ACC1

By Targets:	Acetyl-CoA Carboxylase (8) Antibiotic (1) Bacterial (1) EAAT (1) Isotope-Labeled Compounds (1) Monocarboxylate Transporter (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12942

PF-05175157 1 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

HY-107709

MK-4074 4 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC₅₀ values of approximately 3 nM.

HY-135981

CMS-121 1 Publications Verification	Acetyl-CoA Carboxylase	Neurological Disease Inflammation/Immunology
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀ values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities ^[1] .

HY-147930

ACC1/2-IN-1	Acetyl-CoA Carboxylase	Cancer
ACC1/2-IN-1 (compound 4s) is a potent *ACC1/2* inhibitor with IC₅₀ values of 98.06 and 29.43 nM for ACC1 and ACC2, respectively. ACC1/2-IN-1 can be used for cancer research ^[1].

HY-147932

ACC1/2-IN-2	Acetyl-CoA Carboxylase	Cancer
ACC1/2-IN-2 (compound PF-3) is a potent *ACC1/2* inhibitor with IC₅₀ values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research ^[1].

HY-16944

Soraphen A (-)-Soraphen A; Soraphen A1α
Soraphen A ((-)-Soraphen A; Soraphen A1α) is a polyketide fungal inhibitor that targets acetyl-CoA carboxylase (ACC1) in vivo. Soraphen A can be isolated from Myxobacter cellulosum ^[1].

HY-16901

Firsocostat Maximum Cited Publications 12 Publications Verification ND-630; GS-0976; NDI-010976	Acetyl-CoA Carboxylase	Metabolic Disease
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively.

HY-16946

CP-610431
CP-610431 is a reversible, ATP-uncompetitive, isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor. CP-610431 inhibits *ACC1* and *ACC2* with IC₅₀s of ~50 nM. CP-610431 can be used for the research of metabolic syndrome ^[1].

HY-15259A

CP-640186 hydrochloride 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation ^[1] .

HY-15259

CP-640186 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation ^[1] .

HY-D0067

7ACC1 5+ Cited Publications DEAC; Coumarin D 1421; D 1421	Monocarboxylate Transporter	Cancer
7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.

HY-151931S

JA-ACC-d3

Jasmonyl-ACC-d₃
Isotope-Labeled Compounds Others

JA-ACC-d₃ is deuterium labeled JA-ACC[1].

*JA-ACC-d3* Jasmonyl-ACC-d₃	Isotope-Labeled Compounds	Others
JA-ACC-d₃ is deuterium labeled JA-ACC[1].

HY-144701

SABA1	Antibiotic Bacterial	Infection Inflammation/Immunology
SABA1 possesses antibacterial properties against Pseudomonas aeruginosa and Escherichia coli, with an IC₅₀ of 4.0 µM against E. coli ACC .

HY-12741

LDN-212320 3 Publications Verification LDN-0212320; OSU-0212320	EAAT	Neurological Disease
LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC ^[1]

HY-N8144

Niga-ichigoside F1	Others	Cardiovascular Disease
Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8144

Niga-ichigoside F1	Cardiovascular Disease Triterpenes Inula sericophylla Franch. Classification of Application Fields Terpenoids Labiatae Source classification Plants Disease Research Fields	Others
Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis ^[1].

Cat. No.	Compare	Product Name	Species	Source

HY-P79193

	Fractalkine/CX3CL1 Protein, Rat Fractalkine; Cx3cl1; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; ACC1; Fkn; Scyd1	Rat	E. coli
	Fractalkine/CX3CL1 protein is a versatile chemokine that acts as a ligand for CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. It regulates immune response, inflammation, adhesion, and chemotaxis. It activates integrins via CX3CR1-dependent and -independent pathways, binding to site 1 with CX3CR1 and site 2 without CX3CR1. Soluble Fractalkine/CX3CL1 attracts T-cells and monocytes, not neutrophils. Fractalkine/CX3CL1 Protein, Rat is the recombinant rat-derived Fractalkine/CX3CL1 protein, expressed by E. coli , with tag free. The total length of Fractalkine/CX3CL1 Protein, Rat is 79 a.a., with molecular weight of ~11 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-151931S

JA-ACC-d3

JA-ACC-d₃ is deuterium labeled JA-ACC[1].

*JA-ACC-d3*
JA-ACC-d₃ is deuterium labeled JA-ACC[1].

Cat. No.	Product Name	Application	Reactivity

HY-P80787

Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha	WB	Human
Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 266 kDa, targeting to Phospho-Acetyl Coenzyme A Carboxylase (Ser79). It can be used for WB assays with tag free, in the background of Human.

HY-P80482

*Acetyl CoA Carboxylase 1 (ACC1) Antibody*	WB, IHC-P	Human, Mouse
Acetyl CoA Carboxylase 1 (ACC1) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 266 kDa, targeting to Acetyl CoA Carboxylase 1(ACC1). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P82998

Bcl2 A1 Antibody (YA2743) BCL2A1; ACC-1; ACC-2; Bcl-2-like protein 5; Bcl-2-related protein A1; BCL2-related protein A1; BFL1; Bcl2-L-5; BCL2L5; GRS; HBPA1; Protein BFL-1; Protein GRS	WB, IHC-P, FC	Human, Mouse, Rat

HY-P80528

Acetyl Coenzyme A Carboxylase Antibody ACC; ACAC; ACC1; ACCA; ACACAD	WB, IHC-F, IHC-P, ICC/IF	Human
Acetyl Coenzyme A Carboxylase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 277 kDa, targeting to Acetyl Coenzyme A Carboxylase. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

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ACC1

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