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Targets Recommended: NEDD8-activating Enzyme

Results for "1361227-90-8" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-126214
    JH-RE-06

    DNA/RNA Synthesis Cancer
    JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.