1. Search Result
Search Result
Results for "


" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123929

    MDM-2/p53 Wnt IKK Apoptosis Caspase Cancer
    PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model .

Inquiry Online

Your information is safe with us. * Required Fields.



Country or Region *

Applicant Name *


Organization Name *

Department *


Email Address *


Product Name *

Cat. No.


Requested quantity *

Phone Number *



Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
MCE Japan Authorized Agent: