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Results for "2375840-87-0" in MCE Product Catalog:

Cat. No. Product Name Target Research Area
  • HY-127111
    NDI-091143

    ATP Citrate Lyase Metabolic Disease
    NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate.