Search Result
Results for "
ACLY
" in MedChemExpress (MCE) Product Catalog:
14
Biochemical Assay Reagents
15
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-147286
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Drug-Linker Conjugates for ADC
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Cancer
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Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162) .
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- HY-147286A
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- HY-RS00166
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Small Interfering RNA (siRNA)
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Others
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ACLY Human Pre-designed siRNA Set A contains three designed siRNAs for ACLY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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ACLY Human Pre-designed siRNA Set A
ACLY Human Pre-designed siRNA Set A
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- HY-RS00167
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Small Interfering RNA (siRNA)
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Others
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Acly Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acly gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Acly Mouse Pre-designed siRNA Set A
Acly Mouse Pre-designed siRNA Set A
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- HY-RS00168
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Small Interfering RNA (siRNA)
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Others
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Acly Rat Pre-designed siRNA Set A contains three designed siRNAs for Acly gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Acly Rat Pre-designed siRNA Set A
Acly Rat Pre-designed siRNA Set A
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- HY-111554
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- HY-128919
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HDAC
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Others
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Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs .
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- HY-48668
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ADC Linker
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Cancer
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AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate .
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- HY-157235
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Others
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Inflammation/Immunology
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AC Antibody affinity resin is AC commonly used packing. AC Antibody affinity resin has highly cross-linked agarose matrix with 85 μm of average particle size. AC Antibody affinity resin has alkali-resistant protein A derivative (E. coli) ligand. AC Antibody affinity resin can be used for antibody affinity chromatography .
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- HY-103195
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NKY80
1 Publications Verification
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Adenylate Cyclase
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Metabolic Disease
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NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .
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- HY-124680
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AC-093
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Others
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Inflammation/Immunology
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AC-263093 (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 has the potential for reversing opiate tolerance research . .
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- HY-145830
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Adenylate Cyclase
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Neurological Disease
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AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity .
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- HY-143463
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c-Met/HGFR
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Cancer
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AC-386 is a highly potent c-Met inhibitor with IC50 value of 7.42 nM. AC-386 has antiproliferative activities against certain cancer cell lines. AC-386 can be used for researching anti-cancer resistance .
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- HY-16020
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JAK
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Cancer
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AC-430 hydrobromide (example 1) is a potent JAK2 inhibitor. AC-430 hydrobromide can be used for the research of myeloproliferative disorders and cancer .
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- HY-P1098B
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IKK
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Inflammation/Immunology
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Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
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- HY-106025
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AC-3933
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GABA Receptor
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Neurological Disease
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Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively .
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- HY-118343
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Sirtuin
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Cancer
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AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors .
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- HY-W004066S
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Endogenous Metabolite
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Ac-Ala-OH-d3 is the deuterium labeled Ac-Ala-OH. Ac-Ala-OH is an endogenous metabolite.
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- HY-W004066S1
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- HY-124500
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STAT
Apoptosis
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Cancer
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AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) .
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- HY-117851
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CaSR
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Metabolic Disease
Endocrinology
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AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pKB) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .
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- HY-122025
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Androgen Receptor
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Metabolic Disease
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AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM) .
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- HY-136727
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Caspase
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Cancer
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Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al .
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- HY-P5525
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Autocamtide-3 Derived Inhibitory Peptide
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CaMK
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Others
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AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)
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- HY-P2462
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HDAC
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Others
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Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC .
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- HY-160109A
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Mucin
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Cancer
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Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis.
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- HY-110288
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Sialyltransferase
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Metabolic Disease
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3FAx-Neu5Ac (compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X on myeloid cells .
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- HY-116530
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- HY-122214
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AC-73
3 Publications Verification
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Autophagy
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Cancer
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AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells . AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells .
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- HY-110157
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Estrogen Receptor/ERR
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Neurological Disease
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AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease .
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- HY-154829A
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Others
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Inflammation/Immunology
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AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats .
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- HY-154829
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Others
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Inflammation/Immunology
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AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats .
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- HY-W011254
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Ac-Val-Ala-Asp-CHO
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Caspase
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Cancer
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Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .
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- HY-124004
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Ac-6-FP
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Others
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Inflammation/Immunology
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Acetyl-6-formylpterin (Ac-6-FP) is a hapten that covalently binds to MR1 through residue Lys43 of the protein, resulting in protein upregulation. Acetyl-6-formylpterin (Ac-6-FP) can be used in the study of inflammation .
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- HY-W096146
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PROTAC Linkers
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Cancer
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Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propynyl-PEG1-Ac is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-P3362
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Fluorescent Dye
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Others
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Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
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- HY-W012713S
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- HY-W015241S
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- HY-79490S
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- HY-P1098
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Ac2-26
3 Publications Verification
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NF-κB
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Inflammation/Immunology
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Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
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- HY-P1098A
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NF-κB
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Inflammation/Immunology
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Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
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- HY-153613
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Ac-Pro-Leu-Val-Glu(OMe)-CH2F
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Others
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Cancer
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Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer .
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- HY-W042357S
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- HY-P10146
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Caspase
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Cancer
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Ac-LETD-CHO
is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with
an IC50 value of 6.71 nM. Ac-LETD-CHO
can be used for the research of anticancer .
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- HY-10658
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- HY-W042357S1
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- HY-W042357S2
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- HY-W042357S4
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- HY-157233
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Others
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Cardiovascular Disease
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AC Antibody purification resin 1 is a nano agarose with a particle size of 69μm. AC Antibody purification resin 1 can be used in ADC purification. AC Antibody purification resin 1 contains a ligand: recombinant protein A.
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- HY-B0491A
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AC-17
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Adrenergic Receptor
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Cardiovascular Disease
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Carbazochrome sodium sulfonate (AC-17) is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome sodium sulfonate is an antihemorrhagic agent .
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- HY-W010389S2
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- HY-P4449
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Caspase
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Cancer
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Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
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- HY-P4547
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AC-WEHD-AMC
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Caspase
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Others
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Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
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- HY-160109
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Mucin
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Cancer
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Ac5GalNTGc is a analog of hexosamine. Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis .
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- HY-P1393
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Amylin Receptor
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Endocrinology
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AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects .
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- HY-P3434
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Pyroptosis
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Inflammation/Immunology
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Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor.
Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .
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- HY-14351
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- HY-W042357S5
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Isotope-Labeled Compounds
DNA/RNA Synthesis
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Others
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Ac-rC Phosphoramidite- 13C,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
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- HY-108526
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RAR/RXR
Autophagy
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Others
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AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
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- HY-W713878
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Caspase
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Others
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Ac-VDVAD-pNA is a caspase-2 substrate. Ac-VDVAD-pNA can be used to test the activity of caspase-2 .
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- HY-P10084
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Caspase
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Others
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Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .
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- HY-P1393A
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Amylin Receptor
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Endocrinology
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AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects .
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- HY-W042357S6
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Isotope-Labeled Compounds
DNA/RNA Synthesis
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Others
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Ac-rC Phosphoramidite- 13C9, 15N3 is 13C and 15N-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
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- HY-P3434A
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Pyroptosis
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Inflammation/Immunology
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Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor.
Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .
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- HY-156287
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Glucosidase
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Cancer
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GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM) .
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- HY-P10147
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Caspase
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Cancer
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Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
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- HY-14350
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Protease Activated Receptor (PAR)
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Others
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AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca 2+ mobilization assays and exhibits pronociceptive activity in vivo .
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- HY-113963
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Apoptosis
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Cancer
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Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death .
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- HY-W042357S3
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Isotope-Labeled Compounds
DNA/RNA Synthesis
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Others
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Ac-rC Phosphoramidite- 13C2,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
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- HY-B0393
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- HY-113844
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Ser/Thr Protease
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Others
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Ac-Gly-Lys-OMe is a substrate for urokinase. Ac-Gly-Lys-OMe can be used to measure the effects of small molecule inhibitors on urokinase activity .
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- HY-P10082
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Caspase
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Others
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Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
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- HY-14425
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- HY-108532
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RAR/RXR
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Cancer
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AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0 .
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- HY-138602
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- HY-156757
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Sirtuin
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Cancer
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MDL-811, an allosteric SIRT6 activator, significantly activates SIRT6 histone H3 deacetylation (H3K9Ac, H3K18Ac, and H3K56Ac). MDL-811 could be used in the study of colorectal cancer .
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- HY-161160
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Others
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Others
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Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .
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- HY-N9459
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Others
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Others
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2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
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- HY-P10201
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STAT
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Cancer
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Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .
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- HY-P1003
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Fluorescent Dye
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Others
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Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
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- HY-136733
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Ac-Asp-Asn-Leu-Asp-CHO
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Caspase
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Infection
Neurological Disease
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Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Ki app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .
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- HY-15527
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AC-5216; XBD-173
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Others
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Neurological Disease
Metabolic Disease
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Emapunil (AC-5216), an orally active and selective TSPO (a mitochondrial benzodiazepine receptor) ligand, produces anti-anxiety and antidepressant-like effects in various animal models .
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- HY-P1118
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- HY-45491
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2'-F-Ac-dC Phosphoramidite; DMT-2′Fluoro-dC(ac) Phosphoramidite
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Nucleoside Antimetabolite/Analog
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Others
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Dmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite which can be used in the preparation of cyclic purine dinucleotides .
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- HY-153614
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Ac-Val-Leu-Pro-Glu(OMe)-CH2F
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Cathepsin
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Cancer
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Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness .
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- HY-W004066
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- HY-P4846
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CXCR
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Inflammation/Immunology
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Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
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- HY-122051
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AC1903
1 Publications Verification
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TRP Channel
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Metabolic Disease
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AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model .
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- HY-120019
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L-709049
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Interleukin Related
Apoptosis
Caspase
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Inflammation/Immunology
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Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .
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- HY-120019A
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L-709049 acetate
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Interleukin Related
Caspase
Apoptosis
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Inflammation/Immunology
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Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ .
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- HY-P1118A
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- HY-W048674
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Fmoc-O-acetyl-L-serine
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Amino Acid Derivatives
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Infection
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Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor .
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- HY-P2617
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Caspase
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Inflammation/Immunology
Cancer
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Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
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- HY-151819
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ADC Linker
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Others
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N3Ac-OPhOMe is a click chemistry reagent containing an azide group. N3Ac-OPhOMe can be used for the research of various biochemical .
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- HY-R01635
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MicroRNA
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Cancer
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hsa-miR-548ac mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
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-
hsa-miR-548ac mimic
hsa-miR-548ac mimic
- HY-P0034
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Caspase-3 Inhibitor III
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|
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Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis .
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- HY-D1705
-
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Proteasome
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Inflammation/Immunology
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Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
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- HY-W011982
-
-
- HY-118297
-
|
Biochemical Assay Reagents
|
Metabolic Disease
|
Ac4ManNAz (80% α isomer) is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins. Ac4ManNAz can be used for cell labeling, tracking and proteomic analysis. Ac4ManNAz (80% α isomer) contains Azide groups and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz (80% α isomer) can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-P2617A
-
|
Caspase
|
Inflammation/Immunology
Cancer
|
Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
|
-
- HY-118806
-
|
mAChR
|
Neurological Disease
|
AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively .
|
-
- HY-P10162
-
|
Caspase
|
Cancer
|
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
|
-
- HY-P10142
-
|
Fluorescent Dye
|
Others
|
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .
|
-
- HY-RS08844
-
|
Small Interfering RNA (siRNA)
|
Others
|
MUC5AC Human Pre-designed siRNA Set A contains three designed siRNAs for MUC5AC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
MUC5AC Human Pre-designed siRNA Set A
MUC5AC Human Pre-designed siRNA Set A
- HY-147397
-
|
Pyruvate Kinase
|
Cancer
|
PKM2 activator 3 is a potent PKM2 activator with an AC50 value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer .
(AC50: the concentration which gives 50% activation of enzyme.)
|
-
- HY-150658S
-
-
- HY-117118A
-
-
- HY-P2091
-
|
Caspase
|
Inflammation/Immunology
|
Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .
|
-
- HY-100396
-
-
- HY-101801
-
|
FAP
|
Cancer
|
Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
|
-
- HY-P1448
-
-
- HY-W024554
-
-
- HY-W008986
-
-
- HY-W012713
-
-
- HY-W015241
-
-
- HY-D1258
-
VDP-green
|
Fluorescent Dye
|
Others
|
AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λex/λem=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes .
|
-
- HY-16990
-
Caspase-1 Inhibitor II
|
Caspase
|
Inflammation/Immunology
|
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .
|
-
- HY-P0034A
-
Caspase-3 Inhibitor III TFA
|
Caspase
Apoptosis
|
Metabolic Disease
|
Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .
|
-
- HY-P2615
-
|
Fluorescent Dye
|
Cancer
|
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .
|
-
- HY-P2620
-
|
Fluorescent Dye
|
Metabolic Disease
Cancer
|
Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .
|
-
- HY-P5956
-
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-LEHD-CHO is an inhibitor of caspases 4, 5 and 9. Ac-AAVALLPAVLLALLAP-LEHD-CHO shows protective effects upon Neocarzinostatin (HY-111183)-treated MCF-7 cells .
|
-
- HY-157171
-
|
Others
|
Inflammation/Immunology
|
Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response .
|
-
- HY-RS05088
-
|
Small Interfering RNA (siRNA)
|
Others
|
FRA10AC1 Human Pre-designed siRNA Set A contains three designed siRNAs for FRA10AC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
FRA10AC1 Human Pre-designed siRNA Set A
FRA10AC1 Human Pre-designed siRNA Set A
- HY-RS05955
-
|
Small Interfering RNA (siRNA)
|
Others
|
H2AC18 Human Pre-designed siRNA Set A contains three designed siRNAs for H2AC18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
|
-
H2AC18 Human Pre-designed siRNA Set A
H2AC18 Human Pre-designed siRNA Set A
- HY-P2016
-
|
Proteasome
|
Others
|
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
|
-
- HY-P10144
-
|
Fluorescent Dye
|
Others
|
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd–Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .
|
-
- HY-N6999
-
-
- HY-148415
-
-
- HY-P10083
-
-
- HY-162159
-
|
Others
|
Others
|
Ac-Cys-NHMe is a Cys dipeptide with thiol group .
|
-
- HY-148859
-
-
- HY-123630
-
FD&C RED NO. 40; CI 16035
|
Fluorescent Dye
|
Others
|
Allura Red AC, a food colourant, is dark red and water-soluble powder or granules used in various applications, such as in drinks, syrups, sweets and cereals. Allura Red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching .
|
-
- HY-112942A
-
CMP-Neu5Ac sodium salt
|
Endogenous Metabolite
|
Metabolic Disease
|
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
|
-
- HY-112942
-
CMP-Neu5Ac
|
Endogenous Metabolite
|
Metabolic Disease
|
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
|
-
- HY-P3234
-
|
Casein Kinase
|
Others
|
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .
|
-
- HY-W014130A
-
-
- HY-138583
-
-
- HY-15967
-
PS48
5 Publications Verification
|
PDK-1
|
Cancer
|
PS48 is an activator of PDK1 with an AC50 of 8 μM.
|
-
- HY-104032
-
|
RSV
|
Infection
Metabolic Disease
|
Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 µM . Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV) .
|
-
- HY-P3455
-
|
PGC-1α
|
Metabolic Disease
Cancer
|
Ac-SVVVRT-NH2 is a PGC-1α modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α .
|
-
- HY-W728531
-
|
Biochemical Assay Reagents
|
Others
|
Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-16450
-
-
- HY-147117
-
|
Others
|
Others
|
NHS-SS-Ac is an amine-reactive product synthesized from acetic acid .
|
-
- HY-140343
-
|
PROTAC Linkers
|
Cancer
|
Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-116874
-
|
Dopamine Receptor
|
Neurological Disease
|
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia .
|
-
- HY-P3110
-
|
Fluorescent Dye
|
Others
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
-
- HY-D1652
-
|
Caspase
|
Others
|
Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .
|
-
- HY-W145540
-
|
Biochemical Assay Reagents
|
Others
|
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145622
-
Gal beta(1-3)[Neu5Ac alpha(2-6)]GlcNAc-beta-pNP
|
Biochemical Assay Reagents
|
Others
|
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-P0280
-
-
- HY-P1001
-
|
Caspase
|
Cancer
|
Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM.
|
-
- HY-P1005
-
-
- HY-W570884
-
-
- HY-W013322
-
-
- HY-136728
-
|
Caspase
|
Cancer
|
Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity .
|
-
- HY-158118
-
|
DNA-PK
|
Cancer
|
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-P1316
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
|
-
- HY-P1316A
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
|
-
- HY-P4532
-
|
Cathepsin
|
Neurological Disease
|
Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II .
