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Isoforms Recommended:	ACAT2

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ACAT2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (1)

8

Inhibitors & Agonists

2

Natural
Products

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Pyripyropene A	Acyltransferase	Infection Cardiovascular Disease Inflammation/Immunology
Pyripyropene A is an orally active, potent and selective sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) inhibitor, with an IC₅₀ of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo ^[2] .

Avasimibe Maximum Cited Publications 9 Publications Verification CI-1011; PD-148515	Acyltransferase	Cancer
Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC₅₀s of 24 and 9.2 µM for *ACAT1* and *ACAT2*, respectively . Avasimibe can be used for the research of prostate cancer ^[2].

ACAT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for ACAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACAT2 Human Pre-designed siRNA Set A ACAT2 Human Pre-designed siRNA Set A

Acat2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acat2 Mouse Pre-designed siRNA Set A Acat2 Mouse Pre-designed siRNA Set A

ACAT2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACAT2 Rat Pre-designed siRNA Set A contains three designed siRNAs for ACAT2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACAT2 Rat Pre-designed siRNA Set A ACAT2 Rat Pre-designed siRNA Set A

γ-Sanshool	Acyltransferase	Cardiovascular Disease
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human *ACAT-1* and *ACAT-2* activities with IC₅₀s of 12.0 and 82.6 μM .

Nevanimibe PD-132301; ATR-101
Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer .

Nevanimibe hydrochloride 2 Publications Verification PD-132301 hydrochloride; ATR101 hydrochloride
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .

Species:	Human (2) Rat (1)
Tag:	His (3) Myc (1) Trx (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	ACAT2 Protein, Human (Trx-His) Acetyl-CoA acetyltransferase cytosolic; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase; ACTL; ACAT2	Human	E. coli
	ACAT2, Human (Trx-His) is the major ACAT enzyme in human hepatocytes. ACAT2, Human is an important regulator of susceptibility to the development of atherosclerosis.

	ACAT2 Protein, Human (His, Myc) Acetyl-CoA acetyltransferase cytosolic; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase; ACTL; ACAT2	Human	E. coli
	ACAT2 Protein is essential in cholesterol biosynthesis. ACAT2 Protein, Human (His, Myc) is the recombinant human-derived ACAT2 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of ACAT2 Protein, Human (His, Myc) is 397 a.a., with molecular weight of 48.8 kDa.

	ACAT2 Protein, Rat (His) Acetyl-CoA acetyltransferase cytosolic; ACTL; ACAT2	Rat	E. coli
	ACAT2 Protein is pivotal in cholesterol biosynthesis, intricately contributing to cellular lipid homeostasis regulation. Its involvement underscores its significance in modulating cholesterol levels, highlighting an essential function in cellular physiology. ACAT2 Protein, Rat (His) is the recombinant rat-derived ACAT2 protein, expressed by E. coli , with N-His labeled tag. The total length of ACAT2 Protein, Rat (His) is 397 a.a., with molecular weight of ~43.3 kDa.

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