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" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-128861A

    PAI-1 STAT PI3K Akt Apoptosis Cancer Inflammation/Immunology
    ACT001 is an orally active PAI-1 inhibitor by inhibiting the phosphorylation of PI3K and AKT. ACT001 inhibits the phosphorylation of STAT3 and PD-L1 expression by directly binding to STAT3. ACT001, a fumarate salt form of DMAMCL (a prodrug of Micheliolide), can cross the blood-brain barrier. ACT001 has potent anti-glioblastoma (GBM) activity and immunomodulatory effects.