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Results for "

1177749 58 4 mmp Inhibitors

" in MedChemExpress (MCE) Product Catalog:

295

Inhibitors & Agonists

1

Screening Libraries

8

Fluorescent Dye

5

Biochemical Assay Reagents

44

Peptides

1

Inhibitory Antibodies

39

Natural
Products

38

Recombinant Proteins

7

Isotope-Labeled Compounds

13

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153563

    MMP Others
    MMP-7-IN-2 (compound 16) is a selective inhibitor of MMP7 with an IC50 value of 16 nM .
    <em>MMP</em>-7-IN-2
  • HY-147745

    MMP Cancer
    MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively .
    <em>MMP</em>2-IN-2
  • HY-P2179

    Fluorescent Dye MMP Others
    MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm
    <em>MMP</em>-1/<em>MMP</em>-9 Substrate, Fluorogenic
  • HY-119423

    MMP Cancer
    MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively .
    <em>MMP</em> Inhibitor II
  • HY-P2166

    MMP Cancer
    MMP3 inhibitor 3 is an inhibitor of MMP3. MMP3 inhibitor 3 can used to study breast cancer .
    <em>MMP</em>3 inhibitor 3
  • HY-161284

    MMP Cancer
    MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 Inhibotor with IC50s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) .
    <em>MMP</em>-9/10-IN-1
  • HY-156430

    MMP Cancer
    MMP-7-IN-3 is a potent and selective inhibitor of MMP-7. MMP-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .
    <em>MMP</em>-7-IN-3
  • HY-146754

    MMP Apoptosis Cancer
    MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis .
    <em>MMP</em>2-IN-1
  • HY-146006

    Microtubule/Tubulin MMP Cancer
    Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway .
    Tubulin/<em>MMP</em>-IN-1
  • HY-128026

    MMP Inflammation/Immunology
    MMP-9/MMP-13 Inhibitor I is a potent MMP-9 and MMP-13 inhibitor with IC50s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs .
    <em>MMP</em>-9/<em>MMP</em>-13 Inhibitor I
  • HY-116399

    MMP Cancer
    MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer .
    <em>MMP</em>-2/<em>MMP</em>-9-IN-1
  • HY-P2682

    MMP Metabolic Disease
    MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
    <em>MMP</em>-8/<em>MMP</em>-26 Fluorogenic substrate
  • HY-128133

    mmp8-I

    MMP Cancer
    MMP-8 inhibitor-1 (compound 21), a hydroxamic acid derivative, is a potent MMP-8 inhibitor without significant oral bioavailability .
    <em>MMP</em>-8 inhibitor-1
  • HY-P2414

    MMP Inflammation/Immunology
    MMP-13 Substrate is a substrate of MMP-13. MMP-13 Substrate can be used for the research of osteoarthritis (OA) .
    <em>MMP</em>-13 Substrate
  • HY-14155

    MMP Inflammation/Immunology
    MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch .
    <em>MMP</em>145
  • HY-116302

    MMP Neurological Disease Inflammation/Immunology
    MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects .
    <em>MMP</em>-9-IN-9
  • HY-130076

    MMP Cancer
    MMP-2 Inhibitor II (compound 2) is a selective MMP-2 inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively .
    <em>MMP</em>-2 Inhibitor II
  • HY-146218

    MMP Akt Apoptosis Cancer
    MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers .
    <em>MMP</em>-9-IN-5
  • HY-146216

    MMP Akt Apoptosis Cancer
    MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers .
    <em>MMP</em>-9-IN-3
  • HY-147746

    MMP Cancer
    MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC50 values of 26.6, and 32 μM, respectively .
    <em>MMP</em>2-IN-3
  • HY-146217

    MMP Akt Apoptosis Cancer
    MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers .
    <em>MMP</em>-9-IN-4
  • HY-153913

    MMP Inflammation/Immunology
    MMP-9-IN-7 is a potent MMP9 inhibitor with an IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research .
    <em>MMP</em>-9-IN-7
  • HY-135232
    MMP-9-IN-1
    5 Publications Verification

    MMP Cancer
    MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs .
    <em>MMP</em>-9-IN-1
  • HY-151540

    MMP Cancer
    MMP-7-IN-1 is a potent and selective inhibitor of MMP-7 over MMP-1, -2, -3, -8, -9, -13 with an IC50 value of 10 nM. MMP-7 is a potential target for diseases including cancer and fibrosis .
    <em>MMP</em>-7-IN-1
  • HY-122624

    MMP Inflammation/Immunology
    MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research .
    <em>MMP</em>13-IN-2
  • HY-154868

    MMP Cardiovascular Disease Cancer
    MMP-13-IN-1 is a potent and selective inhibitor of MMP-13 with a IC50 value of 16 nM. MMP-13-in-1 can be used for atherosclerosis research .
    <em>MMP</em>-13-IN-1
  • HY-152030

    Microtubule/Tubulin MMP Apoptosis Cancer
    Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC50 values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer .
    Tubulin/<em>MMP</em>-IN-2
  • HY-112546

    MMP Cancer
    MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor with a Ki of 1.7 μM .
    <em>MMP</em>-2 Inhibitor I
  • HY-149378

