Search Result

Results for "

5'-GMP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cyclic GMP-AMP Synthase (8) ADC Cytotoxin (6) ADC Linker (13) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (5) Apoptosis (9) Autophagy (4) Bacterial (3) Bombesin Receptor (1) Calcium Channel (4) Calmodulin (1) COX (3) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (3) EGFR (2) Endogenous Metabolite (23) ERK (2) Ferroptosis (1) Fungal (1) G-quadruplex (1) GSK-3 (1) Guanylate Cyclase (5) HCV (1) Histone Methyltransferase (1) IFNAR (1) Influenza Virus (1) IRAK (1) Isotope-Labeled Compounds (6) JNK (1) MEK (2) Melanocortin Receptor (1) Microtubule/Tubulin (4) Mitophagy (1) Monoamine Oxidase (1) mTOR (1) Necroptosis (2) NF-κB (1) NOD-like Receptor (NLR) (1) Notch (1) Orthopoxvirus (2) Parasite (2) PARP (1) PDGFR (2) Phosphodiesterase (PDE) (4) PI3K (1) PKA (2) PKC (1) Porcupine (1) PPAR (1) RAR/RXR (4) Reactive Oxygen Species (2) ROCK (2) RSV (1) Small Interfering RNA (siRNA) (1) Smo (1) Sodium Channel (1) Src (1) STAT (1) STING (8) TAM Receptor (1) TGF-β Receptor (3) Thyroid Hormone Receptor (1) Toll-like Receptor (TLR) (2) Topoisomerase (2) VEGFR (2) Wnt (4) β-catenin (1) γ-secretase (2)
By Research Areas:	Cancer (71) Cardiovascular Disease (9) Endocrinology (4) Infection (8) Inflammation/Immunology (23) Metabolic Disease (19) Neurological Disease (9)

By Targets:

Cyclic GMP-AMP Synthase (8)

ADC Cytotoxin (6)

ADC Linker (13)

AMPK (1)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (5)

Apoptosis (9)

Autophagy (4)

Bacterial (3)

Bombesin Receptor (1)

Calcium Channel (4)

Calmodulin (1)

COX (3)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Drug-Linker Conjugates for ADC (3)

EGFR (2)

Endogenous Metabolite (23)

ERK (2)

Ferroptosis (1)

Fungal (1)

G-quadruplex (1)

GSK-3 (1)

Guanylate Cyclase (5)

HCV (1)

Histone Methyltransferase (1)

IFNAR (1)

Influenza Virus (1)

IRAK (1)

Isotope-Labeled Compounds (6)

JNK (1)

MEK (2)

Melanocortin Receptor (1)

Microtubule/Tubulin (4)

Mitophagy (1)

Monoamine Oxidase (1)

mTOR (1)

Necroptosis (2)

NF-κB (1)

NOD-like Receptor (NLR) (1)

Notch (1)

Orthopoxvirus (2)

Parasite (2)

PARP (1)

PDGFR (2)

Phosphodiesterase (PDE) (4)

PI3K (1)

PKA (2)

PKC (1)

Porcupine (1)

PPAR (1)

RAR/RXR (4)

Reactive Oxygen Species (2)

ROCK (2)

RSV (1)

Small Interfering RNA (siRNA) (1)

Smo (1)

Sodium Channel (1)

Src (1)

STAT (1)

STING (8)

TAM Receptor (1)

TGF-β Receptor (3)

Thyroid Hormone Receptor (1)

Toll-like Receptor (TLR) (2)

Topoisomerase (2)

VEGFR (2)

Wnt (4)

β-catenin (1)

γ-secretase (2)

By Research Areas:

Cancer (71)

Cardiovascular Disease (9)

Endocrinology (4)

Infection (8)

Inflammation/Immunology (23)

Metabolic Disease (19)

Neurological Disease (9)

123

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Cyclic GMP-AMP Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N5134

5'-Guanylic acid 1 Publications Verification 5'-GMP; 5'-guanosine monophosphate	Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-W010970

5'-Guanylic acid disodium salt 1 Publications Verification 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt	Endogenous Metabolite	Others
5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes .

HY-N5134S2

5'-Guanylic acid-15N5 dilithium 5'-GMP-¹⁵N₅ dilithium; 5'-guanosine monophosphate-¹⁵N₅ dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹⁵N₅ (5'-GMP- ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹⁵N₅) dilithium is ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S1

5'-Guanylic acid-13C10 dilithium 5'-GMP-¹³C₁₀ dilithium; 5'-guanosine monophosphate-¹³C₁₀ dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹³C₁₀ (5'-GMP- ¹³C₁₀ dilithium; 5'-guanosine monophosphate- ¹³C₁₀) dilithium is ¹³C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S3

5'-Guanylic acid-d12 dilithium 5'-GMP-d₁₂ dilithium; 5'-guanosine monophosphate-d₁₂ dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid-d₁₂ (5'-GMP-d₁₂ dilithium; 5'-guanosine monophosphate-d₁₂) dilithium is deuterium labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S4

5'-Guanylic acid-15N5,d12 dilithium 5'-GMP-¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate-¹⁵N₅,d₁₂ dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹⁵N₅,d₁₂ (5'-GMP- ¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate- ¹⁵N₅,d₁₂) dilithium is deuterium and ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S5

5'-Guanylic acid-13C10,15N5 dilithium 5'-GMP-¹³C₁₀,¹⁵N₅ dilithium; 5'-guanosine monophosphate-¹³C₁₀,¹⁵N₅ dilithium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
5'-Guanylic acid- ¹³C₁₀, ¹⁵N₅ (5'-GMP- ¹³C₁₀, ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-13418G

Dorsomorphin dihydrochloride Compound C dihydrochloride; BML-275 dihydrochloride	AMPK	Neurological Disease Cancer
Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

HY-14649G

Retinoic acid Vitamin A acid; all-trans-Retinoic acid; ATRA	RAR/RXR	Cancer
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

HY-15682G

TTNPB Ro 13-7410; Arotinoid acid; AGN191183	RAR/RXR	Cancer
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist .

HY-13526G

YO-01027 Dibenzazepine; DBZ	Notch γ-secretase	Cancer
YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor .

HY-13740G

Resiquimod R848; S28463	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages .

HY-10254G

Mirdametinib PD0325901; PD325901	MEK	Cancer
Mirdametinib (PD0325901) (GMP) is Mirdametinib (HY-10254) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mirdametinib is an orally active, selective and non-ATP-competitive MEK inhibitor .

HY-15141G

Staurosporine Antibiotic AM-2282; STS; AM-2282	PKC	Infection Cancer
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

HY-10182G

Laduviglusib CHIR-99021; CT99021	GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-B0166G

L-Ascorbic acid L-Ascorbate; Vitamin C	Calcium Channel	Neurological Disease Metabolic Disease Cancer
L-Ascorbic acid (L-Ascorbate) (GMP) is L-Ascorbic acid (HY-B0166) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Ascorbic acid is an inhibitor of Ca_v 3.2 channels .

HY-10475G

AM580 CD336; NSC608001; Ro 40-6055	RAR/RXR	Cancer
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-15162G

Monomethyl auristatin E MMAE; SGD-1010; Vedotin	Microtubule/Tubulin Apoptosis ADC Cytotoxin	Cancer
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-13027G

DAPT GSI-IX	γ-secretase	Neurological Disease Inflammation/Immunology Cancer
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor .

HY-B0434G

Ribavirin Ribasphere; ICN-1229	Antibiotic RSV HCV Orthopoxvirus	Infection
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.

HY-50895G

Gefitinib ZD1839	EGFR Autophagy Apoptosis	Cancer
Gefitinib (ZD1839) (GMP) is Gefitinib (HY-50895) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Gefitinib is a potent, selective and orally active EGFR tyrosine kinase inhibitor .

HY-50751G

Linifanib ABT-869; AL-39324	VEGFR PDGFR	Cancer
Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC₅₀s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells .

HY-10219GL

*Rapamycin (GMP* Like)** Sirolimus (GMP Like); AY-22989 (GMP Like)	mTOR	Cancer
Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin is a potent and specific mTOR inhibitor .

HY-13012G

RepSox E-616452; SJN 2511	TGF-β Receptor	Metabolic Disease
RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor .

HY-12186G

3-Deazaneplanocin A hydrochloride DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride	Histone Methyltransferase Orthopoxvirus	Infection Cancer
3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor .

HY-12318G

IBMX 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine	Phosphodiesterase (PDE)	Inflammation/Immunology
IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor .

HY-101952G

Prostaglandin E2 PGE2; Dinoprostone	Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2 (GMP) is Prostaglandin E2 (HY-101952) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Prostaglandin E2, an inflammatory mediator, is a endogenous hormone-like substance that participate in a wide range of body functions .

HY-13257G

Thiazovivin	ROCK	Cancer
Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor .

HY-17447AG

Tranylcypromine hydrochloride SKF 385 hydrochloride	Monoamine Oxidase	Cardiovascular Disease Endocrinology
Tranylcypromine (SKF 385) hydrochloride (GMP) is Tranylcypromine (HY-17447) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tranylcypromine hydrochloride is a potent monoamine oxidase (MAO) inhibitor .

HY-A0070AG

Liothyronine Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor	Endocrinology Cancer
Liothyronine (Triiodothyronine) (GMP) is Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-12071G

LDN193189 DM-3189	TGF-β Receptor	Cancer
LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective BMP type I receptor inhibitor .

HY-15108G

Purmorphamine	Smo	Neurological Disease Cancer
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM .

HY-14398G

Celecoxib SC 58635	COX	Inflammation/Immunology
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-10583G

Y-27632 dihydrochloride	ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

HY-14397G

Indomethacin Indometacin	Antibiotic Influenza Virus Bacterial COX	Cancer
Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-15575G

VcMMAE MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
VcMMAE (MC-Val-Cit-PAB-MMAE) (GMP) is VcMMAE (HY-15575) produced by using GMP guidelines. VcMMAE is a drug-linker conjugate for ADC .

HY-18085G

Quercetin	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species	Cancer
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a SIRT1 Activator .

HY-16910G

WIKI4	Wnt	Cardiovascular Disease Cancer
WIKI4 (GMP) is WIKI4 (HY-16910) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. WIKI4 is a potent tankyrase inhibitor .

HY-13631AG

Exatecan mesylate DX8951f	Topoisomerase ADC Cytotoxin	Cancer
Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

HY-B0185G

Lidocaine Lignocaine	Apoptosis Sodium Channel MEK ERK NF-κB	Cancer
Lidocaine (GMP) is Lidocaine (HY-B0185) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-15147G

XAV-939	PARP	Neurological Disease Cancer
XAV-939 (GMP) is XAV-939 (HY-15347) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XAV-939 is a tankyrase inhibitor .

HY-160197G

*Aluminum phosphate adjuvant (GMP)*	NOD-like Receptor (NLR)	Infection Inflammation/Immunology
Aluminum phosphate adjuvant GMP is a Aluminum phosphate adjuvant produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Aluminum phosphate adjuvant is a safe and effective adjuvant that activates immune system and immune system-related pathways in monocytes .

HY-15150G

Bemcentinib (GMP)

R428 (GMP); BGB324 (GMP)
TAM Receptor Cancer

Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC₅₀ of 14 nM .

*Bemcentinib (GMP)* R428 (GMP); BGB324 (GMP)	TAM Receptor	Cancer
Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC₅₀ of 14 nM .

HY-15764G

A 419259 RK-20449	Src Apoptosis	Cancer
A 419259 GMP is the GMP grade A 419259 (HY-15764), inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC₅₀s of 9 nM, <3 nM, and <3 nM, respectively .

HY-15582G

Auristatin E	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor .

HY-B0497G

Niclosamide BAY2353	Antibiotic Parasite STAT	Cancer
Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-B0450AG

Ciclopirox olamine Ciclopirox ethanolamine; HOE 296	Bacterial Fungal Ferroptosis	Infection
Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .

HY-111582G

*BBIQ (GMP)*	Toll-like Receptor (TLR)	Inflammation/Immunology
BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC₅₀ of  59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses .

HY-10431G

SB-431542	TGF-β Receptor	Neurological Disease Cancer
SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling .

HY-15659G

Wnt-C59

C59
Porcupine Wnt Cancer

Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659). Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC₅₀ of 74 pM.

Cat. No.	Product Name	Type

HY-13418G

Dorsomorphin dihydrochloride (GMP)

Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP)

Fluorescent Dye

Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

HY-14649G

*Retinoic acid (GMP)* Vitamin A acid (GMP); all-trans-Retinoic acid (GMP); ATRA (GMP)	Fluorescent Dye
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

HY-15682G

*TTNPB (GMP)* Ro 13-7410 (GMP); Arotinoid acid (GMP); AGN191183 (GMP)	Fluorescent Dye
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist .

HY-13526G

*YO-01027 (GMP)* Dibenzazepine (GMP); DBZ (GMP)	Fluorescent Dye
YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor .

HY-13740G

*Resiquimod (GMP)* R848 (GMP); S28463 (GMP)	Fluorescent Dye
Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages .

HY-10254G

*Mirdametinib (GMP)* PD0325901 (GMP); PD325901 (GMP)	Fluorescent Dye
Mirdametinib (PD0325901) (GMP) is Mirdametinib (HY-10254) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mirdametinib is an orally active, selective and non-ATP-competitive MEK inhibitor .

HY-15141G

*Staurosporine (GMP)* Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)	Fluorescent Dye
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases .

HY-10182G

*Laduviglusib (GMP)* CHIR-99021 (GMP); CT99021 (GMP)	Fluorescent Dye
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-B0166G

*L-Ascorbic acid (GMP)* L-Ascorbate (GMP); Vitamin C (GMP)	Fluorescent Dye
L-Ascorbic acid (L-Ascorbate) (GMP) is L-Ascorbic acid (HY-B0166) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Ascorbic acid is an inhibitor of Ca_v 3.2 channels .

HY-10475G

*AM580 (GMP)* CD336 (GMP); NSC608001 (GMP); Ro 40-6055 (GMP)	Fluorescent Dye
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-15162G

*Monomethyl auristatin E (GMP)* MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)	Fluorescent Dye
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-13027G

*DAPT (GMP)* GSI-IX (GMP)	Fluorescent Dye
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor .

HY-B0434G

*Ribavirin (GMP)* Ribasphere (GMP); ICN-1229 (GMP)	Fluorescent Dye
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.

HY-50895G

*Gefitinib (GMP)* ZD1839 (GMP)	Fluorescent Dye
Gefitinib (ZD1839) (GMP) is Gefitinib (HY-50895) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Gefitinib is a potent, selective and orally active EGFR tyrosine kinase inhibitor .

HY-50751G

Linifanib (GMP)

ABT-869 (GMP); AL-39324 (GMP)

Fluorescent Dye

Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC₅₀s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells .

HY-10219GL

*Rapamycin (GMP* Like)** Sirolimus (GMP Like); AY-22989 (GMP Like)	Fluorescent Dye
Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin is a potent and specific mTOR inhibitor .

HY-13012G

*RepSox (GMP)* E-616452 (GMP); SJN 2511 (GMP)	Fluorescent Dye
RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor .

HY-12186G

*3-Deazaneplanocin A hydrochloride (GMP)* DZNep hydrochloride (GMP); NSC 617989 hydrochloride (GMP); 3-Deazaneplanocin hydrochloride (GMP)	Fluorescent Dye
3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor .

HY-12318G

*IBMX (GMP)* 3-Isobutyl-1-methylxanthine (GMP); Isobutylmethylxanthine (GMP)	Fluorescent Dye
IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor .

HY-101952G

*Prostaglandin E2 (GMP)* PGE2 (GMP); Dinoprostone (GMP)	Fluorescent Dye
Prostaglandin E2 (GMP) is Prostaglandin E2 (HY-101952) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Prostaglandin E2, an inflammatory mediator, is a endogenous hormone-like substance that participate in a wide range of body functions .

HY-13257G

*Thiazovivin (GMP)*	Fluorescent Dye
Thiazovivin (GMP) is Thiazovivin (HY-13257) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Thiazovivin is a potent ROCK inhibitor .

HY-17447AG

*Tranylcypromine hydrochloride (GMP)* SKF 385 hydrochloride (GMP)	Fluorescent Dye
Tranylcypromine (SKF 385) hydrochloride (GMP) is Tranylcypromine (HY-17447) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tranylcypromine hydrochloride is a potent monoamine oxidase (MAO) inhibitor .

HY-A0070AG

*Liothyronine (GMP)* Triiodothyronine (GMP); 3,3',5-Triiodo-L-thyronine (GMP); T3 (GMP)	Fluorescent Dye
Liothyronine (Triiodothyronine) (GMP) is Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively .

HY-12071G

*LDN193189 (GMP)* DM-3189 (GMP)	Fluorescent Dye
LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective BMP type I receptor inhibitor .

HY-15108G

*Purmorphamine (GMP)*	Fluorescent Dye
Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC₅₀ of 1 μM .

HY-14398G

*Celecoxib (GMP)* SC 58635 (GMP)	Fluorescent Dye
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-10583G

*Y-27632 dihydrochloride (GMP)*	Fluorescent Dye
Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect .

HY-14397G

Indomethacin (GMP)

Indometacin (GMP)

Fluorescent Dye

Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-15575G

*VcMMAE (GMP)* MC-Val-Cit-PAB-MMAE (GMP); mc-vc-PAB-MMAE (GMP)	Fluorescent Dye
VcMMAE (MC-Val-Cit-PAB-MMAE) (GMP) is VcMMAE (HY-15575) produced by using GMP guidelines. VcMMAE is a drug-linker conjugate for ADC .

HY-18085G

*Quercetin (GMP)*	Fluorescent Dye
Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a SIRT1 Activator .

HY-16910G

*WIKI4 (GMP)*	Fluorescent Dye
WIKI4 (GMP) is WIKI4 (HY-16910) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. WIKI4 is a potent tankyrase inhibitor .

HY-13631AG

*Exatecan mesylate (GMP)* DX8951f (GMP)	Fluorescent Dye
Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

HY-B0185G

Lidocaine (GMP)

Lignocaine (GMP)

Fluorescent Dye

Lidocaine (GMP) is Lidocaine (HY-B0185) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-15147G

*XAV-939 (GMP)*	Fluorescent Dye
XAV-939 (GMP) is XAV-939 (HY-15347) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XAV-939 is a tankyrase inhibitor .

HY-160197G

*Aluminum phosphate adjuvant (GMP)*	Fluorescent Dye
Aluminum phosphate adjuvant GMP is a Aluminum phosphate adjuvant produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Aluminum phosphate adjuvant is a safe and effective adjuvant that activates immune system and immune system-related pathways in monocytes .

HY-15150G

Bemcentinib (GMP)

R428 (GMP); BGB324 (GMP)
Fluorescent Dye

Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC₅₀ of 14 nM .

