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Results for "

2 3a Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) ADAMTS (1) Aldose Reductase (1) Amylases (1) Apoptosis (4) Autophagy (6) Bacterial (3) Bcl-2 Family (1) Calcium Channel (1) Caspase (1) CDK (2) Cholinesterase (ChE) (1) COX (1) Cyclophilin (1) Cytochrome P450 (5) DNA Methyltransferase (2) Drug Derivative (1) E1/E2/E3 Enzyme (2) EGFR (1) Endogenous Metabolite (1) Enterovirus (2) Flavivirus (1) Fungal (1) FXR (1) GSK-3 (4) HCV (9) HCV Protease (8) HIV (3) iGluR (1) Interleukin Related (1) Isotope-Labeled Compounds (6) LPL Receptor (1) MAP4K (1) MDM-2/p53 (2) Monoamine Oxidase (2) nAChR (1) P-glycoprotein (1) p38 MAPK (1) Parasite (1) Phosphodiesterase (PDE) (9) Potassium Channel (1) RAD51 (1) Reference Standards (2) RIP kinase (1) SARS-CoV (6) SGK (2) Sodium Channel (1) Succinate Dehydrogenase (1) Topoisomerase (1) TRP Channel (1) VEGFR (1) Virus Protease (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (7) Infection (26) Inflammation/Immunology (8) Metabolic Disease (6) Neurological Disease (8)

By Targets:

5-HT Receptor (1)

ADAMTS (1)

Aldose Reductase (1)

Amylases (1)

Apoptosis (4)

Autophagy (6)

Bacterial (3)

Bcl-2 Family (1)

Calcium Channel (1)

Caspase (1)

CDK (2)

Cholinesterase (ChE) (1)

COX (1)

Cyclophilin (1)

Cytochrome P450 (5)

DNA Methyltransferase (2)

Drug Derivative (1)

E1/E2/E3 Enzyme (2)

EGFR (1)

Endogenous Metabolite (1)

Enterovirus (2)

Flavivirus (1)

Fungal (1)

FXR (1)

GSK-3 (4)

HCV (9)

HCV Protease (8)

HIV (3)

iGluR (1)

Interleukin Related (1)

Isotope-Labeled Compounds (6)

LPL Receptor (1)

MAP4K (1)

MDM-2/p53 (2)

Monoamine Oxidase (2)

nAChR (1)

P-glycoprotein (1)

p38 MAPK (1)

Parasite (1)

Phosphodiesterase (PDE) (9)

Potassium Channel (1)

RAD51 (1)

Reference Standards (2)

RIP kinase (1)

SARS-CoV (6)

SGK (2)

Sodium Channel (1)

Succinate Dehydrogenase (1)

Topoisomerase (1)

TRP Channel (1)

VEGFR (1)

Virus Protease (3)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (29)

Cardiovascular Disease (7)

Infection (26)

Inflammation/Immunology (8)

Metabolic Disease (6)

Neurological Disease (8)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106312A

Enviroxime LY122772	Enterovirus	Infection
Enviroxime (LY122772) is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses. Enviroxime blocks the replication of plus-strand viral RNA by targeting the viral 3A coding region. Enviroxime can be a useful tool for investigating the natural function of the 3A protein .

HY-10029

Nutlin-3a Maximum Cited Publications 49 Publications Verification Rebemadlin	MDM-2/p53 E1/E2/E3 Enzyme Autophagy Apoptosis	Cancer
Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC₅₀=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas .

HY-W969907

GSK3-IN-7	GSK-3	Others
GSK3a-IN-38 is a groundbreaking small molecule that effectively inhibits GSK-3a activity.

HY-18899

Nec-3a	RIP kinase	Cancer
Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC₅₀: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain .

HY-173288

MAO-B-IN-40	Monoamine Oxidase	Neurological Disease
MAO-B-IN-40 (3a), a MAOB inhibitor (IC₅₀ = 0.493 μM for hMAOB), demonstrates robust neuroprotective and antioxidant effect. MAO-B-IN-40 (3a) can be used in the research of Parkinson’s disease .

HY-162996

Spns2-IN-2	LPL Receptor	Cancer
Spns2-IN-2 (compund 3a) is a SPNS2 inhibitor .

HY-P10802

ER-DRI	Enterovirus Virus Protease	Infection
ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi .

HY-157537

α-Amylase-IN-5	Amylases	Metabolic Disease
α-Amylase-IN-5 (compound 3a) is a α-amylase inhibitor, with an IC₅₀ of 18.8 mM .

