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Results for "

70S

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (11) AMPK (2) Antibiotic (7) Apoptosis (7) Autophagy (3) Bacterial (10) DNA/RNA Synthesis (2) Drug Metabolite (1) EGFR (2) Endogenous Metabolite (1) ERK (1) FAK (1) HIF/HIF Prolyl-Hydroxylase (1) HSP (2) HSV (1) Isotope-Labeled Compounds (1) mTOR (2) Necroptosis (1) NF-κB (2) p38 MAPK (2) PI3K (1) PKA (3) Proteasome (1) Ribosomal S6 Kinase (RSK) (11) ROCK (2) Toll-like Receptor (TLR) (1) VEGFR (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (2) Infection (12) Inflammation/Immunology (5) Metabolic Disease (1)

By Targets:

Akt (11)

AMPK (2)

Antibiotic (7)

Apoptosis (7)

Autophagy (3)

Bacterial (10)

DNA/RNA Synthesis (2)

Drug Metabolite (1)

EGFR (2)

Endogenous Metabolite (1)

ERK (1)

FAK (1)

HIF/HIF Prolyl-Hydroxylase (1)

HSP (2)

HSV (1)

Isotope-Labeled Compounds (1)

mTOR (2)

Necroptosis (1)

NF-κB (2)

p38 MAPK (2)

PI3K (1)

PKA (3)

Proteasome (1)

Ribosomal S6 Kinase (RSK) (11)

ROCK (2)

Toll-like Receptor (TLR) (1)

VEGFR (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (2)

Infection (12)

Inflammation/Immunology (5)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5723A

Api137 TFA	Bacterial	Infection
Api137 TFA is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 TFA inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain .

HY-13858A

Sarecycline hydrochloride 4 Publications Verification P-005672 hydrochloride	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .

HY-B1864B

Kasugamycin hydrochloride hydrate 1 Publications Verification Ksg hydrochloride hydrate	Bacterial Antibiotic	Infection
Kasugamycin hydrochloride hydrate (Ksg hydrochloride hydrate) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride hydrate (Ksg hydrochloride hydrate) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-P5723

Api137	Bacterial	Infection
Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain .

HY-16770

Sarecycline P-005672	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne .

HY-B1864A

Kasugamycin hydrochloride 1 Publications Verification Ksg hydrochloride	Bacterial Antibiotic	Infection
Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-118099

Florfenicol amine hydrochloride	Bacterial Drug Metabolite	Infection
Florfenicol amine hydrochloride is a metabolite of Florfenicol (HY-B1374). Florfenicol inhibits bacterial protein synthesis by binding to 50S and 70S subunits in the ribosome to abolish the activity of peptidyltransferase. Florfenicol, is a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases .

HY-B0239S3

Chloramphenicol-d4	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Chloramphenicol-d₄ is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis[1][2]. Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity[3].

HY-135748A

Poly (I:C):Kanamycin (1:1) (sodium) Maximum Cited Publications 13 Publications Verification	Toll-like Receptor (TLR) Apoptosis	Infection Cancer
Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and b>MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .

HY-13595

Chrysophanol 3 Publications Verification Chrysophanic acid	EGFR	Cancer
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and *mTOR/p70S6K*.

HY-N1050

Zederone
Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells .

HY-N1333

Rubioncolin C	NF-κB	Cancer
Rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic Cell Death and inhibiting the NF-κB and *Akt/mTOR/P70S6K* Pathway in Human Cancer Cells .

HY-13595R

Chrysophanol (Standard) Chrysophanic acid (Standard)	EGFR	Cancer
Chrysophanol (Standard) is the analytical standard of Chrysophanol. This product is intended for research and analytical applications. Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and *mTOR/p70S6K*.

HY-12059

AT7867 4 Publications Verification	Akt PKA Ribosomal S6 Kinase (RSK)	Cancer
AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and *p70S6K/PKA* with IC₅₀s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.

HY-12059A

AT7867 dihydrochloride 4 Publications Verification	Akt PKA Ribosomal S6 Kinase (RSK)	Cancer
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and *p70S6K/PKA* with IC₅₀s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.

HY-100501

M2698 MSC2363318A
M2698 (MSC2363318A) is an orally active, ATP competitive, selective *p70S6K* and Akt dual-inhibitor with IC₅₀s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity .

HY-130723

AMPK activator 2	AMPK	Cancer
AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-130723A

AMPK activator 2 hydrochloride	AMPK	Cancer
AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .

HY-12059B

AT7867 hydrochloride

Akt Cancer

AT7867 hydrochloride is a potent and orally active inhibitor of AKT and p70 S6 kinase. AT7867 hydrochloride has anticancer effect .
HY-18313

S6K1-IN-1

Ribosomal S6 Kinase (RSK) Metabolic Disease

S6K-18 is a potent and selective p70S6K1 inhibitor with an IC₅₀ of 52 nM .
HY-P0141

Akt/SKG Substrate Peptide

Akt Others

Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .
HY-P0141A

Akt/SKG Substrate Peptide TFA

Akt Others

Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .
HY-152944

S6K1-IN-DG2

Ribosomal S6 Kinase (RSK) Cancer

S6K1-IN-DG2 (Compound 66) is a p70S6K inhibitor (IC₅₀: < 100 nM) .

AT7867 hydrochloride	Akt	Cancer
AT7867 hydrochloride is a potent and orally active inhibitor of AKT and p70 S6 kinase. AT7867 hydrochloride has anticancer effect .

S6K1-IN-1	Ribosomal S6 Kinase (RSK)	Metabolic Disease
S6K-18 is a potent and selective *p70S6K1* inhibitor with an IC₅₀ of 52 nM .

Akt/SKG Substrate Peptide	Akt	Others
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

Akt/SKG Substrate Peptide TFA	Akt	Others
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

S6K1-IN-DG2	Ribosomal S6 Kinase (RSK)	Cancer
S6K1-IN-DG2 (Compound 66) is a *p70S6K* inhibitor (IC₅₀: < 100 nM) .

HY-12493A

LY-2584702 tosylate salt 5 Publications Verification	Ribosomal S6 Kinase (RSK)	Cancer
LY-2584702 tosylate salt is a selective ATP competitive inhibitor of *p70S6K* with an IC₅₀ of 4 nM. In S6K1 enzyme assay, the IC₅₀ of LY-2584702 is 2 nM.

HY-12493B

LY-2584702 hydrochloride	Ribosomal S6 Kinase (RSK)	Cancer
LY-2584702 hydrochloride is a selective ATP competitive inhibitor of *p70S6K* with an IC₅₀ of 4 nM. In S6K1 enzyme assay, the IC₅₀ of LY-2584702 is 2 nM.

HY-12493

LY-2584702 free base	Ribosomal S6 Kinase (RSK)	Cancer
LY-2584702 free base is a selective ATP competitive inhibitor of *p70S6K* with an IC₅₀ of 4 nM. In S6K1 enzyme assay, the IC₅₀ of LY-2584702 is 2 nM.

HY-148877

AT-533	HSP HSV HIF/HIF Prolyl-Hydroxylase VEGFR NF-κB ERK Akt FAK	Infection Inflammation/Immunology Cancer
AT-533 is a potent Hsp90 and HSV inhibitor. AT-533 suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits the activation of the downstream pathways, including *Akt/mTOR/p70S6K, Erk1/2* and FAK. AT-533 inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs) .

HY-134903

(32-Carbonyl)-RMC-5552	mTOR	Cancer
(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC₅₀s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2) .

HY-14362

GSK-25	ROCK Ribosomal S6 Kinase (RSK)	Cardiovascular Disease
GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC₅₀=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC₅₀=398 nM, p70S6K: IC₅₀=1 μM). GSK-25 inhibits P450 profile (IC₅₀s of 2.5, 5.2, 2.5 µM for CYP2C9, CYP2D6, CYP3A4, respectively) .

HY-N8380

(-)-Latifolin	Apoptosis Autophagy PI3K Necroptosis	Cardiovascular Disease Inflammation/Immunology Cancer
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting *PI3K/AKT/mTOR/p70S6K* signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

HY-120035

DD1	Proteasome Ribosomal S6 Kinase (RSK) Apoptosis	Cancer
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation .

HY-16071

AT13148 2 Publications Verification	Akt PKA ROCK Ribosomal S6 Kinase (RSK)	Cancer
AT13148 is an orally active and ATP-competitive, multi-AGC kinase inhibitor with IC₅₀s of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.

HY-120909

YK5	HSP Apoptosis	Cancer
YK5 is a potent and selective *Hsp70* inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes .

HY-155721

22-(4′-py)-JA 22-(4′-Pyridinecarbonyl) jorunnamycin A	Akt mTOR	Cancer
22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC) .

HY-114038

SB-747651A	p38 MAPK	Inflammation/Immunology
SB-747651A is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC₅₀ of 11 nM. SB-747651A also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A can be used for inflammation research .

HY-110313

SB-747651A dihydrochloride	p38 MAPK	Inflammation/Immunology
SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC₅₀ of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research .

HY-16566

Kanamycin Kanamycin A	Antibiotic Bacterial	Infection Inflammation/Immunology
Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

HY-16566A

Kanamycin sulfate 5+ Cited Publications Kanamycin A sulfate	Bacterial Antibiotic	Infection
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

HY-112400

Bisindolylmaleimide V BIM V	Ribosomal S6 Kinase (RSK)	Cancer
Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC₅₀ value over 100 µM . Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70 ^s6k/p85 ^s6k (S6K) in vivo with an IC₅₀ of 8 µM .

HY-112234

L-Sepiapterin Sepiapterin	Endogenous Metabolite	Cancer
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression .

HY-13260

CCT128930 3 Publications Verification	Akt Autophagy Apoptosis	Cancer
CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC₅₀=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC₅₀=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC₅₀=120 nM). Antitumor activity.

HY-13260A

CCT128930 hydrochloride 3 Publications Verification	Akt Autophagy Apoptosis	Cancer
CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC₅₀=6 nM). CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC₅₀=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC₅₀=120 nM). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity .

HY-126257

AKT-IN-3	Akt Apoptosis	Cancer
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells .

Api137 TFA	Bacterial	Infection
Api137 TFA is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 TFA inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain .

Api137	Bacterial	Infection
Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain .

Cat. No.	Product Name	Category	Target	Chemical Structure