-PEG10-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-133285

m-PEG10-CH2COOH
PROTAC Linker Cancer

m-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-140631

Ald-CH2-PEG10-Boc
PROTAC Linker Cancer

Ald-CH2-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-100359

CL-82198	MMP	Cancer Inflammation/Immunology
CL-82198 is a selective inhibitor of *MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs.* CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression.

HY-B0107

Acitretin Ro 10-1670	RAR/RXR Autophagy Apoptosis	Inflammation/Immunology Cancer
Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

HY-N6846

10-Isobutyryloxy-8,9-epoxythymol isobutyrate	Bacterial	Infection
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively.

HY-16786

AI-10-49
Others Cancer

AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM.

HY-135425

10,12-Tricosadiynoic acid	Acyltransferase	Metabolic Disease
10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.

HY-W017772

Boc-NH-PEG3
PROTAC Linker 10
PROTAC Linker Cancer

Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-12169

Marimastat BB2516; TA2516	MMP	Cancer
Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of *MMPs, with potent activity against MMP-9 (IC₅₀=3 nM), MMP-1 (IC₅₀=5 nM), MMP-2 (IC₅₀=6 nM), MMP-14 (IC₅₀=9 nM) and MMP-7 (IC₅₀*=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.

HY-130716

Thalidomide-NH-C10-COOH	E3 Ligase Ligand-Linker Conjugate	Cancer
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based von Hippel-Lindau (VHL) ligand and a linker used in PROTAC technology.

HY-N7008

Fructo-oligosaccharide DP11/GF10	Others	Metabolic Disease
Fructo-oligosaccharide DP11/GF10 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=11). Fructo-oligosaccharides (FOS) are composed of 10 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end.

HY-P0236A

Neurokinin A(4-10) TFA
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.
HY-130137

m-PEG8-C10-phosphonic acid
PROTAC Linker Cancer

m-PEG8-C10-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-P0273

Histatin 5
MMP Inflammation/Immunology

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-43586

BR351 precursor
MMP Cancer

BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.

HY-B0914A

10-Undecenoic acid zinc salt Zinc undecylenate	Fungal Antibiotic	Infection
10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

HY-113794

DSHS00884
SSYA10-001
Filovirus Infection

DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC₅₀ of 10 μM.

HY-124373

ND-336	MMP	Metabolic Disease
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, *MMP-9, and MMP-14, with K_i*s of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.

HY-P0273A

Histatin 5 TFA
MMP Inflammation/Immunology

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-B0018

Docetaxal 10-Acetyl docetaxel; PNU-101383	Microtubule/Tubulin	Cancer
Docetaxal (10-Acetyl docetaxel; PNU-101383), an analog of Docetaxel (HY-B0011), is a microtubule disassembly inhibitor, with antimitotic activity. Docetaxal has cytotoxicity for murine leukemic cells.

HY-124373A

(R)-ND-336	MMP	Metabolic Disease
(R)-ND-336 is a potent and selective *MMP-9* inhibitor with a K_i of 19 nM. (R)-ND-336 inhibits MMP-2 (K_i=127 nM) and MMP-14 (K_i=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research.

HY-16674

10-Oxo Docetaxel Docetaxel Impurity 1	Microtubule/Tubulin	Cancer
10-Oxo Docetaxel (Docetaxel Impurity 1) is a novel taxoid having remarkable anti-tumor properties and a Docetaxel intermediate.

HY-P1053

Amyloid β-Protein 10-20
Amyloid-β Neurological Disease

Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
HY-133357

Cbz-NH-PEG10-CH2COOH
PROTAC Linker Cancer

Cbz-NH-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-19711

STING agonist-1 G10	STING Virus Protease	Infection
STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC₉₀ of 24.57 μM.

HY-130642

(S,R,S)-AHPC-Me-C10-Br	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901.

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-133552

RORγt Inverse agonist 10	ROR	Inflammation/Immunology
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀ of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R

HY-113952

Actinonin (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Cancer Infection
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities.

HY-140320

DBCO-mPEG (MW 10kDa)
PROTAC Linker Cancer

DBCO-mPEG (MW 10kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-10398

CTS-1027 Ro 1130830; RS 130830	MMP	Cancer
CTS-1027 is a potent small molecule inhibitor of *MMPs, with IC₅₀s of 0.3 nM, 0.5 nM for MMP2, MMP13, respectively, and has > 1,000 fold selectivity over MMP*1.

HY-P1787

β-Amyloid (4-10)	Amyloid-β	Neurological Disease
β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model.

HY-130847

(S,R,S)-AHPC-Me-C10-NH2	E3 Ligase Ligand-Linker Conjugate	Cancer
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602).

HY-N1940

β-Anhydroicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties^{[1]MMP-3 in diabetic rats. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca²⁺, and markedly decreases iNOS protein expression.}

HY-126355

4,7,10,13,16-Docosapentaenoic acid
Endogenous Metabolite Metabolic Disease

4,7,10,13,16-Docosapentaenoic acid is an endogenous metabolite.

HY-128826

cIAP1 Ligand-Linker Conjugates 10 E3 ligase Ligand-Linker Conjugates 47	E3 Ligase Ligand-Linker Conjugate	Cancer
cIAP1 Ligand-Linker Conjugates 10 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 10 can be used to design SNIPERs.

HY-103482

JNJ0966
MMP Cancer

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC₅₀ of 440 nM.

HY-N0431

Astragaloside IV	MMP ERK JNK	Cancer
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-13488

HG-10-102-01	LRRK2	Neurological Disease
HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM) IC50 Value: 23.3 nM (WT LRRK2); 3.2 nM (LRRK2 G2019S) [1] Target: LRRK2 HG-10-102-01 maintains the ability to potently inhibit the biochemical activity of wild-type and G2019S mutant LRRK2.

HY-B0107A

Acitretin sodium Ro 10-1670 sodium	RAR/RXR Autophagy	Inflammation/Immunology
Acitretin sodium(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

HY-N0532

Morroniside
MMP Metabolic Disease Neurological Disease

Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
HY-N2117

Isoginkgetin
MMP Cancer

Isoginkgetin is a MMP-9 inhibitor, also a Pre-mRNA Splicing Inhibitor with IC 50 of 30 uM.
HY-107643

Reversan
CBLC4H10
P-glycoprotein Cancer

Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor.

HY-16787

ICA-121431	Sodium Channel	Cardiovascular Disease
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Na_v) blocker, shows equipotent selectivity for human Na_v1.1 and Na_v1.3 subtypes with IC₅₀ values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Na_v1.2 (IC₅₀=240 nM) and 1,000 fold selectivity against Na_v1.4, Na_v1.6, and the TTX-resistant human Na_v1.5 and Na_v1.8 channels (IC₅₀s >10 µM).

HY-16675

7-Epi-10-oxo-docetaxel Docetaxel Impurity 2	Microtubule/Tubulin	Cancer
7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC).

HY-P1375

[D-Trp7,9,10]-Substance P	mAChR
[D-Trp7,9,10]-Substance P is the substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. [D-Trp7,9,10]-Substance P does not inhibit Gi/o activation by M2 ACh receptors.

HY-140471

Boc-NH-PEG10-CH2CH2COOH
PROTAC Linker Cancer

Boc-NH-PEG10-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140325

Tetraethyl decane-1,10-diylbis(phosphonate)	PROTAC Linker	Cancer
Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-N0069

Solamargine Solamargin; δ-Solanigrine	P-glycoprotein Apoptosis	Cancer
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity.

HY-130865

Mal-NH-PEG10-CH2CH2COOPFP ester
PROTAC Linker Cancer

Mal-NH-PEG10-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-N1981

Triolein	MMP Endogenous Metabolite	Inflammation/Immunology
Triolein is a symmetrical triacylglycerol, reduces *MMP-1* upregulation, with strong antioxidant and anti-inflammatory properties.

HY-126509

Mal-amido-PEG10-C2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-N0262

Cordycepin 3'-Deoxyadenosine	MMP Bacterial Autophagy Antibiotic	Cancer Infection Inflammation/Immunology
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative isolated from Cordyceps and inhibits IL-1β-induced *MMP-1* and *MMP-3* expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner. Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase.

HY-135930

Boc-NH-PEG10-CH2CH2NH2
PROTAC Linker Cancer

Boc-NH-PEG10-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-N0318

Salvianolic acid A
MMP Inflammation/Immunology

Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

HY-P1375A

[D-Trp7,9,10]-Substance P TFA	mAChR
[D-Trp7,9,10]-Substance P TFA is the substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. [D-Trp7,9,10]-Substance P TFA does not inhibit Gi/o activation by M2 ACh receptors.

HY-16978

TG6-10-1	5-HT Receptor Prostaglandin Receptor	Neurological Disease Endocrinology
TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.

HY-B0099

Edaravone MCI-186	MMP Apoptosis	Neurological Disease
Edaravone is a strong novel free radical scavenger, and inhibits *MMP*-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

HY-12354

SB-3CT	MMP	Cancer
SB-3CT is a potent and competitive matrix metalloproteinase *MMP-2* and *MMP-9* inhibitor with K_i values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity.

HY-12270

T-5224	MMP	Others
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.

HY-N6862

Lucideric acid A
MMP Cancer

Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.

HY-100211

TAPI-2 TNF Protease Inhibitor 2	MMP SARS-CoV	Cancer
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP. TAPI-2 blocks the entry of infectious SARS-CoV.

HY-N6860

Lucidenic acid C
MMP Cancer

Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.

HY-128976

10β,17β-dihydroxyestra-1,4-dien-3-one DHED	Estrogen Receptor/ERR	Metabolic Disease
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain.

HY-P1031

[bAla8]-Neurokinin A(4-10)
MEN 10210
Neurokinin Receptor Endocrinology

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.
HY-101703

Ro 31-9790
GI4747
MMP Inflammation/Immunology

Ro 31-9790 is a synthetic metalloproteinase (MMP) inhibitor.

HY-N6844

8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol	Others	Cancer
8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. 8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol also shows marked antipro-liferative activity against human cancer cell lines in vitro.

HY-111456

DBCO-NHCO-PEG4-NHS ester	ADC Linker	Cancer
DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-131005

Ehp inhibitor 2
Ephrin Receptor Cancer

Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor.

HY-101671

S-methyl-KE-298 M-2	MMP Drug Metabolite	Inflammation/Immunology
S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.

HY-12290

Arg-Gly-Asp-Ser RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function, decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9.

HY-19422

PNU-248686A
MMP Cancer

PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor.

HY-125166

DB04760	MMP	Cancer Neurological Disease
DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating *MMP-13* inhibitor with an IC₅₀ of 8 nM. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity.

HY-W011120

Ethyl docosa-4,7,10,13,16,19-hexaenoate	Others	Metabolic Disease
Ethyl cis-4,7,10,13,16,19-Docosahexaenoate, the ethyl ester of Docosahexaenoate (DHA), is enriched in the ethyl ester fraction by the selective alcoholysis of fatty acid ethyl esters originating from tuna oil with lauryl alcohol.

HY-B0099S

Edaravone D5 MCI-186 D5	MMP Apoptosis	Neurological Disease
Edaravone D5 is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

HY-N3063

Pimaric acid	Others
Pimaric acid is a resin acid that has been found in A. cordata and various pines. Pimaric acid reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs).

HY-17468

Bumetanide Ro 10-6338; PF 1593	NKCC	Cardiovascular Disease
Bumetanide (Ro 10-6338;PF 1593) is a selective Na⁺-K⁺-Cl^- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC₅₀s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

HY-77813

Benzyl isothiocyanate	Bacterial Apoptosis Antibiotic	Cancer Endocrinology
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells.

HY-100518

T-26c	MMP	Inflammation/Immunology
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC₅₀ of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes.

HY-N0565

Doxycycline
MMP Bacterial Parasite Antibiotic Infection

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.
HY-N0565A

Doxycycline hydrochloride
MMP Bacterial Antibiotic Infection

Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.
HY-121879

SHP836
Phosphatase Cancer

SHP836 is a SHP2 allosteric inhibitor, with an IC₅₀ of 12 μM for the full length SHP2.
HY-W008923

Doxycycline monohydrate
MMP Bacterial Parasite Antibiotic Infection

Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.

HY-N0565B

Doxycycline (hyclate) Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031	MMP Bacterial Antibiotic	Infection
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity A	Endogenous Metabolite	Others
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D.

HY-N6013

Aloin(mixture of A&B)	MMP Bacterial Fungal	Cancer Infection Inflammation/Immunology
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases *(MMPs)*.

HY-15581

MMAD Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10	Microtubule/Tubulin ADC Cytotoxin	Cancer
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs).

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-N2388

Auraptene	MMP	Inflammation/Immunology Cancer
Auraptene is the most abundant naturally occurring geranyloxycoumarin. Auraptene is primarily isolated from plants in the Rutaceae family, such as citrus fruits. Auraptene decreases the secretion of matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8, and chemokine (C-C motif) ligand-5(CCL5).

HY-N0774

Isofraxidin	COX MMP Toll-like Receptor (TLR)	Inflammation/Immunology
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits *MMP-7* expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.

HY-130234

SP-8356	NF-κB Apoptosis	Cancer Cardiovascular Disease
SP-8356, an anti-inflammatory synthetic verbenone derivative, is a potent, orally active cluster of differentiation 147 (CD147) inhibitor. SP-8356 inhibits CD147-cyclophilin A (CypA) interaction and reduces MMP-9 activity. SP-8356 exerts anti-breast cancer effects by inhibiting NF-κB signaling. Anti-atherosclerotic effects.

HY-U00439A

*Protein kinase inhibitors* 1 hydrochloride** (E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride	DYRK	Cancer
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC₅₀s of 136 and 74 nM for HIPK1 and HIPK2, and a K_d of 9.5 nM for HIPK2.

HY-13648

Incyclinide CMT-3; COL-3	MMP	Cancer
Incyclinide (CMT-3, COL-3) is a matrix metalloproteinase (MMP) inhibitor, thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.

HY-W012037

8-Hydroxyquinoline hemisulfate 8-Quinolinol hemisulfate	Bacterial Antibiotic	Infection
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.

HY-N2205

Esculentoside H	NF-κB JNK	Cancer
Esculentoside H (EsH) is a water-soluble saponin isolated and purified from the root extract of perennial plant Phytolacca esculenta. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease. Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression.

HY-P2004

FFAGLDD	MMP	Cancer
FFAGLDD is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.

HY-16657

TAPI-1	MMP	Cancer Inflammation/Immunology
TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor.

HY-P2004A

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.

HY-122214

AC-73	Autophagy	Cancer
AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the *CD147*/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells. AC-73 is also an anti-proliferative drug and an inducer of autophagy in leukemic cells.

HY-135813

LtaS-IN-1	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.

HY-125957

A-3 hydrochloride	PKA Casein Kinase CaMK PKC	Others
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (K_i=4.3 µM), casein kinase II (K_i=5.1 µM) and myosin light chain kinase (MLCK) (K_i=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with K_i values of 47 µM and 80 µM, respectively.

HY-B2162

Chondroitin sulfate Chondroitin polysulfate	NO Synthase MMP Endogenous Metabolite	Inflammation/Immunology
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and *MMPs*.

HY-15581S

D8-MMAD Demethyldolastatin 10 D8; Monomethylauristatin D D8; Monomethyl Dolastatin 10 D8	ADC Cytotoxin Microtubule/Tubulin	Cancer
D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-128349

MT-3014	Phosphodiesterase (PDE)	Neurological Disease
MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC₅₀s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively.

HY-130296

Palbociclib-propargyl PROTAC CDK6 ligand 1	Ligand for Target Protein for PROTAC	Cancer
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC₅₀ of 2.1 nM for CDK6.

HY-101918

DS-1040 Tosylate	Others	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.

HY-18728

STF-31
GLUT Autophagy Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1μM^[1][2].
HY-12913

AMG 579
Phosphodiesterase (PDE) Neurological Disease

AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC₅₀ of 0.1 nM.

HY-B1069

Molsidomine SIN-10; Morsydomine	Others	Cardiovascular Disease
Molsidomine is an orally active, long acting vasodilating drug, metabolized in the liver to the active metabolite linsidomine, which is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

HY-15459

Cabazitaxel XRP6258; RPR-116258A; taxoid XRP6258	Microtubule/Tubulin Autophagy	Cancer
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-P1580

PA (224-233), Influenza
Influenza Virus Infection

PA (224-233), Influenza is a 10-aa peptide, a fragment of polymerase 2 protein in influenza A virus.

HY-N2350

Cynaropicrin	MMP NF-κB TNF Receptor	Cancer
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

HY-15586

L67
DNA Ligase Inhibitor
DNA/RNA Synthesis Cancer

L67 is a novel, competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM.
HY-16676

7-Epi-docetaxel
4-epi-Docetaxel; 7-Epidocetaxel; 7-Epitaxotere
Microtubule/Tubulin Cancer

7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel.
HY-135848

N-Methylbenzamide
Phosphodiesterase (PDE) Cancer

N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity.

HY-101757

NO-prednisolone NCX-1015	Interleukin Related	Inflammation/Immunology
NO-prednisolone is a nitric oxide (NO)-releasing derivative of Prednisolone. NO-prednisolone potently stimulates *IL-10* production in vivo.

HY-N0303

Idebenone	Ferroptosis	Neurological Disease
Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which initially developed for the treatment of Alzheimer's disease and other cognitive defects.

HY-15583

Auristatin F	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

HY-18673

PROTO-1	Others	Inflammation/Immunology
PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).

HY-117604

THPP-1	Phosphodiesterase (PDE)	Neurological Disease
THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species.

HY-N2497

Isoliquiritin apioside	NF-κB MMP p38 MAPK	Cancer
Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in *MMP9* activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.

HY-N5072

Desmethylglycitein 4',6,7-Trihydroxyisoflavone	CDK PI3K PKC	Cancer
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes.

HY-12970A

EPZ020411 hydrochloride	Histone Methyltransferase	Cancer
EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC₅₀ of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.

HY-130976

N-Boc-Val-Dil-Dap-Doe	ADC Cytotoxin	Cancer
N-Boc-Val-Dil-Dap-Doe is a compound used to synthesize Dolastatin 10. Dolastatin 10, a potent antimitotic peptide, inhibits tubulin polymerization.

HY-12970

EPZ020411
Histone Methyltransferase Cancer

EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
HY-B0192A

Alfuzosin hydrochloride
SL 77499-10
Adrenergic Receptor Endocrinology

Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).

HY-119307

Apratastat	MMP TNF Receptor	Cancer
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and *matrix metalloproteinases (MMPs)* . Apratastat can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC₅₀s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively.

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively.

HY-N6957

8-Keto-berberine	Others	Metabolic Disease
8-Keto-berberine (compound 29) is a non-naturally occurring 11, 12-oxygenated protoberberine derived from naturally occurring 9, 10-oxygenated protoberberine.

HY-103667

2-HBA
Caspase Cancer

2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

HY-13959

MS436	Epigenetic Reader Domain	Cancer
MS436 is a new class of bromodomain inhibitor, exhibits potent affinity of an estimated K_i=30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2.

HY-N0088

Apocynin
Acetovanillone
Autophagy Apoptosis Cancer

Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM.
HY-13635

Finasteride
MK-906
5 alpha Reductase Cancer

Finasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM).

HY-10963

Momelotinib Mesylate CYT387 (Mesylate)	JAK Autophagy	Cancer
Momelotinib Mesylate (CYT387 Mesylate) is an ATP-competitive inhibitor of JAK1/JAK2 with IC₅₀ of 11 nM/18 nM, appr 10-fold selectivity versus JAK3.

HY-U00389

WQ3810
KPI-10 free base
Bacterial Infection

WQ3810 is an orally active fluoroquinolone, with potent antibacterial activities.
HY-141232

Decaethylene glycol
HO-PEG10-OH
PROTAC Linker Cancer

Decaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-N0845

Epoxymicheliolide
1β,10β-Epoxymicheliolide
Others Inflammation/Immunology

Epoxymicheliolide is a micheliolide derivative.

HY-A0023

Alogliptin Benzoate SYR 322	Dipeptidyl Peptidase	Cancer Metabolic Disease
Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

HY-42034

Hydroquinine	Others	Inflammation/Immunology
Hydroquinine is a cinchona alkaloid, can be used in the preparation of its derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine and 10,11-dihydroquinine monohydrochloride.

HY-23119

Sodium thiocyanate Thiocyanate sodium	Interleukin Related Reactive Oxygen Species	Inflammation/Immunology
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine *IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation.

HY-15507

VGX-1027 GIT 27	Interleukin Related TNF Receptor	Inflammation/Immunology
VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.

HY-N2194

Bergamottin
5-Geranoxypsoralen; Bergamotine; Bergaptin
Cytochrome P450 Cancer

Bergamottin is a potent and competitive CYP1A1 inhibitor with a K_i of 10.703 nM.
HY-16706

Remodelin
Histone Acetyltransferase Cancer

Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
HY-101799

NCGC00244536
KDM4B Inhibitor B3
Histone Demethylase Cancer

NCGC00244536 is a potent KDM4B inhibitor with an IC₅₀ of 10 nM.
HY-16461

Solenopsin
Akt Cardiovascular Disease

Solenopsin is an ATP-competitive AKT inhibitor with IC₅₀ value of 10 μM .
HY-B0170

Azatadine
Histamine Receptor Inflammation/Immunology Endocrinology

Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.
HY-10836

Cruzain-IN-1
Others Others

Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC₅₀ of 10 nM.
HY-114405

SJFδ
PROTAC p38 MAPK Autophagy Cancer

SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC₅₀ of 46.17 nM, but does not degrade p38α, p38β, or p38γ.

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Cancer Inflammation/Immunology
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of *MMP-1*, it can be considered as an active ingredient in new topically applied anti-ageing formulations.

HY-A0023A

Alogliptin SYR-322 free base	Dipeptidyl Peptidase Ferroptosis	Metabolic Disease Cancer
Alogliptin (SYR-322 free base) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

HY-11007

GNF-2
Bcr-Abl SARS-CoV Cancer

GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC₅₀ of 138 nM .
HY-13074

VO-Ohpic trihydrate
PTEN Autophagy Cancer

VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC₅₀ of 46±10 nM.
HY-14981

GSK2334470
PDK-1 Cancer

GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC₅₀ of 10 nM.
HY-16706A

Remodelin hydrobromide
Histone Acetyltransferase Cancer

Remodelin hydrobromide is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.

HY-B0170A

Azatadine dimaleate Azatadine maleate	Histamine Receptor	Inflammation/Immunology Endocrinology
Azatadine dimaleate is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

HY-101214

UK-371804
PAI-1 Inflammation/Immunology

UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50	E3 Ligase Ligand-Linker Conjugate	Cancer
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM.

HY-15320

NBI-74330	CXCR	Inflammation/Immunology Endocrinology
NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (¹²⁵I)CXCL10 and (¹²⁵I)CXCL11 specific binding with K_i of 1.5 and 3.2 nM, respectively.

HY-10962

Momelotinib sulfate CYT387 sulfate salt	JAK Autophagy Apoptosis	Cancer
Momelotinib sulfate (CYT387 sulfate salt) is an ATP-competitive inhibitor of JAK1/JAK2 with IC₅₀ of 11 nM/18 nM, 10-fold selectivity versus JAK3 (IC₅₀=155 nM).

HY-14672

Soblidotin
Auristatin PE; TZT-1027
Microtubule/Tubulin Cancer

Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization.
HY-12471

VLX1570
Deubiquitinase Cancer

VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC₅₀ of approximate 10 μM.
HY-16905

T338C Src-IN-1
Src Cancer

T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase).

HY-122586

BRD6989	CDK Interleukin Related	Inflammation/Immunology
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates *IL-10. BRD6989 selectively binds a complex of CDK8 with an IC₅₀* of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes.

HY-15996

Seviteronel VT-464	Cytochrome P450	Cancer
Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC₅₀=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.

HY-112597

Pparδ agonist
PPAR Metabolic Disease

PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10.
HY-15842

SF1670
PTEN Phosphatase Autophagy Cancer

SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor.
HY-14770

Ibodutant
MEN 15596
Neurokinin Receptor Neurological Disease Endocrinology

Ibodutant (MEN 15596) is a potent and selective tachykinin NK2 receptor antagonist with a pK_i of 10.1.
HY-13101

MCOPPB triHydrochloride
MCOPPB 3HCl
Opioid Receptor Others

MCOPPB 3Hcl is a nociceptin receptor agonist with pKi of 10.07; weaker activity at other opioid receptors.
HY-15774

CBB1003
Histone Demethylase Cancer

CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM.
HY-113252

2-Methoxyestrone
Endogenous Metabolite Metabolic Disease

2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
HY-13532

AS-252424
PI3K Cancer

AS-252424 is a potent and selective PI3Kγ inhibitor with an IC₅₀ of 30±10 nM.
HY-10303

PIK-294
PI3K Cancer

PIK-294 is a potent p110δ-selective inhibitor with an IC₅₀ of 10 nM.
HY-15878

LDC000067
LDC067
CDK Apoptosis Cancer

LDC000067 is a highly specific CDK9 inhibitor with an IC₅₀ value of 44±10 nM in vitro.

HY-B1287

Citalopram hydrobromide (±)-Citalopram hydrobromide; Lu 10-171	Serotonin Transporter Autophagy	Neurological Disease Cancer
Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.

HY-100116A

Mitoquinone mesylate MitoQ mesylate; MitoQ10 mesylate	Reactive Oxygen Species	Metabolic Disease Cancer
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage.

HY-15245

GSK2636771	PI3K	Cancer
GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with a K_i of 0.89 nM and an IC₅₀ of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms.

HY-15951

ML167 CID44968231; NCGC00188654	CDK	Cancer
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC₅₀ of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B.

HY-105185

Fidarestat SNK 860	Aldose Reductase	Metabolic Disease
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC₅₀s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

HY-123984

LTβR-IN-1	Others	Metabolic Disease
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC₅₀ of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC₅₀ of 10 μM and did not alter TNF-α–induced p65 nuclear translocation.

HY-112831

BI-409306	Phosphodiesterase (PDE)	Neurological Disease
BI-409306 is a potent and selective PDE9A inhibitor, with an IC₅₀ of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC₅₀, 1.4 µM), PDE1C (IC₅₀, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC₅₀ all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders.

HY-N0801

Polygalacic acid	MMP AChE	Inflammation/Immunology Neurological Disease
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits *MMP* expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.

HY-15774A

CBB1003 hydrochloride
Histone Demethylase Cancer

CBB1003 Hcl is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM.
HY-19741

A-1331852
Bcl-2 Family Cancer

A-1331852 is an orally available BCL-XL selective inhibitor with a K_i of less than 10 pM.
HY-101054

NQ301
Thrombin Cardiovascular Disease

NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an IC₅₀ of 10 mg/mL.
HY-12014

SU11274
PKI-SU11274
c-Met/HGFR Autophagy Apoptosis Cancer

SU11274 is a selective Met inhibitor with IC₅₀ of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2.

HY-101019

Ossirene AS101	Interleukin Related Caspase	Cancer Inflammation/Immunology
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor. Ossirene abolishes phosphorylation of STAT3 by inhibiting *IL-10. Ossirene potently inhibits Caspase-1* and is used for the autoimmune diseases and certain malignancies.

HY-126508

Mal-amido-PEG5-C2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules

HY-12519

Oltipraz RP 35972; NSC 347901	HIF/HIF Prolyl-Hydroxylase HIV Keap1-Nrf2	Cancer
Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC₅₀ of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

HY-136531

XMU-MP-3	Btk Apoptosis	Cancer
XMU-MP-3 is a potent non-covalent BTK inhibitor with IC₅₀s of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation in the presence of 10 μM ATP, respectively. XMU-MP-3 also induces apoptosis.

HY-136466

A2ti-2	Virus Protease	Infection
A2ti-2 is a selective and low-affinity *annexin A2/S100A10* heterotetramer (A2t) inhibitor with an IC₅₀ of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16**) infection.

HY-136465

A2ti-1	Virus Protease	Infection
A2ti-1 is a selective and high-affinity *annexin A2/S100A10* heterotetramer (A2t) inhibitor with an IC₅₀ of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16**) infection.

HY-B0494

Bufexamac
Bufexamic acid
HDAC Inflammation/Immunology

Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent.
HY-118180

CAY10595
Prostaglandin Receptor Inflammation/Immunology Endocrinology

CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a K_i of 10 nM.
HY-100790

Ciliobrevin A
HPI-4
Hedgehog Cancer

Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC₅₀) less than 10 μM.
HY-100509

NPS-1034
TAM Receptor c-Met/HGFR Apoptosis Cancer

NPS-1034 is a dual inhibitor of AXL and MET with IC₅₀s of 10.3 and 48 nM, respectively.
HY-112789

(+)-JQ1 PA
Epigenetic Reader Domain Cancer

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC₅₀ of 10.4 nM.
HY-10257

BAY 11-7085
BAY 11-7083
NF-κB Ferroptosis Apoptosis Cancer

BAY 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC₅₀ of 10 μM.
HY-112609

QCA570
PROTAC Epigenetic Reader Domain Cancer

QCA570 is a potent BET degrader based on PROTAC, with an IC₅₀ of 10 nM for BRD4 BD1 Protein.

HY-P2080

GIP (1-30) amide,Human	Glucagon Receptor	Metabolic Disease
GIP (1-30) amide,Human is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide (Human) dose-dependently promotes insulin secretion over the range 10 -9-10 -6 M.

HY-P2080B

GIP (1-30) amide,Human acetate	Glucagon Receptor	Metabolic Disease
GIP (1-30) amide,Human acetate is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide (Human) dose-dependently promotes insulin secretion over the range 10 -9-10 -6 M.

HY-111874

SNIPER(ABL)-039	SNIPER Bcr-Abl	Cancer
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 nM. IC₅₀s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.

HY-B0590B

(+)-Tetrabenazine (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine	Monoamine Transporter	Cancer
(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

HY-101075

L-690330	Phosphatase	Others
L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with K_is of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase.

HY-119424

SP4206	Interleukin Related	Inflammation/Immunology
SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (K_d=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (K_d=10 nM).

HY-12050

CP-673451
PDGFR Cancer

CP-673451 is a potent and selective inhibitor of PDGFR with IC₅₀s of 10 and 1 nM for PDGFRα and PDGFRβ, respectively.
HY-W018061

Traxoprodil
iGluR Neurological Disease

Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC₅₀ of 10 nM.
HY-12859

BAY1217389
Mps1 Cancer

BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC₅₀ value less than 10 nM.
HY-111482

SM 16
TGF-β Receptor Cancer Inflammation/Immunology Cardiovascular Disease

SM 16 is a ALK5/ALK4 kinase inhibitor with K_is of 10 and 1.5 nM, respectively.

HY-15991

Tenapanor AZD1722; RDX5791	Sodium Channel	Cardiovascular Disease
Tenapanor is an inhibitor of the Na⁺/H⁺ exchanger NHE3 with IC₅₀ values of 5 and 10 nM against human and Rat NHE3, respectively.

HY-10406

Talmapimod SCIO-469	p38 MAPK	Cancer
Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC₅₀ of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.

HY-117639

AUT1	Potassium Channel	Cancer
AUT1 is a Kv3 potassium channel modulator, with pEC₅₀s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC₅₀, 4.5).

HY-10228

Motesanib AMG 706	c-Kit VEGFR	Cancer
Motesanib is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC₅₀s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is appr 10-fold more selective for VEGFR than PDGFR and Ret.

HY-109571

HZ-1157	HCV Protease	Infection Inflammation/Immunology
HZ-1157 inhibits HCV NS3/4A protease with an IC₅₀ of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC₅₀ = 0.15 μM) and is a relatively nontoxic (CC₅₀ > 10 μM) dengue antiviral agent.

HY-10406A

Talmapimod hydrochloride SCIO-469 hydrochloride	p38 MAPK	Cancer
Talmapimod (SCIO-469) hydrochloride is an orally active, selective, and ATP-competitive p38α inhibitor with an IC₅₀ of 9 nM. Talmapimod hydrochloride shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.

HY-131328

BTK inhibitor 16	Btk	Cancer
BTK inhibitor 16 is a potent Bruton's tyrosine kinase (BTK) inhibitor extracted from patent WO2017103611A1, example 163b, with IC₅₀s of <10 nM for BTK WT and BTK C81S, respectively. BTK inhibitor 16 shows low EGFR inhibition, with an IC₅₀ ranging 1~10 μM.

HY-10229

Motesanib Diphosphate AMG 706 Diphosphate	c-Kit VEGFR	Cancer
Motesanib Diphosphate (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC₅₀s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret.

HY-12808

STF-118804
Nampt Apoptosis Cancer

STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.
HY-16916

NS1643
Potassium Channel Autophagy Others

NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K(+) channels with an EC₅₀ of 10.5 μM.
HY-100275

MK-3328
Amyloid-β Neurological Disease

MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC₅₀ of 10.5 nM.
HY-100685

MS-444
BE-34776
Myosin Cancer

MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC₅₀ value of 10 μM.

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-15401

WAY 163909
5-HT Receptor Cancer

WAY 163909 is a potent and selective 5-HT(2C) receptor agonist with a K_i of 10.5±1.1 nM.
HY-N6816

Ludaconitine
Parasite Infection

Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC₅₀ of 36.10 μg/mL.
HY-50710

KU-0063794
mTOR Cancer

KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC₅₀s of 10 nM.
HY-15646

UNC1999
Histone Methyltransferase Autophagy Cancer

UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC₅₀s of <10 nM and 45 nM, repectively.
HY-13248

AR-C155858
Monocarboxylate Transporter Others

AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with K_is of 2.3 nM and 10 nM, respectively.

HY-12142

Vofopitant GR 205171	Neurokinin Receptor	Neurological Disease Endocrinology
Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively.

HY-19189

Terbogrel BIBV 308SE	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor, with both IC₅₀s of about 10 nM.

HY-12746

DC-05
DNA Methyltransferase Cancer

DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 10.3 μM and 1.09 μM, respectively.
HY-18306

SB 242235
p38 MAPK Autophagy Cancer

SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC₅₀ of 1.0　μM in primary human chondrocytes.

HY-B1101

Pimethixene Pimetixene	5-HT Receptor Histamine Receptor	Neurological Disease Endocrinology
Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT_1A, 5-HT_2A, 5-HT_2B, 5-HT_2C, histamine H₁, dopamine D₂ and D_4.4 as well as muscarinic M₁ and M₂ receptors, with pK_is of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

HY-B1101A

Pimethixene maleate Pimetixene maleate	5-HT Receptor Histamine Receptor	Neurological Disease Endocrinology
Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT_1A, 5-HT_2A, 5-HT_2B, 5-HT_2C, histamine H₁, dopamine D₂ and D_4.4 as well as muscarinic M₁ and M₂ receptors, with pK_is of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

HY-16615

SIRT-IN-1
Sirtuin Metabolic Disease Neurological Disease Cancer Inflammation/Immunology

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC₅₀s of 15, 10, 33 μM, respectively.
HY-13461

PHA-767491
CAY10572
CDK Cancer

PHA-767491 is a dual Cdc7/Cdk9 inhibitor, with IC₅₀s of 10 nM and 34 nM, respectively.
HY-16297A

Abemaciclib
LY2835219
CDK Cancer

Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC₅₀ values of 2 nM and 10 nM for CDK4 and CDK6, respectively.

HY-19205A

CMI-392	Lipoxygenase	Inflammation/Immunology
CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC₅₀s of 100 and 10 nM, respectively.

HY-13461A

PHA-767491 hydrochloride
CAY-10572 hydrochloride
CDK Apoptosis Cancer

PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC₅₀s of 10 nM and 34 nM, respectively.
HY-15224

PCI-34051
HDAC Apoptosis Cancer

PCI-34051 is a potent and selective HDAC8 inhibitor with IC₅₀ of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
HY-13689

Go 6983
Gö 6983; Goe 6983
PKC Cancer

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

HY-N2337

11beta-Hydroxyprogesterone 11β-Hydroxyprogesterone	Endogenous Metabolite	Cardiovascular Disease
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀ of 10 nM.

HY-111149

PS372424
CXCR Inflammation/Immunology Endocrinology

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity.

HY-W013215

Adrenic Acid cis-7,10,13,16-Docosatetraenoic acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Adrenic Acid is an inflammation enhancer in non-alcoholic fatty liver disease.

HY-129966

PROTAC IRAK4 degrader-1	PROTAC IRAK	Cancer
PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively.

HY-N2300

Kuwanon A	NO Synthase	Metabolic Disease Inflammation/Immunology
Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC₅₀ of 10.5 μM.

HY-13577A

Oclacitinib maleate PF-03394197 maleate	JAK	Inflammation/Immunology
Oclacitinib maleate (PF-03394197 maleate) is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC₅₀=10 nM).

HY-19339

Tenovin-3
MDM-2/p53 Cancer

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.

HY-12589

ZM39923 hydrochloride	JAK	Cancer Neurological Disease
ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC₅₀ of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC₅₀ of 10 nM.

HY-12589A

ZM39923
JAK Cancer Neurological Disease

ZM39923 is a JAK3 inhibitor, with a pIC₅₀ of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC₅₀ of 10 nM.

HY-15724

Vercirnon GSK-1605786; CCX282-B; Traficet-EN	CCR	Inflammation/Immunology Endocrinology
Vercirnon (GSK-1605786) is an orally bioavailable, selective, and potent antagonist of CCR9, with an IC₅₀ of 10 nM, used in the research of inflammatory bowel diseases.

HY-100611

CaCCinh-A01	Chloride Channel	Inflammation/Immunology Cancer
CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC₅₀s of 2.1 and 10 μM, respectively.

HY-15799

AZD1283
P2Y Receptor Cardiovascular Disease

AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10; with binding IC50 of 11 nM.

HY-P1206A

CH 275 TFA	Somatostatin Receptor	Neurological Disease
CH 275 TFA is a potent and selective somatostatin receptor 1 (sst₁) agonist and display IC₅₀ values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst₁, sst₃, sst₄, sst₂ and sst₅ respectively. CH 275 can be used for the research of Alzheimer’s disease.

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a potent and selective somatostatin receptor 1 (sst₁) agonist and display IC₅₀ values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst₁, sst₃, sst₄, sst₂ and sst₅ respectively. CH 275 can be used for the research of Alzheimer’s disease.

HY-10472

LY2811376	Beta-secretase	Neurological Disease
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC₅₀ of 239 nM-249 nM, that acts to decrease Aβ secretion with EC₅₀ of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

HY-B0278

Bacitracin Zinc Zinc bacitracin; Bacitracin zinc salt	Bacterial Antibiotic	Infection
Bacitracin Zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.

HY-16578

GW9662
PPAR Cancer

GW9662 is a potent and selective PPARγ antagonist with an IC₅₀ of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.

HY-17402

Nisoldipine BAY-k 5552	Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

HY-10871A

Otenabant Hydrochloride CP 945598 Hydrochloride	Cannabinoid Receptor	Metabolic Disease
Otenabant Hydrochloride is a potent and selective cannabinoid receptor CB1 antagonist with K_i of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.

HY-13455

LDN-192960
Haspin Kinase DYRK Cancer

LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively.
HY-118224

BPH-715
Parasite Infection

BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC₅₀ of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells.
HY-112113

SLV-2436
SEL201-88; SEL-201
MNK Cancer

SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC₅₀s of 10.8 nM and 5.4 nM, respectively.
HY-16355

NVP-QAV-572
PI3K Cancer

NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC₅₀ of 10 nM.

HY-P1203

BIM-23056	Somatostatin Receptor	Neurological Disease
BIM 23056, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with K_i values of 10.8, 5.7, respectively.

HY-10871

Otenabant CP-945598	Cannabinoid Receptor	Metabolic Disease
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with K_i of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.

HY-13296

PYR-41	E1/E2/E3 Enzyme Apoptosis	Cancer
PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC₅₀ of < 10 μM, with little activity at E2 and E3.

HY-13455A

LDN-192960 hydrochloride	Haspin Kinase DYRK	Cancer
LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively.

HY-N1401

20(R)-Ginsenoside Rh2	MMP Apoptosis HSV	Cancer Infection Inflammation/Immunology
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC₅₀ of 2.77 μM for murine MHV-68.

HY-P2036

FSL-1	Toll-like Receptor (TLR) Antibiotic	Infection
FSL-1 is a TLR2/6 agonist (also a putative TLR10 ligand). FSL-1 activates NF-κB. FSL-1 induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. FSL-1 synergizes with IFNγ to induce CXCL10 release from melanoma cells.

HY-107589A

BIO5192 hydrate	Integrin	Inflammation/Immunology
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (K_d<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC₅₀=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.

HY-107589

BIO5192	Integrin	Inflammation/Immunology
BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (K_d<10 pM). BIO5192 selectively binds to α4β1 (IC₅₀=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.

HY-51424

PLX-4720	Raf	Cancer
PLX-4720 is a potent and selective inhibitor of B-Raf^V600E with IC₅₀ of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-Raf^V600E than wild-type B-Raf.

HY-N5132

(-)-Fenchone	Others	Others
(-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Thuja occidentalis. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6.

HY-16749A

Pexidartinib hydrochloride PLX-3397 hydrochloride	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity.

HY-12648A

FASN-IN-4 tosylate	Fatty Acid Synthase (FASN)	Cancer
FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) extracted from patent WO 2012064642 A1, compound 29; has an IC₅₀ of 10 nM.

HY-10372

PP121
mTOR PDGFR VEGFR Src Apoptosis Cancer

PP121 is a multi-targeted kinase inhibitor with IC₅₀s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively.

HY-P1203A

BIM-23056 TFA	Somatostatin Receptor	Neurological Disease
BIM 23056 TFA, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with K_i values of 10.8, 5.7, respectively.

HY-10535

Evofosfamide
TH-302
Apoptosis Cancer

Evofosfamide (TH-302) is a hypoxia-activated prodrug with IC₅₀ of 10 μM and 1000 μM in hypoxia (N₂) and normoxia (21% O₂), respectively.
HY-133739

NBD-125
RAR/RXR Cancer

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC₅₀ of 31.10 μM in KM12C cell.

HY-112147

IDO1 and HDAC1 Inhibitor	Indoleamine 2,3-Dioxygenase (IDO) HDAC	Cancer
IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively.

HY-101840

EIPA L593754; MH 12-43	TRP Channel Sodium Channel	Cancer Inflammation/Immunology
EIPA (L593754) is a TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also inhibits Na⁺/H⁺-exchanger (NHE) and macropinocytosis.

HY-U00308

5-Lipoxygenase-In-1	Lipoxygenase	Inflammation/Immunology Cardiovascular Disease
5-Lipoxygenase-In-1 is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

HY-101840A

EIPA hydrochloride L593754 hydrochloride; MH 12-43 hydrochloride	TRP Channel Sodium Channel	Cancer Inflammation/Immunology
EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also inhibits Na⁺/H⁺-exchanger (NHE) and macropinocytosis.

HY-B1486

Oxprenolol hydrochloride Ba 39089	Adrenergic Receptor	Cardiovascular Disease
Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle.

HY-12648

FASN-IN-4	Fatty Acid Synthase (FASN)	Metabolic Disease
FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) extracted from patent WO 2012064642 A1, compound 29; has an IC₅₀ of 10 nM.

HY-103662

GW-870086	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC₅₀ of 10.1 in A549 cells expressing NF-κB.

HY-18300

Filgotinib
GLPG0634
JAK Cancer

Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC₅₀ of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
HY-12437

BDP5290
ROCK Cancer

BDP5290 is a potent inhibitor of both ROCK and MRCK with IC₅₀s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.
HY-101281B

(R)-VU 6008667
Others Neurological Disease

(R)-VU 6008667, the less active (R)-enantiomer to VU 6008667, is devoid of M5 NAM activity (IC₅₀>10 μM).

HY-15145

SRT 1720 Hydrochloride	Sirtuin Autophagy	Metabolic Disease
SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.

HY-107390A

AX-024 hydrochloride	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-119037

UK-101	Proteasome Apoptosis	Cancer
UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC₅₀ value of 104 nM, displays 144- and 10-fold selectivity over β1c (IC₅₀=15 μM) and β5 subunit (IC₅₀=1 μM), respectivey. UK-101 induces cell apoptosis and can be used for the study of prostate cancer.

HY-107390

AX-024	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-N1490

14-Deoxy-11,12-didehydroandrographolide 14-dehydro Andrographolide; AP10	NF-κB	Inflammation/Immunology Cancer
14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide that can be isolated from A. paniculata. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation.

HY-101284

DMU2105
Cytochrome P450 Cancer

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC₅₀s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
HY-13560

AVN-944
VX-944
Others Cancer

AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
HY-129171

TGFBR1-IN-1
TGF-β Receptor Cancer Inflammation/Immunology

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC₅₀ of 10-100 nM.

HY-128583

G150	Others	Inflammation/Immunology
G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor for repression of dsDNA-triggered interferon expression, with an IC₅₀ of 10.2 nM.

HY-12425

DGAT1-IN-1
Acyltransferase Metabolic Disease

DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

HY-135667

DHODH-IN-9	Influenza Virus Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC₅₀ of 7.4.

HY-10678

BMS-687453	PPAR	Cardiovascular Disease
BMS-687453 is a potent and selective PPARα agonist, with an EC₅₀ and IC₅₀ of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.

HY-B1136

Menbutone Genabilic acid	Others	Inflammation/Immunology
Menbutone is an oxobutyric acid derivative, and is a choleretic.Menbutone has a rapid onset of action, reaching its maximum plasma level within 1 hour and lasting for roughly 10 hours.

HY-126140

MDRTB-IN-1
Bacterial Infection

MDRTB-IN-1 (5aα) is an antibiotic which is against Mycobacterium tuberculosis H37Rv with a MIC₉₀ value of 10.5 μM.

HY-12472

Balipodect TAK-063	Phosphodiesterase (PDE)	Neurological Disease
Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC₅₀ of 0.30 nM; >15000-fold selectivity over other PDEs.

HY-18650

KU 59403
ATM/ATR Cancer

KU 59403 is a potent ATM inhibitor, with IC₅₀ values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively.

HY-P2036A

FSL-1 TFA	Toll-like Receptor (TLR) Antibiotic	Infection
FSL-1 TFA is a TLR2/6 agonist (also a putative TLR10 ligand). FSL-1 TFA activates NF-κB. FSL-1 TFA induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. FSL-1 TFA synergizes with IFNγ to induce CXCL10 release from melanoma cells.

HY-P1682

Balixafortide POL6326	CXCR	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.

HY-122882

HOIPIN-8	E1/E2/E3 Enzyme	Inflammation/Immunology
HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC₅₀ of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC.

HY-N2503

Ginsenoside F4	Apoptosis MMP	Inflammation/Immunology
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues.

HY-15600

UPF-648	Others	Neurological Disease
UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity.

HY-135893

SGK1-IN-2
SGK Inflammation/Immunology

SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC₅₀ of 5 nM at 10 μM ATP concentration.
HY-12990

Spautin-1
Autophagy Apoptosis Cancer

Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC₅₀s of 0.6-0.7 μM.

HY-15600B

UPF-648 sodium salt	Others	Neurological Disease
UPF-648 sodium salt is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at blocking KAT activity.

HY-129571

BioE-1115	Ser/Thr Protease Casein Kinase	Metabolic Disease
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC₅₀ of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC₅₀ of ~10 μM.

HY-15613

Maritoclax Marinopyrrole A	Bcl-2 Family	Cancer
Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC₅₀ value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC₅₀ > 80 μM).

HY-15100

Balicatib AAE581	Cathepsin	Inflammation/Immunology
Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.

HY-128763

HDAC-IN-4
HDAC Cancer

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC₅₀s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity.

HY-112724

SHR0302	JAK Apoptosis	Cancer Inflammation/Immunology
SHR0302 is a potent and orally active all members of the JAK family inhibitor, particularly JAK1. The selectivity of SHR0302 for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2. SHR0302 inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. SHR0302 has anti-proliferative and anti-inflammatory effects.

HY-108539A

(R)-CE3F4	Others	Metabolic Disease
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC₅₀ of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC₅₀, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4.

HY-P1682A

Balixafortide TFA POL6326 TFA	CXCR	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.

HY-13522

Fimepinostat CUDC-907	PI3K HDAC Apoptosis	Cancer
Fimepinostat (CUDC-907) potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC₅₀ of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

HY-113402A

Gamma-glutamylcysteine TFA γ-glutamylcysteine TFA	Interleukin Related TNF Receptor	Inflammation/Immunology
Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine *IL-10* and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes.

HY-16749

Pexidartinib PLX-3397	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

HY-107145A

Ningetinib	TAM Receptor VEGFR c-Met/HGFR	Cancer
Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC₅₀s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

HY-13493

AC710
PDGFR c-Kit FLT3 Cancer

AC710 is a potent PDGFR inhibitor with K_ds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

HY-N2396

N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide	Others	Others
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide (Macamide impurity 10), the impurity of Macamide isolated from Lepidium meyenii.

HY-12960

SKLB4771
FLT3-IN-1
FLT3 Cancer

SKLB4771 is a novel potent and selective Flt3 inhibitor with IC50 of 10 nM; against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM.

HY-13592

HDAC-IN-7 Chidamide impurity	HDAC	Cancer
HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor.

HY-15594

Phen-DC3
DNA/RNA Synthesis Cancer

Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-107145

Ningetinib Tosylate	TAM Receptor VEGFR c-Met/HGFR	Cancer
Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC₅₀s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

HY-106369

HMR 1556	Potassium Channel	Cardiovascular Disease
HMR 1556, a chromanol derivative, is a potent I_Ks blocker with IC₅₀s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively.

HY-15513

TC-DAPK 6
DAPK Cancer

TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC₅₀=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP).

HY-111859

SNIPER(ABL)-058	SNIPER Bcr-Abl	Cancer
SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 μM.

HY-N0163

Magnolol	RAR/RXR PPAR Autophagy Bacterial	Cancer Inflammation/Immunology Neurological Disease Cardiovascular Disease
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-13493A

AC710 Mesylate
PDGFR Cancer

AC710 Mesylate is a potent PDGFR inhibitor with K_ds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

HY-12149

A-867744	nAChR Autophagy	Neurological Disease
A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC₅₀ of 1.0 μM.

HY-100595

Sodium stibogluconate Stibogluconate trisodium nonahydrate	Phosphatase	Cancer
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

HY-50943

AT7519 Hydrochloride	CDK Apoptosis	Cancer
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC₅₀s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.

HY-16680

Helioxanthin 8-1 Helioxanthin analogue 8-1	HBV	Infection
Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM.

HY-50940

AT7519
CDK Apoptosis Cancer

AT7519 as a potent inhibitor of CDKs, with IC₅₀s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.

HY-50940A

AT7519 trifluoroacetate	CDK	Cancer
AT7519 trifluoroacetate as a potent inhibitor of CDKs, with IC₅₀s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.

HY-100113

AT2 receptor agonist C21	Angiotensin Receptor	Cardiovascular Disease Endocrinology
AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with K_i values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively.

HY-15356

BIO-acetoxime BIA	GSK-3 Apoptosis HSV	Infection Inflammation/Immunology Neurological Disease
BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC₅₀s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity.

HY-120142

EC359	Apoptosis	Cancer
EC359 is a potent, selective, high affinity and orally active leukemia inhibitory factor receptor (LIFR) inhibitor with a K_d of 10.2 nM, which directly interacts with LIFR to effectively block LIF/LIFR interactions.

HY-12954

PTACH NCH-51	HDAC	Cancer
PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.

HY-107999

CADD522
Others Cancer

CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC₅₀ of 10 nM. CADD522 exhibits antitumor activity.

HY-13237

GSK2578215A	LRRK2 Autophagy Mitophagy	Neurological Disease
GSK2578215A is a potent and highly selective LRRK2 inhibitor, which exhibits IC₅₀s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.

HY-15594A

Phen-DC3 Trifluoromethanesulfonate Phen-DC3 Triflate	G-quadruplex	Cancer
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-126290

Tyk2-IN-8	JAK	Inflammation/Immunology
Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC₅₀ of 17 nM, used in the treatment of psoriasis.

HY-13785

ZM 306416 CB 676475	VEGFR	Cancer
ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC₅₀s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC₅₀ of <10 nM.

HY-13275

IRAK inhibitor 1	IRAK	Inflammation/Immunology
IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC₅₀ of 216 nM, is poorly active against JNK-1 and JNK-2 with IC₅₀ of 3.801 μM, and >10 μM, respectively.

HY-108697A

(Rac)-PT2399	HIF/HIF Prolyl-Hydroxylase	Cancer
(Rac)-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC₅₀ of 0.01 μM.

HY-50898

Lapatinib GW572016; GW2016	EGFR Autophagy Ferroptosis	Cancer
Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.

HY-N6774

Cytochalasin C	Others	Infection
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D.

HY-16297

Abemaciclib methanesulfonate LY2835219 methanesulfonate	CDK	Cancer
Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC₅₀s of 2 nM and 10 nM for CDK4 and CDK6, respectively.

HY-102031

PI3Kδ-IN-2
PI3K Cancer Inflammation/Immunology

PI3Kδ-IN-2 is a potent and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC₅₀ of 6.4 nM.

HY-13003

Torin 1	mTOR Autophagy	Cancer
Torin 1 is a potent inhibitor of mTOR with an IC₅₀ of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC₅₀ values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.

HY-N1272

Secaubryenol	Endogenous Metabolite	Others
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 µg/mL.

HY-N4070

6"-O-Acetylgenistin	Others	Others
6"-O-Acetylgenistin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetylgenistin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 10.6 μM.

HY-10991

MGCD-265 analog	c-Met/HGFR VEGFR Apoptosis	Cancer
MGCD-265-analog (structurally related to MGCD-265) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively.

HY-111862

SNIPER(ABL)-044	SNIPER Bcr-Abl	Cancer
SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 μM.

HY-10009

Semagacestat LY450139	γ-secretase Amyloid-β Notch	Neurological Disease
Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC₅₀ of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC₅₀ of 14.1 nM.

HY-102026

Formycin A NSC 102811	HIV Nucleoside Antimetabolite/Analog Antibiotic	Cancer Infection
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC₅₀ of 10 μM. Formycin A shows antitumor and antiviral activities.