HY-172997

GluN1/3A-IN-1	iGluR	Neurological Disease
GluN1/3A-IN-1 (Compound GM-10) is a GluN1/GluN3A NMDA receptor inhibitor. GluN1/3A-IN-1 exhibits potent inhibitory activity against GluN1/GluN3A (IC₅₀ 0.98 µM). GluN1/3A-IN-1 exerts its inhibitory effect by targeting the pre-M1 region and forming hydrogen bond interactions with key residues. GluN1/3A-IN-1 can be used to study GluN1/GluN3A-related neurological diseases .

HY-168119

HPK1-IN-53	MAP4K	Cancer
HPK1-IN-53 (compund 3a) is the potent HPK1 inhibitor (IC₅₀=48 nM) .

HY-157090

AChE/MAO-B-IN-6	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/MAO-B-IN-6 (compound 3a) is a dual inhibitor of AChE and h-MAO-B with potential to inhibit Alzheimer's disease .

HY-149479

Quorum sensing-IN-3	Bacterial	Infection
Quorum sensing-IN-3 (Compound 3a) is a quorum sensing inhibitor against pseudomonas aeruginosa. Quorum sensing-IN-3 inhibits biofilm formation .

HY-161293

p38-α MAPK-IN-6	p38 MAPK	Cancer
p38-α MAPK-IN-6 (compound 3a) is a p38α mitogen-activated protein kinase inhibitor .

HY-169192

BAR-2227	FXR	Inflammation/Immunology
BAR-2227 (compound 3a) is a FXR agonist and LIFR inhibitor. BAR-2227 can be used to study liver fibrosis and inflammation .

HY-163706

SARS-CoV-2-IN-88	SARS-CoV	Infection
SARS-CoV-2-IN-88 (compound 3a) is a potent SARS-CoV-2 inhibitor with inhibitory value of 96.00% .

HY-162913

*GSK-3β inhibitor* 20**	GSK-3	Neurological Disease
GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC₅₀ value of 74.4 nM .

HY-17464

Cilostazol 4 Publications Verification OPC 13013	Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease Cancer
Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM .

HY-151136

DY-46-2	DNA Methyltransferase	Cancer
DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC₅₀ value of 0.39 μM .

HY-146163

*Topoisomerase II inhibitor* 7**	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC₅₀ of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis .

HY-168003

ADAMTS7-IN-1	ADAMTS	Cardiovascular Disease
ADAMTS7-IN-1 (Compound 3a) is an effective and selective inhibitor of ADAMTS7 with a K_i value of 9 nM. ADAMTS7-IN-1 can be used in the research of atherosclerosis .

HY-115981

NS5A-IN-2	HCV Protease	Infection
NS5A-IN-2 (Compound 33) is a potent inhibitor of NS5A. NS5A-IN-2 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability . NS5A-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10493

Cobicistat 10+ Cited Publications GS-9350	Cytochrome P450 HIV	Infection Cancer
Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC₅₀s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.

HY-17464S

Cilostazol-d11	Isotope-Labeled Compounds Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease Cancer
Cilostazol-d₁₁ is the deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM .

HY-17464S1

Cilostazol-d4 OPC-13013-d₄	Isotope-Labeled Compounds Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease Cancer
Cilostazol-d₄ is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM .

HY-17464R

Cilostazol (Standard)	Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease Cancer
Cilostazol (Standard) is the analytical standard of Cilostazol. This product is intended for research and analytical applications. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM .

HY-N6748

Roquefortine C 1 Publications Verification	P-glycoprotein Cytochrome P450 Bacterial Endogenous Metabolite	Infection Cancer
Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits *P450-3A* and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria .

HY-148284

Berbamine acetate	Drug Derivative	Cancer
Berbamine acetate (Compound 3a) is the derivative of Berbamine (HY-N0714). Berbamine acetate exhibits antitumor activity, inhibits growth of Imatinib (HY-15463)-resistant K562 leukemia cells, with IC₅₀ of 6.6 μM .

HY-173203

CDK2-IN-43	CDK	Cancer
CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC₅₀ value of 6.0 nM. CDK2-IN-43 can be used in the research of the anti-cancer field .

HY-133086

Hydrodolasetron	5-HT Receptor nAChR	Neurological Disease Cancer
Hydrodolasetron is a metabolite of Dolasetron (HY-B0750). Hydrodolasetron is more potent than Dolasetron in inhibiting nAChR. Hydrodolasetron is a *5-HT(3A)R* blocker with an IC₅₀ of 0.29 nM. Hydrodolasetron has antiemetic activity .

HY-W028690

DNMDP 3 Publications Verification	Phosphodiesterase (PDE)	Cancer
DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity .

HY-151445

ZIKV-IN-2	DNA Methyltransferase Virus Protease Flavivirus	Infection
ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC₅₀ value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV) .

HY-17464S2

Cilostazol-d2 OPC 13013-d₂	Isotope-Labeled Compounds Autophagy Phosphodiesterase (PDE)	Cardiovascular Disease Cancer
Cilostazol-d₂ (OPC 13013-d₂) is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM .

HY-17464S3

Cilostazol-d6 OPC 13013-d₆	Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Cilostazol-d₆ (OPC 13013-d₆) is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC₅₀ of 0.2 μM .

HY-126144

*GSK-3β inhibitor* 1** 3 Publications Verification	GSK-3	Metabolic Disease Cancer
GSK-3β inhibitor 1 (compound 3a) inhibits GSK-3β with an IC₅₀ of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753)-treated rats .

HY-W009689

*TbPTR1 inhibitor* 2**	Parasite	Infection
TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC₅₀s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC₅₀: 34.2 μM) .

HY-115982

NS5A-IN-3	HCV Protease	Infection
NS5A-IN-3 (Compound 15) is a potent inhibitor of NS5A. NS5A-IN-3 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability. NS5A-IN-3 exhibits a higher resistance barrier than daclatasvir against genotype 1b . NS5A-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159486

SDH-IN-18	Succinate Dehydrogenase Fungal	Infection
SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ of 0.48 and 1.4 mg/L .

HY-10493R

Cobicistat (Standard) GS-9350 (Standard)	Reference Standards Cytochrome P450 HIV	Infection Cancer
Cobicistat (Standard) is the analytical standard of Cobicistat. This product is intended for research and analytical applications. Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC₅₀s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.

HY-169055

SARS-CoV-2 Mpro-IN-25	Virus Protease	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-25 (Compound 3a) is a SARS-CoV-2 protease inhibitor with an IC₅₀ value of 0.26 μM. SARS-CoV-2 Mpro-IN-25 exhibits antiviral activity and can be used in pneumonia-related research .

HY-P990228

Anti-Mouse IL-10R/CD210 Antibody (1B1.3A)	Interleukin Related	Others
Anti-Mouse IL-10R/CD210 Antibody (1B1.3A) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-10R/CD210.

HY-10568

TC-E 5005	Phosphodiesterase (PDE)	Metabolic Disease
TC-E 5005 is a potent and selective PDE10A inhibitor with IC₅₀ values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate .

HY-N12209

Neohelmanthicin A	Others	Cancer
Neohelmanthicin A (compound 3A) is a phenylpropanoid compound with antitumor activity. The IC₅₀s of Neohelmanthicin A for inhibiting leukemia cell line EL4, breast cancer cell line S180 and breast cancer cell line MCF7 are 0.13 μM, 7 μM and 23 μM respectively .

HY-147885

HCV-IN-41	HCV	Infection
HCV-IN-41 (compound 4) is a highly potent hepatitis C virus (HCV) inhibitor with an EC₅₀ value of 0.006762 nM, 5.183 nM, 1.365 nM and 142.2 nM for HCV genotype 1b, 2a, 3a and 4a, respectively. HCV-IN-41 reduces HCV RNA replication .

HY-120187

DDCPPB-Glu	Others	Others
DDCPPB-Glu (compound 3a) is a compound with anti-tumor activity, which has the activity of inhibiting tumor cell growth and prolonging survival. DDCPPB-Glu has growth inhibition effect on various tumor cell lines, can increase the survival time of leukemia mice, and has inhibitory effect on tumors such as colon cancer and lung cancer.

HY-155610

VEGFR-2-IN-32	VEGFR	Cancer
VEGFR-2-IN-32 (Comp 3a) is an inhibitor of VEGFR-2 with an IC₅₀ of 8.93 nM. VEGFR-2-IN-32 has cytotoxic activity against PC-3 cells with an IC₅₀ of 1.22 μM. VEGFR-2-IN-32 can be used for anti-prostate cancer research .

HY-10493S

Cobicistat-d8 GS-9350-d₈	Isotope-Labeled Compounds HIV Cytochrome P450	Infection
Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat (HY-10493). Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC₅₀ values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules .

HY-161839

AKR1C2/3-IN-1	Aldose Reductase	Cancer
AKR1C2/3-IN-1 (compound 3a) is a potent AKR1C2 and AKR1C3 inhibitor with IC₅₀ values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity .

HY-155979

SARS-CoV-2 3CLpro-IN-16	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-16 (Compound 3a) is a covalent SARS-CoV-2 3CLpro inhibitor (IC₅₀s: 2.124 μM). SARS-CoV-2 3CLpro-IN-16 binds to the active site and forms a covalent bond with Cys145 of 3CLpro .

HY-142686

SGK1-IN-3	SGK	Inflammation/Immunology
SGK1-IN-3 (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 has the potential for the research of osteoarthritis .

HY-142686A

SGK1-IN-3 hydrochloride	SGK	Inflammation/Immunology
SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride has the potential for the research of osteoarthritis .

Cat. No.	Product Name	Target	Research Area