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Results for "

109 99 9 99.9 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (1) Apoptosis (8) Aurora Kinase (1) Autophagy (6) Bacterial (2) Beta-lactamase (1) Biochemical Assay Reagents (4) CDK (2) Cholinesterase (ChE) (1) COX (1) Dopamine Receptor (3) Dopamine Transporter (1) Epigenetic Reader Domain (2) ERK (1) FAK (1) FGFR (2) FLT3 (1) Fungal (1) Haspin Kinase (1) Histamine Receptor (2) Histone Demethylase (1) Histone Methyltransferase (1) HIV (1) Insecticide (1) Integrin (1) Isotope-Labeled Compounds (3) JAK (1) MASTL (1) MEK (9) MMP (1) Monoamine Oxidase (1) mTOR (2) Opioid Receptor (2) Oxytocin Receptor (1) P-selectin (1) Parasite (1) PDGFR (2) PGE synthase (1) Phosphodiesterase (PDE) (2) PI3K (5) PI5P4K (1) Platelet-activating Factor Receptor (PAFR) (1) Prostaglandin Receptor (1) Proton Pump (1) RET (1) RSV (1) SARS-CoV (1) Small Interfering RNA (siRNA) (1) Trk Receptor (1) VEGFR (3)
By Research Areas:	Cancer (29) Cardiovascular Disease (3) Endocrinology (3) Infection (5) Inflammation/Immunology (7) Neurological Disease (10)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: GPR109A Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1881A

*Copper sulfate pentahydrate, 99.9%*	Biochemical Assay Reagents	Others
Copper sulfate pentahydrate, commonly used biochemical reagents. Copper sulfate pentahydrate, 99.9% indicates that it is almost entirely pure, making it suitable for uses in laboratory experiments, chemical synthesis, and some pharmaceutical applications.

HY-W088074A

*Chromium(III)oxide, 99.9% trace metals basis*	Biochemical Assay Reagents	Others
Chromium(III)oxide, 99.9% trace metals basis is an important refractory material with its high melting point temperature and oxidation resistance .

HY-100315

XL 999 Tyrosine kinase-IN-1	VEGFR PDGFR FGFR	Cardiovascular Disease Cancer
XL999 is a multi-target tyrosine kinase inhibitor. XL999 has IC₅₀ values for KDR, Flt-1, FGFR1 and PDGFRα of 4 nM, 20 nM, 4 nM and 2 nM, respectively. XL999 can be used in the research of cancer .

HY-111371

PF-05180999 PF-999	Phosphodiesterase (PDE)	Neurological Disease
PF-05180999 (PF-999) is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC₅₀ of 1.6 nM.

HY-ER013B

Sodium carbonate anhydrous, 99.999% trace metals basis Calcined soda 99.999% trace metals basis	Biochemical Assay Reagents	Others
Sodium carbonate anhydrous, 99.999% trace metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-116578

Metopimazine EXP999; RP9965	Dopamine Receptor	Neurological Disease
Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

HY-148507

GSK1790627 1 Publications Verification	MEK	Cancer
GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis .

HY-153181

Trametiglue	MEK	Cancer
Trametiglue, a derivative of Trametinib (HY-10999), targets both KSR-MEK and RAF-MEK with unprecedented potency and selectivity via unique interfacial binding interactions .

HY-121810

LBT-999	Dopamine Transporter	Others
LBT-999 is a phenyltropane derivative used for positron emission tomography (PET) exploration of the dopamine transporter (DAT). It has high affinity binding to DAT on rat striatal membranes and human postmortem brain slices in vitro, high uptake in the striatum in rat and baboon models in vivo, and its binding can be blocked by specific compounds.

HY-Y0286A

Diammonium carbonate, 99.999% trace metals basis Carbonic acid (diammonium), 99.999% trace metals basis	Biochemical Assay Reagents	Others
Diammonium carbonate, 99.999% trace metals basis is a biochemical reagent and a buffer component .

HY-116578S

Metopimazine-d6 EXP999-d₆; RP9965-d₆	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease
Metopimazine-d₆ is the deuterium labeled Metopimazine (HY-116578). Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

HY-169407

AKT-IN-24	Akt mTOR MEK ERK Apoptosis	Cancer
KT-IN-24 (Compound M17) is a AKT allosteric inhibitor with anti-tumor activity. KT-IN-24 can target the AKT/mTOR and MEK/ERK signaling pathways and inhibit epithelial-mesenchymal transition, which has a synergistic suppressive effect on TNBC, promoting cell apoptosis while inhibiting proliferation and migration when used in combination with Trametinib (HY-10999) .

