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ABCA1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) AP-1 (1) Apoptosis (1) Autophagy (1) Endogenous Metabolite (1) Fatty Acid Synthase (FASN) (1) Histone Methyltransferase (1) JNK (1) Keap1-Nrf2 (1) LXR (2) MicroRNA (1) NF-κB (1) PPAR (1) Sirtuin (2) Small Interfering RNA (siRNA) (1) TGF-β Receptor (1) VDAC (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (3) Metabolic Disease (6)

11

Inhibitors & Agonists

1

Fluorescent Dye

4

Natural
Products

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

OSBPL7-IN-1 1 Publications Verification	Others	Metabolic Disease
OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of *ABCA1* at the plasma membrane without affecting mRNA expression ^[1].

HY-D0086

DIDS sodium salt

Maximum Cited Publications

10 Publications Verification

MDL101114ZA
VDAC Others

DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor.

Falcarindiol 1 Publications Verification	Apoptosis Autophagy PPAR	Infection Metabolic Disease Inflammation/Immunology Cancer
Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties ^[1] . Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

GSK3987	LXR	Metabolic Disease
GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation ^[1].

ABCA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ABCA1 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ABCA1 Human Pre-designed siRNA Set A ABCA1 Human Pre-designed siRNA Set A

Erythrodiol	Endogenous Metabolite	Metabolic Disease
Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of *ABCA1* protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis ^[1].

IMB-808	LXR	Inflammation/Immunology
IMB-808 is a potent LXRα/β dual agonist with EC₅₀ values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research ^[1].

E1231 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one	Sirtuin	Cardiovascular Disease
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC₅₀=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with *SIRT1* (K_D=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE ^-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases ^[1].

IMM-H007 WS070117	AMPK TGF-β Receptor NF-κB JNK AP-1	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and *JNK/AP1* signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis ^[1] .

Pseudoprotodioscin 1 Publications Verification	Fatty Acid Synthase (FASN) MicroRNA	Metabolic Disease
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides ^[1].

Tanshindiol C	Histone Methyltransferase Keap1-Nrf2 Sirtuin	Cardiovascular Disease Cancer
Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research ^[1] .

Cat. No.	Compare	Product Name	Species	Source

	ABCA1 Protein, Human (Sf9, His, Strep, FLAG) ABCA1; ABC1; CERP	Human	Sf9 insect cells
	The ABCA1 protein catalyzes the translocation of specific phospholipids from the cytoplasm to the extracellular/luminal membrane leaflet in response to ATP hydrolysis. It achieves phospholipid translocation by forcing phospholipids through its channels and loops into elongated hydrophobic tunnels in its extracellular domain. ABCA1 Protein, Human (Sf9, His, Strep, FLAG) is the recombinant human-derived ABCA1 protein, expressed by Sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag. The total length of ABCA1 Protein, Human (Sf9, His, Strep, FLAG) is 2260 a.a., .

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