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Results for "135897-06-2" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-107407
    SB-218078

    Checkpoint Kinase (Chk) CDK PKC Cancer
    SB-218078 is a potent, selective and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest.