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Results for "

2487526-28-1

" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-143411
    GEM144

    HDAC Apoptosis Cancer
    GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts.