8-13

By Targets:	Adrenergic Receptor (1) Apoptosis (1) Dopamine Receptor (1) EGFR (2) Fluorescent Dye (4) Free Fatty Acid Receptor (2) mAChR (1) Neurotensin Receptor (6) PAK (1) PARP (1) PI3K (1)
By Research Areas:	Cancer (5) Metabolic Disease (2) Neurological Disease (8)
Click Chemistry:	DBCO (1) Alkynes (2)

Targets Recommended: CX3CR1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0251

*Neurotensin(8-13)* 1 Publications Verification	Neurotensin Receptor	Neurological Disease
Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.

HY-P2544

*[Lys8, Lys9]-Neurotensin (8-13)* JMV438	Neurotensin Receptor	Neurological Disease
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with K_i values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively .

HY-W248594

*IR 813* tosylate**	Fluorescent Dye	Others
IR 813 tosylate is a near-infrared (NIR) fluorescent dye (λ_ex=815 nm, λ_em=840 nm) and can be used for visualizing regional lymph nodes in mice .

HY-P4223

*Acetyl neurotensin (8-13)*	Neurotensin Receptor	Neurological Disease
Acetyl neurotensin (8-13) is the shortest analog of neurotensin with full binding and pharmacological activities .

HY-D1535

*IR 813* perchlorate**	Fluorescent Dye	Others
IR 813 perchlorate is a near-infrared (NIR) fluorescent dye (Ex=815 nm, Em=840 nm) and can be used for visualizing regional lymph nodes in mice .

HY-135414A

Cyanine5 NHS ester bromide	Fluorescent Dye	Others
Cyanine5 NHS ester bromide is a active compound, can be used to label amino groups in peptides, proteins, and oligonucleotides. Cyanine5 NHS ester bromide is a cyanine dye, fluorescence-labeling neurotensin (8-13) via arginine residues .

HY-143319

SPH5030	Others	Cancer
SPH5030 is a selective and irreversible HER2 inhibitor. SPH5030 inhibits HER2 ^WT and EGFR ^WT with IC₅₀s of 3.51 and 8.13 nM, respectively. SPH5030 shows excellent activities against HER2 mutants. SPH5030 can be used for the research of cancer .

HY-141496

A-77636	Dopamine Receptor	Neurological Disease
A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity .

HY-149941

hNTS1R agonist-1	Neurotensin Receptor	Neurological Disease
hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (K_i: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent .

HY-129707

AMG 837 hemicalcium	Free Fatty Acid Receptor	Metabolic Disease
AMG 837 hemicalcium is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 hemicalcium inhibits specific [ ³H]AMG 837 binding at the human FFA1 receptor with a pIC₅₀ of 8.13. AMG 837 hemicalcium could enhance insulin secretion and lower glucose levels in rodents .

HY-139300

Epitinib HMPL-813	EGFR	Cancer
Epitinib is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib can be used for the research of cancer . Epitinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139300A

Epitinib succinate HMPL-813 succinate	EGFR	Cancer
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer . Epitinib (succinate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13967B

AMG 837 calcium hydrate 1 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 calcium hydrate inhibits specific [ ³H]AMG 837 binding at the human FFA1 receptor with a pIC₅₀ of 8.13. AMG 837 calcium hydrate could enhance insulin secretion and lower glucose levels in rodents . AMG 837 (calcium hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity .

HY-W588722

ICG-DBCO	Fluorescent Dye	Others
ICG-DBCO is a near-infrared fluorescent dye that is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling.Ex/Em = 789/813 nm

HY-133124

PARP/PI3K-IN-1	PARP PI3K Apoptosis	Cancer
PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC₅₀ values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound targeted against a wide range of oncologic diseases .

HY-P1256

JMV 449	Neurotensin Receptor	Neurological Disease
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [ ¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P1256C

JMV 449 acetate	Neurotensin Receptor	Neurological Disease
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-15542A

FRAX597

5 Publications Verification

PAK Cancer

FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC₅₀ of 8, 13 and 19 nM for PAK1, 2 and 3.

FRAX597 5 Publications Verification	PAK	Cancer
FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC₅₀ of 8, 13 and 19 nM for PAK1, 2 and 3.

Cat. No.	Product Name	Type

HY-W588722

ICG-DBCO	Fluorescent Dyes/Probes
ICG-DBCO is a near-infrared fluorescent dye that is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling.Ex/Em = 789/813 nm

HY-D1535

*IR 813* perchlorate**	Fluorescent Dyes/Probes
IR 813 perchlorate is a near-infrared (NIR) fluorescent dye (Ex=815 nm, Em=840 nm) and can be used for visualizing regional lymph nodes in mice .

HY-135414A

Cyanine5 NHS ester bromide	Fluorescent Dyes/Probes
Cyanine5 NHS ester bromide is a active compound, can be used to label amino groups in peptides, proteins, and oligonucleotides. Cyanine5 NHS ester bromide is a cyanine dye, fluorescence-labeling neurotensin (8-13) via arginine residues .

Cat. No.	Product Name	Target	Research Area

HY-P0251

*Neurotensin(8-13)* 1 Publications Verification	Neurotensin Receptor	Neurological Disease
Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.

HY-P2544

*[Lys8, Lys9]-Neurotensin (8-13)* JMV438	Neurotensin Receptor	Neurological Disease
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with K_i values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively .

HY-P4223

Acetyl neurotensin (8-13)

Neurotensin Receptor Neurological Disease

Acetyl neurotensin (8-13) is the shortest analog of neurotensin with full binding and pharmacological activities .

*Acetyl neurotensin (8-13)*	Neurotensin Receptor	Neurological Disease
Acetyl neurotensin (8-13) is the shortest analog of neurotensin with full binding and pharmacological activities .

HY-149941

hNTS1R agonist-1	Neurotensin Receptor	Neurological Disease
hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (K_i: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent .

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity .

HY-P1256

JMV 449	Neurotensin Receptor	Neurological Disease
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC₅₀ of 0.15 nM for inhibition of [ ¹²⁵I]-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

HY-P1256C

JMV 449 acetate	Neurotensin Receptor	Neurological Disease
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC₅₀ of 0.15 nM for inhibition of ¹²⁵I-neurotensin binding to neonatal mouse brain and an EC₅₀ of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .

Cat. No.	Product Name	Application	Reactivity

HY-P80579

Calumenin Antibody (YA813) CALU; CALU_HUMAN; Calumenin 1; Calumenin 2; Calumenin; Crocalbin; crocalbin-like protein; FLJ90608; IEF SSP 9302; multiple EF-hand protein; OTTHUMP00000212712; OTTHUMP00000212713; OTTHUMP00000212714; OTTHUMP00000212715.	WB	Human, Mouse
Calumenin Antibody (YA813) is a non-conjugated and Mouse origined monoclonal antibody about 37 kDa, targeting to Calumenin (4C6). It can be used for WB assays with tag free, in the background of Human, Mouse.

Cat. No.	Product Name		Classification

HY-139300A

Epitinib succinate HMPL-813 succinate		Alkynes
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer . Epitinib (succinate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W588722

ICG-DBCO

DBCO

ICG-DBCO is a near-infrared fluorescent dye that is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling.Ex/Em = 789/813 nm

ICG-DBCO		DBCO
ICG-DBCO is a near-infrared fluorescent dye that is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling.Ex/Em = 789/813 nm

HY-139300

Epitinib HMPL-813		Alkynes
Epitinib is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib can be used for the research of cancer . Epitinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Click Chemistry