|
-
- HY-P4764
-
|
Melanocortin Receptor
|
Cardiovascular Disease
|
Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure .
|
-
- HY-P4417A
-
|
Fluorescent Dye
|
Others
|
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
|
-
- HY-100336
-
-
- HY-21648
-
|
DNA/RNA Synthesis
|
Others
|
2'-OMe-Ac-C Phosphoramidite is a modified phosphoramidite and can be used for the oligonucleotide synthesis.
|
-
- HY-138586
-
-
- HY-154036
-
|
DNA/RNA Synthesis
|
Others
|
5’-DMTr-dC (Ac)-Methylphosphonamidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-134567
-
-
- HY-W145531
-
|
Biochemical Assay Reagents
|
Others
|
Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-P4019
-
|
HIV Protease
|
Others
|
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 acts as the variable substrate in a peptidolytic assay to quantify the inhibition of the protease .
|
-
- HY-158125
-
|
PSMA
|
Cancer
|
PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-W102456
-
L-4-Acetylphenylalanine
|
Others
|
Others
|
H-Phe(4-Ac)-OH is a keto-containing amino acid, which can be conversed from α-keto acids containing acetyl. H-Phe(4-Ac)-OH can be incorporated at the amber position to afford the mutant Z domain protein .
|
-
- HY-P4040
-
-
- HY-20560
-
|
ADC Linker
|
Cancer
|
(Ac)Phe-Lys(Alloc)-PABC-PNP is an useful cleavable chemical linker in antibody drug conjugates.
|
-
- HY-P1006
-
|
Caspase
|
Others
|
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.
|
-
- HY-141136
-
|
PROTAC Linkers
|
Cancer
|
Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141128
-
|
PROTAC Linkers
|
Cancer
|
Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-P2285
-
-
- HY-W042357
-
|
DNA/RNA Synthesis
|
Others
|
Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA) .
|
-
- HY-127111
-
|
ATP Citrate Lyase
|
Cancer
|
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .
|
-
- HY-P3940
-
|
PKC
|
Others
|
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
|
-
- HY-RI01635
-
|
MicroRNA
|
|
hsa-miR-548ac inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
|
-
hsa-miR-548ac inhibitor
hsa-miR-548ac inhibitor
- HY-163106
-
|
Ceramidase
|
Cancer
|
W000113414_I13 is an acid ceramidase (AC) inhibitor. W000113414_I13 exhibits dose-dependent inhibition of AC with an IC50 value of 6.6?μM. W000113414_I13 can be used for the research of cancer .
|
-
- HY-151852
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
-
- HY-158119
-
|
PSMA
|
Cancer
|
Ac-PSMA-trillium is a PSMA targeting compound, consisting of a PSMA targeting molecule (PSMA binder), a Macropa chelating molecule, and a group that regulates pharmacokinetics (PK modifier). Ac-PSMA-trillium is a non-radioactive form of Actinium-225-PSMA-Trillium (BAY 3563254) with improved PSMA targeting and pharmacokinetic properties. PSMA-trillium can bind Ac through the Macropa chelating molecule, or the radioactive isotope 225Actinium. Actinium-225-PSMA-Trillium is a potent inhibitor of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-101279
-
-
- HY-123051
-
-
- HY-P1093
-
|
Caspase
|
Others
|
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .
|
-
- HY-150246
-
|
DNA/RNA Synthesis
|
Others
|
RNA splicing modulator 1 (compound 233) is a RNA splicing modulator, with an AC50 value of <100 nM .
|
-
- HY-150248
-
|
DNA/RNA Synthesis
|
Others
|
RNA splicing modulator 3 (compound 236) is a RNA splicing modulator, with an AC50 value of <100 nM .
|
-
- HY-P5938
-
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity .
|
-
- HY-P5955
-
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable caspase-4 inhibitor that has antitumor activity .
|
-
- HY-P5936
-
DEVD-CHO-CPP 32
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor .
|
-
- HY-P5983
-
|
Caspase
|
Cancer
|
Ac-VEID-AFC is a caspase-6 fluorogenic substrate, and can be used in the caspase 6 activity assay .
|
-
- HY-111675
-
|
Caspase
Pyroptosis
|
Inflammation/Immunology
|
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3 .
|
-
- HY-141464
-
Fmoc-Asn(Ac3AcNH-beta-Glc)-OH
|
Amino Acid Derivatives
|
Cancer
|
Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET) .
|
-
- HY-108312A
-
|
Caspase
|
Neurological Disease
|
AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .
|
-
- HY-134684
-
|
PROTAC Linkers
|
Cancer
|
Mal-PEG3-O-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-156020
-
-
- HY-P6079
-
-
- HY-W415798
-
|
Endogenous Metabolite
|
Others
|
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .
|
-
- HY-P1169
-
|
Caspase
|
Others
|
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
|
-
- HY-P2377
-
|
Fluorescent Dye
|
Others
|
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
|
-
- HY-138159
-
-
- HY-P4535
-
-
- HY-138165
-
|
Others
|
Others
|
Ac-Phe-NH2 is a non-competitive inhibitor of polyubiquitin chain elongation at Ki value of 8 mM by destabilizing the active trimer .
|
-
- HY-P3662
-
|
Tyrosinase
|
Cancer
|
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model .
|
-
- HY-E70019
-
|
Endogenous Metabolite
|
Metabolic Disease
|
alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors .
|
-
- HY-W014130
-
Ac-Arg-OH
|
Endogenous Metabolite
|
Others
|
N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.
|
-
- HY-113338
-
|
Endogenous Metabolite
|
Others
|
8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.
|
-
- HY-138614
-
-
- HY-138612
-
-
- HY-66007
-
-
- HY-N10628
-
|
Others
|
Others
|
Neu5Acα(2-6) N-Glycan is a N-Glycan, and can be used for labeling and modification of proteins.
|
-
- HY-P5280
-
|
Ser/Thr Protease
|
Others
|
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
|
-
- HY-P6079A
-
|
Biochemical Assay Reagents
|
Others
|
Ac-IHIHIYI-NH2 TFA is an amyloid self-assembling peptide variant that can be used as a bioactive nanomaterial with esterase activity .
|
-
- HY-141133
-
|
PROTAC Linkers
|
Cancer
|
Propargyl-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141135
-
|
PROTAC Linkers
|
Cancer
|
Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141127
-
|
PROTAC Linkers
|
Cancer
|
Azido-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-158123
-
|
PSMA
|
Cancer
|
PSMA binder-1 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or it can be labeled with 225Ac (to obtain Actinium-225-PSMA-Trillium (BAY 3563254)), which has a radioactive killing effect; it can be used as a Macropa chelator for targeted radionuclide therapy (TRT) , has a strong inhibitory effect on metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-P1318
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [ 35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain .
|
-
- HY-P1318A
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRIK-NH2 TFA is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [ 35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain .
|
-
- HY-115748
-
-
- HY-P4688
-
-
- HY-R01635A
-
|
MicroRNA
|
|
hsa-miR-548ac agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-miR-548ac agomir
hsa-miR-548ac agomir
- HY-103430
-
|
Dopamine Receptor
5-HT Receptor
Adenylate Cyclase
|
Neurological Disease
|
SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM) . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta . SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation .
|
-
- HY-103430A
-
|
Dopamine Receptor
5-HT Receptor
Adenylate Cyclase
|
Neurological Disease
|
SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM) . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta . SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation .
|
-
- HY-144287
-
|
Glucokinase
|
Endocrinology
|
Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes .
|
-
- HY-123052
-
-
- HY-121738
-
-
- HY-161021
-
|
Adenylate Cyclase
|
Others
|
AC2 selective-IN-1 (compound 14) is a? potent (IC50=4.45 μM), non-toxic, and selective mAC2 inhibitor .
|
-
- HY-P1200
-
|
Src
|
Cancer
|
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions .
|
-
- HY-107636
-
DC_AC50
1 Publications Verification
|
Apoptosis
|
Cancer
|
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance .
|
-
- HY-P2065
-
|
Fluorescent Dye
|
Others
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
-
- HY-148313
-
|
Pyruvate Kinase
|
Cancer
|
PKM2 activator 4 is a PKM2 activator with an AC50 value of 1-10 μM. PKM2 activator 4 can be used for the research of cancer .
|
-
- HY-115748A
-
-
- HY-W145646
-
|
Biochemical Assay Reagents
|
Others
|
Fmoc-L-Ser((Ac)4-β-D-Glc)-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-161024
-
AQB
|
Histone Methyltransferase
|
Cancer
|
AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of Tazemetostat in endometrial cancer .
|
-
- HY-132934
-
|
BCRP
|
Cancer
|
Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC50 value of 13 nM in the
BCRP-overexpressed HEK293/R2 cells.
|
-
- HY-W145548
-
4-Methoxyphenyl 4-O-Acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-beta-D-glucopyranoside
|
Biochemical Assay Reagents
|
Others
|
GlcNPhth[36Bn,4Ac]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-128433
-
-
- HY-P1200A
-
|
Src
|
Cancer
|
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions .
|
-
- HY-P4832
-
|
Amyloid-β
|
Neurological Disease
|
Acetyl-Tau Peptide (273-284) amide is an acetylated Tau peptide fragment. Acetyl-Tau Peptide (273-284) amide limits the substantial aggregation of Ac-Aβ(25–35)-NH2 and can be used as an inhibitor of Ac-Aβ(25–35)-NH2. Acetyl-Tau Peptide (273-284) amide can be used as an experimental model to investigate the Aβ/Tau cross-interaction .
|
-
- HY-141077
-
|
PROTAC Linkers
|
Cancer
|
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-P3307
-
|
Tau Protein
|
Neurological Disease
|
Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ42.
|
-
- HY-141139
-
|
PROTAC Linkers
|
Cancer
|
1-(Isopropylthio)-2,3,4,6-tetra-o-Ac-beta-D-glucosylpyranose is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-13493
-
|
PDGFR
c-Kit
FLT3
|
Cancer
|
AC710 is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.
|
-
- HY-18657
-
TEPP-46
Maximum Cited Publications
29 Publications Verification
ML-265
|
Pyruvate Kinase
|
Cancer
|
TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, showing little or no effect on PKM1, PKL and PKR .
|
-
- HY-13493A
-
|
PDGFR
|
Cancer
|
AC710 Mesylate is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.
|
-
- HY-151516
-
|
MicroRNA
|
Cancer
|
microRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. microRNA-21-IN-2 can be used for the research of cancer .
|
-
- HY-P3761
-
|
Caspase
|
Others
|
Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .
|
-
- HY-P4039
-
|
HCV Protease
|
Infection
|
Ac-EEVVAC-pNA is a chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease. The sequence EEVVAC is derived from the 5A-5B cleavage junction of the HCV polyprotein .
|
-
- HY-136744
-
Ac-LEHD-cmk
|
Caspase
|
Cardiovascular Disease
|
Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury .
|
-
- HY-W145561
-
Neu5Ac alpha(2-3)Gal beta MP glycoside
|
Biochemical Assay Reagents
|
Others
|
Neu5Acα(2-3)Galβ MP Glycoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N12336
-
|
Others
|
Metabolic Disease
|
Gnetuhainin I (Compound 5) is a lignin derived from Pouzolzia zeylanica. Gnetuhainin I shows good inhibitory effect on ATP citrate lyase (ACLY) (IC50=2.63 μM) .
|
-
- HY-157234
-
|
Others
|
Others
|
AC mAb-X purification resin is a special protein A resin.
Matrix: high rigidity agarose; particle size: 40~120 μm; ligand: recombinant alkali-resistant Protein A (~24KD); ADC purification resin.
|
-
- HY-148324
-
|
Pyruvate Kinase
|
Cancer
|
PKM2 activator 5 (compound 8) is a PKM2 activator with an AC50 value of 0.316 µM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells .
|
-
- HY-N10772
-
-
- HY-RI01635A
-
|
MicroRNA
|
|
hsa-miR-548ac antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
|
-
hsa-miR-548ac antagomir
hsa-miR-548ac antagomir
- HY-125501
-
Biotin-(AC5)2-hydrazide
|
Biochemical Assay Reagents
|
Others
|
Biotin-XX hydrazide (Biotin-(AC5)2-hydrazide) is a carbonyl-reactive biotinylation reagent which contains two aminohexanoic acid spacers. Biotin-XX hydrazide has higher efficiency of avidin-binding .
|
-
- HY-141866
-
|
Ceramidase
|
Neurological Disease
|
Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice .
|
-
- HY-144549
-
|
LXR
|
Cardiovascular Disease
|
LXR (Liver X receptor) agonist 1 is potent LXR agonist with AC50s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively. LXR agonist 1 has the potential for the research of atherosclerosis .
|
-
- HY-147368
-
|
Pyruvate Kinase
|
Cancer
|
PKM2 activator 2 (compound 28) is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 can restore normal glycolytic metabolism in cells .
|
-
- HY-P3690
-
|
Proteasome
|
Others
|
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST) .
|
-
- HY-P4521
-
|
MMP
|
Others
|
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .
|
-
- HY-P4787
-
|
Cathepsin
|
Others
|
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .
|
-
- HY-79490
-
|
ADC Cytotoxin
Topoisomerase
|
Cancer
|
Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) .
|
-
- HY-100738
-
NSC144303
|
Apoptosis
|
Cancer
|
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
|
-
- HY-103411
-
|
Dopamine Receptor
|
Neurological Disease
|
SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors .
|
-
- HY-P10177
-
|
Opioid Receptor
|
Neurological Disease
|
Acetalin-3 (Ac-RFMWMT-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .
|
-
- HY-P10175
-
|
Opioid Receptor
|
Neurological Disease
|
Acetalin-1 (Ac-RFMWMK-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .
|
-
- HY-120833
-
|
Caspase
|
Others
|
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
|
-
- HY-145765
-
-
- HY-P2977
-
Sialic acid aldolase (CgNal)
|
Endogenous Metabolite
|
Others
|
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .
|
-
- HY-148041
-
|
Others
|
Others
|
ATPase-IN-2 is an ATPase inhibitor with an IC50 value of 0.9 μM. ATPase-IN-2 inhibits C. difficile toxin B (TcdB) glycohydrolase activity with an AC50 value of 30.91 μM. ATPase-IN-2 can be used for the research of ATP-related .
|
-
- HY-117616
-
(+)-Laurotetanine
|
NF-κB
|
Cancer
|
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways .
|
-
- HY-154213
-
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-P0266B
-
Ac-SDKP acetate
|
Angiotensin-converting Enzyme (ACE)
|
Inflammation/Immunology
|
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .
|
-
- HY-W145609
-
|
Biochemical Assay Reagents
|
Others
|
Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N2098
-
|
NF-κB
|
Cancer
|
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .
|
-
- HY-W016584
-
|
Others
|
Infection
|
4,5-Dichlorocatechol is a substrate of the broad-spectrum chlorocatechol 1,2-dioxygenase of pseudomonas chlororaphis RW71. The Ki values for 4,5-dichlorocatechol is 30 nM for the dioxygenase of the Chlorobenzoate-degrading strain Pseudomonas putida AC27 and 4 nM for the dioxygenase of Acidovorax sp. strain PS14 .
|
-
- HY-N8356
-
13-cis-Retinyl palmitate
|
Endogenous Metabolite
|
Others
|
13-cis-Vitamin A palmitate (13-cis-Retinyl palmitate) is a 13-cis isomer formed by vitamin A palmitate in corn flakes. 13-cis-Vitamin A palmitate has a biological activity of 75% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .
|
-
- HY-N8356A
-
9-cis-Retinyl palmitate
|
Endogenous Metabolite
|
Others
|
9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer formed by vitamin A palmitate in corn flakes. 9-cis-Vitamin A palmitate has a biological activity of 26% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .
|
-
- HY-P3155
-
|
MCHR1 (GPR24)
|
Metabolic Disease
|
Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R .
|
-
- HY-146356
-
|
Adenylate Cyclase
|
Inflammation/Immunology
|
Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases .
|
-
- HY-144289
-
|
Glucokinase
|
Metabolic Disease
|
BMS-820132 is an orally active and partial glucokinase (GK) activator with a AC50 of 29 nM. BMS-820132 decreases the glucose levels in glucose tolerance test (OGTT) model in normal rats, but not Zucker diabetic fatty (ZDF) rats. BMS-820132 exhibits pharmacological toxicity secondary to strong GK activation .
|
-
- HY-154592
-
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-18700
-
|
HDAC
|
Cancer
|
BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 µM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin .
|
-
- HY-14277A
-
R 50547 hydrochloride
|
Histamine Receptor
Neurotensin Receptor
Integrin
|
Inflammation/Immunology
|
Levocabastine (R 50547) hydrochloride is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine hydrochloride can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC) .
|
-
- HY-14277
-
R 50547
|
Histamine Receptor
Neurotensin Receptor
Integrin
|
Inflammation/Immunology
|
Levocabastine (R 50547) is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC) .
|
-
- HY-158122
-
|
DNA-PK
|
Cancer
|
Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu can increase the residence time of PSMA ligand in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-O-tBu also reduces salivary gland absorption, possibly extending the half-life of the active compound. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-W560961
-
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
3',5'-TIPS-N-Ac-Adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
|
-
- HY-P1368
-
Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)
|
CRFR
|
Endocrinology
|
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats .
|
-
- HY-B0091
-
CD271
|
RAR/RXR
Autophagy
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .
|
-
- HY-B0091A
-
CD 271 sodium salt
|
RAR/RXR
Autophagy
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity .
|
-
- HY-106560
-
|
COX
SARS-CoV
|
Inflammation/Immunology
|
Proglumetacin is an orally active and potent cyclo-oxygenase inhibitor. Proglumetacin can inhibits SARS-CoV Mpro (main protease of the SARS-CoV-2), with an AC50 of 8.9 μM (activity concentration at half maximal activity). Proglumetacin has anti-inflammatory activity, can be used for inflammation (such as Rheumatoid arthritis, and Allergic air pouch inflammation) research[1][2][3].
|
-
- HY-P99715
-
ABT-806
|
EGFR
|
Cancer
|
Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody. Losatuxizumab binds to EGFR with EC50s of 0.96 nM for EGFR wild-type, 0.09 nM for EGFR C271A,C283A, 0.12 nM for EGFRvIII, 0.66 nM for EGFR1-501. Losatuxizumab can be used for research of EGFR-expressing cancers .
|
-
- HY-P1368A
-
Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA
|
CRFR
|
Endocrinology
|
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats .
|
-
- HY-157232
-
|
Others
|
Others
|
AC Antibody purification resin 2 is based on spherical, highly cross-linked agarose beads with a narrow size distribution and high mechanical stability. Used for the separation and purification of complex antibodies such as monoclonal antibody, double antibody, multi-antibody and Fc fusion protein .
Substrate: highly crosslinked agarose microspheres; Particle size: 65μm; Ligand: alkali-resistant recombinant Protein A; ADC purified resin.
|
-
- HY-N2609
-
|
CCR
NF-κB
|
Inflammation/Immunology
Endocrinology
|
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
|
-
- HY-13856
-
|
PDK-1
|
Cancer
|
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment .
|
-
- HY-W077279
-
N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine
|
DNA/RNA Synthesis
|
Others
|
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis .
|
-
- HY-132197
-
|
Epigenetic Reader Domain
Histone Acetyltransferase
|
Cancer
|
CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450 .
|
-
- HY-148043
-
|
Others
|
Others
|
Schnurri-3 inhibitor-1 is a potent schnurri-3 inhibitor which is an essential regulator of adult bone formation. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in osteoblast cell line Shn3FFL with an AC50 value of 2.09 μM. Schnurri-3 inhibitor-1 can be used to research osteoporosis .
|
-
- HY-149302
-
|
Apoptosis
Autophagy
Histone Acetyltransferase
|
Cancer
|
MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively .
MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells .
|
-
- HY-155115
-
|
Histone Demethylase
PD-1/PD-L1
|
Cancer
|
LSD1-IN-27 (Compound 5ac) is a LSD1 inhibitor (IC50: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer .
|
-
- HY-12010
-
AC480 Hydrochloride
|
EGFR
|
Cancer
|
BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy .
|
-
- HY-B0091S
-
|
RAR/RXR
Autophagy
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
Adapalene-d3 is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3].
|
-
- HY-P1454
-
Fz7-21
3 Publications Verification
Ac-LPSDDLEFWCHVMY-NH2
|
Wnt
|
Cancer
|
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids .
|
-
- HY-10251
-
AC480
|
EGFR
|
Cancer
|
BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy .
|
-
- HY-155229
-
-
- HY-B0091R
-
CD271 (Standard)
|
RAR/RXR
Autophagy
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
Adapalene (Standard) is the analytical standard of Adapalene. This product is intended for research and analytical applications. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .
|
-
- HY-13001
-
AC220
|
FLT3
Ligands for Target Protein for PROTAC
Apoptosis
Autophagy
|
Cancer
|
Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis .
|
-
- HY-P1454A
-
Ac-LPSDDLEFWCHVMY-NH2 TFA
|
Wnt
|
Cancer
|
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids .
|
-
- HY-125798
-
Neu5Ac2en; DANA
|
Influenza Virus
|
Infection
|
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .
|
-
- HY-153094
-
|
HIV
HIV Integrase
|
Infection
|
BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-P1003
-
|
Chromogenic Substrates
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
- HY-P1448
-
-
- HY-D1258
-
VDP-green
|
Fluorescent Dyes/Probes
|
AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λex/λem=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes .
|
-
- HY-P3362
-
|
Fluorescent Dyes/Probes
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
- HY-D1705
-
|
Fluorescent Dyes/Probes
|
Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
|
-
- HY-123630
-
FD&C RED NO. 40; CI 16035
|
Dyes
|
Allura Red AC, a food colourant, is dark red and water-soluble powder or granules used in various applications, such as in drinks, syrups, sweets and cereals. Allura Red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching .
|
-
- HY-P3110
-
|
Dyes
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
-
- HY-P1005
-
-
- HY-123051
-
-
- HY-P1093
-
|
Chromogenic Substrates
|
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .
|
-
- HY-P1169
-
|
Fluorescent Dyes/Probes
|
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
|
-
- HY-P2377
-
|
Dyes
|
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
|
-
- HY-138159
-
-
- HY-P3236
-
Ac-IEPD-pNA
|
Fluorescent Dyes/Probes
|
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity .
|
-
- HY-P2065
-
|
Fluorescent Dyes/Probes
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
-
- HY-P4039
-
|
Chromogenic Substrates
|
Ac-EEVVAC-pNA is a chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease. The sequence EEVVAC is derived from the 5A-5B cleavage junction of the HCV polyprotein .
|
Cat. No. |
Product Name |
Type |
-
- HY-148859
-
|
Drug Delivery
|
AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts .
|
-
- HY-W145540
-
|
Biochemical Assay Reagents
|
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145622
-
Gal beta(1-3)[Neu5Ac alpha(2-6)]GlcNAc-beta-pNP
|
Biochemical Assay Reagents
|
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145531
-
|
Biochemical Assay Reagents
|
Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-P2939
-
|
Biochemical Assay Reagents
|
Chondroitinase AC is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-E70019
-
|
Biochemical Assay Reagents
|
alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors .
|
-
- HY-W145646
-
|
Biochemical Assay Reagents
|
Fmoc-L-Ser((Ac)4-β-D-Glc)-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145548
-
4-Methoxyphenyl 4-O-Acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-beta-D-glucopyranoside
|
Biochemical Assay Reagents
|
GlcNPhth[36Bn,4Ac]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W145561
-
Neu5Ac alpha(2-3)Gal beta MP glycoside
|
Biochemical Assay Reagents
|
Neu5Acα(2-3)Galβ MP Glycoside is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-125501
-
Biotin-(AC5)2-hydrazide
|
Biochemical Assay Reagents
|
Biotin-XX hydrazide (Biotin-(AC5)2-hydrazide) is a carbonyl-reactive biotinylation reagent which contains two aminohexanoic acid spacers. Biotin-XX hydrazide has higher efficiency of avidin-binding .
|
-
- HY-P2977
-
Sialic acid aldolase (CgNal)
|
Biochemical Assay Reagents
|
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .
|
-
- HY-W145609
-
|
Biochemical Assay Reagents
|
Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W077279
-
N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine
|
Gene Sequencing and Synthesis
|
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis .
|
-
- HY-154818
-
Ac-BSA
|
Native Proteins
|
Bovine Serum Albumin, Acetylated (Ac-BSA) is a polypeptide of known structure with strong antigenicity. Bovine Serum Albumin, Acetylated produced a significant immune response, validating the accuracy and reliability of the experimental method. Bovine Serum Albumin, Acetylated can be used as a positive control substance in ELISA or WB experiments, and can be used in experiments with acetylated lysine monoclonal or polyclonal antibodies. Bovine Serum Albumin, Acetylated also improves encapsulation efficiency at low concentrations of PLGA, a polymer for biopharmaceutical delivery with biocompatibility, degradability, and controlled release properties .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1098B
-
|
IKK
|
Inflammation/Immunology
|
Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
|
-
- HY-P4519
-
|
Peptides
|
Others
|
Ac-Lys(Ac)-D-Ala-D-Lactic acid is a depsipeptide substrate for penicillin-sensitive D-alanine carboxypeptidases (DD-carboxypeptidases) .
|
-
- HY-P3729
-
|
Peptides
|
Others
|
Ac-Lys-D-Ala-D-Ala-OH is an oligopeptide. Ac-Lys-D-Ala-D-Ala-OH can be used for the research of various biochemical .
|
-
- HY-P4837
-
|
Peptides
|
Others
|
Ac-Lys-D-Ala-D-lactic acid is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
-
- HY-P1963
-
|
Peptides
|
Cancer
|
Ac-IEVDIDVEH TFA is a short peptide sequence with Ac at the end.
|
-
- HY-P1964
-
|
Peptides
|
Cancer
|
Ac-IEVDIDVE TFA is a short peptide sequence with Ac at the end.
|
-
- HY-P1965
-
|
Peptides
|
Cancer
|
Ac-IEVDIDV TFA is a short peptide sequence with Ac at the end.
|
-
- HY-P1966
-
|
Peptides
|
Cancer
|
Ac-IEVDID TFA is a short peptide sequence with Ac at the end.
|
-
- HY-P1967
-
|
Peptides
|
Cancer
|
Ac-VDID TFA is a short peptide sequence with Ac at the end.
|
-
- HY-136727
-
|
Caspase
|
Cancer
|
Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al .
|
-
- HY-P5525
-
Autocamtide-3 Derived Inhibitory Peptide
|
CaMK
|
Others
|
AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)
|
-
- HY-P1099
-
Ac2-12
1 Publications Verification
|
Peptides
|
Inflammation/Immunology
|
Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models .
|
-
- HY-P2462
-
|
HDAC
|
Others
|
Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC .
|
-
- HY-P1099A
-
|
Peptides
|
Inflammation/Immunology
|
Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 TFA has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models .
|
-
- HY-W011254
-
Ac-Val-Ala-Asp-CHO
|
Caspase
|
Cancer
|
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .
|
-
- HY-P3362
-
|
Fluorescent Dye
|
Others
|
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
|
-
- HY-P1098
-
Ac2-26
3 Publications Verification
|
NF-κB
|
Inflammation/Immunology
|
Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
|
-
- HY-P1098A
-
|
NF-κB
|
Inflammation/Immunology
|
Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
|
-
- HY-P4416
-
|
Peptides
|
Others
|
Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
-
- HY-P10146
-
|
Caspase
|
Cancer
|
Ac-LETD-CHO
is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with
an IC50 value of 6.71 nM. Ac-LETD-CHO
can be used for the research of anticancer .
|
-
- HY-18234B
-
-
- HY-P4449
-
|
Caspase
|
Cancer
|
Ac-VRPR-AMC is a fluorogenic metacaspase substrate. Ac-VRPR-AMC can be used to tests metacaspase activity .
|
-
- HY-P4547
-
AC-WEHD-AMC
|
Caspase
|
Others
|
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
|
-
- HY-P1393
-
|
Amylin Receptor
|
Endocrinology
|
AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects .
|
-
- HY-P3434
-
|
Pyroptosis
|
Inflammation/Immunology
|
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor.
Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .
|
-
- HY-P5512
-
|
Peptides
|
Others
|
MUC5AC-3 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)
|
-
- HY-P5511
-
|
Peptides
|
Others
|
MUC5AC-3/13 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)
|
-
- HY-W713878
-
|
Caspase
|
Others
|
Ac-VDVAD-pNA is a caspase-2 substrate. Ac-VDVAD-pNA can be used to test the activity of caspase-2 .
|
-
- HY-P10084
-
|
Caspase
|
Others
|
Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .
|
-
- HY-P1393A
-
|
Amylin Receptor
|
Endocrinology
|
AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects .
|
-
- HY-P3434A
-
|
Pyroptosis
|
Inflammation/Immunology
|
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor.
Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .
|
-
- HY-P10147
-
|
Caspase
|
Cancer
|
Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
|
-
- HY-113963
-
|
Apoptosis
|
Cancer
|
Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death .
|
-
- HY-113844
-
|
Ser/Thr Protease
|
Others
|
Ac-Gly-Lys-OMe is a substrate for urokinase. Ac-Gly-Lys-OMe can be used to measure the effects of small molecule inhibitors on urokinase activity .
|
-
- HY-P10082
-
|
Caspase
|
Others
|
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
|
-
- HY-P5508
-
|
Peptides
|
Others
|
MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T*). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)
|
-
- HY-P10201
-
|
STAT
|
Cancer
|
Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .
|
-
- HY-P1003
-
|
Fluorescent Dye
|
Others
|
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
|
-
- HY-136733
-
Ac-Asp-Asn-Leu-Asp-CHO
|
Caspase
|
Infection
Neurological Disease
|
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Ki app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .
|
-
- HY-P1118
-
-
- HY-P4846
-
|
CXCR
|
Inflammation/Immunology
|
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
|
-
- HY-120019
-
L-709049
|
Interleukin Related
Apoptosis
Caspase
|
Inflammation/Immunology
|
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .
|
-
- HY-P10161
-
|
Peptides
|
Others
|
Ac-DMQD-pNA is a peptide substrate. Both of the recombinant CgCaspase-1 (rCgCaspase-1) and the C-terminus of CgCaspase-1 (rCgCaspase-1-C) exhibits similar caspase activity towards proteolytic substrate Ac-DMQD-pNA and Ac-DEVD-pNA (HY-P1006) .
|
-
- HY-P1118A
-
-
- HY-W048674
-
Fmoc-O-acetyl-L-serine
|
Amino Acid Derivatives
|
Infection
|
Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor .
|
-
- HY-P2617
-
|
Caspase
|
Inflammation/Immunology
Cancer
|
Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
|
-
- HY-P2617A
-
|
Caspase
|
Inflammation/Immunology
Cancer
|
Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
|
-
- HY-P10162
-
|
Caspase
|
Cancer
|
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
|
-
- HY-P10142
-
|
Fluorescent Dye
|
Others
|
Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .
|
-
- HY-P2091
-
|
Caspase
|
Inflammation/Immunology
|
Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .
|
- HY-P1448
-
- HY-P1092
-
- HY-W024554
-
- HY-W008986
-
- HY-W012713
-
- HY-W015241
-
- HY-P0034A
-
Caspase-3 Inhibitor III TFA
|
Caspase
Apoptosis
|
Metabolic Disease
|
Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .
|
- HY-P2615
-
|
Fluorescent Dye
|
Cancer
|
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .
|
- HY-P2620
-
|
Fluorescent Dye
|
Metabolic Disease
Cancer
|
Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .
|
- HY-P5956
-
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-LEHD-CHO is an inhibitor of caspases 4, 5 and 9. Ac-AAVALLPAVLLALLAP-LEHD-CHO shows protective effects upon Neocarzinostatin (HY-111183)-treated MCF-7 cells .
|
- HY-P2016
-
|
Proteasome
|
Others
|
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
|
- HY-P10144
-
|
Fluorescent Dye
|
Others
|
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd–Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .
|
- HY-P10083
-
- HY-P4147
-
|
Peptides
|
Others
|
Ac-IHIHIQI-NH2 is a fibril-forming heptapeptide with high catalytic activity to laccase mimics. Ac-IHIHIQI-NH2 exhibits selectivity for hydrophobic p-nitrophenyl (ONp) ester substrates in the process of self-assembly .
|
- HY-P4443
-
|
Peptides
|
Others
|
Ac-GAK-AMC is a fluorescent substrate that can be used to measure protease activity. AMC (7-amino-4-methylcoumarin) is a fluorescent group. In the presence of protease, the protease will hydrolyze Ac-GAK-AMC into a fluorescent product .
|
- HY-P3234
-
|
Casein Kinase
|
Others
|
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .
|
- HY-P4840
-
|
Peptides
|
Others
|
Ac-Phe-Lys-OH is a inverted Aspartame type sweetener .
|
- HY-P3455
-
|
PGC-1α
|
Metabolic Disease
Cancer
|
Ac-SVVVRT-NH2 is a PGC-1α modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α .
|
- HY-P2633
-
AC-100
|
Peptides
|
Metabolic Disease
|
Dentonin (AC-100) is a synthetic fragment derived from MEPE. Dentonin enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin has no significant effect to mature osteoblasts. Dentonin can be used for the research of phosphate homeostasis and bone metabolism .
|
- HY-P4166
-
|
Peptides
|
Cancer
|
Ac-{Gly(N-me)}-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar is a decapeptide. Ac-{Gly(N-me)}-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar-Sar can be used to preparation of antibody-drug conjugate .
|
- HY-P4417
-
|
Peptides
|
Others
|
Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
- HY-P3110
-
|
Fluorescent Dye
|
Others
|
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
|
- HY-P0280
-
- HY-P1001
-
Ac-DEVD-CHO
Maximum Cited Publications
27 Publications Verification
|
Caspase
|
Cancer
|
Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM.
|
- HY-P1005
-
- HY-W013322
-
- HY-P5245
-
- HY-136728
-
|
Caspase
|
Cancer
|
Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity .
|
- HY-P10149
-
|
Peptides
|
Cancer
|
Ac-IEPD-CHO is a granzyme B inhibitor and can be used in cancer research .
|
- HY-P1316
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
|
- HY-P1316A
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [ 3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors .
|
- HY-P4532
-
|
Cathepsin
|
Neurological Disease
|
Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II .
|
- HY-P4764
-
|
Melanocortin Receptor
|
Cardiovascular Disease
|
Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure .
|
- HY-P4417A
-
|
Fluorescent Dye
|
Others
|
Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
|
- HY-134567
-
- HY-P4019
-
|
HIV Protease
|
Others
|
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 acts as the variable substrate in a peptidolytic assay to quantify the inhibition of the protease .
|
- HY-P4408
-
|
Peptides
|
Others
|
Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
|
- HY-P2633A
-
AC-100 TFA
|
Peptides
|
Metabolic Disease
|
Dentonin TFA (AC-100 TFA) is a synthetic fragment derived from MEPE. Dentonin TFA enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin TFA has no significant effect to mature osteoblasts. Dentonin TFA can be used for the research of phosphate homeostasis and bone metabolism .
|
- HY-P4040
-
- HY-P1006
-
|
Caspase
|
Others
|
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.
|
- HY-P2285
-
- HY-P3940
-
|
PKC
|
Others
|
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .
|
- HY-123051
-
- HY-P2939
-
|
Peptides
|
Others
|
Chondroitinase AC is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-P4448
-
|
Peptides
|
Others
|
Ac-Gly-Pro-AFC is a fluorogenic substrate for the determination of fibroblast activation protein (FAP) endopeptidase activity .
|
- HY-P3047
-
|
Peptides
|
Others
|
Ac-Decapeptide is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
|
- HY-P5938
-
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity .
|
- HY-P5955
-
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable caspase-4 inhibitor that has antitumor activity .
|
- HY-P1734
-
- HY-P5936
-
DEVD-CHO-CPP 32
|
Caspase
|
Cancer
|
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor .
|
- HY-P5983
-
|
Caspase
|
Cancer
|
Ac-VEID-AFC is a caspase-6 fluorogenic substrate, and can be used in the caspase 6 activity assay .
|
- HY-P10070
-
|
Peptides
|
Others
|
Ac-pSar16-OH is a polysarcosine which can replace PEG for therapeutic protein conjugation .
|
- HY-108312A
-
|
Caspase
|
Neurological Disease
|
AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .
|
- HY-P4833
-
|
Peptides
|
Others
|
Ac-Gly-Ala-Val-Ile-Leu-Arg-Arg-NH2 is a conical peptide with a nanodonut structure .
|
- HY-P10069
-
|
Peptides
|
Others
|
Ac-pSar12-OH, as a linker, can be used for preparation of Ligand-Drug-Conjugate (LDC) .
|
- HY-P10145
-
|
Peptides
|
Others
|
Ac-LEVD-pNA is a chromogenic substrate for caspase-4 and can be used to detect caspase-4 activity .
|
- HY-P6079
-
- HY-P1169
-
|
Caspase
|
Others
|
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
|
- HY-P2377
-
|
Fluorescent Dye
|
Others
|
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
|
- HY-P4535
-
- HY-P3115
-
|
Peptides
|
Others
|
Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies .
|
- HY-P3662
-
|
Tyrosinase
|
Cancer
|
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model .
|
- HY-P5280
-
|
Ser/Thr Protease
|
Others
|
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .
|
- HY-P6079A
-
|
Biochemical Assay Reagents
|
Others
|
Ac-IHIHIYI-NH2 TFA is an amyloid self-assembling peptide variant that can be used as a bioactive nanomaterial with esterase activity .
|
- HY-P1318
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [ 35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain .
|
- HY-P1318A
-
|
Opioid Receptor
|
Neurological Disease
|
Ac-RYYRIK-NH2 TFA is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [ 35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain .
|
- HY-P4688
-
- HY-P3236
-
Ac-IEPD-pNA
|
Peptides
|
Cancer
|
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity .
|
- HY-P1200
-
|
Src
|
Cancer
|
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions .
|
- HY-P2065
-
|
Fluorescent Dye
|
Others
|
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
|
- HY-P4844
-
|
Peptides
|
Others
|
Ac-Phe-Phe-OH is a negatively charged analogue of the diphenylalanine peptide that forms large aggregates when combined with the NH2-Phe-Phe-OH peptide .
|
- HY-P1200A
-
|
Src
|
Cancer
|
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions .
|
- HY-P4832
-
|
Amyloid-β
|
Neurological Disease
|
Acetyl-Tau Peptide (273-284) amide is an acetylated Tau peptide fragment. Acetyl-Tau Peptide (273-284) amide limits the substantial aggregation of Ac-Aβ(25–35)-NH2 and can be used as an inhibitor of Ac-Aβ(25–35)-NH2. Acetyl-Tau Peptide (273-284) amide can be used as an experimental model to investigate the Aβ/Tau cross-interaction .
|
- HY-P3307
-
|
Tau Protein
|
Neurological Disease
|
Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ42.
|
- HY-P3788
-
|
Peptides
|
Others
|
Ac-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2 is a peptide, can be used to synthesise tyrosine kinase inhibitor for hair growth reduction .
|
- HY-P5922
-
Ac-Gly-Val-Nle-Arg-Ile-NH2
|
Peptides
|
Cancer
|
PTD2 (Ac-Gly-Val-Nle-Arg-Ile-NH2) is a potent, selective inhibitor of WHSC1. PTD2 exhibits micromolar affinity towards WHSC1 .
|
- HY-P3761
-
|
Caspase
|
Others
|
Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia .
|
- HY-P4039
-
|
HCV Protease
|
Infection
|
Ac-EEVVAC-pNA is a chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease. The sequence EEVVAC is derived from the 5A-5B cleavage junction of the HCV polyprotein .
|
- HY-P5045
-
|
Peptides
|
Inflammation/Immunology
Cancer
|
Fmoc-Thr(GalNAc(Ac)3-β-D)-OH inhibits cancer cell growth, through targeting intricate cancer-specific pathways while simultaneously strengthening immunologic response .
|
- HY-P0211
-
|
Peptides
|
Cardiovascular Disease
|
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), a growth hormone releasing factor (GRF) analogue, is a vasoactive intestinal peptide (VIP) antagonist .
|
- HY-P3690
-
|
Proteasome
|
Others
|
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST) .
|
- HY-P4521
-
|
MMP
|
Others
|
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .
|
- HY-P4787
-
|
Cathepsin
|
Others
|
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay .
|
- HY-P10176
-
|
Peptides
|
Others
|
Acetalin-2 is an opioid peptide with a sequence of Ac-Arg-Phe-Met-Trp-Met-Arg-NH2. Acetalin-2 is selectively bound to [ 3H]DAMGO with a K i value of 93.3 nM .
|
- HY-P10177
-
|
Opioid Receptor
|
Neurological Disease
|
Acetalin-3 (Ac-RFMWMT-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .
|
- HY-P10175
-
|
Opioid Receptor
|
Neurological Disease
|
Acetalin-1 (Ac-RFMWMK-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .
|
- HY-P3787
-
|
Peptides
|
Metabolic Disease
|
Ac-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2 is the SH2 domain ligand. SH2 domains participate in protein tyrosine kinase (PTK)-mediated cellular signal .
|
- HY-120833
-
|
Caspase
|
Others
|
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
|
- HY-P2977
-
Sialic acid aldolase (CgNal)
|
Endogenous Metabolite
|
Others
|
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .
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- HY-P4850
-
|
Peptides
|
Others
|
Ac-Pro-Leu-Gly-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P0266B
-
Ac-SDKP acetate
|
Angiotensin-converting Enzyme (ACE)
|
Inflammation/Immunology
|
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .
|
- HY-P4854
-
|
Peptides
|
Others
|
Ac-Val-Tyr-Lys-NH2 is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P4687
-
|
Peptides
|
Others
|
(Ser(Ac)3)-Ghrelin (mouse, rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P3155
-
|
MCHR1 (GPR24)
|
Metabolic Disease
|
Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R .
|
- HY-P5348
-
|
Peptides
|
Others
|
Ac-LEHD-pNA is a biological active peptide. (Caspase-9 substrate; pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.)
|
- HY-P4616
-
|
Peptides
|
Others
|
(Lys(Ac)12)-Histone H4 (1-21)-Gly-Gly-Lys(biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P10215
-
|
Peptides
|
Infection
|
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .
|
- HY-P1368
-
Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)
|
CRFR
|
Endocrinology
|
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats .
|
- HY-P1368A
-
Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA
|
CRFR
|
Endocrinology
|
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats .
|
- HY-P4614
-
|
Peptides
|
Others
|
(Lys(Ac)5,8,12,16)-Histone H4 (1-25)-Gly-Ser-Gly-Ser-Lys(biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P1454
-
Fz7-21
3 Publications Verification
Ac-LPSDDLEFWCHVMY-NH2
|
Wnt
|
Cancer
|
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids .
|
- HY-P5378
-
Cathepsin S substrate
|
Peptides
|
Others
|
Ac-KQKLR-AMC (Cathepsin S substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.)
|
- HY-P1454A
-
Ac-LPSDDLEFWCHVMY-NH2 TFA
|
Wnt
|
Cancer
|
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids .
|
- HY-P5510
-
HCV NS3 protease substrate
|
Peptides
|
Others
|
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. (This peptide is a HCV protease substrate incorporating an ester bond between residues P1 and P1. Due to ready transesterification of the scissile bond to the acyl-enzyme intermediate, this substrate shows very high kcat/Km values, enabling detection of activity with subnanomolar nonstructural protein 3 (NS3 protease) concentrations. It is widely used for the continuous assay of NS3 protease activity. Substrate cleavage is proportional to the enzyme concentration with a detection limit for NS3 between 1 nM and 250 pM. Upon cleavage of this substrate, fluorescence can be monitored at Abs/Em = 355/500 nm.)
|
-
- HY-K0221
-
|
MCE Affinity Chromatography (AC) Columns are designed for purification of recombinant proteins with different tags, enzymes, antibodies, antigens and nucleic acids.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99362
-
Anti-MUC5AC Reference Antibody (ensituximab); NEO-102
|
Inhibitory Antibodies
|
Cancer
|
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer .
|
-
- HY-P99715
-
ABT-806
|
EGFR
|
Cancer
|
Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody. Losatuxizumab binds to EGFR with EC50s of 0.96 nM for EGFR wild-type, 0.09 nM for EGFR C271A,C283A, 0.12 nM for EGFRvIII, 0.66 nM for EGFR1-501. Losatuxizumab can be used for research of EGFR-expressing cancers .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N9459
-
-
-
- HY-W004066
-
-
-
- HY-W011982
-
-
-
- HY-112942A
-
-
-
- HY-N6999
-
-
-
- HY-112942
-
-
-
- HY-W014130A
-
-
-
- HY-151852
-
-
-
- HY-W415798
-
-
-
- HY-W014130
-
-
-
- HY-113338
-
-
-
- HY-66007
-
-
-
- HY-N12336
-
-
-
- HY-N10772
-
-
-
- HY-117616
-
-
-
- HY-N2098
-
-
-
- HY-N8356
-
-
-
- HY-N8356A
-
-
-
- HY-N2609
-
|
Structural Classification
Flavonoids
Classification of Application Fields
Flavones
Leguminosae
Source classification
Phenols
Polyphenols
Plants
Disease Research Fields
Glycyrrhiza uralensis Fisch.
Endocrinology
|
CCR
NF-κB
|
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
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Product Name |
Species |
Source |
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* This product has been "discontinued".
Optimized version of product available:
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Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W004066S
-
|
Ac-Ala-OH-d3 is the deuterium labeled Ac-Ala-OH. Ac-Ala-OH is an endogenous metabolite.
|
-
-
- HY-W012713S
-
|
Ac-D-Ala-OH-d4 is the deuterium labeled Ac-D-Ala-OH.
|
-
-
- HY-W015241S
-
|
Ac-D-Glu-OH-d5 is the deuterium labeled Ac-D-Glu-OH.
|
-
-
- HY-W004066S1
-
|
Ac-Ala-OH-d4 is the deuterium labeled Ac-Ala-OH. Ac-Ala-OH is an endogenous metabolite.
|
-
-
- HY-79490S
-
|
Ac-Exatecan-d5 is the deuterium labeled Ac-Exatecan (HY-79490) .
|
-
-
- HY-W042357S
-
|
Ac-rC Phosphoramidite- 15N is 15N labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
-
- HY-W042357S1
-
|
Ac-rC Phosphoramidite- 15N2 is 15N labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
-
- HY-W042357S2
-
|
Ac-rC Phosphoramidite- 15N3 is 15N labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
-
- HY-W042357S4
-
|
Ac-rC Phosphoramidite- 13C9 is 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
-
- HY-W010389S2
-
|
Ac-DL-Ala-OH-d4 is the deuterium labeled Ac-DL-Ala-OH[1].
|
-
-
- HY-W042357S5
-
|
Ac-rC Phosphoramidite- 13C,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
-
- HY-W042357S6
-
|
Ac-rC Phosphoramidite- 13C9, 15N3 is 13C and 15N-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
-
- HY-W042357S3
-
|
Ac-rC Phosphoramidite- 13C2,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
-
- HY-150658S
-
|
DMT-2′O-TBDMS-rA(ac)-1- 15N phosphoramidite is the 15N labeled DMT-2′O-TBDMS-rA(ac) phosphoramidite[1].
|
-
-
- HY-B0091S
-
|
Adapalene-d3 is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3].
|
-
Cat. No. |
Product Name |
Application |
Reactivity |
-
- HY-P80560
-
ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme
|
WB, ICC/IF, FC
|
Human, Mouse, Monkey |
ATP Citrate Lyase Antibody (YA829) is a non-conjugated and Mouse origined monoclonal antibody about 121 kDa, targeting to ATP Citrate Lyase (3D9). It can be used for WB,ICC/IF,FC assays with tag free, in the background of Human, Mouse, Monkey.
|
Cat. No. |
Product Name |
|
Classification |
-
- HY-W096146
-
|
|
PROTAC Synthesis
Alkynes
|
Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propynyl-PEG1-Ac is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-118297
-
|
|
Azide
Labeling and Fluorescence Imaging
|
Ac4ManNAz (80% α isomer) is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins. Ac4ManNAz can be used for cell labeling, tracking and proteomic analysis. Ac4ManNAz (80% α isomer) contains Azide groups and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz (80% α isomer) can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-151819
-
|
|
Azide
|
N3Ac-OPhOMe is a click chemistry reagent containing an azide group. N3Ac-OPhOMe can be used for the research of various biochemical .
|
-
- HY-140343
-
|
|
Alkynes
PROTAC Synthesis
|
Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W145531
-
|
|
Azide
|
Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-141136
-
|
|
Alkynes
|
Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141128
-
|
|
Azide
|
Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-151852
-
|
|
Labeling and Fluorescence Imaging
Azide
|
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
-
- HY-W415798
-
|
|
Alkynes
|
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .
|
-
- HY-141133
-
|
|
Alkynes
|
Propargyl-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141135
-
|
|
Alkynes
|
Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141127
-
|
|
Azide
|
Azido-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141077
-
|
|
Azide
|
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133870
-
ITalk
|
|
Alkynes
|
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate . Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
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