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Results for "2136247-12-4" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-114312
    MD-224

    PROTAC MDM-2/p53 Cancer
    MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent.