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Targets Recommended: CRISPR/Cas9

Results for "1609392-27-9" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-117287

    JAK Inflammation/Immunology
    BMS-986165, an orally bioavailable, allosteric inhibitor of TYK2, selectively binds to TYK2 pseudokinase (JH2) domain. BMS-986165 is highly specific for binding to TYK2 JH2 (IC50=0.2 nM) and JAK1 JH2 (IC50=1.0 nM), whereas does not show any significant binding affinity in the canonical TYK2, JAK1, JAK2, and JAK3 JH1 assays (IC50s >10000 nM).