1. Search Result

Search Result

Targets Recommended: PI4K FXR Serotonin Transporter Oct3/4 MAP4K

Results for "146062-44-4" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-117727
    Leriglitazone

    Hydroxypioglitazone

    PPAR Metabolic Disease
    Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM,induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM.