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" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-147054

    Wee1 Cancer
    WEE1-IN-5 (Debio 0123) is a potent, orally available and highly specific WEE1 inhibitor with an IC50 in the low nanomolar range. WEE1-IN-5 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. WEE1-IN-5 increases antitumoral activity of Carboplatin in vivo where neither agent was active alone.