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Results for "1450833-55-2" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-100487
    TAK-243

    MLN7243; AOB87172

    E1/E2/E3 Enzyme NF-κB Apoptosis Cancer
    TAK-243 is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis.