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Targets Recommended: GPR40 NEDD8-activating Enzyme

Results for "1241902-40-8" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-123824
    GNE-0439

    Others Others
    GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders.