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Targets Recommended: NEDD8-activating Enzyme

Results for "2229856-58-8" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-122653
    CCT367766

    PROTAC Cancer
    CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein.