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Pathways Recommended:	TGF-beta/Smad

Results for "

A-beta Monomer Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Beta-secretase (1) Cathepsin (1) Cholinesterase (ChE) (1) Interleukin Related (1) NF-κB (1) NOD-like Receptor (NLR) (1) TNF Receptor (1) γ-secretase (1)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (3)

4

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Targets Recommended: Amyloid-β TGF-β Receptor Beta-secretase TGF-beta/Smad 17β-HSD β-catenin 11β-HSD Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas

Muscone 3 Publications Verification	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology Cardiovascular Disease
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

Aβ-IN-7	Amyloid-β	Neurological Disease
Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM.

Z-Phe-Ala-diazomethylketone PADK	γ-secretase Cathepsin	Neurological Disease
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research.

AChE/BChE-IN-12	Cholinesterase (ChE) Beta-secretase Amyloid-β	Neurological Disease
AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC₅₀ values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of *amyloid-β* monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research.

Cat. No.	Product Name	Target	Research Area

Cat. No.	Product Name	Target	Category

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