    MMP Metabolic Disease
    MMP13-IN-5 (compound 13m) is a potent and selective inhibitor of MMP-2/MMP-13 (IC50=3.6 μM/14.6 μM),involved in osteoarthritis (OA) .
    <em>MMP</em>13-IN-5
  • HY-110046

    MMP Others
    CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE .
    CL-82198 hydrochloride
  • HY-152092

    MMP Cancer
    MMP-1-IN-1 (Compound 6) is a highly potent MMP-1 inhibitor with an IC50 of 0.034 μM .
    <em>MMP</em>-1-IN-1
  • HY-130391

    MMP Inflammation/Immunology
    MMP12-IN-3 (compound 32) is a potent MMP12 inhibitor with an IC50 value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema .
    <em>MMP</em>12-IN-3
  • HY-161285

    MMP Cancer
    MMP-9/10-IN-2 (compound 6e) is a potent inhibitor of MMP10 and MMP9, with IC50 of 0.076 μM for MMP10, and 93.18% inhibition at 0.5 μM for MMP9. MMP-9/10-IN-2 plays an important role in anti-tumor .
    <em>MMP</em>-9/10-IN-2
  • HY-149377

    MMP Metabolic Disease
    MMP13-IN-4 (compound 13) is a potent and selective inhibitor of MMP-13 (IC50=14.6 μM),involved in osteoarthritis (OA) .
    <em>MMP</em>13-IN-4
  • HY-149848

    MMP Inflammation/Immunology
    MMP-9-IN-6 (Compound 3g) is a MMP-9 inhibitor with IC50 value of 50 μM, which has good anti-ulcer effect .
    <em>MMP</em>-9-IN-6
  • HY-147867

    MMP Cancer
    MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and MMP-9 inhibitor with IC50 values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation .
    <em>MMP</em>-2/9-IN-1
  • HY-157138

    Others Cancer
    MMP-9-IN-8 (Compound 3) is an MMP-9 inhibitor with inhibitory activities of 42.16% and 58.28% at 10 μM and 50 μM concentrations, respectively. MMP-9-IN-8 has anti-cancer activity and can induce apoptosis in MCF-7 cells with an IC50 value of 23.42 μM .
    <em>MMP</em>-9-IN-8
  • HY-162039

    MMP Cancer
    MMP-11-IN-1 (compound 9) is a new class of phosphinate prodrug. MMP-11-IN-1 is a glycosyl ester of RXP03 and improves blood–brain barrier (BBB) behavior .
    <em>MMP</em>-11-IN-1
  • HY-114418
    MMP3 inhibitor 1
    1 Publications Verification

    MMP Cancer
    MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC50 of 1 nM .
    <em>MMP</em>3 inhibitor 1
  • HY-124029

    mmp13-IN-3

    MMP Inflammation/Immunology
    BI-4394 (MMP13-IN-3) is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM ) for the potential treatment of osteoarthritis . BI-4394 is >1000 selective over other MMPs .
    BI-4394
  • HY-156247

    NF-κB MMP Cancer
    IVMT-Rx-3 is a inhibitor of SDCBP targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin. IVMT-Rx-3 blocks MDA-9/Syntenin interaction with Src, reduces NF-κB activation, and inhibits MMP-2/MMP-9 expression. IVMT-Rx-3 inhibits Melanoma Metastasis [1]
    IVMT-Rx-3
  • HY-14240

    PG 530742; PGE 530742; PGE 7113313

    MMP Inflammation/Immunology
    PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research .
    PG 116800
  • HY-P3474

    MMP Cancer
    Mca-PLGL-Dpa-AR-NH2 is a fluorescent peptide MMP substrate .
    Mca-PLGL-Dpa-AR-NH2
  • HY-107428

    MMP Cardiovascular Disease
    PD-166793 is a potent, selective, orally active and wide‐broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .
    PD-166793
  • HY-P3474A

    MMP Cancer
    Mca-PLGL-Dpa-AR-NH2 (TFA) is a fluorescent peptide MMP substrate .
    Mca-PLGL-Dpa-AR-NH2 TFA
  • HY-RS08516

    Small Interfering RNA (siRNA) Others
    MMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MMP1 Human Pre-designed siRNA Set A
    MMP1 Human Pre-designed siRNA Set A
  • HY-RS08517

    Small Interfering RNA (siRNA) Others

    Mmp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mmp1 Rat Pre-designed siRNA Set A
    Mmp1 Rat Pre-designed siRNA Set A
  • HY-RS08518

    Small Interfering RNA (siRNA) Others

    MMP10 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MMP10 Human Pre-designed siRNA Set A
    MMP10 Human Pre-designed siRNA Set A
  • HY-RS08519

    Small Interfering RNA (siRNA) Others

    Mmp10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mmp10 Mouse Pre-designed siRNA Set A
    Mmp10 Mouse Pre-designed siRNA Set A
  • HY-RS08520

    Small Interfering RNA (siRNA) Others
    Mmp10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mmp10 Rat Pre-designed siRNA Set A
    Mmp10 Rat Pre-designed siRNA Set A

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