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592474-91-4

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Cat. No. Product Name Target Research Areas
  • HY-123418
    PKUMDL-WQ-2201

    Phosphoglycerate Dehydrogenase (PHGDH) Cancer
    PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor (IC50=35.7 μM). PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth.