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AAAS Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Apoptosis (1) Bacterial (2) Checkpoint Kinase (Chk) (1) E1/E2/E3 Enzyme (1) Epigenetic Reader Domain (2) Fluorescent Dye (1) Hedgehog (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) NF-κB (1) p97 (3) Phosphatase (1) Proton Pump (1) Sirtuin (1) STAT (1) Thyroid Hormone Receptor (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (2) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Isotope-Labeled Compounds

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148900

SCFSkp2-IN-2	E1/E2/E3 Enzyme	Cancer
SCFSkp2-IN-2 (Compound AAA-237) is a Skp2 inhibitor with a K_D of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .

HY-134883

PRMT5-IN-4	Histone Methyltransferase	Cancer
PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor with anti-tumor activity .

HY-145147

AAA-10 1 Publications Verification	Bacterial	Infection
AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC₅₀s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively .

HY-119254

BAY-850 4 Publications Verification	Epigenetic Reader Domain	Metabolic Disease
BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC₅₀ of 166 nM.

HY-111548

Spastazoline 3 Publications Verification	Microtubule/Tubulin	Others
Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC₅₀ of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research .

HY-12861

CB-5083 Maximum Cited Publications 29 Publications Verification	p97	Cancer
CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the *p97 AAA* ATPase/VCP*. CB-5083 selectively inhibits* p97 through its D2 site with the IC₅₀ of 11 nM .

HY-122632

Ciliobrevin D 3 Publications Verification	Hedgehog	Cancer
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro .

HY-100817

Rbin-2	Phosphatase	Others
Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly .

HY-145147A

AAA-10 formic	Bacterial	Infection
AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC₅₀s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH, respectively .

HY-D2376

BH-Vis	Fluorescent Dye	Cancer
BH-Vis is a two-photon fluorescent probe that inhibits cell plasma membrane (CPM). BH-Vis has great potential to accurately identify pyroptosis at the cellular level during AAA development in the mouse abdominal aortic aneurysm AAA model .

HY-119254A

trans-BAY-850	Epigenetic Reader Domain	Metabolic Disease
trans-BAY-850 is the trans isomer of BAY-850 (HY-119254). BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC₅₀ of 166 nM.

HY-124776

NPD8733	p97	Cancer
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .

HY-Q04764

TI17	Thyroid Hormone Receptor Apoptosis	Cancer
TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage .

HY-B0130S1

Perindopril-d5 S-9490-d₅	Isotope-Labeled Compounds Sirtuin Angiotensin-converting Enzyme (ACE) NF-κB STAT	Cardiovascular Disease Neurological Disease Cancer
Perindopril-d₅ (S-9490-d₅) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension .

HY-122198

ML367	Checkpoint Kinase (Chk)	Cancer
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation .

HY-123872

MSC1094308	p97	Cancer
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively . MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer .

HY-146074

RUVBL1/2 ATPase-IN-1	Proton Pump	Cancer
RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC₅₀ values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases .

Cat. No.	Product Name	Type

HY-D2376

BH-Vis	Dyes
BH-Vis is a two-photon fluorescent probe that inhibits cell plasma membrane (CPM). BH-Vis has great potential to accurately identify pyroptosis at the cellular level during AAA development in the mouse abdominal aortic aneurysm AAA model .

Cat. No.	Product Name	Chemical Structure

HY-B0130S1

Perindopril-d5
Perindopril-d₅ (S-9490-d₅) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension .

Perindopril-d5

Perindopril-d₅ (S-9490-d₅) is deuterium labeled Perindopril. Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension .

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