HY-15764G

*A 419259 (GMP)* RK-20449 (GMP)	Fluorescent Dye
A 419259 GMP is the GMP grade A 419259 (HY-15764), inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC₅₀s of 9 nM, <3 nM, and <3 nM, respectively .

HY-15582G

Auristatin E (GMP)

Fluorescent Dye

Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor .

HY-B0497G

Niclosamide (GMP)

BAY2353 (GMP)

Fluorescent Dye

Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-B0450AG

Ciclopirox olamine (GMP)

Ciclopirox ethanolamine (GMP); HOE 296 (GMP)

Fluorescent Dye

Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .

HY-111582G

*BBIQ (GMP)*	Fluorescent Dye
BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC₅₀ of  59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses .

HY-10431G

*SB-431542 (GMP)*	Fluorescent Dye
SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling .

HY-15659G

Wnt-C59 (GMP)

C59 (GMP)
Fluorescent Dye

Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659). Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC₅₀ of 74 pM.

HY-13319G

*JNK-IN-8 (GMP)* JNK Inhibitor XVI (GMP)	Fluorescent Dye
JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC₅₀s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively .

HY-15579G

*MMAF (GMP)* Monomethylauristatin F (GMP)	Fluorescent Dye
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-15579BG

*MMAF sodium (GMP)* Monomethylauristatin F sodium (GMP)	Fluorescent Dye
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-78932G

*Dap-NE hydrochloride (GMP)*	Fluorescent Dye
Dap-NE hydrochloride (GMP) is Dap-NE hydrochloride (HY-78932A) produced by using GMP guidelines. Dap-NE hydrochloride is an intermediate used in the synthesis of antibody-drug conjugates (ADCs) .

HY-153209G

*ISATM51 (GMP)*	Fluorescent Dye
ISATM51 (GMP) is a GMP grade ISATM51. ISATM51 is a vaccine adjuvant that enhances antigen-specific antibody titers and cytotoxic T lymphocyte (CTL) responses .

HY-10432G

*A 83-01 (GMP)*	Fluorescent Dye
A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent ALK4/5/7 inhibitor .

HY-14398GL

*Celecoxib (GMP* Like)** SC 58635 (GMP Like)	Fluorescent Dye
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5134

5'-Guanylic acid 1 Publications Verification 5'-GMP; 5'-guanosine monophosphate	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-W010970

5'-Guanylic acid disodium salt 1 Publications Verification 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes .

HY-113469A

*Cyclic GMP* sodium**	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation .

HY-107780

Cyclic-di-GMP c-di-GMP; cyclic diguanylate; 5GP-5GP	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	STING Endogenous Metabolite
Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research .

HY-107780A

*Cyclic-di-GMP* sodium** c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	STING Endogenous Metabolite
Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research .

HY-107780B

*Cyclic-di-GMP* diammonium** 2 Publications Verification c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	STING Endogenous Metabolite
Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research .

HY-110382

*Cyclic-di-GMP* disodium** 2 Publications Verification c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	STING Endogenous Metabolite
Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .

HY-100564A

2',3'-cGAMP sodium Maximum Cited Publications 9 Publications Verification 2'-3'-cyclic GMP-AMP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite STING IFNAR
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm .

HY-110385

cGAMP disodium 5+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-110385A

cGAMP diammonium 5+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-50723

3-Methylxanthine	Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate *(GMP)* inhibitor, with an IC₅₀ of 920 μM on guinea-pig isolated trachealis muscle.

HY-50723R

3-Methylxanthine (Standard)	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Methylxanthine (Standard) is the analytical standard of 3-Methylxanthine. This product is intended for research and analytical applications. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate *(GMP)* inhibitor, with an IC₅₀ of 920 μM on guinea-pig isolated trachealis muscle .

Species:	Human (50) Rhesus Macaque (2) Mouse (4) Rat (3)
Tag:	His (28) SUMO (1) Tag Free (23) Avi (3) Fc (6)
Source:	HEK293 (33) CHO (1) E. coli (24)

Cat. No.	Compare	Product Name	Species	Source

HY-P7055G

	GMP PDGF-BB Protein, Human 2 Publications Verification PDGFBB; PDGF-BB	Human	E. coli
	The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. GMP PDGF-BB Protein, Human is the recombinant human-derived PDGF-BB protein, expressed by E. coli , with tag free. The total length of GMP PDGF-BB Protein, Human is 109 a.a., with molecular weight of ~14.0 kDa.

HY-P70558G

	GMP Noggin Protein, Human (HEK293) Noggin; NOG	Human	HEK293
	Noggin protein is an important BMP inhibitor that plays an indispensable role in the neural tube, somite growth, cartilage morphogenesis, and joint formation. Its homodimeric structure promotes significant interactions with GDF5 and possibly GDF6, inhibiting chondrocyte differentiation. GMP Noggin Protein, Human (HEK293) is the recombinant human-derived Noggin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP Noggin Protein, Human (HEK293) is 205 a.a., with molecular weight of ~28-32 kDa.

HY-P70465G

	GMP OSM Protein, Human (His) Oncostatin-M; OSM	Human	E. coli
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. GMP OSM Protein, Human (His) is the recombinant human-derived OSM protein, expressed by E. coli , with N-6*His labeled tag. The total length of GMP OSM Protein, Human (His) is 196 a.a., with molecular weight of ~28.0 kDa.

HY-P7109G

	GMP EGF Protein, Human 1 Publications Verification Pro-epidermal growth factor; EGF; Urogastrone	Human	E. coli
	EGF proteins act as potent stimulators of growth in a variety of epidermal and epithelial tissues in both in vivo and in vitro settings, while promoting the proliferation of specific fibroblasts in cell culture. This multifaceted protein also acts as a magnesium stimulating hormone, driving magnesium reabsorption in the renal distal tubule through engagement of EGFR and activation of the magnesium channel TRPM6. GMP EGF Protein, Human is the recombinant human-derived EGF protein, expressed by E. coli , with tag free. The total length of GMP EGF Protein, Human is 53 a.a., with molecular weight of ~9.6 kDa.

HY-P70776G

	GMP IL-15 Protein, Human Interleukin-15; IL-15; IL15	Human	E. coli
	IL-15 protein regulates immune cells, stimulates the proliferation of NK cells, T cells, and B cells, and promotes cytokine secretion. GMP IL-15 Protein, Human is the recombinant human-derived IL-15 protein, expressed by E. coli , with tag free. The total length of GMP IL-15 Protein, Human is 114 a.a., with molecular weight of ~12.0 kDa.

HY-P78550

	GMP IL-7 Protein, Human Interleukin-7; IL-7; IL7	Human	E. coli
	IL-7 protein is an important hematopoietic cytokine that is essential for the development, expansion and survival of T cells and B cells, regulating mature lymphocyte populations and maintaining lymphatic homeostasis. IL-7 interacts with IL7RA and CSF2RG subunits, activates kinases, including JAK1 or JAK3, and initiates signaling cascades, such as the PI3K/Akt/mTOR or JAK-STAT5 pathway. GMP IL-7 Protein, Human is the recombinant human-derived IL-7 protein, expressed by E. coli , with tag free. The total length of GMP IL-7 Protein, Human is 152 a.a., with molecular weight of ~17.5 kDa.

HY-P78552

	GMP IFN-gamma Protein, Human Interferon Gamma; IFN-Gamma; Immune Interferon; IFNG	Human	E. coli
	IFN-gamma Protein is a dimeric soluble cytokine. It exerts antibacterial, antiviral and antitumor effects through JAK-STAT, mTOR, MAPK and PI3K/AKT signaling pathways. GMP IFN-gamma Protein, Human is the recombinant human-derived IFN-gamma protein, expressed by E. coli , with tag free. The total length of GMP IFN-gamma Protein, Human is 143 a.a., with molecular weight of ~16.7 kDa.

HY-P7038G

	GMP IL-21 Protein, Human Interleukin-21; IL-21; Za11; IL21	Human	E. coli
	IL-21 protein is an immunomodulatory cytokine that promotes the transition from innate immunity to adaptive immunity. It induces B cells to produce IgG(1) and IgG(3), harnessing an effective antibody response to fight viral infections. GMP IL-21 Protein, Human is the recombinant human-derived IL-21 protein, expressed by E. coli , with tag free. The total length of GMP IL-21 Protein, Human is 133 a.a., with molecular weight of ~16.0 kDa.

HY-P70610G

	GMP IFN-gamma Protein, Human (HEK293) Interferon Gamma; IFN-Gamma; Immune Interferon; IFNG	Human	HEK293
	IFN-gamma Protein is a dimeric soluble cytokine. It exerts antibacterial, antiviral and antitumor effects through JAK-STAT, mTOR, MAPK and PI3K/AKT signaling pathways. GMP IFN-gamma Protein, Human (HEK293) is the recombinant human-derived IFN-gamma protein, expressed by HEK293 , with tag free. The total length of GMP IFN-gamma Protein, Human (HEK293) is 143 a.a., with molecular weight of 16 & 18 & 25 kDa, respectively.

HY-P70755G

	GMP IL-7 Protein, Human (HEK293, His) Interleukin-7; IL-7; IL7	Human	HEK293
	IL-7 protein is an important hematopoietic cytokine that is essential for the development, expansion and survival of T cells and B cells, regulating mature lymphocyte populations and maintaining lymphatic homeostasis. IL-7 interacts with IL7RA and CSF2RG subunits, activates kinases, including JAK1 or JAK3, and initiates signaling cascades, such as the PI3K/Akt/mTOR or JAK-STAT5 pathway. GMP IL-7 Protein, Human (HEK293, His) is the recombinant human-derived IL-7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP IL-7 Protein, Human (HEK293, His) is 152 a.a., with molecular weight of 19-30 kDa.

HY-P70637G

	GMP TPO/Thrombopoietin Protein, Human (HEK293, His) Thrombopoietin; C-mpl ligand; MGDF; THPO	Human	HEK293
	TPO/Thrombopoietin Protein, a lineage-specific cytokine, significantly influences megakaryocyte proliferation and maturation, particularly in late developmental stages from committed progenitor cells. It emerges as a potential major physiological regulator, underscoring its crucial role in the intricate orchestration of circulating platelets and emphasizing its importance in megakaryocyte biology and platelet formation. GMP TPO/Thrombopoietin Protein, Human (HEK293, His) is the recombinant human-derived TPO/Thrombopoietin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP TPO/Thrombopoietin Protein, Human (HEK293, His) is 332 a.a., with molecular weight of 70-90 kDa.

HY-P70593G

	GMP Fibronectin Protein, Human NovoNectin; Fibronectin; FN; Cold-insoluble globulin; CIG; FN; Fibronectin 1	Human	E. coli
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. GMP Fibronectin Protein, Human is a recombinant protein dimer complex containing human-derived Fibronectin protein, expressed by E. coli , with tag free. GMP Fibronectin Protein, Human, has molecular weight of ~60.0 kDa.

HY-P70757G

	GMP SCF Protein, Human (HEK293, His) Kit Ligand; MGF; SCF; c-Kit ligand; KITLG; sKITLG	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. GMP SCF Protein, Human (HEK293, His) is the recombinant human-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP SCF Protein, Human (HEK293, His) is 189 a.a., with molecular weight of 30-50 kDa.

HY-P75791

	GMPR Protein, Human (His) GMP Reductase 1; Guanosine Monophosphate Reductase 1; GMPR; GMPR1	Human	E. coli
	GMPR protein plays a crucial role in nucleotide metabolism by catalyzing the irreversible NADPH-dependent deamination of to IMP. This enzymatic activity is pivotal for the conversion of nucleobase, nucleoside, and nucleotide derivatives of guanine (G) to adenine (A) nucleotides, contributing to the intricate network of biochemical processes involved in maintaining the essential intracellular balance between A and G nucleotides. GMPR Protein, Human (His) is the recombinant human-derived GMPR protein, expressed by E. coli , with N-His labeled tag. The total length of GMPR Protein, Human (His) is 345 a.a., with molecular weight of ~37 kDa.

HY-P70586G

	GMP IL-1 beta Protein, Human Interleukin-1 beta; Catabolin; IL1F2; IL1B	Human	E. coli
	IL-1 beta is a potent proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta plays a key role in inflammation and immunologic reactions. GMP IL-1 beta Protein, Human, is a recombinant GMP-grade protein, consists of 153 amino acids (A117-S269) and is expressed in E. coli.

HY-P70440G

	GMP FGF basic/bFGF Protein, Human Fibroblast growth factor 2; FGF-2; bFGF; HBGF-2	Human	E. coli
	FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.GMP FGF basic/bFGF Protein, Human, consists of 157 amino acids, produced by E.coli with tag free.

HY-P70485G

	GMP Vitronectin Protein, Human (HEK293, His) Vitronectin; VN; S-Protein; Serum-Spreading Factor; V75; VTN	Human	HEK293
	Vitronectin is a key cell adhesion factor in serum and tissues and plays a crucial role in cell interactions by binding to glycosaminoglycans and proteoglycans. It is recognized by specific integrins and serves as an important adhesion molecule, facilitating cell-matrix interactions. GMP Vitronectin Protein, Human (HEK293, His) is the recombinant human-derived Vitronectin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP Vitronectin Protein, Human (HEK293, His) is 459 a.a., with molecular weight of 60-80 kDa.

HY-P70627G

	GMP HGF Protein, Human (HEK293, His) Hepatocyte growth factor; HPTA; HGF; SF; Scatter factor; Hepatopoietin-A	Human	HEK293
	HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and exhibits hepatotrophic properties. It acts as a growth factor for diverse tissues, functioning as an activating ligand for MET receptor tyrosine kinase. Upon binding, HGF promotes MET dimerization, activating the MAPK signaling cascade via TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains linked by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. GMP HGF Protein, Human (HEK293, His) is the recombinant human-derived HGF protein, expressed by HEK293, with C-6*His labeled tag. The total length of GMP HGF Protein, Human (HEK293, His) is 697 a.a., with molecular weight of 32-38 & 50-65 kDa, respectively.

HY-P73383

	P-Selectin Protein, Mouse (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Mouse	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes. It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X. P-Selectin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of P-Selectin Protein, Mouse (HEK293, Fc) is 668 a.a., with molecular weight of ~135 kDa.

HY-P73385

	P-Selectin Protein, Rat (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rat	HEK293
	P-Selectin, a Ca(2+)-dependent receptor on myeloid cells, binds to neutrophils and monocytes via carbohydrates. It interacts with SELPLG to enable rapid leukocyte rolling over vascular surfaces in early inflammation. P-Selectin also interacts with SNX17 and promotes neutrophil adhesion and rolling, requiring SELPLG's sialyl-Lewis X and tyrosine sulfation. P-Selectin Protein, Rat (HEK293, Fc) is the recombinant rat-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of P-Selectin Protein, Rat (HEK293, Fc) is 659 a.a., with molecular weight of ~98.7 kDa.

HY-P73689

	P-Selectin Protein, Rat (HEK293, His) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rat	HEK293
	P-Selectin, a Ca(2+)-dependent receptor on myeloid cells, binds to neutrophils and monocytes via carbohydrates. It interacts with SELPLG to enable rapid leukocyte rolling over vascular surfaces in early inflammation. P-Selectin also interacts with SNX17 and promotes neutrophil adhesion and rolling, requiring SELPLG's sialyl-Lewis X and tyrosine sulfation. P-Selectin Protein, Rat (HEK293, His) is the recombinant rat-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-Selectin Protein, Rat (HEK293, His) is 659 a.a., with molecular weight of ~115 kDa.

HY-P73690

	P-Selectin Protein, Human (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Human	HEK293
	P-selectin, a Ca(2+)-dependent receptor on myeloid cells, crucially binds to sialyl-Lewis X on neutrophils and monocytes, facilitating the interaction of activated endothelial cells or platelets with leukocytes. This engagement, primarily with SELPLG/PSGL1 and PODXL2, is vital for the rapid rolling of leukocytes during early inflammation. P-selectin's interactions with SNX17 further mediate neutrophil adhesion and rolling, dependent on the sialyl-Lewis X epitope and specific tyrosine sulfation on SELPLG. P-Selectin Protein, Human (HEK293, Fc) is the recombinant human-derived P-Selectin protein, expressed by HEK293, with C-hFc labeled tag. The total length of P-Selectin Protein, Human (HEK293, Fc) is 730 a.a., with molecular weight of 130-150 kDa.

HY-P78551

	GMP IL-2 Protein, Human (solution) Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	E. coli
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. GMP IL-2 Protein, Human is the recombinant human-derived IL-2 protein, expressed by E. coli , with tag free. The total length of GMP IL-2 Protein, Human is 133 a.a., with molecular weight of ~15.5 kDa.

HY-P70311G

	GMP Activin A Protein, Human/Mouse/Rat (HEK293) rHuActivin A; Inhibin beta A chain; INHBA; Activin A	Rat;Mouse;Human	HEK293
	The INHBA protein plays a key role in regulating pituitary function by regulating follicle-stimulating hormone secretion together with activin. Its broad effects span a variety of physiological processes, including hormone secretion, germ cell development, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic development, and bone growth, depending on unique subunit composition. GMP Activin A Protein, Human/Mouse/Rat (HEK293) is the recombinant rat, mouse, human-derived Activin A protein, expressed by HEK293 , with tag free. The total length of GMP Activin A Protein, Human/Mouse/Rat (HEK293) is 116 a.a., with molecular weight of 13-15 kDa.

HY-P73687

	P-Selectin Protein, Rhesus Macaque (HEK293, His) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rhesus Macaque	HEK293
	P-Selectin Protein, Rhesus Macaque (HEK293, His) is a member of the selectin family of cell adhesion molecules. P-selectin (CD62P) has an N-terminal lectin domain, an epidermal growth factor motif, (generally) nine regulatory protein repeats, a transmembrane section and a short intracytoplasmic tail. P-selectin mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. P-selectin glycoprotein ligand-1 (PSGL-1) is a major ligand for P-selectin. P-Selectin Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-Selectin Protein, Rhesus Macaque (HEK293, His) is 730 a.a., with molecular weight of ~81.2 kDa.

HY-P73688

	P-Selectin Protein, Rhesus Macaque (HEK293, Fc) P-selectin; GMP-140; LECAM3; PADGEM; CD62P; Selp	Rhesus Macaque	HEK293
	P-Selectin Protein, Rhesus Macaque (HEK293, His) is a member of the selectin family of cell adhesion molecules. P-selectin (CD62P) has an N-terminal lectin domain, an epidermal growth factor motif, (generally) nine regulatory protein repeats, a transmembrane section and a short intracytoplasmic tail. P-selectin mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. P-selectin glycoprotein ligand-1 (PSGL-1) is a major ligand for P-selectin. P-Selectin Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived P-Selectin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of P-Selectin Protein, Rhesus Macaque (HEK293, Fc) is 730 a.a., with molecular weight of ~106.8 kDa.

HY-P7037G

	GMP IL-2 Protein, Human (Tag Free) Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	E. coli
	IL-2 Protein, Human is an adjunctive immunotherapeutic agent to treat tuberculosis (TB).

HY-P70758G

	GMP IL-2 Protein, Human (HEK293, His) Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin; IL2	Human	HEK293
	IL-2 protein is mainly produced by activated CD4-positive helper T cells and plays an important role in immune response and tolerance. Binding to IL-2R induces downstream signaling through JAK1 and JAK3 phosphorylation, thereby activating various pathways, including STAT, PI3K, and MAPK. GMP IL-2 Protein, Human (HEK293, His) is the recombinant human-derived IL-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP IL-2 Protein, Human (HEK293, His) is 133 a.a., with molecular weight of 14-18 kDa.

HY-P70567G

	GMP GM-CSF Protein, Human (HEK293, His) Granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; CSF; Molgramostin and Sargramostim	Human	HEK293
	The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GMP GM-CSF Protein, Human (HEK293, His) is the recombinant human-derived GM-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP GM-CSF Protein, Human (HEK293, His) is 127 a.a., with molecular weight of 17-30 kDa.

HY-P70454G

	GMP IL-1 alpha Protein, Human Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1	Human	E. coli
	IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. GMP IL-1 alpha Protein, Human is a recombinant protein consisting of 153 amino acids (A117-S269) and is produced by E. coli.

HY-P72408

	P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) CD62 antigen-like family member P; GMP-140; LECAM3; PADGEM	Mouse	HEK293
	P-selectin is a Ca(2+)-dependent receptor on myeloid cells that specifically binds to carbohydrates on neutrophils and monocytes. It mediates interactions between activated endothelial cells or platelets and leukocytes by recognizing sialic acid-Lewis X. P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) is the recombinant mouse-derived P-selectin protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His) is 668 a.a., with molecular weight of 102-122 kDa.

HY-P77728

	GMP-CRISPR-Cas9 Protein, S. pyogenes (His) CRISPR-associated endonuclease Cas9/Csn1; cas9; SpCas9; SpyCas9	Others	E. coli
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. GMP-CRISPR-Cas9 Protein, S. pyogenes (His) is the recombinant GMP-CRISPR-Cas9 protein, expressed by E. coli , with His labeled tag. The total length of GMP-CRISPR-Cas9 Protein, S. pyogenes (His) is 1367 a.a., with molecular weight of ~163 kDa.

HY-P70609G

	GMP CD40L/CD154/TRAP Protein, Human (HEK293) CD40 ligand; CD40-L; TRAP; CD154; TNFSF5	Human	HEK293
	CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in human, cleaved into 2 chains of membrane form (1-261 a.a.) and soluble form (113-261 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Human (HEK293) has a total length of 149 amino acids (M113-L261), is expressed in HEK293 cells with tag free.

HY-P78349

	P-Selectin Protein, Mouse (HEK293, His) FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-Selectin; SELP; CD62P; CD62; LECAM3	Mouse	HEK293
	P-selectin, a Ca(2+)-dependent receptor on myeloid cells, binds specifically to carbohydrates on neutrophils and monocytes. It mediates interaction between activated endothelial cells or platelets and leukocytes through recognition of sialyl-Lewis X. P-selectin facilitates leukocyte rolling over vascular surfaces during inflammation by interacting with SELPLG and SNX17. It also promotes neutrophil adhesion and leukocyte rolling through interactions with SELPLG/PSGL1 and PODXL2, requiring sialyl-Lewis X and tyrosine sulfation on SELPLG. P-Selectin Protein, Mouse (HEK293, His) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-Selectin Protein, Mouse (HEK293, His) is 668 a.a., with molecular weight of 110-130 kDa.

HY-P70544G

	GMP FLT3LG Protein, Human (HEK293, His) Fms-related tyrosine kinase 3 ligand; Flt3L; SL cytokine; FLT3LG	Human	HEK293
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. GMP FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP FLT3LG Protein, Human (HEK293, His) is 158 a.a., with molecular weight of 24-32 kDa.

HY-P77242

	TMED4 Protein, Human (HEK293, His) Transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, His) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMED4 Protein, Human (HEK293, His) is 165 a.a., with molecular weight of ~23 kDa.

HY-P77243

	TMED4 Protein, Human (HEK293, Fc) Transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMED4 Protein, Human (HEK293, Fc) is 194 a.a., with molecular weight of ~45.6 KDa.

HY-P78511

P-Selectin Protein, Human (HEK293, His-Avi)

FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-Selectin; SELP; CD62P; CD62; LECAM3
Human HEK293

HY-P70487G

	GMP Glypican-3/GPC3 Protein, Human (HEK293, His) Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5	Human	HEK293
	The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. GMP Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP Glypican-3/GPC3 Protein, Human (HEK293, His) is 535 a.a., with molecular weight of 70-150 & 38 kDa, respectively.

HY-P70955

	GMPR Protein, Human (HEK293, His) GMP Reductase 1; Guanosine 5' -Monophosphate Oxidoreductase 1; Guanosine Monophosphate Reductase 1; GMPR; GMPR1	Human	HEK293
	GMP reductase 1 (GMPR1) catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. GMPR1 functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. GMPR1 contributes to non-shivering thermogenesis while promoting the progression of Alzheimer's disease. GMPR Protein, Human (HEK293, His) is the recombinant human-derived GMPR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMPR Protein, Human (HEK293, His) is 345 a.a., with molecular weight of ~40.0 kDa.

HY-P78201

	P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-Selectin; SELP; CD62P; CD62; LECAM3	Human	HEK293
	P-selectin, a Ca(2+)-dependent receptor on myeloid cells, crucially binds to sialyl-Lewis X on neutrophils and monocytes, facilitating the interaction of activated endothelial cells or platelets with leukocytes. This engagement, primarily with SELPLG/PSGL1 and PODXL2, is vital for the rapid rolling of leukocytes during early inflammation. P-selectin's interactions with SNX17 further mediate neutrophil adhesion and rolling, dependent on the sialyl-Lewis X epitope and specific tyrosine sulfation on SELPLG. P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived P-Selectin protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) is 730 a.a., with molecular weight of 115-140 kDa.

HY-P73156

	GMP IL-12 Protein, Human (HEK293, His) GMP IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Human	HEK293
	Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Human (HEK293, His), a recombinant GMP-grade protein, is produced in HEK293 cells with a C-Terminal His-tag . It consists of IL-12A (M1-S219) and IL-12B (M1-S328).

HY-P70426G

	GMP TNF-alpha/TNFSF2 Protein, Human 1 Publications Verification Tumor Necrosis Factor; Cachectin; TNF-Alpha; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF-a; TNF; TNFA; TNFSF2	Human	E. coli
	Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine. TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-α MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse. TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury. GMP TNF-alpha/TNFSF2 Protein, Human is a recombinant protein consisting of 157 amino acids (V77-L233) and is produced in E. coli.

HY-P70576G

	GMP IL-3 Protein, Human (His) Interleukin-3; IL-3; Hematopoietic Growth Factor; Mast Cell Growth Factor; MCGF; Multipotential Colony-Stimulating Factor; P-Cell-Stimulating Factor; IL3	Human	E. coli
	IL-3 protein is mainly secreted by T lymphocytes, mast cells and osteoblasts and is critical for the generation and differentiation of hematopoietic progenitor cells. It stimulates mature basophils, eosinophils and monocytes, promoting functional activation. GMP IL-3 Protein, Human (His) is the recombinant human-derived IL-3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GMP IL-3 Protein, Human (His) is 133 a.a., with molecular weight of 13-16 kDa.

HY-P76678

	TMED9 Protein, Human (HEK293, His) Transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2	Human	HEK293
	TMED9, a key player in vesicular protein trafficking, operates prominently in the early secretory pathway, specifically in COPI vesicle-mediated retrograde transport. It facilitates coatomer recruitment to membranes, enhances ARFGAP2 activity, and ensures specific retention of p24 complexes in cis-Golgi membranes, notably influencing TMED2 and TMED10 localization. Beyond retrograde transport, TMED9 contributes to intracellular membrane organization, including the ER-Golgi intermediate compartment and Golgi apparatus, and participates in PTPN2 isoform PTPB ER localization. TMED9's dynamic oligomeric states involve monomers and homodimers, influenced by its interactions with EMP24/GP25L family members (TMED2, TMED7, and TMED10) and specific associations with TMED5, COPG1, PTPN2, SPAST, and STX17. TMED9 Protein, Human (HEK293, His) is the recombinant human-derived TMED9 protein, expressed by HEK293, with C-His labeled tag. The total length of TMED9 Protein, Human (HEK293, His) is 165 a.a., with molecular weight of ~20.8 kDa.

HY-P76679

	TMED9 Protein, Human (HEK293, Fc) Transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2	Human	HEK293
	TMED9, a key player in vesicular protein trafficking, operates prominently in the early secretory pathway, specifically in COPI vesicle-mediated retrograde transport. It facilitates coatomer recruitment to membranes, enhances ARFGAP2 activity, and ensures specific retention of p24 complexes in cis-Golgi membranes, notably influencing TMED2 and TMED10 localization. Beyond retrograde transport, TMED9 contributes to intracellular membrane organization, including the ER-Golgi intermediate compartment and Golgi apparatus, and participates in PTPN2 isoform PTPB ER localization. TMED9's dynamic oligomeric states involve monomers and homodimers, influenced by its interactions with EMP24/GP25L family members (TMED2, TMED7, and TMED10) and specific associations with TMED5, COPG1, PTPN2, SPAST, and STX17. TMED9 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED9 protein, expressed by HEK293, with C-mFc labeled tag. The total length of TMED9 Protein, Human (HEK293, Fc) is 202 a.a., with molecular weight of ~45.8 kDa.

HY-P78549

	GMP IL-4 Protein, Human 3 Publications Verification Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	E. coli
	The IL-4 protein is primarily secreted by mast cells, T cells, eosinophils, and basophils and is critical for antibody production, hematopoiesis, and immune responses. It induces MHC class II expression on B cells, enhances IgE and IgG1 secretion, and modulates CD23 and IL31RA expression. GMP IL-4 Protein, Human is the recombinant human-derived IL-4 protein, expressed by E. coli , with tag free. The total length of GMP IL-4 Protein, Human is 129 a.a., with molecular weight of ~15.6 kDa.

HY-P70750G

	GMP IL-4 Protein, Human (HEK293) Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4	Human	HEK293
	GMP IL-4 Protein, Human (HEK293) is a recombinant GMP-grade protein produced by HEK293 cells with C-His tag. IL-4 is an anti-inflammatory cytokine acting as a pleiotropic regulator of numerous immune and inflammatory processes.

HY-P70783G

	GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1	Human	E. coli
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is the recombinant human-derived LR3 IGF-I/IGF-1 protein, expressed by E. coli , with tag free. The total length of GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is 70 a.a., with molecular weight of ~11 kDa.

HY-P72337

	cGAS Protein, Human (His) 1 Publications Verification Cyclic GMP-AMP synthase; cGAMP synthase; h-cGAS; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1; MB21D1; C6orf150	Human	E. coli
	The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His) is the recombinant human-derived cGAS protein, expressed by E. coli , with C-6*His labeled tag. The total length of cGAS Protein, Human (His) is 522 a.a., with molecular weight of ~58.9 kDa.

Cat. No.	Product Name	Chemical Structure

HY-N5134S2

5'-Guanylic acid-15N5 dilithium
5'-Guanylic acid- ¹⁵N₅ (5'-GMP- ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹⁵N₅) dilithium is ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S1

5'-Guanylic acid-13C10 dilithium

5'-Guanylic acid- ¹³C₁₀ (5'-GMP- ¹³C₁₀ dilithium; 5'-guanosine monophosphate- ¹³C₁₀) dilithium is ¹³C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S3

5'-Guanylic acid-d12 dilithium
5'-Guanylic acid-d₁₂ (5'-GMP-d₁₂ dilithium; 5'-guanosine monophosphate-d₁₂) dilithium is deuterium labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S4

5'-Guanylic acid-15N5,d12 dilithium

5'-Guanylic acid- ¹⁵N₅,d₁₂ (5'-GMP- ¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate- ¹⁵N₅,d₁₂) dilithium is deuterium and ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-N5134S5

5'-Guanylic acid-13C10,15N5 dilithium

5'-Guanylic acid- ¹³C₁₀, ¹⁵N₅ (5'-GMP- ¹³C₁₀, ¹⁵N₅ dilithium; 5'-guanosine monophosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-128790S1

4-Methoxyestrone-13C6
4-Methoxyestrone- ¹³C₆ is a ¹³C-labeled 5'-Guanylic acid. 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and

HY-50723S

3-Methylxanthine-13C4,15N3
3-Methylxanthine- ¹³C₄, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled 3-Methylxanthine. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.

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