HY-100018

BAY1125976
Akt Cancer

BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC₅₀ values of 5.2 nM and 18 nM at 10 μM ATP, respectively.

HY-124108

Eicosatetraynoic acid ETYA	COX PPAR	Others
Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID₅₀=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM.

HY-18770

IDO-IN-5 NLG-1489	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC₅₀ of 1-10 μM.

HY-18770C

IDO-IN-8 NLG-1487	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1487, has an IC₅₀ of 1-10 μM.

HY-100483

A-804598	P2X Receptor	Cancer
A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC₅₀s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively.

HY-12659

LX7101	ROCK	Others
LX7101 is a potent inhibitor of LIMK and ROCK2 with IC₅₀ values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC₅₀ less than 1 nM.

HY-122872

MKK7-COV-9	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

HY-N6607

Tryptanthrin	Others	Inflammation/Immunology
Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin inhibits LT formation in human whole blood (IC₅₀ = 10 µM) and reduces LTB4 levels in the rat pleurisy model.

HY-128971

LHVS	Cathepsin Parasite	Infection
LHVS is a potent, non-selective cysteine protease inhibitor. LHVS effectively blocks T. gondii microneme protein secretion (IC₅₀=10 μM), gliding motility, and cell invasion.

HY-13250

Silvestrol aglycone	Others	Cancer
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC₅₀s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity.

HY-17642

Omidenepag	Prostaglandin Receptor	Endocrinology
Omidenepag,a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC₅₀ of 1.1 nM. Omidenepag shows binding affinities (IC₅₀) 10 nM for h-EP2.

HY-100331

MCH-1 antagonist 1	MCHR1 (GPR24) Cytochrome P450	Metabolic Disease Endocrinology
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a K_i of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC₅₀ of 10 μM.

HY-13057

O6BTG-octylglucoside Glucose-conjugated MGMT inhibitor	DNA Methyltransferase	Cancer
O6BTG-octylglucoside is a potent O⁶-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC₅₀s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.

HY-N1910

4'-O-Methylbavachalcone	SARS-CoV	Infection
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM.

HY-10192

NVP-TAE 684 TAE 684	ALK Apoptosis	Cancer
NVP-TAE 684 (TAE 684) is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC₅₀ values between 2 and 10 nM.

HY-16652

Apabetalone RVX-208; RVX000222	Epigenetic Reader Domain HIV	Cancer
Apabetalone (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC₅₀s are 87±10 μM and 0.51±0.041 μM for BD1 and BD2, respectively.

HY-133141

DI-87	Others	Cancer
DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC₅₀ of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK.

HY-N3511

Triptonine B	HIV	Infection
Triptonine B, a sesquiterpene pyridine alkaloid that isolated from Tripterygium hypoglaucum and Tripterygium wilfordii, inhibits HIV replication in H9 lymphocytes with an EC₅₀ value of <0.10 μg/mL.

HY-50898A

Lapatinib ditosylate GW572016 ditosylate; GW2016 ditosylate	EGFR Autophagy Ferroptosis	Cancer
Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.

HY-15196

TAK-285	EGFR	Cancer
TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC₅₀ of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity. TAK-285 can cross the blood-brain barrier (BBB).

HY-110353

CU-T12-9	Toll-like Receptor (TLR)	Cancer Infection Inflammation/Immunology
CU-T12-9 is a specific TLR1/2 agonist with EC₅₀ of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.

HY-112803

GNE-371	DNA/RNA Synthesis	Cancer
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC₅₀ of 10 nM for TAF1(2).

HY-W016867

4-Chlorosalicylic acid	Fungal Bacterial	Infection
4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC₅₀s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.

HY-N3797A

Echitamine chloride	Apoptosis	Cancer
Echitamine chloride is the major monoterpene indole alkaloid present in Alstonia with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 µM.

HY-P1495

Small Cardioactive Peptide B SCPB	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀s of 0.1 and 1.0 μM, respectively.

HY-115658

VU0420373	Bacterial	Infection Metabolic Disease
VU0420373 is a potent heme sensor system (HssRS) activator with an EC₅₀ of 10.7 μM and a pEC₅₀ of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus.

HY-121385

Hydroxy bosentan Ro 48-5033	Endogenous Metabolite	Cardiovascular Disease
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities.

HY-111947

c-Fms-IN-6	c-Fms	Inflammation/Immunology
c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC₅₀ of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC₅₀, > 1 μM). Used in the research of autoimmune diseases.

HY-N1363

Royal Jelly acid Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid	Endogenous Metabolite	Neurological Disease
Royal Jelly acid (Queen Bee Acid) is a fatty acid constituent of royal jelly, promotes the growth and protection of neurons, reduces anxiety-like phenotypes.

HY-119689

Umibecestat CNP520	Beta-secretase	Neurological Disease
Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC₅₀s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.

HY-13696

MSX-122	CXCR	Cancer Inflammation/Immunology Endocrinology
MSX-122 is an orally active partial antagonist of CXCR4, inhibiting CXCR4/CXCL12 actions, with an IC₅₀ of ∼10 nM. MSX-122 has anti-inflammatory and anti-metastatic activity.

HY-14276A

Gallopamil hydrochloride Methoxyverapamil hydrochloride	Calcium Channel	Cardiovascular Disease
Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC₅₀ of 10.9 μM. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent.

HY-12009

Pazopanib Hydrochloride GW786034 (Hydrochloride)	PDGFR VEGFR FGFR c-Kit c-Fms Autophagy	Cancer
Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC₅₀ of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

HY-50898B

Lapatinib ditosylate monohydrate GW572016 ditosylate monohydrate; GW2016 ditosylate monohydrate	EGFR Autophagy Ferroptosis	Cancer
Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.

HY-15777A

Ribociclib hydrochloride LEE011 hydrochloride	CDK	Cancer
Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

HY-14276

Gallopamil Methoxyverapamil	Calcium Channel	Cardiovascular Disease
Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC₅₀ of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent.

HY-119039

RU-301	TAM Receptor	Cancer
RU-301 is a pan-TAM receptor inhibitor, exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs with K_d and IC₅₀ values of 12 μM and 10 μM, respectively.

HY-10328

Neflamapimod VX-745	p38 MAPK Autophagy	Inflammation/Immunology
Neflamapimod (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC₅₀ for p38α of 10 nM and for p38β of 220 nM. Neflamapimod (VX-745) possesses anti-inflammatory activity.

HY-100781A

L-APB L-AP 4	mGluR	Neurological Disease
L-APB is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively.

HY-108539

CE3F4	Others	Metabolic Disease
CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC₅₀s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.

HY-129150

Ganoderic acid TR	Influenza Virus	Infection
Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H5N1 and H1N1 neuraminidases. The IC₅₀ values of 10.9 and 4.6 μM, respectively.

HY-44103

Desmethyl-QCA276 PROTAC BRD4-binding moiety 4	Ligand for Target Protein for PROTAC	Cancer
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC₅₀ of 10 nM, and with a K_i of 2.3 nM.

HY-15319

AMG 487	CXCR	Cancer Inflammation/Immunology Endocrinology
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively.

HY-136084

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO)
ADC Linker Cancer

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-13487

USP7/USP47 inhibitor	Deubiquitinase	Cancer
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC₅₀s of 0.42 μM and 1.0 μM, respectively.

HY-50098

Mardepodect PF-2545920	Phosphodiesterase (PDE)	Neurological Disease
Mardepodect (PF-2545920) is a potent, orally active and selective *PDE10A* inhibitor with an IC₅₀ of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier.

HY-50098A

Mardepodect hydrochloride PF-2545920 hydrochloride	Phosphodiesterase (PDE)	Cancer
Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective *PDE10A* inhibitor with an IC₅₀ of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier.

HY-123892

RK-287107	PARP	Cancer
RK-287107 is a potent and specific tankyrase inhibitor with IC₅₀s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth.

HY-114191

SSTR5 antagonist 2	Somatostatin Receptor	Metabolic Disease Endocrinology
SSTR5 antagonist 2 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential to treat type 2 diabetes mellitus (T2DM).

HY-15162

Monomethyl auristatin E MMAE; SGD-1010	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

HY-114191A

SSTR5 antagonist 2 TFA	Somatostatin Receptor	Metabolic Disease Endocrinology
SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential to treat type 2 diabetes mellitus (T2DM).

HY-10163

Dabigatran BIBR 953; BIBR 953ZW	Thrombin	Cardiovascular Disease
Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (K_i=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC₅₀=10 nM).

HY-10208

Pazopanib GW786034	VEGFR c-Kit PDGFR Autophagy FGFR	Cancer
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC₅₀s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

HY-15777

Ribociclib LEE011	CDK	Cancer
Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

HY-111818

TH34
HDAC Cancer

TH34, an HDAC6/8/10 inhibitor with IC₅₀s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3.

HY-127105A

LNP023 hydrochloride	Complement System	Metabolic Disease Inflammation/Immunology
LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. LNP023 inhibits factor B with an IC₅₀ value of 10 nM.

HY-108333

SB-633825	Others	Cancer Cardiovascular Disease
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC₅₀s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.

HY-N1504

Loureirin B	PAI-1 Potassium Channel ERK JNK	Metabolic Disease
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-127105

LNP023	Complement System	Metabolic Disease Inflammation/Immunology
LNP023 is an orally bioavailable, highly potent and highly selective factor B inhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a K_D of 7.9 nM. LNP023 inhibits factor B with an IC₅₀ value of 10 nM.

HY-15777C

Ribociclib succinate hydrate LEE011 succinate hydrate	CDK	Cancer
Ribociclib succinate hydrate (LEE011 succinate hydrate) is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

HY-19754

CRA-026440	HDAC	Cancer Cardiovascular Disease
CRA-026440 is a potent, broad-spectrum HDAC inhibitor. The K_i values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and *HDAC10* are 4, 14, 11, 15, 7, and 20 nM respectively.

HY-15777B

Ribociclib succinate LEE011 succinate	CDK	Cancer
Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

HY-P1299

UFP-101	Opioid Receptor	Neurological Disease
UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pK_i of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect.

HY-B1213

Trimipramine maleate	5-HT Receptor Bacterial	Neurological Disease
Trimipramine maleate is a 5-HT receptor antagonist, with pK_is of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively.

HY-18012A

Spebrutinib besylate AVL-292 (benzenesulfonate); CC-292 (besylate)	Btk	Cancer
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC₅₀<0.5 nM, *K_inact/K_i*=7.69×10 4 M^-1s^-1s) in biochemical assays.

HY-112617A

Thalidomide-O-amido-PEG2-C2-NH2 TFA Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA	E3 Ligase Ligand-Linker Conjugate	Cancer Inflammation/Immunology
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

HY-108568

15-Deoxy-Δ-12,14-prostaglandin J2 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2	PPAR Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM.

HY-B0324A

Crystal Violet Basic Violet 3; Gentian Violet; Methyl Violet 10B	Influenza Virus Bacterial	Infection
Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.

HY-101355B

CGP 20712 A CGP 20712 mesylate	Adrenergic Receptor	Cardiovascular Disease
CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC₅₀ of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.

HY-114953

BMS-248360	Angiotensin Receptor Endothelin Receptor	Cardiovascular Disease
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ET_A) receptor, with K_is of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects.

HY-15510B

Tenovin-6 Hydrochloride	Sirtuin MDM-2/p53 Autophagy	Cancer
Tenovin-6 Hydrochloride is an inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC₅₀s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively.

HY-103194

KH7	Others	Others
KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sAC_t protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis chinensis.

HY-114739

MA-0204	PPAR	Metabolic Disease
MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC₅₀s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD).

HY-125970

CRTh2 antagonist 2	Prostaglandin Receptor	Endocrinology
CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC₅₀ of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia.

HY-N0505

Rosiridin	Monoamine Oxidase	Neurological Disease
Rosiridin, which is isolated from Rhodiola rosea L., inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC₅₀=5.38).

HY-110079

TNP	Others	Cancer
TNP is a cell-permeable inhibitor of IP6K1 and IP3K, with IC₅₀ values of 0.55 µM and 10.2 µM for IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes.

HY-136459

NMDA receptor antagonist 2	iGluR	Neurological Disease
NMDA receptor antagonist 2 is a potent and orally active NR2B subtype-selective NMDA antagonist with an IC₅₀ and a K_i of 1.0 nM and 0.88 nM, respectively. NMDA receptor antagonist 2 is used for the study of neuropathic pain and Parkinson’s disease.

HY-14435

Pyridone 6	JAK	Cancer
Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC₅₀s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

HY-15464

(R)-(-)-Gossypol AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-133084

ERK-IN-2	ERK	Cancer
ERK-IN-2 is a potent, highly seletive and orally active ERK2 inhibitor probe with an IC₅₀ value of 1.8 nM. ERK-IN-2 might lead to off-target toxicity and/or off-target activity at dose >10 μM.

HY-15391

Lucitanib E-3810	VEGFR FGFR	Cancer
Lucitanib (E-3810) is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC₅₀s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.

HY-15510

Tenovin-6	Sirtuin MDM-2/p53 Autophagy	Cancer
Tenovin-6 is an inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC₅₀s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively.

HY-12334

HTH-01-015
AMPK Cancer

HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC₅₀ is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).

HY-13213

AM211 AM211 free acid	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC₅₀s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.

HY-19843

MK-0941	Glucokinase	Metabolic Disease
MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC₅₀s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes.

HY-19962

Paxalisib GDC-0084	PI3K mTOR	Cancer
Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with K_is of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.

HY-N2016

Arteannuin B	SARS-CoV Ferroptosis	Infection
Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae). Arteannuin B shows anti-SARS-CoV-2 potential with an EC₅₀ of 10.28 μM.

HY-136256

DCC-3014	c-Fms c-Kit	Cancer
DCC-3014 is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC₅₀s of <0.01 μM and 0.1-1 μM, respectively.

HY-100290

5-HT1A modulator 1	5-HT Receptor	Neurological Disease
5-HT1A modulator 1 displays very high affinities for the 5HT_1A, adrenergic α₁ and dopamine D₂ receptor with IC₅₀s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.

HY-W062835

CGP77675	Src	Cancer
CGP77675 is a potent inhibitor of Src family kinases. CGP77675 inhibits Src, EGFR, KDR, v-Abl, and Lck with IC₅₀s of 0.02, 0.15, 1.0, 0.31, and 0.29 μM, respectively. Anticancer activity.

HY-119402

BCL6-IN-8c	Bcl-2 Family	Cancer
BCL6-IN-8c is a potent and orally active B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor with an IC₅₀ of 0.10 µM in cell-free enzyme-linked immunosorbent assay.

HY-13504

PIK-293	PI3K	Cancer Metabolic Disease
PIK-293, an analog of IC87114, is a PI3K inhibitor, with IC₅₀ values of 0.24 μM, 10 μM, 25 μM and 100 μM for p110δ, p110β, p110γ and p110α, respectively.

HY-10528

Tasquinimod ABR-215050	HDAC	Cancer
Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor.

HY-12753S1

Debutyldronedarone D6 hydrochloride SR35021 D6 hydrochloride	Others	Cardiovascular Disease
Debutyldronedarone D6 hydrochloride (SR35021 D6 hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent.

HY-10579

Pluripotin SC1	Ribosomal S6 Kinase (RSK) ERK	Cancer
Pluripotin is a dual inhibitor of ERK1 and RasGAP with K_Ds of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC₅₀s of 0.5, 2.5, 3.3, and 10.0 µM, respectively.

HY-107018

AR-A 2 AR-A 000002	5-HT Receptor	Neurological Disease
AR-A 2 is a selective 5-HT_1B receptor antagonist, with high affinity to guinea pig cortex 5HT_1B/1D and recombinant guinea pig 5-HT_1B receptors (K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT_1D receptor (K_i, 5 nM), and shows an EC₅₀ of 4.5 nM for the guinea pig 5-HT_1B receptor; AR-A 2 can be used in the research of depression and anxiety.

HY-120504

N-Acetyltyramine	Bacterial	Cancer Infection
N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells.

HY-123242

FTI-2153	Farnesyl Transferase	Cancer
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity.

HY-112762

LHF-535	Arenavirus	Infection
LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC₅₀s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.

HY-12753S

Debutyldronedarone D7 SR35021 D7	Others	Cardiovascular Disease
Debutyldronedarone D7 (SR35021 D7) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans.Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent.

HY-111388

SEL120-34A	CDK	Cancer
SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC₅₀s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.

HY-15464A

(R)-(-)-Gossypol acetic acid AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-P1299A

UFP-101 TFA	Opioid Receptor	Neurological Disease
UFP-101 TFA is a potent, selective, and competitive antagonist of the NOP receptor, with a pK_i of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect.

HY-18901

RIPK1-IN-4	RIP kinase	Inflammation/Immunology
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC₅₀s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase.

HY-15319A

(±)-AMG 487	CXCR	Cancer
(±)-AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively.

HY-103254

ML221	Others	Neurological Disease
ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC₅₀s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC₈₀ of 10 nM in both assays.

HY-10261A

Afatinib dimaleate BIBW 2992MA2	EGFR Autophagy	Cancer
Afatinib dimaleate is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively.

HY-15433

Quisinostat JNJ-26481585	HDAC	Cancer
Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with IC₅₀s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10, HDAC11, respectively.

HY-100369A

DMCM hydrochloride	GABA Receptor	Neurological Disease
DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with K_is of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively.

HY-136546

Stafia-1
STAT Cancer

Stafia-1 is a potent STAT5a inhibitor (K_i=10.9 μM, IC₅₀=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.

HY-116761

GSK467	Histone Demethylase	Cancer
GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a K_i of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members.

HY-111388B

SEL120-34A HCl	CDK	Cancer
SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC₅₀s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.

HY-130262

PDE1-IN-3	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE1-IN-3, compound 4 (WO2019156861), is a selective human phosphodiesterase 1 (PDE1) inhibitor. PDE1-IN-3 inhibits PDE4D and PDE6AB with IC₅₀ values of 23.99 μM and 10 μM, respectively.

HY-14674

CP-724714	EGFR Apoptosis	Cancer
CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc.

HY-13998

Dasabuvir ABT-333	HCV	Infection
Dasabuvir (ABT-333) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the HCV NS5B gene, inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with IC₅₀ between 2.2 and 10.7 nM.

HY-101522

CHMFL-EGFR-202	EGFR BMX Kinase Btk MEK	Cancer
CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC₅₀s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ∼10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines.

HY-B1424

Benzthiazide	Carbonic Anhydrase	Cardiovascular Disease Cancer
Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with K_is of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells.

HY-125286

AB-680	CD73	Cancer
AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a K_i of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

HY-50905

Dovitinib TKI258; CHIR-258	FLT3 c-Kit FGFR VEGFR PDGFR	Cancer
Dovitinib (TKI258) is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively.

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	TNF Receptor Interleukin Related	Inflammation/Immunology Neurological Disease
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 and 10.8 μM, respectively.

HY-17547

NMS-E973	HSP	Cancer
NMS-E973 is a potent and selective inhibitor of HSP90. NMS-E973 binds to the ATP binding site of Hsp90α with a DC₅₀ of <10 nM. NMS-E973 is able to cross the blood-brain barrier (BBB). Antitumor efficacy.

HY-N6775

Sonolisib PX-866	PI3K	Cancer
Sonolisib (PX-866), an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC₅₀=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). Antitumor activity.

HY-109015S

Tucidinostat D4 Chidamide D4; HBI-8000 D4; CS 055 D4	HDAC	Cancer
Tucidinostat D4 (Chidamide D4) is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively.

HY-10261

Afatinib BIBW 2992	EGFR Autophagy	Cancer
Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively.

HY-15280

GSK2292767	PI3K	Inflammation/Immunology
GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC₅₀ of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease.

HY-12522

PF-06380101 Aur0101; Auristatin-0101	Microtubule/Tubulin ADC Cytotoxin	Cancer
PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.

HY-103697

Gardiquimod	Toll-like Receptor (TLR) HIV	Cancer Infection
Gardiquimod, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM.

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10).

HY-13267

Droxinostat NS 41080	HDAC Apoptosis	Cancer
Droxinostat(NS41080) is a selective inhibitor of HDAC3, HDAC6, and HDAC8 with IC50 of 16.9, 2.47 and 1.46 μM, respectively; > 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.

HY-109035

Inarigivir soproxil SB9200	HCV	Infection
Inarigivir soproxil is an agonist of innate immunity and shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC₅₀s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems.

HY-N7450

Icariside D2	Angiotensin-converting Enzyme (ACE) Apoptosis HIV	Cancer Infection Inflammation/Immunology
Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC₅₀ value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis .

HY-U00326

PI3Kα/mTOR-IN-1	PI3K mTOR	Cancer
PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC₅₀ of 7 nM for PI3Kα in a cell assay, and K_is of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.

HY-12418

E7449	PARP	Cancer
E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC₅₀s of 2.0, 1.0, ∼50 and ∼50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using ³²P-NAD⁺ as substrate.

HY-114324

PROTAC PARP1 degrader	PROTAC PARP	Cancer
PROTAC PARP1 degrader is a PARP1 degrader based on the PROTAC technology. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC₅₀ of 6.12 μM.

HY-120877

MRT199665	Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370.

HY-103606

(S,R,S)-AHPC-PEG6-C4-Cl VH032-PEG6-C4-Cl; VHL Ligand-Linker Conjugates 10; E3 ligase Ligand-Linker Conjugates 9	PROTAC	Cancer
(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

HY-103607

(S,R,S)-AHPC-PEG2-C4-Cl VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10	PROTAC	Cancer
(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

HY-101299A

Dihydrexidine DAR-0100	Dopamine Receptor	Neurological Disease
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC₅₀ of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity.

HY-N0171B

Beta-Sitosterol (purity>75%) β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%)	Apoptosis	Cancer Inflammation/Immunology Cardiovascular Disease
Beta-Sitosterol (purity>75%) includes 75% β-sitosterol and 10% campesterol. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (purity>75%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation.

HY-129769

CMLD012073	Eukaryotic Initiation Factor (eIF)	Cancer
CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC₅₀ of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).

HY-10207

Dovitinib lactate CHIR-258 lactate; TKI-258 lactate	FLT3 c-Kit FGFR VEGFR PDGFR	Cancer
Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively.

HY-108669

AZ10606120 dihydrochloride	P2X Receptor	Cancer Neurological Disease
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC₅₀ of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth.

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Tyrosinase	Cancer
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC₅₀ of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant.

HY-101299B

Dihydrexidine hydrochloride DAR-0100 hydrochloride	Dopamine Receptor	Neurological Disease
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC₅₀ of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity.

HY-109785A

(R)-Gyramide A hydrochloride
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC₅₀ value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.

HY-B0708

β-Estradiol 17-acetate
1,3,5(10)-Estratriene-3,17β-diol 17-acetate
Estrogen Receptor/ERR Endocrinology

β-Estradiol 17-acetate is a metabolite of estradiol.

HY-103697A

Gardiquimod diTFA	Toll-like Receptor (TLR) HIV	Cancer Infection
Gardiquimod diTFA, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod diTFA could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 when used at concentrations below 10 μM.

HY-P1126

Dolastatin 15 DLS 15	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin.

HY-14788

Drinabant AVE1625	Cannabinoid Receptor	Metabolic Disease
Drinabant (AVE1625) is an orally active CB1 receptor antagonist. Drinabant (AVE1625) inhibits the agonist-stimulated calcium signal with IC₅₀ values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R.

HY-10046

Plerixafor AMD 3100; JM3100; SID791	CXCR HIV Virus Protease	Cancer Infection Endocrinology Inflammation/Immunology
Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM.

HY-12143

Vofopitant dihydrochloride GR 205171A	Neurokinin Receptor	Cancer Neurological Disease Endocrinology
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [³H]SP binding to the NK1 receptor with pK_i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent.

HY-15777S

Ribociclib D6 LEE011 D6	CDK	Cancer
Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

HY-P1422

Spadin	Potassium Channel	Neurological Disease
Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice.

HY-18613

CAY10603 BML-281	HDAC	Cancer
CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor, with an IC₅₀ of 2 pM; CAY10603 (BML-281) also inhibits HDAC1, HDAC2, HDAC3, HDAC8, HDAC10, with IC₅₀s of 271, 252, 0.42, 6851, 90.7 nM.

HY-N2450

Sulforaphene	Apoptosis EGFR ERK NF-κB	Cancer
Sulforaphene, isolated from radish seeds, exhibits an ED₅₀ against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals.

HY-136175

SNDX-5613	Epigenetic Reader Domain	Cancer
SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding K_i of 0.149 nM and a cell based IC₅₀ of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

HY-N5020

Carabrone	Bacterial	Infection
Carabrone is isolated from the fruits of Carpesium abrotanoides , is a well-known sesquiterpene and exhibits significant anti-bacterial and anti-tumor activities. Carabrone exhibits antifungal activities in vitro and in vivo against Botrytis cinerea, Colletotrichum lagenarium(EC₅₀=7.10 μg/mL) and Erysiphe graminis.

HY-14520

Tetrahydrofolic acid L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.

HY-118743

KMN-80	Prostaglandin Receptor	Metabolic Disease
KMN-80, a derivative of PGE1 (HY-B0131), is a selective and potent agonist of EP₄ receptor with an IC₅₀ and a K_i of 3 nM and 2.35 nM, respectively. KMN-80 is against EP₃ receptor with an IC₅₀ of 1.4 μM and >10 μM for all other prostanoid receptors.

HY-16903

PKC-IN-1	PKC	Inflammation/Immunology
PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with K_is of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC₅₀s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

HY-18009

LFM-A13	Btk Polo-like Kinase (PLK) JAK	Cancer
LFM-A13 is a potent BTK, JAK2, PLK inhibitor, inhibits recombinant BTK, Plx1 and PLK3 with IC₅₀s of 2.5 μM, 10 μM and 61 μM; LFM-A13 shows no effects on JAK1 and JAK3, Src family kinase HCK, EGFR and IRK.

HY-12305

Q-VD-OPh QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone	Caspase HIV	Cancer Infection
Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC₅₀ of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.

HY-10498

Lexibulin CYT-997	Microtubule/Tubulin Reactive Oxygen Species Apoptosis	Cancer
Lexibulin (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin induces cell apoptosis and induces mitochondrial ROS generation in GC cells.

HY-130504

Propargyl-PEG1-acid	PROTAC Linker	Cancer
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM.

HY-10498A

Lexibulin dihydrochloride CYT-997 dihydrochloride	Microtubule/Tubulin Reactive Oxygen Species Apoptosis	Cancer
Lexibulin dihydrochloride (CYT-997 dihydrochloride) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin dihydrochloride induces cell apoptosis and induces mitochondrial ROS generation in GC cells.

HY-116699

CP-868388 free base	PPAR	Metabolic Disease Inflammation/Immunology Neurological Disease
CP-868388 free base is a potent, selective and orally active PPARα agonist with a K_i value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (K_i of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions.

HY-130992

Androgen receptor antagonist 1	Androgen Receptor Ligand for Target Protein for PROTAC	Cancer
Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC₅₀ of 59 nM. Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.

HY-12456

Duocarmycin SA	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
Duocarmycin SA is a potent antitumor antibiotic with an IC₅₀ of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.

HY-129522

Sulfo-ara-F-NMN CZ-48	Toll-like Receptor (TLR)	Neurological Disease
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC₅₀ around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production.

HY-14722C

NVP-BSK805 trihydrochloride	JAK	Cancer
NVP-BSK805 trihydrochloride trihydrochloride is an ATP-competitive JAK2 inhibitor, with IC₅₀s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

HY-126679

Apoptolidin	ATP Synthase Apoptosis	Cancer
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F₁F_O ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC₅₀=10-17 ng/ml) but not in normal cells.

HY-14722A

NVP-BSK805 dihydrochloride	JAK	Cancer
NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor, with IC₅₀s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

HY-101930A

(Rac)-BMS-816336	Others	Metabolic Disease
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability.

HY-A0077

Perphenazine	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Perphenazine is a typical antipsychotic drug, inhibits 5-HT_2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with K_i values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

HY-19843A

MK-0941 free base	Glucokinase	Metabolic Disease
MK-0941 free base is an orally active glucokinase activator, with EC₅₀s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.

HY-14722

NVP-BSK805	JAK	Cancer
NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC₅₀s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

HY-100131

GSK481	RIP kinase	Inflammation/Immunology
GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC₅₀ of 1.3 nM, which inhibits Ser¹⁶⁶ phosphorylation in wild-type human RIP1 (IC₅₀=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC₅₀ of 10 nM.

HY-103076

EZ-482	Others	Neurological Disease
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with K_ds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas.

HY-N4110

Friedelin	Cytochrome P450	Metabolic Disease
Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC₅₀ and K_ivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC₅₀ and K_i values of 22.54 μM and 18.02 μM, respectively.

HY-101517

PI3K-IN-2	PI3K	Cancer
PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC₅₀=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC₅₀=13/190 nM, respectively).

HY-P1422A

Spadin TFA	Potassium Channel	Neurological Disease
Spadin TFA, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin TFA binds specifically to TREK-1 with an affinity of 10 nM. Spadin TFA is an efficient antidepressant in mice.

HY-129240S

13-cis Acitretin D3 Isoacitretin D3; Ro 13-7652 D3	Drug Metabolite	Inflammation/Immunology
13-cis Acitretin D3 （Isoacitretin D3） is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

HY-122347A

Orvepitant maleate GW823296 maleate	Neurokinin Receptor	Neurological Disease
Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pK_i of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.

HY-14328

Sonepiprazole PNU-101387G; U-101387G	Dopamine Receptor	Neurological Disease
Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with K_is of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively.

HY-122058A

KRH-3955 hydrochloride	CXCR HIV	Infection Inflammation/Immunology
KRH-3955 hydrochloride is an orally bioavailable CXCR4 antagonist. KRH-3955 hydrochloride inhibits SDF-1α binding to CXCR4 with an IC₅₀ of 0.61 nM. KRH-3955 hydrochloride is also a highly potent and selective inhibitor of X4 HIV-1, with an EC₅₀ of 0.3 to 1.0 nM.

HY-133780

Afatinib impurity 11	EGFR Autophagy	Cancer
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively.

HY-90009C

ent-Tadalafil ent-IC-351	Phosphodiesterase (PDE)	Cancer
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC₅₀ of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM.

HY-13941B

1-Naphthyl PP1 hydrochloride 1-NA-PP 1 hydrochloride	Src	Cancer
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.

HY-126248

Tankyrase-IN-2	PARP	Cancer
Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC₅₀s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model.

HY-13941

1-Naphthyl PP1 1-NA-PP 1	Src	Cancer
1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.

HY-P2336

CCZ01048	Melanocortin Receptor	Cancer
CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.

HY-112373

Aurora Kinase Inhibitor 3	Aurora Kinase	Others
Aurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC₅₀ of 42 nM, and weakly inhibits EGFR with an IC₅₀>10 μM. Aurora Kinase Inhibitor 3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures.

HY-125108

PHPS1 sodium	Phosphatase	Cancer Cardiovascular Disease
PHPS1 sodium is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.

HY-N6785

Okadaic acid	Phosphatase Parasite Apoptosis	Infection
Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A and PP3 inhibitor with IC₅₀s of 10-15 nM, 0.5 nM and 4 nM, respectively. Okadaic acid eliminate metazoan symbionts/parasites by apoptosis.

HY-P2336A

CCZ01048 TFA	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma.

HY-125841

EGFR mutant-IN-1	EGFR	Cancer
EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFR^{L858R/T790M/C797S} mutant inhibitor with an IC₅₀ of 27.5 nM, while being a significantly less potent for EGFR^WT (IC₅₀ >1.0 μM).

HY-101147

YKL-05-099	Salt-inducible Kinase (SIK)	Inflammation/Immunology
YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC₅₀s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC₅₀=40 nM).

HY-19432

UBP-282	iGluR	Neurological Disease
UBP-282 is a potent, selective and competitive AMPA and kainate receptor antagonist. UBP-282 inhibits the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) with an IC₅₀ value of 10.3 μM. UBP-282 antagonizes kainate-induced depolarisations of dorsal roots with a pA₂ value of 4.96.

HY-101254

Luzindole N-0774	Melatonin Receptor	Neurological Disease
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel_1b) over MT1 (Mel_1a) with K_i values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity.

HY-17377

Vicriviroc maleate SCH-417690 maleate; SCH-D maleate	CCR HIV	Infection Endocrinology
Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a K_i of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC₉₀s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).

HY-100213

EAI045	EGFR	Cancer
EAI045 is an allosteric and the fourth-generation inhibitor of mutant EGFR with IC₅₀s of 1.9, 0.019, 0.19 and 0.002 μM for EGFR, EGFR^L858R, EGFR^T790M and EGFR^L858R/T790M at 10 μM ATP, respectively.

HY-112762A

(E)-LHF-535	Arenavirus	Infection
(E)-LHF-535 is the E-isomer of LHF-535. LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC₅₀s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.

HY-133123

EP4 receptor antagonist 1	Prostaglandin Receptor	Cancer Inflammation/Immunology
EP4 receptor antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist for cancer immunotherapy. EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC₅₀s of 6.1 nM and 16.2 nM, respectively. IC₅₀s >10 μM for human EP1, EP2,and EP3 receptors.

HY-131064

RIPK3-IN-1	RIP kinase	Inflammation/Immunology
RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC₅₀ of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC₅₀s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC₅₀ of 1.1 μM.

HY-20878

Tyrphostin AG 879 AG 879	Trk Receptor EGFR Apoptosis	Cancer
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC₅₀ of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC₅₀ of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.

HY-124308

PS315	PKC	Cancer
PS315, a derivative of PS48, is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKC_ζ (IC₅₀=10 μM) and PKC_ι (IC₅₀=30 μM). PS315 has anti-cancer activity.

HY-112704

PDE5-IN-2	Phosphodiesterase (PDE)	Cardiovascular Disease
PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC₅₀ of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC₅₀s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity.

HY-109015

Tucidinostat Chidamide; HBI-8000; CS 055	HDAC	Cancer
Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC₅₀s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC₅₀s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9.

HY-103665

STING agonist-3	STING	Cancer
STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC₅₀ and pIC₅₀ of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer.

HY-131335

p38α inhibitor 2	p38 MAPK	Inflammation/Immunology
p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC₅₀ of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC₅₀=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets.

HY-10322

Falnidamol BIBX 1382	EGFR	Cancer
Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC₅₀ of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC₅₀=3.4 μM) and a range of other related tyrosine kinases (IC₅₀>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity.

HY-103665A

STING agonist-3 trihydrochloride	STING	Cancer
STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC₅₀ and pEC₅₀ of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer.

HY-108628

SU16f	PDGFR	Cancer
SU16f is a potent and selective PDGFRβ inhibitor with IC₅₀s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively. Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration.

HY-133016

M8891	Others	Cancer
M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM). M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity.

HY-100421

CPI-455	Histone Demethylase	Cancer
CPI-455 is a specific, pan-KDM5 inhibitor with an IC₅₀ of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents.

HY-112714

GSK3532795 BMS-955176	HIV	Infection
GSK3532795 (BMS-955176) is a potent, orally active, second-generation HIV-1 maturation inhibitor, with EC₅₀s of 1.9, 10.2, 2.7 and 13 nM for HIV-1 WT, HIV-1 WT(human serum), HIV-1 V370A, and HIV-1 ΔV370, respectively.

HY-N2284

Sophoflavescenol	AChE Beta-secretase Phosphodiesterase (PDE)	Cancer
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-18299

Purvalanol B NG 95	CDK	Cancer
Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

HY-107419

NU6140	CDK Aurora Kinase	Cancer
NU6140 is a selective CDK2-cyclin A inhibitor (IC₅₀, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. NU6140 also potently inhibits Aurora A and Aurora B, with IC₅₀s of 67 and 35 nM, respectively. Enhances the apoptotic effect, with anti-cancer activity.

HY-108044

ONO-5334	Cathepsin SARS-CoV	Metabolic Disease
ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with K_i values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC₅₀ value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease.