HY-135856

SARS-CoV-IN-2 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC₅₀ of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 21.5 and 30 nM; and IC₉₀s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .

HY-113945

Abbeymycin	Antibiotic Bacterial	Infection
Abbeymycin is an antibiotic derived from the actinobacterium Streptomyces sp. AB-999F-52. Abbeymycin is a specifically acting antibiotic with antimicrobial activity, primarily targeting anaerobic bacteria. Abbeymycin is employed in research concerning antibiotic discovery and screening .

HY-141843

BRD4-IN-2	Epigenetic Reader Domain	Inflammation/Immunology
BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC₅₀ value of 9.9 nM.

HY-19535B

Nemiralisib succinate GSK2269557 succinate	PI3K	Cancer
Nemiralisib Succinate is a potent and highly selective PI3Kδ inhibitor with a pK_i of 9.9.

HY-11097

TMC353121 5+ Cited Publications	RSV	Infection
TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC₅₀ of 9.9.

HY-10999S

Trametinib-d4	MEK Autophagy Apoptosis	Cancer
Trametinib-d₄ is the deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-10999S2

Trametinib-13C,d3 GSK1120212-¹³C,d₃; JTP-74057-¹³C,d₃	Isotope-Labeled Compounds MEK Autophagy Apoptosis	Cancer
Trametinib- ¹³C,d₃ is the ¹³C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-10999

Trametinib Maximum Cited Publications 211 Publications Verification GSK1120212; JTP-74057	MEK Autophagy Apoptosis	Cancer
Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC₅₀s of about 2 nM. Trametinib activates autophagy and induces apoptosis .

HY-10999S1

Trametinib-13C6	MEK Autophagy Apoptosis	Cancer
Trametinib- ¹³C₆ is the ¹³C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-10999R

Trametinib (Standard)	MEK Autophagy Apoptosis	Cancer
Trametinib (Standard) is the analytical standard of Trametinib. This product is intended for research and analytical applications. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC₅₀s of about 2 nM. Trametinib activates autophagy and induces apoptosis .

HY-10999A

Trametinib (DMSO solvate) Maximum Cited Publications 211 Publications Verification GSK-1120212 (DMSO solvate); JTP-74057 (DMSO solvate)	MEK Apoptosis	Cancer
Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC₅₀s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis .

HY-N3453

Isotaxiresinol 9,9'-acetonide	Others	Others
Isotaxiresinol 9,9'-acetonide is a Lignans product that can be isolated from the branches of Taxus wallichiana .

HY-19535

Nemiralisib hydrochloride GSK2269557	PI3K	Cancer
Nemiralisib hydrochloride (GSK2269557) is a potent and highly selective PI3Kδ inhibitor with a pK_i of 9.9.

HY-N3475

9,9'-O-Isopropyllidene-isolariciresinol	Others	Others
9,9'-O-Isopropyllidene-isolariciresinol is a Lignans product that can be isolated from the barks of Pseudolarix kaempferi .

HY-105018

Epelsiban GSK 557296	Oxytocin Receptor	Endocrinology
Epelsiban (GSK 557296) is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pK_i of 9.9 for human oxytocin receptor.

HY-13470

GSK126 70+ Cited Publications GSK2816126A	Histone Methyltransferase	Cancer
GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC₅₀ of 9.9 nM .

HY-19535A

Nemiralisib GSK2269557 free base	PI3K	Cancer
Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pK_i of 9.9.

HY-164768

LT25	Integrin	Cancer
LT25 (compound 17) is a agonist of α5β1 integrin with EC₅₀ value of 9.9 nM .

HY-126134

HPGDS inhibitor 2	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC₅₀ of 9.9 nM .

HY-135002

LDN-209929	Haspin Kinase	Cancer
LDN-209929 is a potent haspin kinase inhibitor, with IC₅₀ values of 55 nM and 9.9 μM for Haspin and DYRK2, respectively .

HY-13806

XL388 4 Publications Verification	mTOR Autophagy	Cancer
XL388 is a highly potent and ATP-competitive mTOR inhibitor with an IC₅₀ of 9.9 nM. XL388 simultaneously inhibits both mTORC1 and mTORC2.

HY-16765A

Axelopran sulfate TD-1211 sulfate	Opioid Receptor	Neurological Disease
Axelopran sulfate is an opioid receptor antagonist with pKi values of 9.8, 8.8 and 9.9 for human recombinant μ and δ receptors and guinea pig κ receptor, respectively.

HY-114207

VinSpinIn	Epigenetic Reader Domain	Others
VinSpinIn is a Spindlin1 inhibitor (K_D: 9.9 nM for SPIN1_49-262). VinSpinIn is a chemical probe for tudor domain of Spindlin1. VinSpinIn can be used to study chromatin function .

HY-16765

Axelopran TD-1211	Opioid Receptor	Neurological Disease
Axelopran (TD-1211) is an opioid receptor antagonist with pKi values of 9.8, 8.8 and 9.9 for human recombinant μ and δ receptors and guinea pig κ receptor, respectively.

HY-N2563

Neocnidilide	Fungal	Infection
Neocnidilide is an alkylphthalide, which has the activity of inhibiting the growth of mycotoxin-producing fungi. Neocnidilide also has larvicidal activity against D. melanogaster with a LC₅₀ value of 9.9 μmol/mL .

HY-137552

MKI-1 MASTL Kinase Inhibitor-1	MASTL	Cancer
MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC₅₀ of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer .

HY-170911

KIT/PDGFRA-IN-1	PDGFR	Cancer
KIT/PDGFRA-IN-1 (compound 19) is a stem cell growth factor receptor (KIT) and platelet-derived growth factor receptor alpha (PDGFRA) inhibitor. KIT/PDGFRA-IN-1 inhibits KIT-wt, KIT-D816H, KIT-T670I, PDGFRA-wt, PDGFRA-D842V, PDGFRA-T674I and PDGFRA-G680R with IC₅₀s of 2.3, 12, 492, 0.8, 99.9, 42.3, and 4.3 μM, respectively. KIT/PDGFRA-IN-1 inhibits GIST-T1, T1-a-D842V and GIST-48B cells (PDGFR- and KIT-Mutant GIST cell Lines) with GR₅₀s of 12, 8900, ≥10 000 nM, respectively .

HY-NP109

Highly purified type I collagen, from mouse skin Mouse Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-N10999

Z-GMCA	Others	Others
GMCA is a natural product isolated from Matricaria chamomilla .

HY-RS10999

PPP1R3B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PPP1R3B Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1R3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PPP1R3B Human Pre-designed siRNA Set A PPP1R3B Human Pre-designed siRNA Set A

HY-109193

Tovinontrine IMR-687	Phosphodiesterase (PDE)	Cardiovascular Disease
Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC₅₀s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively .

HY-114338A

Dalpiciclib hydrochloride SHR-6390 hydrochloride	CDK	Cancer
Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC₅₀ values of 12.4 nM and 9.9 nM, respectively . Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esophageal squamous cell carcinoma .

HY-114338

Dalpiciclib SHR-6390	CDK	Cancer
Dalpiciclib (SHR-6390) is an orally active and highly selective inhibitor of CDK4 and 6 with IC₅₀ values of 12.4 nM and 9.9 nM, respectively . Dalpiciclib shows antitumor activity against breast cancer and esophageal squamous cell carcinoma .

HY-176042

Insecticidal agent 22	Insecticide	Others
Insecticidal agent 22 (Compound A13) is an insecticide, with LC₅₀s of 1.4 and 9.9 μg/mL for diamondback moth (Plutella xylostella) and fall armyworm (Spodoptera frugiperda), respectively. Insecticidal agent 22 can be used as a low-toxicity alternative to Fluralaner (HY-16973) .

HY-108634

Apafant 1 Publications Verification WEB 2086	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_i of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-19153

Nepaprazole rel-TY-11345 free base	Proton Pump	Inflammation/Immunology
Nepaprazole (rel-TY-11345 free base) is a proton pump inhibitor. Nepaprazole inhibits H ⁺/K ⁺-ATPase activity in isolated rabbit gastric mucosal microsomes with the IC₅₀ values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively. Nepaprazole can be used for study of peptic ulcer diseases .

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

HY-155028

FGFR-IN-11	FGFR	Cancer
FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC₅₀ values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models .

Cat. No.	Product Name

HY-L109

Protein-protein Interaction Inhibitor Library

674 compounds

Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs.

However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.

With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 674 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.

