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Targets Recommended: NEDD8-activating Enzyme
Results for "

2412734-00-8

" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-146727
    JAK3-IN-11

    JAK Inflammation/Immunology
    JAK3-IN-11 (Compound 12), a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T cell proliferation, is a promising tool for study autoimmune diseases.