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41bbl Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CD19 (1)
By Research Areas:	Cancer (1)

1

Inhibitors & Agonists

1

Inhibitory Antibodies

3

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Englumafusp alfa CD19-4-1BBL; RO7227166; RG6076	CD19	Cancer
Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion construct comprised of a CD19-specific antibody domain fused to a trimerized extracellular domains of human *41BBL*. Englumafusp alfa promotes CD19-specific 4-1BB cross-linking on the surface of T and NK cells .

Species:	Human (1) Mouse (2)
Tag:	His (2) Fc (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700160AF

	Animal-Free 4-1BBL/TNFSF9 Protein, Mouse (His) 41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9	Mouse	E. coli
	4-1BBL/TNFSF9 Protein, a cytokine, binds TNFRSF9, inducing proliferation in activated peripheral blood T-cells. It's implicated in activation-induced cell death (AICD) and contributes to cognate interactions between T-cells and B-cells/macrophages. Functioning as a homotrimer enhances its biological activity. Animal-Free 4-1BBL/TNFSF9 Protein, Mouse (His) is the recombinant mouse-derived animal-Free4-1BBL/TNFSF9 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free 4-1BBL/TNFSF9 Protein, Mouse (His) is 108 a.a., with molecular weight of ~23.91 kDa.

	4-1BBL/TNFSF9 Protein, Human (Biotinylated, HEK293, Fc) 41BB Ligand; 4-1BB Ligand; 4-1BBL; CD137L; TNFSF9	Human	HEK293
	4-1BBL (4-1BB ligand) is a type II membrane protein of the TNF superfamily, is expressed on antigen-presenting cells. 4-1BB with 4-1BBL can induce T-cell expansion, cytokine induction, differentiation, and upregulation of anti-apoptotic genes as well as protect T cells from activation-induced cell death (AICD). 4-1BBL stimulates T cell proliferation and induces effective anti-tumor immune responses. 4-1BBL is an immunostimulant molecule that interacts with the 4-1BB high-affinity receptor during the antigen presentation, providing costimulatory signals to both CD4+ and CD8+ T cells through the activation of NF-kB, c-Jun, and p38 downstream pathways, triggering pleiotropic effects on the immune system. 4-1BBL/TNFSF9 Protein, Human (Biotinylated, HEK293, Fc) is a biotinylated recombinant protein with a N-Terminal Fc label, It consists of 184 amino acids (R71-E254) and is produced in HEK293 cells.

	4-1BBL/TNFSF9 Protein, Mouse (HEK293, His) rMu4-1BB Ligand/TNFSF9, His; 4-1BBL; CD137L; 4-1BB Ligand; TNFSF9	Mouse	HEK293
	4-1BBL (4-1BB ligand) is a type II membrane protein of the TNF superfamily, is expressed on antigen-presenting cells. 4-1BB with 4-1BBL can induce T-cell expansion, cytokine induction, differentiation, and upregulation of anti-apoptotic genes as well as protect T cells from activation-induced cell death (AICD). 4-1BBL stimulates T cell proliferation and induces effective anti-tumor immune responses. 4-1BBL is an immunostimulant molecule that interacts with the 4-1BB high-affinity receptor during the antigen presentation, providing costimulatory signals to both CD4+ and CD8+ T cells through the activation of NF-kB, c-Jun, and p38 downstream pathways, triggering pleiotropic effects on the immune system. 4-1BBL/TNFSF9 Protein, Mouse (HEK293, His) is a recombinant protein with a N-Terminal His label, It consists of 206 amino acids (R104-E309) and is produced in HEK293 cells.

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