Cat. No.	Product Name	Type

HY-Y1881A

*Copper sulfate pentahydrate, 99.9%*	Buffer Reagents
Copper sulfate pentahydrate, commonly used biochemical reagents. Copper sulfate pentahydrate, 99.9% indicates that it is almost entirely pure, making it suitable for uses in laboratory experiments, chemical synthesis, and some pharmaceutical applications.

HY-W088074A

*Chromium(III)oxide, 99.9% trace metals basis*	Cell Assay Reagents
Chromium(III)oxide, 99.9% trace metals basis is an important refractory material with its high melting point temperature and oxidation resistance .

HY-ER013B

Sodium carbonate anhydrous, 99.999% trace metals basis Calcined soda 99.999% trace metals basis	Buffer Reagents
Sodium carbonate anhydrous, 99.999% trace metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y0286A

Diammonium carbonate, 99.999% trace metals basis Carbonic acid (diammonium), 99.999% trace metals basis	Chelators
Diammonium carbonate, 99.999% trace metals basis is a biochemical reagent and a buffer component .

HY-NP109

Highly purified type I collagen, from mouse skin Mouse Type I collagen, immunization grade	Native Proteins
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

Cat. No.	Product Name	Target	Research Area

HY-P99263

Inclacumab 1 Publications Verification Anti-Human selectin P Recombinant Antibody	P-selectin	Cardiovascular Disease
Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a K_d value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC₅₀ value of 1.9 μg/mL and strongly inhibits cell adhesion .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113945

Abbeymycin	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Antibiotic Bacterial
Abbeymycin is an antibiotic derived from the actinobacterium Streptomyces sp. AB-999F-52. Abbeymycin is a specifically acting antibiotic with antimicrobial activity, primarily targeting anaerobic bacteria. Abbeymycin is employed in research concerning antibiotic discovery and screening .

HY-N3453

Isotaxiresinol 9,9'-acetonide	Structural Classification Taxaceae Source classification Lignans Phenylpropanoids Plants Taxus wallichiana Zucc.	Others
Isotaxiresinol 9,9'-acetonide is a Lignans product that can be isolated from the branches of Taxus wallichiana .

HY-N3475

9,9'-O-Isopropyllidene-isolariciresinol	Structural Classification Pinaceae Source classification Lignans Pseudolarix amabilis (J. Nelson) Rehder Phenylpropanoids Plants	Others
9,9'-O-Isopropyllidene-isolariciresinol is a Lignans product that can be isolated from the barks of Pseudolarix kaempferi .

HY-N2563

Neocnidilide	Infection Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields	Fungal
Neocnidilide is an alkylphthalide, which has the activity of inhibiting the growth of mycotoxin-producing fungi. Neocnidilide also has larvicidal activity against D. melanogaster with a LC₅₀ value of 9.9 μmol/mL .

HY-N10999

Z-GMCA	Structural Classification Natural Products Source classification Distemonanthus benthamianus Baill. Plants Compositae	Others
GMCA is a natural product isolated from Matricaria chamomilla .

HY-152120

(±)-Aiphanol Aiphanol	Structural Classification Source classification Phenols Polyphenols Arecaceae Plants Aiphanes aculeata Willd	COX VEGFR
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC₅₀ = 1.9 μM) is particularly strong, while the effect on COX-2 (IC₅₀= 9.9 μM) is relatively weak .(±)-Aiphanol effectively inhibits VEGFR2 (IC₅₀=0.92 μM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active .

Cat. No.	Product Name	Chemical Structure

HY-116578S

Metopimazine-d6

Metopimazine-d₆ is the deuterium labeled Metopimazine (HY-116578). Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

HY-10999S

Trametinib-d4
Trametinib-d₄ is the deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-10999S2

Trametinib-13C,d3
Trametinib- ¹³C,d₃ is the ¹³C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-10999S1

Trametinib-13C6
Trametinib- ¹³C₆ is the ¹³C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

HY-143994S

Metopimazine acid-d6 hydrochloride

Metopimazine-d₆ hydrochloride is the deuterium labeled Metopimazine (HY-116578). Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81288

	Natriuretic Peptides B Antibody (YA999) NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide	ELISA	Human
	Natriuretic Peptides B Antibody (YA999) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA999), targeting Natriuretic Peptides B. Natriuretic Peptides B Antibody (YA999) can be used for ELISA experiment in human background.

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109 99 9 99.9 Inhibitors

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products