HY-80002

BMX-IN-1 BMX kinase inhibitor	Btk BMX Kinase	Cancer
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys⁴⁹⁶ in the BMX ATP binding domain with an IC₅₀ of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC₅₀ value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

HY-111415

EGFR-IN-5
EGFR Cancer

EGFR-IN-5 is a EGFR inhibitor with IC₅₀s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFR^L858R, EGFR^L858R/T790M, and EGFR^{L858R/T790M/C797S}, respectively.

HY-W000434

Fmoc-NH-PEG4-CH2CH2COOH Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid	ADC Linker	Cancer
Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-107422A

PAT-1251 Hydrochloride	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively). PAT-1251 Hydrochloride is used in the research of fibrotic diseases.

HY-P1300

[(pF)Phe4]Nociceptin(1-13)NH2	Opioid Receptor	Neurological Disease
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pK_i of 10.68 and a pEC₅₀ of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).

HY-14300A

Vilanterol trifenatate GW642444 trifenatate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β₂-adrenoceptor (β₂-AR) agonist with inherent 24-hour activity. The pEC₅₀s for β₂-AR, β₁-AR and β₃-AR are 10.37, 6.98 and 7.36, respectively.

HY-13240

LY2886721	Beta-secretase	Neurological Disease
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC₅₀ of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

HY-135797

DB1976	Apoptosis	Cancer
DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC₅₀ of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, K_D of 12 nM) in vitro. DB1976 has apoptosis-inducing effect.

HY-108467

GGsTop Nahlsgen	Others	Cardiovascular Disease
GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ−glutamyl transpeptidase (GGT) inhibitor, with a K_i of 170 μM for Human GGT. GGsTop shows a pK_a of 9.71, also exhibits K_ons of 150±10 and 51±3 M^-1 s^-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model.

HY-P1300A

[(pF)Phe4]Nociceptin(1-13)NH2 TFA	Opioid Receptor	Neurological Disease
[(pF)Phe4]Nociceptin(1-13)NH2 TFA is a highly potent and selective NOP receptor (OP4) agonist, with a pK_i of 10.68 and a pEC₅₀ of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 TFA displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).

HY-15971A

AMD 3465 GENZ-644494	CXCR HIV	Infection Endocrinology
AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12^AF647 to CXCR4, with IC₅₀s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC₅₀: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-124151

Adenosine-2'-monophosphate 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation.

HY-117621

PF-04634817	CCR	Metabolic Disease
PF-0463481 is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC₅₀=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC₅₀=470 nM). PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy.

HY-135797A

DB1976 hydrochloride	Apoptosis	Cancer
DB1976 hydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 hydrochloride potently inhibits PU.1 binding (IC₅₀ of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, K_D of 12 nM) in vitro. DB1976 hydrochloride has apoptosis-inducing effect.

HY-107422

PAT-1251	Monoamine Oxidase	Inflammation/Immunology
PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC₅₀s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC₅₀s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 is used in the research of fibrotic diseases.

HY-14300

Vilanterol GW642444	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Vilanterol (GW642444) is a long-acting β₂-adrenoceptor (β₂-AR) agonist with 24 h activity. The pEC₅₀s for β₂-AR,β₁-AR and β₃-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

HY-P2231A

Cotadutide acetate MEDI0382 acetate	Glucagon Receptor	Metabolic Disease
Cotadutide acetate (MEDI0382 acetate) is a potent peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate (MEDI0382 acetate) exhibits ability to facilitate both weight loss and glycaemic control, has the potential for obesity and type 2 diabetes (T2D) treatment.

HY-107417

Hypothemycin	VEGFR MEK FLT3 PDGFR ERK	Cancer
Hypothemycin, a fungal polyketide, is a multikinase inhibitor with K_is of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively.

HY-19807

Indirubin-3'-monoxime Indirubin-3'-oxime	GSK-3 Lipoxygenase	Cancer
Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC₅₀s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC₅₀s of 100 and 180 nM.

HY-10221

Vorinostat SAHA; Suberoylanilide hydroxamic acid	HDAC Autophagy Mitophagy Filovirus	Cancer Infection
Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.

HY-120323

DRI-C21045	TNF Receptor	Inflammation/Immunology
DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC₅₀ of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC₅₀s of 17.1 µM and 4.5 µM, respectively.

HY-N2484

Methylnissolin Astrapterocarpan	PDGFR ERK	Cardiovascular Disease
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade.

HY-N2959

Brevilin A	JAK STAT Apoptosis Autophagy	Cancer
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC₅₀ = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.

HY-113038

D-α-Hydroxyglutaric acid (R)-2-Hydroxypentanedioic acid	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
D-α-Hydroxyglutaric acid ((R)-2-Hydroxypentanedioic acid) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-112898

DC1SMe	ADC Cytotoxin	Cancer
DC1Sme, a DC1 derivative, exhibits IC₅₀ values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

HY-125269

TED-347	YAP	Cancer
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC₅₀ of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a K_i of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity.

HY-120214

TAS05567	Syk	Inflammation/Immunology
TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC₅₀ of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC₅₀s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases.

HY-112780

UC2288	MDM-2/p53	Cancer
UC2288 is a novel, cell-permeable, and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM.

HY-15971

AMD 3465 hexahydrobromide GENZ-644494 hexahydrobromide	CXCR HIV	Infection Endocrinology
AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12^AF647 to CXCR4, with IC₅₀s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC₅₀: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8).

HY-135582

Raloxifene 4'-glucuronide	Estrogen Receptor/ERR	Endocrinology
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression.

HY-117621A

PF-04634817 succinate	CCR	Metabolic Disease
PF-0463481 succinate is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC₅₀=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC₅₀=470 nM). PF-0463481 succinate is safe and well-tolerated and has the potential for the study of diabetic nephropathy.

HY-123611

Supinoxin RX-5902	DNA/RNA Synthesis Apoptosis	Cancer
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC₅₀s ranging from 10 nM to 20 nM.

HY-N7176

Kaempferol 3-O-β-D-glucuronide Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide	Interleukin Related	Inflammation/Immunology
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.

HY-124602

DI-591	E1/E2/E3 Enzyme	Cancer
DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with K_i values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members.

HY-12355

Siponimod BAF-312	LPL Receptor	Others
Siponimod (BAF-312) is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. It is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC₅₀s of 0.39, 0.98, >10,000, >1,000, and 750 nM, respectively). Used to treat adult multiple sclerosis.

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8).

HY-136314

DBCO-PEG4-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-103387

DuP-697	COX Apoptosis	Cancer Inflammation/Immunology
DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active COX-2 inhibitor (IC₅₀ of 10 nM and 800 nM for human COX-2 and COX-1, respectively). DuP-697 exerts antiproliferative (IC₅₀ of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects.

HY-107691

GR 159897	Neurokinin Receptor	Cancer Endocrinology Neurological Disease
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK₂) receptor antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [³H]GR100679 to human NK₂ (hNK₂)-CHO cells and rat colon membranes with pK_is of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects.

HY-126249

AAPK-25	Aurora Kinase Polo-like Kinase (PLK) Apoptosis	Cancer
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3^Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with K_d values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with K_d values ranging from 55-456 nM.

HY-112429

HJB97	Epigenetic Reader Domain	Cancer
HJB97 is a high-affinity BET inhibitor with K_is of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. HJB97 is employed for the design of potential PROTAC BET degrader and has antitumor activity.

HY-115613

ML-180 SR1848	Others	Cancer
ML-180 (SR1848) is a potent orphan nuclear receptor *liver receptor homolog 1 (LRH-1; NR5A2)* inverse agonist with an IC₅₀ of 3.7 µM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC₅₀>10 µM). ML-180 has the potential for LRH-1-dependent cancers.

HY-P1274A

ShK-Dap22 TFA	Potassium Channel	Inflammation/Immunology
ShK-Dap22 TFA is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 TFA is a selective Kv1.3 channel blocker with IC₅₀s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively.

HY-114358

ONO-7475	TAM Receptor Trk Receptor	Cancer
ONO-7475 is a potent, selective, and orally active novel Axl/Mer inhibitor with IC₅₀ values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).

HY-P1274

ShK-Dap22	Potassium Channel	Inflammation/Immunology
ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC₅₀s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively.

HY-100542

D-α-Hydroxyglutaric acid disodium Disodium (R)-2-hydroxyglutarate	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-10182B

CHIR-99021 trihydrochloride CT99021 trihydrochloride	GSK-3 Wnt β-catenin Autophagy	Cancer
CHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. CHIR-99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 trihydrochloride induces autophagy.

HY-N6791

KT5823	PKA PKC Bacterial Apoptosis Antibiotic	Infection Inflammation/Immunology
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and PKC with K_i values of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na⁺/I^- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation.

HY-76474

BAY 61-3606	Syk Apoptosis	Cancer Inflammation/Immunology
BAY 61-3606 is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a K_i of 7.5 nM and an IC₅₀ of 10 nM. BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

HY-10182

CHIR-99021 CT99021	GSK-3 Wnt β-catenin Autophagy	Cancer
CHIR-99021 (CT99021) is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. CHIR-99021 shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 induces autophagy.

HY-10264

Edoxaban DU-176	Factor Xa Thrombin	Cardiovascular Disease
Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is a also weak inhibitor of thrombin and factor IXaβ (FIXa), with K_is of 6.00 μM and 41.7 μM, respectively, exhibits >10 000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment.

HY-14985

BAY 61-3606 dihydrochloride	Syk Apoptosis	Inflammation/Immunology Cancer
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a K_i of 7.5 nM an IC₅₀ of 10 nM. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

HY-136379

CID44216842 Cdc42-IN-1	Ras	Cancer
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC₅₀s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC₅₀s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.

HY-P1345

TLQP-21	Complement System	Endocrinology Neurological Disease
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions.

HY-131061

BET bromodomain inhibitor 1	Epigenetic Reader Domain	Cancer
BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC₅₀ of 2.6 nM for BRD4. BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (K_d values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). bromodomain inhibitor 1 has anti-cancer activity.

HY-101513

eIF4A3-IN-1	Eukaryotic Initiation Factor (eIF) Autophagy	Cancer
eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC₅₀=0.26 μM; K_d=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.

HY-16558

Butein 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein, isolated from Dalbergia odorifera T. Chen, is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60^c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

HY-119271

CMLD010509 SDS-1-021	c-Myc Apoptosis	Cancer
CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC₅₀ below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism.

HY-112614

ATM Inhibitor-1	ATM/ATR	Cancer
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC₅₀ of 0.7 nM, shows weak activity against mTOR (IC₅₀, 21 μM), DNAPK (IC₅₀, 2.8 μM), PI3Kα (IC₅₀, 3.8 μM), PI3Kβ (IC₅₀, 10.3 μM), PI3Kγ (IC₅₀, 3 μM) and PI3Kδ (IC₅₀, 0.73 μM). ATM Inhibitor-1 exhibits anti-tumor activity.

HY-D1110

TFAX 594,SE	Others
TFAX 594,SE, an amine reactive red fluorescent dye, is insensitive to pH in the range 4-10. TFAX 594,SE forms bright and photostable conjugates with proteins and antibodies. TFAX 594,SE is suitable for use in flow cytometry, 2-photon excitation microscopy, and super resolution mircoscopy techniques, such as dSTORM. Excitation/emission maxima ~ 590 / 660 nm; extinction coefficient=92,000 M-1cm-1; quantum yield=0.66.

HY-B0822

Fipronil	GABA Receptor Cytochrome P450	Neurological Disease
Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC₅₀s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC₅₀0s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-D1111

TFAX 568, SE	Others
TFAX 568, SE, an amine reactive orange fluorescent dye, is insensitive to pH in the range 4-10. TFAX 568, SE forms bright and photostable conjugates with proteins and antibodies. TFAX 568, SE is suitable for use in flow cytometry, 2-photon excitation microscopy, and super resolution mircoscopy techniques, such as dSTORM. Excitation maximum=578 nm; emission maximum=602 nm; quantum yield=0.69; extinction coefficient=60720 M-1cm-1.

HY-10264A

Edoxaban tosylate DU-176b	Factor Xa Thrombin	Cardiovascular Disease
Edoxaban tosylate (DU-176b) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban tosylate is an anticoagulant agent and can be used for stroke prevention. Edoxaban tosylate is a also weak inhibitor of thrombin and factor IXaβ (FIXa), with K_is of 6.00 μM and 41.7 μM, respectively, exhibits >10 000-fold selectivity for FXa. Edoxaban tosylate has antithrombotic properties and has potential for thromboembolic diseases treatment.

HY-10264B

Edoxaban tosylate monohydrate DU-176b monohydrate	Factor Xa Thrombin	Cardiovascular Disease
Edoxaban tosylate monohydrate (DU-176b monohydrate) is a selective, potent and orally active factor Xa (FXa) inhibitor with K_is of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban tosylate monohydrate is an anticoagulant agent and can be used for stroke prevention. Edoxaban tosylate monohydrate is a also weak inhibitor of thrombin and factor IXaβ (FIXa), with K_is of 6.00 μM and 41.7 μM, respectively, exhibits >10 000-fold selectivity for FXa. Edoxaban tosylate monohydrate has antithrombotic properties and has potential for thromboembolic diseases treatment.

HY-19336

BAZ2-ICR	Epigenetic Reader Domain	Cancer
BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC₅₀s of 130 nM and 180 nM, and K_ds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe.

HY-10182A

CHIR-99021 monohydrochloride CT99021 monohydrochloride	GSK-3 Wnt β-catenin Autophagy	Cancer
CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. CHIR-99021 monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 monohydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 monohydrochloride induces autophagy.

HY-135858

SARS-CoV-IN-3	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC₅₀ of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 11.7 and 20.4 nM; and IC₉₀s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 10 μM in MT-4 cells.

HY-D1114

TFAX 488,SE dilithium	Others
TFAX 488,SE dilithium, an amine reactive green fluorescent dye, is insensitive to pH in the range 4-10. TFAX 488,SE dilithium forms bright and photostable conjugates with proteins and antibodies. TFAX 488,SE dilithium is suitable for use in flow cytometry, two-photon excitation microscopy (TPE), and super resolution microscopy techniques, such as dSTORM, SIM and STED. Excitation maximum=495 nm; emission maximum=515 nm; extinction coefficient=73,000 M-1cm-1; quantum yield=0.92.

HY-P1345A

TLQP-21 TFA	Complement System	Endocrinology Neurological Disease
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions.

HY-15514A

Merestinib dihydrochloride LY2801653 dihydrochloride	c-Met/HGFR FLT3 ROS Discoidin Domain Receptor	Cancer
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM).

HY-10238

Danoprevir ITMN-191; R7227; RO5190591; RG7227	HCV Protease HCV	Infection
Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC₅₀ of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC₅₀ higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s=0.2-0.4 nM) as well as 2b and 3a (IC₅₀s=1.6, 3.5 nM).

HY-129602

SD-36	PROTAC STAT Apoptosis	Cancer
SD-36 is a potent and efficacious PROTAC STAT3 degrader (K_d=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC₅₀=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of CRBN ligand Lenalidomide for E3 ubiquitin ligase.

HY-15514

Merestinib LY2801653	c-Met/HGFR FLT3 ROS Discoidin Domain Receptor	Cancer
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM).

HY-111388A

SEL120-34A monohydrochloride	CDK	Cancer
SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC₅₀s of 4.4 nM and 10.4 nM, respectively, with a K_d of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC₅₀=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726. Has anti-tumor activity.

HY-136254

BzATP triethylammonium salt	P2X Receptor	Cancer Inflammation/Immunology
BzATP triethylammonium salt acts as a P2X receptor agonist with pEC₅₀s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. BzATP triethylammonium salt is potent at P2X7 receptors with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively.

HY-108596

BL-1249	Potassium Channel	Inflammation/Immunology
BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 potently activates K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) with EC₅₀ values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K_2P subfamilies. BL-1249 exhibits more selective for the bladder (EC₅₀ of 1.26 μM) than vascular tissue (EC₅₀ of 21.0 μM).

HY-10847B

SB-277011 hydrochloride SB-277011A hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor (D₃R) antagonist with K_i values of 10.7 nM and 11.2 nM at rodent and human D₃R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK_is of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-107836

Methiothepin mesylate Metitepine mesylate; Ro 8-6837 mesylate	5-HT Receptor	Neurological Disease
Methiothepin mesylate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-P1404

R8-T198wt	Pim
R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

HY-D1113

TFAX 488,TFP	Others
TFAX 488,TFP, an amine reactive green fluorescent dye, is insensitive to pH in the range 4-10. TFAX 488,TFP forms bright and photostable conjugates with proteins and antibodies. TFAX 488,TFP is less susceptible to spontaneous hydrolysis during conjugation reactions compared to SE or NHS dyes. TFAX 488,TFP also displays greater stability compared to NHS and SE versions, typically lasting several hours. TFAX 488,TFP is suitable for use in flow cytometry, two-photon excitation microscopy (TPE), and super resolution microscopy techniques, such as dSTORM, SIM and STED. Excitation maximum=495 nm; emission maximum=515 nm; extinction coefficient=73,000 M-1cm-1; quantum yield=0.92.

HY-112608

CHMFL-PI3KD-317	PI3K	Cancer
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC₅₀ of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC₅₀, 62.6 nM), PI3Kβ (IC₅₀, 284 nM), PI3Kγ (IC₅₀, 202.7 nM), PIK3C2A (IC₅₀, >10000 nM), PIK3C2B (IC₅₀, 882.3 nM), VPS34 (IC₅₀, 1801.7 nM), PI4KIIIA (IC₅₀, 574.1 nM) and PI4KIIIB (IC₅₀, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC₅₀ of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells.

Cat. No.	Product Name

HY-L0054V

Discovery Diversity Set 10

10,560 compounds

Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 10 compose of 10,560 highly diverse compounds produced only within last three years. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

HY-L0055V

Discovery Diversity Set 50

50,240 compounds

Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 50 compose of 50,240 highly diverse compounds produced only within last three years. The two sets do not overlap and deliver a total of 60 thousand compounds. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

HY-L0072V

Agro-like Library 10,240 compounds

A unique library composed of 10,240 compounds intended for use in agro/crop science.

HY-L012

Metabolism/Protease Compound Library

2018 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 2018 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

HY-L063

Chemical Probe Library

88 compounds

Chemical probes are simply reagents with high potency, selectivity and cell-permeability which play important roles in both fundamental and applied biological research. In their most common application, chemical probes can establish the tractability of a specific target. They are used to interrogate the relationship between a target and its phenotype (biological tractability) as well as an ability to modulate that phenotype using a small molecule. Otherwise, chemical probes also have had a major impact in enabling and accelerating discoveries along the path to pioneer medicines. They have helped to improve the understanding of targets and pathways and have created opportunities for proprietary drug discovery efforts to an extent that would not have been possible otherwise.

MCE provides a unique collection of 88 chemical probes with high potency (at least 100 nM potency), selectivity (at least 10-fold selectivity against any other target) and cell-permeability (at least 10 μM potency). MCE Chemical probe library is a useful tool for target identification and mechanism research.

HY-L0058V

GPCR Library	54,080 compounds
A unique collection of 54,080 small molecules targeting G protein coupled receptors (GPCRs) used in GPCR screening for various research and drug development projects.

HY-L058

Glycolysis Compound Library

342 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 342 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Cat. No.	Product Name	Type

HY-D0993

Acridine Orange 10-Nonyl Bromide
Nonylacridine orange
Fluorescent Dyes/Probes

Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λ_ex: 489 nm, λ_em: 525 nm).

HY-Y0016

Rhodamine B Basic Violet 10; Brilliant Pink B; Rhodamine O; Tetraethylrhodamine	Fluorescent Dyes/Probes
Rhodamine B is a staining fluorescent dye, commonly used for dyeing textiles, paper, soap, leather, and drugs.

HY-101880

ADHP
10-Acetyl-3,7-dihydroxyphenoxazine
Fluorescent Dyes/Probes

ADHP is a fluorogenic peroxidase substrate (λ_ex=530 nm, λ_em=590 nm).

HY-131010

Flutax-2	Dyes
Flutax-2 is a green fluorescent taxol derivative and can be used for microtubule imaging. Flutax-2 binds microtubules with high affinity (K_a=10 7M^-1). (λ_{Excitation/emission}~496/526 nm).

HY-112803

GNE-371	Fluorescent Dyes/Probes
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC₅₀ of 10 nM for TAF1(2).

HY-B0324A

Crystal Violet Basic Violet 3; Gentian Violet; Methyl Violet 10B	Dyes
Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.

HY-D0784

5-ROX 5-Carboxy-X-rhodamine	Oligonucleotide Labeling
5-ROX (5-Carboxy-X-rhodamine), a rhodamine dye, exhibits strong fluorescence property in aqueous buffer with the λ_exit of 580 nm (ε=3.6×10 4 M^-1 cm^-1), and λ_emit of 604 nm (ϕ=0.94).

HY-128868

FITC-Dextran (MW 10000)	Fluorescent Dyes/Probes
FITC-Dextran (MW 10000) is a marker consisting of coupling fluorescein-isothiocyanate to dextran (10 kDa). FITC-Dextran are polysaccharides comprised of varying lengths of branched glucose molecules and can be used to determine solute, ion and protein permeability of the blood-brain barrier (BBB) based on the size of the dextran used.

HY-D1069

DBCO-Cy3 DBCO-Sulfo-Cy3	Fluorescent Dyes/Probes
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dye with excitation maximum 555 nm and emission maximum of 580 nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations.

Cat. No.	Product Name	Type

HY-W004544

o-Phenanthroline 1,10-phenanthroline	Biochemical Assay Reagents
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe²⁺ that absorbs maximally at 510 nm.

HY-Y1841

*o-Phenanthroline* monohydrate** 1,10-phenanthroline monohydrate	Biochemical Assay Reagents
o-Phenanthroline monohydrate (1,10-Phenanthroline monohydrate), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe²⁺ that absorbs maximally at 510 nm.

Cat. No.	Product Name	Target	Research Area

HY-15580

Dolastatin 10 DLS 10; NSC 376128	Microtubule/Tubulin ADC Cytotoxin	Cancer
Dolastatin 10 (DLS 10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.

HY-P1197

Kisspeptin-10, rat	Peptides	Inflammation/Immunology Cardiovascular Disease
Kisspeptin-10, rat is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, rat is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound.

HY-P0254

Kisspeptin-10, human	Peptides	Cancer Cardiovascular Disease
Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.

HY-P0254A

Kisspeptin-10, human TFA	Peptides	Cancer Cardiovascular Disease
Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.

HY-P2246

JTP10-△-TATi TFA
JNK Cancer

JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor, with an IC₅₀ of 92 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

HY-P1978

CysHHC10	Bacterial	Infection
CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 against *E. coli, P. aeruginosa, S. aureus* and *S. epidermidis* are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively.

HY-P1116A

PBP10 TFA	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects.

HY-P1279

[Lys5,MeLeu9,Nle10]-NKA(4-10)
Neurokinin Receptor Inflammation/Immunology

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.

HY-107024

Osteogenic Growth Peptide (10-14) OGP(10-14); Historphin	Src	Others
Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor.

HY-P1279A

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.

HY-P2247

JTP10-△-R9 TFA
JNK Cancer

JTP10-△-R9 TFA is a selective JNK2 peptide inhibitor, with an IC₅₀ of 89 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

HY-P1978A

CysHHC10 TFA	Bacterial	Infection
CysHHC10 TFA is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria. The MIC values of CysHHC10 TFA against *E. coli, P. aeruginosa, S. aureus* and *S. epidermidis* are 10.1 mM, 20.2 mM, 2.5 mM and 1.3 mM, respectively.

HY-P1594

Dynorphin A 1-10	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P0236

Neurokinin A(4-10)
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Cancer Inflammation/Immunology
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM.

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Cancer Inflammation/Immunology
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM.

HY-P1567

β-Amyloid (10-35), amide	Amyloid-β	Neurological Disease
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

HY-P1825

TNF-α (10-36), human
Peptides Inflammation/Immunology

TNF-α (10-36), human is a peptide of human TNF-α.

HY-P1594A

Dynorphin A (1-10) (TFA)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P1825A

TNF-α (10-36), human TFA
Peptides Inflammation/Immunology

TNF-α (10-36), human (TFA) is a peptide of human TNF-α.
HY-P0236A

Neurokinin A(4-10) TFA
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.
HY-P0273

Histatin 5
MMP Inflammation/Immunology

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-P0273A

Histatin 5 TFA
MMP Inflammation/Immunology

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-P1053

Amyloid β-Protein 10-20
Amyloid-β Neurological Disease

Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-P1478

Adrenocorticotropic Hormone (ACTH) (4-10), human
Peptides Metabolic Disease

Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

HY-P1787

β-Amyloid (4-10)	Amyloid-β	Neurological Disease
β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model.

HY-P1375

[D-Trp7,9,10]-Substance P	mAChR
[D-Trp7,9,10]-Substance P is the substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. [D-Trp7,9,10]-Substance P does not inhibit Gi/o activation by M2 ACh receptors.

HY-P1518

Adrenocorticotropic Hormone (ACTH) (1-10), human	Peptides	Metabolic Disease
Adrenocorticotropic Hormone (ACTH) (1-10), human, an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).

HY-P1375A

[D-Trp7,9,10]-Substance P TFA	mAChR
[D-Trp7,9,10]-Substance P TFA is the substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. [D-Trp7,9,10]-Substance P TFA does not inhibit Gi/o activation by M2 ACh receptors.

HY-P1031

[bAla8]-Neurokinin A(4-10)
MEN 10210
Neurokinin Receptor Endocrinology

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

HY-P2004

FFAGLDD	MMP	Cancer
FFAGLDD is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.

HY-P2004A

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.

HY-P1580

PA (224-233), Influenza
Influenza Virus Infection

PA (224-233), Influenza is a 10-aa peptide, a fragment of polymerase 2 protein in influenza A virus.

HY-P1520

Prolactin Releasing Peptide (1-31), human	Peptides	Neurological Disease
Prolactin Releasing Peptide (1-31), human is a high affinity *GPR10* ligand that cause the release of the prolactin. Human and rat Prolactin Releasing Peptide (1-31) binds to GPR10 with K_is of 1.03 and 0.33 nM, respectively.

HY-P1122

Cyclosporin H	Peptides
Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin or prostaglandin E2. Cyclosporin H lacks immunosuppressant activity of cyclosporin A.

HY-P2080

GIP (1-30) amide,Human	Glucagon Receptor	Metabolic Disease
GIP (1-30) amide,Human is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide (Human) dose-dependently promotes insulin secretion over the range 10 -9-10 -6 M.

HY-P2080B

GIP (1-30) amide,Human acetate	Glucagon Receptor	Metabolic Disease
GIP (1-30) amide,Human acetate is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide (Human) dose-dependently promotes insulin secretion over the range 10 -9-10 -6 M.

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1206A

CH 275 TFA	Somatostatin Receptor	Neurological Disease
CH 275 TFA is a potent and selective somatostatin receptor 1 (sst₁) agonist and display IC₅₀ values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst₁, sst₃, sst₄, sst₂ and sst₅ respectively. CH 275 can be used for the research of Alzheimer’s disease.

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a potent and selective somatostatin receptor 1 (sst₁) agonist and display IC₅₀ values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst₁, sst₃, sst₄, sst₂ and sst₅ respectively. CH 275 can be used for the research of Alzheimer’s disease.

HY-P1203

BIM-23056	Somatostatin Receptor	Neurological Disease
BIM 23056, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with K_i values of 10.8, 5.7, respectively.

HY-P2036

FSL-1	Toll-like Receptor (TLR) Antibiotic	Infection
FSL-1 is a TLR2/6 agonist (also a putative TLR10 ligand). FSL-1 activates NF-κB. FSL-1 induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. FSL-1 synergizes with IFNγ to induce CXCL10 release from melanoma cells.

HY-P1203A

BIM-23056 TFA	Somatostatin Receptor	Neurological Disease
BIM 23056 TFA, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with K_i values of 10.8, 5.7, respectively.

HY-P2036A

FSL-1 TFA	Toll-like Receptor (TLR) Antibiotic	Infection
FSL-1 TFA is a TLR2/6 agonist (also a putative TLR10 ligand). FSL-1 TFA activates NF-κB. FSL-1 TFA induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. FSL-1 TFA synergizes with IFNγ to induce CXCL10 release from melanoma cells.

HY-P1682

Balixafortide POL6326	CXCR	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.

HY-P1682A

Balixafortide TFA POL6326 TFA	CXCR	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects.

HY-P1530

Prolactin Releasing Peptide (12-31), human	Peptides	Neurological Disease
Prolactin Releasing Peptide (12-31), human is a fragment of the prolactin releasing peptide (PrRP). Prolactin Releasing Peptide (1-31), human is a high affinity *GPR10* ligand that cause the release of the prolactin.

HY-P0292

GnRH-I	Peptides	Endocrinology
GnRH-I is a small 10 amino acid long peptide (decapeptide) from the hypothalamus, acts at the hypophysis to cause an increase in release of biologically active Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the blood.

HY-P1495

Small Cardioactive Peptide B SCPB	Adenylate Cyclase	Neurological Disease Cardiovascular Disease
Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀s of 0.1 and 1.0 μM, respectively.

HY-P1299

UFP-101	Opioid Receptor	Neurological Disease
UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pK_i of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect.

HY-P1299A

UFP-101 TFA	Opioid Receptor	Neurological Disease
UFP-101 TFA is a potent, selective, and competitive antagonist of the NOP receptor, with a pK_i of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect.

HY-P1126

Dolastatin 15 DLS 15	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin.

HY-P1422

Spadin	Potassium Channel	Neurological Disease
Spadin, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin binds specifically to TREK-1 with an affinity of 10 nM. Spadin is an efficient antidepressant in mice.

HY-P1422A

Spadin TFA	Potassium Channel	Neurological Disease
Spadin TFA, a natural peptide derived from a propeptide released in blood, is able to block the TREK-1 (KCNK2 or K_2P2.1) channel activity. Spadin TFA binds specifically to TREK-1 with an affinity of 10 nM. Spadin TFA is an efficient antidepressant in mice.

HY-P0329

X-press Tag Peptide	Peptides	Others
X-press Tag Peptide is a tag peptide used for protein purification. X-press Tag is also an N-terminal leader peptide; this N-terminal peptide contains a polyhistidine sequence, the Xpress epitope (part of bacteriophage T7 gene 10 protein) and an enterokinase cleavage site. Anti-Xpress antibodies recognize the Xpress epitope sequence found in this leader peptide.

HY-P2336

CCZ01048	Melanocortin Receptor	Cancer
CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.

HY-P2336A

CCZ01048 TFA	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma.

HY-P1300

[(pF)Phe4]Nociceptin(1-13)NH2	Opioid Receptor	Neurological Disease
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pK_i of 10.68 and a pEC₅₀ of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).

HY-P2231A

Cotadutide acetate MEDI0382 acetate	Glucagon Receptor	Metabolic Disease
Cotadutide acetate (MEDI0382 acetate) is a potent peptide dual agonist of glucagon-like peptide-1 (GLP-1) and glucagon receptor with EC₅₀ values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate (MEDI0382 acetate) exhibits ability to facilitate both weight loss and glycaemic control, has the potential for obesity and type 2 diabetes (T2D) treatment.

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8).

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8).

HY-P1274A

ShK-Dap22 TFA	Potassium Channel	Inflammation/Immunology
ShK-Dap22 TFA is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 TFA is a selective Kv1.3 channel blocker with IC₅₀s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively.

HY-P1345

TLQP-21	Complement System	Endocrinology Neurological Disease
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions.

HY-P1345A

TLQP-21 TFA	Complement System	Endocrinology Neurological Disease
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions.

HY-P1404

R8-T198wt	Pim
R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

Cat. No.	Product Name

HY-K1011

3-Color Prestained Protein Marker (10-190 kDa)
MCE 3-Color Prestained Protein Marker (10-190 kDa) is a three-color protein standard with 10 prestained proteins ranging from 10 kDa to 190 kDa.

HY-K0200

Magnetic Stand

The MCE Magnetic Stand is optimized for efficient magnetic separation of all types of MCE Magnetic Beads with sample volumes ranging from 10 μL to 15 mL.

HY-K1007

Red Nucleic Acid Gel Stain (10,000×)
Red Nucleic Acid Gel Stain (10,000×) is a nucleic acid stain that can be used as a safer alternative to the traditional ethidium bromide (EB) stain for detecting nucleic acids in agarose gels or polyacrylamide gels.

Cat. No.	Product Name	Target	Research Area

HY-P1279A

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.

Cat. No.	Product Name	Target	Category

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Microtubule/Tubulin	Natural Products
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines.

HY-N0095

(S)-10-Hydroxycamptothecin 10-HCPT; 10-Hydroxycamptothecin	Topoisomerase Apoptosis	Alkaloids
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.

HY-N0275

(±)-10-Hydroxycamptothecin (±)-10-HCPT	Topoisomerase	Alkaloids
(±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-N0446

10-Methoxycamptothecin	Others	Alkaloids
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines.

HY-15580

Dolastatin 10 DLS 10; NSC 376128	Microtubule/Tubulin ADC Cytotoxin	Natural Products
Dolastatin 10 (DLS 10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.

HY-N2434

[10]-Shogaol	COX	Phenols
[10]-Shogaol is an antioxidant from Zingiber officinale for human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC₅₀ of 7.5 μM and has antiproliferation activity.

HY-N0448

10-Gingerol	Others	Natural Products
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC₅₀ of 12.1 μM.

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	Others	Natural Products
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM.

HY-16565

10-Deacetylbaccatin III
Others Terpenoids and Glycosides

10-Deacetylbaccatin-III is an intermediate for taxol analog preparations.

HY-N0111

Coenzyme Q10 CoQ10; Ubiquinone-10	Endogenous Metabolite Reactive Oxygen Species Ferroptosis	Quinones
Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Microtubule/Tubulin ADC Cytotoxin	Alkaloids Saccharides and Glycosides
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-N6679A

10,11-Dehydrocurvularin	HSP TGF-beta/Smad	Natural Products
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.

HY-113450

10Z-Nonadecenoic acid
Endogenous Metabolite Acids and Aldehydes

10Z-Nonadecenoic acid is a kind of long-chain fatty acid with anti-tumor activity.

HY-129554

cis-9,10-Epoxystearic acid cis-9,10-Epoxyoctadecanoic acid	Endogenous Metabolite	Acids and Aldehydes
cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) is an endogenous constituent in human blood and urine. cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) can be produced from oleic acid by enzymic and non-enzymic epoxidation.

HY-B0914

10-Undecenoic acid Undecylenic acid	Fungal Endogenous Metabolite Antibiotic	Acids and Aldehydes
10-Undecenoic acid was used as a starting reagent in the syntheses of Pheromone (11Z)-hexadecenal.

HY-N0181A

Lumisterol 9β,10α-Ergosterol	Endogenous Metabolite	Steroids
Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities.

HY-N1463

Luteolin 7-O-glucuronide Luteolin 7-glucuronide	MMP	Flavonoids Saccharides and Glycosides
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-Y0148

10-Hydroxydecanoic acid NSC 15139	Others	Acids and Aldehydes
10-Hydroxydecanoic acid (NSC 15139) is a saturated fatty acid of 10-hydroxy-trans-2-decenoic acid from royal jelly, with anti-inflammatory activity.

HY-N1454

Apigenin-7-glucuronide Apigenin 7-O-glucuronide	MMP	Flavonoids
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-N6834

Fructo-oligosaccharide DP10/GF9	Others	Saccharides and Glycosides
Fructo-oligosaccharide DP10/GF9 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=10). Fructo-oligosaccharides (FOS) are composed of 9 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end.

HY-128553

Antineoplaston A10	Ras Endogenous Metabolite	Natural Products
Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

HY-N6679

(R)-10,11-Dehydrocurvularin	Others	Natural Products
(R)-10,11-Dehydrocurvularin is a secondary metabolite isolated from Curvularia sp.. (R)-10,11-Dehydrocurvularin displays concentration-dependent cytotoxicity towards human tumor cell lines with a mean IC₅₀ value of 1.25 µM.

HY-B0107

Acitretin
Ro 10-1670
RAR/RXR Autophagy Apoptosis Acids and Aldehydes

Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

HY-N6846

10-Isobutyryloxy-8,9-epoxythymol isobutyrate	Bacterial	Natural Products
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively.

HY-N7008

Fructo-oligosaccharide DP11/GF10	Others	Saccharides and Glycosides
Fructo-oligosaccharide DP11/GF10 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=11). Fructo-oligosaccharides (FOS) are composed of 10 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end.

HY-B0914A

10-Undecenoic acid zinc salt Zinc undecylenate	Fungal Antibiotic	Acids and Aldehydes
10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.

HY-113952

Actinonin (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Natural Products
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities.

HY-N1940

β-Anhydroicaritin	Interleukin Related TNF Receptor MMP	Flavonoids
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties^{[1]MMP-3 in diabetic rats. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca²⁺, and markedly decreases iNOS protein expression.}

HY-N0431

Astragaloside IV	MMP ERK JNK	Saccharides and Glycosides Terpenoids and Glycosides
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-N0532

Morroniside
MMP Saccharides and Glycosides Terpenoids and Glycosides

Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
HY-N2117

Isoginkgetin
MMP Flavonoids

Isoginkgetin is a MMP-9 inhibitor, also a Pre-mRNA Splicing Inhibitor with IC 50 of 30 uM.

HY-N0069

Solamargine Solamargin; δ-Solanigrine	P-glycoprotein Apoptosis	Alkaloids Saccharides and Glycosides Steroids
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity.

HY-N1981

Triolein
MMP Endogenous Metabolite Natural Products

Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties.

HY-N0262

Cordycepin 3'-Deoxyadenosine	MMP Bacterial Autophagy Antibiotic	Alkaloids
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative isolated from Cordyceps and inhibits IL-1β-induced *MMP-1* and *MMP-3* expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner. Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase.

HY-N0318

Salvianolic acid A
MMP Acids and Aldehydes

Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

HY-N6862

Lucideric acid A	MMP	Terpenoids and Glycosides
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells.

HY-N6860

Lucidenic acid C	MMP	Terpenoids and Glycosides
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells.

HY-N6844

8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol	Others	Natural Products
8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. 8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol also shows marked antipro-liferative activity against human cancer cell lines in vitro.

HY-77813

Benzyl isothiocyanate	Bacterial Apoptosis Antibiotic	Natural Products
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells.

HY-N0565B

Doxycycline (hyclate) Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031	MMP Bacterial Antibiotic	Natural Products
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

HY-N6013

Aloin(mixture of A&B)	MMP Bacterial Fungal	Quinones Saccharides and Glycosides
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases *(MMPs)*.

HY-N2388

Auraptene	MMP	Phenylpropanoids
Auraptene is the most abundant naturally occurring geranyloxycoumarin. Auraptene is primarily isolated from plants in the Rutaceae family, such as citrus fruits. Auraptene decreases the secretion of matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8, and chemokine (C-C motif) ligand-5(CCL5).

HY-N0774

Isofraxidin	COX MMP Toll-like Receptor (TLR)	Phenylpropanoids
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits *MMP-7* expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.

HY-N2205

Esculentoside H	NF-κB JNK	Saccharides and Glycosides Terpenoids and Glycosides
Esculentoside H (EsH) is a water-soluble saponin isolated and purified from the root extract of perennial plant Phytolacca esculenta. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease. Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression.

HY-B2162

Chondroitin sulfate Chondroitin polysulfate	NO Synthase MMP Endogenous Metabolite	Natural Products
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and *MMPs*.

HY-15459

Cabazitaxel XRP6258; RPR-116258A; taxoid XRP6258	Microtubule/Tubulin Autophagy	Natural Products
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

HY-N2350

Cynaropicrin	MMP NF-κB TNF Receptor	Terpenoids and Glycosides
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

HY-N2497

Isoliquiritin apioside	NF-κB MMP p38 MAPK	Flavonoids
Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in *MMP9* activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.

HY-N5072

Desmethylglycitein 4',6,7-Trihydroxyisoflavone	CDK PI3K PKC	Alkaloids
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes.

HY-N0088

Apocynin
Acetovanillone
Autophagy Apoptosis Phenols

Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM.
HY-N0845

Epoxymicheliolide
1β,10β-Epoxymicheliolide
Others Terpenoids and Glycosides

Epoxymicheliolide is a micheliolide derivative.

HY-42034

Hydroquinine	Others	Natural Products
Hydroquinine is a cinchona alkaloid, can be used in the preparation of its derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine and 10,11-dihydroquinine monohydrochloride.

HY-23119

Sodium thiocyanate Thiocyanate sodium	Interleukin Related Reactive Oxygen Species	Natural Products
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine *IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation.

HY-N2194

Bergamottin
5-Geranoxypsoralen; Bergamotine; Bergaptin
Cytochrome P450 Phenylpropanoids

Bergamottin is a potent and competitive CYP1A1 inhibitor with a K_i of 10.703 nM.

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Natural Products
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of *MMP-1*, it can be considered as an active ingredient in new topically applied anti-ageing formulations.

HY-113252

2-Methoxyestrone
Endogenous Metabolite Steroids

2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
HY-N6816

Ludaconitine
Parasite Alkaloids

Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC₅₀ of 36.10 μg/mL.

HY-N2337

11beta-Hydroxyprogesterone 11β-Hydroxyprogesterone	Endogenous Metabolite	Steroids
11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED₅₀ of 10 nM.

HY-W013215

Adrenic Acid
cis-7,10,13,16-Docosatetraenoic acid
Endogenous Metabolite Natural Products

Adrenic Acid is an inflammation enhancer in non-alcoholic fatty liver disease.

HY-N2300

Kuwanon A	NO Synthase	Flavonoids
Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC₅₀ of 10.5 μM.

HY-N1401

20(R)-Ginsenoside Rh2	MMP Apoptosis HSV	Saccharides and Glycosides Terpenoids and Glycosides
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC₅₀ of 2.77 μM for murine MHV-68.

HY-N5132

(-)-Fenchone	Others	Terpenoids and Glycosides
(-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Thuja occidentalis. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6.

HY-N1490

14-Deoxy-11,12-didehydroandrographolide 14-dehydro Andrographolide; AP10	NF-κB	Terpenoids and Glycosides
14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide that can be isolated from A. paniculata. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation.

HY-N2503

Ginsenoside F4	Apoptosis MMP	Saccharides and Glycosides Terpenoids and Glycosides
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues.

HY-P0292

GnRH-I	Others	Natural Products
GnRH-I is a small 10 amino acid long peptide (decapeptide) from the hypothalamus, acts at the hypophysis to cause an increase in release of biologically active Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the blood.

HY-N0163

Magnolol	RAR/RXR PPAR Autophagy Bacterial	Phenylpropanoids
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC₅₀ values of 10.4 µM and 17.7 µM, respectively.

HY-N6774

Cytochalasin C	Others	Natural Products
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D.

HY-N1272

Secaubryenol	Endogenous Metabolite	Terpenoids and Glycosides
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 µg/mL.

HY-N4070

6"-O-Acetylgenistin	Others	Flavonoids
6"-O-Acetylgenistin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetylgenistin significantly inhibits lipid peroxidation in rat liver microsome with an IC₅₀ of 10.6 μM.

HY-N6607

Tryptanthrin	Others	Natural Products
Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin inhibits LT formation in human whole blood (IC₅₀ = 10 µM) and reduces LTB4 levels in the rat pleurisy model.

HY-N1910

4'-O-Methylbavachalcone	SARS-CoV	Flavonoids
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM.

HY-N3511

Triptonine B	HIV	Alkaloids
Triptonine B, a sesquiterpene pyridine alkaloid that isolated from Tripterygium hypoglaucum and Tripterygium wilfordii, inhibits HIV replication in H9 lymphocytes with an EC₅₀ value of <0.10 μg/mL.

HY-W016867

4-Chlorosalicylic acid	Fungal Bacterial	Acids and Aldehydes
4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC₅₀s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.

HY-N3797A

Echitamine chloride	Apoptosis	Alkaloids
Echitamine chloride is the major monoterpene indole alkaloid present in Alstonia with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 µM.

HY-N1363

Royal Jelly acid Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid	Endogenous Metabolite	Acids and Aldehydes
Royal Jelly acid (Queen Bee Acid) is a fatty acid constituent of royal jelly, promotes the growth and protection of neurons, reduces anxiety-like phenotypes.

HY-129150

Ganoderic acid TR	Influenza Virus	Terpenoids and Glycosides
Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H5N1 and H1N1 neuraminidases. The IC₅₀ values of 10.9 and 4.6 μM, respectively.

HY-N1504

Loureirin B	PAI-1 Potassium Channel ERK JNK	Flavonoids
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-B1213

Trimipramine maleate	5-HT Receptor Bacterial	Natural Products
Trimipramine maleate is a 5-HT receptor antagonist, with pK_is of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively.

HY-108568

15-Deoxy-Δ-12,14-prostaglandin J2 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2	PPAR Endogenous Metabolite	Natural Products
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM.

HY-N0505

Rosiridin	Monoamine Oxidase	Terpenoids and Glycosides
Rosiridin, which is isolated from Rhodiola rosea L., inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC₅₀=5.38).

HY-15464

(R)-(-)-Gossypol AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Phenols
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N2016

Arteannuin B	SARS-CoV Ferroptosis	Natural Products
Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae). Arteannuin B shows anti-SARS-CoV-2 potential with an EC₅₀ of 10.28 μM.

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	TNF Receptor Interleukin Related	Flavonoids
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 and 10.8 μM, respectively.

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Saccharides and Glycosides Terpenoids and Glycosides
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10).

HY-N7450

Icariside D2	Angiotensin-converting Enzyme (ACE) Apoptosis HIV	Saccharides and Glycosides
Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC₅₀ value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis .

HY-N0171B

Beta-Sitosterol (purity>75%) β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%)	Apoptosis	Steroids
Beta-Sitosterol (purity>75%) includes 75% β-sitosterol and 10% campesterol. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (purity>75%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation.

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Tyrosinase	Phenols
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC₅₀ of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant.

HY-B0708

β-Estradiol 17-acetate
1,3,5(10)-Estratriene-3,17β-diol 17-acetate
Estrogen Receptor/ERR Steroids

β-Estradiol 17-acetate is a metabolite of estradiol.

HY-N2450

Sulforaphene	Apoptosis EGFR ERK NF-κB	Natural Products
Sulforaphene, isolated from radish seeds, exhibits an ED₅₀ against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals.

HY-N5020

Carabrone	Bacterial	Terpenoids and Glycosides
Carabrone is isolated from the fruits of Carpesium abrotanoides , is a well-known sesquiterpene and exhibits significant anti-bacterial and anti-tumor activities. Carabrone exhibits antifungal activities in vitro and in vivo against Botrytis cinerea, Colletotrichum lagenarium(EC₅₀=7.10 μg/mL) and Erysiphe graminis.

HY-14520

Tetrahydrofolic acid L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Natural Products
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.

HY-N4110

Friedelin	Cytochrome P450	Natural Products
Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC₅₀ and K_ivalues of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC₅₀ and K_i values of 22.54 μM and 18.02 μM, respectively.

HY-N6785

Okadaic acid	Phosphatase Parasite Apoptosis	Alkaloids
Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A and PP3 inhibitor with IC₅₀s of 10-15 nM, 0.5 nM and 4 nM, respectively. Okadaic acid eliminate metazoan symbionts/parasites by apoptosis.

HY-N2284

Sophoflavescenol	AChE Beta-secretase Phosphodiesterase (PDE)	Flavonoids
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.

HY-124151

Adenosine-2'-monophosphate 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate	Adenosine Receptor Endogenous Metabolite	Acids and Aldehydes
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation.

HY-107417

Hypothemycin	VEGFR MEK FLT3 PDGFR ERK	Natural Products
Hypothemycin, a fungal polyketide, is a multikinase inhibitor with K_is of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively.

HY-N2484

Methylnissolin Astrapterocarpan	PDGFR ERK	Saccharides and Glycosides
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade.

HY-N2959

Brevilin A	JAK STAT Apoptosis Autophagy	Terpenoids and Glycosides
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC₅₀ = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.

HY-113038

D-α-Hydroxyglutaric acid (R)-2-Hydroxypentanedioic acid	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite	Acids and Aldehydes
D-α-Hydroxyglutaric acid ((R)-2-Hydroxypentanedioic acid) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.

HY-N7176

Kaempferol 3-O-β-D-glucuronide Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide	Interleukin Related	Saccharides and Glycosides Flavonoids
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.

HY-16558

Butein 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Phenols
Butein, isolated from Dalbergia odorifera T. Chen, is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60^c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC).

Cat. No.	Product Name	Species	Source

HY-P7226

Recombinant Human IP-10/CXCL10 rHuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1	Human	E. coli
Recombinant Human IP-10/CXCL10 is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties.

HY-P7227

Recombinant Mouse IP-10/CXCL10 rMuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1	Mouse	E. coli
Recombinant Mouse IP-10/CXCL10 is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties.

HY-P7513

Recombinant Human Annexin A10
rHuAnnexin A10; ANXA10; Annexin A10
Human E. coli
HY-P7567

Recombinant Mouse Interleukin-10
rMuIL-10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10
Mouse E. coli
HY-P7594

Recombinant Mouse FGF-10 Protein
rMuFGF-10 Protein; Fibroblast growth factor 10; FGF-10; Keratinocyte growth factor 2; Fgf10
Mouse E. coli

HY-P7225

*Recombinant Rat IP-10/CRG-2/CXCL10* (HEK293-expressed)** rRtIP-10/CRG-2/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1	Rat	HEK 293
Recombinant Rat IP-10/CRG-2/CXCL10 (HEK293-expressed) is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties.

HY-P7030

Recombinant Human Interleukin-10
rHuIL-10; CSIF
Human E. coli

Recombinant Human Interleukin-10 is an anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P7098

Recombinant Rat Interleukin-10 rRtIL-10; CSIF	Rat	E. coli
Recombinant Rat Interleukin-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macophages, monocytes, B-cells, T-cells and keratinocytes.

HY-P7170

Recombinant Mouse Fibroblast Growth Factor-10 rMuFGF-10; Keratinocyte growth factor-2; Fgf10	Mouse	E. coli
Recombinant Mouse Fibroblast Growth Factor-10 is a paracrine signaling molecule and is involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands.

HY-P7030A

Recombinant Human Interleukin-10 (CHO-expressed) rHuIL-10; CSIF	Human	CHO
Recombinant Human Interleukin-10 (CHO-expressed) is a CHO cell derived anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P7098A

Recombinant Rat Interleukin-10 (CHO-expressed) rRtIL-10; CSIF	Rat	CHO
Recombinant Rat Interleukin-10 (CHO-expressed) is a CHO cell derived immunosuppressive cytokine produced by a variety of mammalian cell types including macophages, monocytes, B-cells, T-cells and keratinocytes.

HY-P7074A

Recombinant Mouse Interleukin-10 (CHO-expressed) rMuIL-10; CSIF	Mouse	CHO
Recombinant Mouse Interleukin-10 (CHO-expressed) is a potent CHO cell derived anti-inflammatory cytokine results in increased immune-mediated demyelination in mice infected with a neurotropic coronavirus.

HY-P7048

Recombinant Human Keratinocyte Growth Factor-2/FGF-10 rHuKGF-2/FGF-10; Fibroblast Growth Factor-10	Human	E. coli
Recombinant Human Keratinocyte Growth Factor-2/FGF-10 is a heparin-binding protein that binds to FGF2 IIIb and FGFR1III-b receptors, promotes the growth, proliferation, and differentiation of epithelial cells and can enhance corneal wound healing.

HY-P7342

Recombinant Human Fibroblast Growth Factor 10, His rHuFGF-10, His; Fibroblast Growth Factor-10; Keratinocyte growth factor-2	Human	E. coli
Recombinant Human Fibroblast Growth Factor 10, His is a polypeptide chain with His Tag. FGF-10 is a heparin-binding growth factor that belongs to the FGF family.

HY-P7214

Recombinant Human Interleukin-20 rHuIL-20; IL20; Cytokine Zcyto10	Human	E. coli
Recombinant Human Interleukin-20 is a member of the IL-10 family of cytokines. Interleukin-20 binds to the IL-20 heterodimeric receptor with a K_d of 1.5 nM.

HY-P7307

Recombinant Human Tumor necrosis factor-related apoptosis-inducing ligand Receptor-2/TNFRSF10B (HEK293-expressed) rHuTRAILR-2/TNFRSF10B; CD262; DR5; KILLER	Human	HEK 293
Recombinant Human Tumor necrosis factor-related apoptosis-inducing ligand Receptor-2/TNFRSF10B (HEK293-expressed) is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

HY-P7306

Recombinant Human TRAIL/Apo2L rHuTRAIL/Apo2L; TNFSF10; CD253	Human	E. coli
Recombinant Human TRAIL/Apo2L is a protein functioning as a ligand that induces the process of apoptosis through engagement of death receptors.

HY-P7332

Recombinant Human Bone Morphogenetic Protein-3B rHuBMP-3B; BIP; BMP-3B; GDF-10	Human	E. coli
Recombinant Human Bone Morphogenetic Protein-3B belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). Recombinant Human Bone Morphogenetic Protein-3B plays a role in head formation and may have multiple roles in skeletal morphogenesis.

HY-P7143

Recombinant Mouse CCL6 rMuCCL6; C-C motif chemokine 6; Scya6; C10	Mouse	E. coli
Recombinant Mouse CCL6, a CC chemokine, plays a role in chronic inflammation associated with macrophage infiltration.

HY-P7239

Recombinant Mouse MCP-2/CCL8 rMuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8	Mouse	E. coli
Recombinant Mouse Monocyte Chemotactic Protein-2/CCL8 is a small cytokine of the CC chemokine family which activates many different immune cells, including mast cells, eosinophils, basophils, and monocytes, T cells, and NK cells.

HY-P7238

Recombinant Human Monocyte Chemotactic Protein-2/CCL8 rHuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8	Human	E. coli
Recombinant Human Monocyte Chemotactic Protein-2/CCL8 is a small cytokine of the CC chemokine family which activates many different immune cells, including mast cells, eosinophils, basophils, and monocytes, T cells, and NK cells.

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