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ACLY Inhibitors

" in MedChemExpress (MCE) Product Catalog:

111

Inhibitors & Agonists

47

Peptides

4

Natural
Products

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-116530
    9-Cyclopentyladenine monomethanesulfonate

    9-CP-Ade mesylate

    		 Adenylate Cyclase Others Neurological Disease
    9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties .
    9-Cyclopentyladenine monomethanesulfonate
  • HY-145830
    AC1-IN-1

    		Adenylate Cyclase Neurological Disease
    AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity .
    AC1-IN-1
  • HY-118343
    AC-93253

    		Sirtuin Cancer
    AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors .
    AC-93253
  • HY-16020
    AC-430 hydrobromide

    		JAK Cancer
    AC-430 hydrobromide (example 1) is a potent JAK2 inhibitor. AC-430 hydrobromide can be used for the research of myeloproliferative disorders and cancer .
    AC-430 hydrobromide
  • HY-143463
    AC-386

    		c-Met/HGFR Cancer
    AC-386 is a highly potent c-Met inhibitor with IC50 value of 7.42 nM. AC-386 has antiproliferative activities against certain cancer cell lines. AC-386 can be used for researching anti-cancer resistance .
    AC-386
  • HY-W011254
    Ac-VAD-CHO

    Ac-Val-Ala-Asp-CHO

    		 Caspase Cancer
    Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .
    Ac-VAD-CHO
  • HY-136727
    Ac-LEVD-CHO

    		Caspase Cancer
    Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al .
    Ac-LEVD-CHO
  • HY-P1098B
    Ac2-26 ammonium
    3 Publications Verification

    		 IKK Inflammation/Immunology
    Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .
    Ac2-26 ammonium
  • HY-122214
    AC-73
    3 Publications Verification

    		 Autophagy Cancer
    AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells . AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells .
    AC-73
  • HY-110288
    3FAx-Neu5Ac

    		Sialyltransferase Metabolic Disease
    3FAx-Neu5Ac (compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X on myeloid cells .
    3FAx-Neu5Ac
  • HY-124500
    AC-4-130
    3 Publications Verification

    		 STAT Apoptosis Cancer
    AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) .
    AC-4-130
  • HY-P5525
    AC3-I, myristoylated

    Autocamtide-3 Derived Inhibitory Peptide

    		 CaMK Others
    AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)
    AC3-I, myristoylated
  • HY-113963
    Ac-​IETD-​CHO

    		Apoptosis Cancer
    Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death .
    Ac-​IETD-​CHO
  • HY-153613
    Ac-PLVE-FMK

    Ac-Pro-Leu-Val-Glu(OMe)-CH2F

    		 Others Cancer
    Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer .
    Ac-PLVE-FMK
  • HY-P10146
    Ac-LETD-CHO

    		Caspase Cancer
    Ac-LETD-CHO is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with an IC50 value of 6.71 nM. Ac-LETD-CHO can be used for the research of anticancer .
    Ac-LETD-CHO
  • HY-160109
    Ac5GalNTGc

    		Mucin Cancer
    Ac5GalNTGc is a analog of hexosamine. Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis .
    Ac5GalNTGc
  • HY-P3434
    Ac-FEID-CMK

    		Pyroptosis Inflammation/Immunology
    Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .
    Ac-FEID-CMK
  • HY-P1098
    Ac2-26
    3 Publications Verification

    		 NF-κB Inflammation/Immunology
    Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
    Ac2-26
  • HY-P1098A
    Ac2-26 TFA
    3 Publications Verification

    		 NF-κB Inflammation/Immunology
    Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue .
    Ac2-26 TFA
  • HY-P3434A
    Ac-FEID-CMK TFA

    		Pyroptosis Inflammation/Immunology
    Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .
    Ac-FEID-CMK TFA
  • HY-P0034
    Ac-DEVD-CMK

    Caspase-3 Inhibitor III
    Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis .
    Ac-DEVD-CMK
  • HY-P10147
    Ac-LDESD-AMC

    		Caspase Cancer
    Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
    Ac-LDESD-AMC
  • HY-B0393
    Fudosteine
    1 Publications Verification

    		 Amino Acid Derivatives Inflammation/Immunology
    Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression .
    Fudosteine
  • HY-113844
    Ac-Gly-Lys-OMe

    		Ser/Thr Protease Others
    Ac-Gly-Lys-OMe is a substrate for urokinase. Ac-Gly-Lys-OMe can be used to measure the effects of small molecule inhibitors on urokinase activity .
    Ac-Gly-Lys-OMe
  • HY-147286
    Ac-Lys-Val-Cit-PABC-MMAE

    		Drug-Linker Conjugates for ADC Cancer
    Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162) .
    Ac-Lys-Val-Cit-PABC-MMAE
  • HY-14425
    NB001

    HTS 09836

    		 Adenylate Cyclase Neurological Disease
    NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity .
    NB001
  • HY-P0034A
    Ac-DEVD-CMK TFA
    1 Publications Verification

    Caspase-3 Inhibitor III TFA

    		 Caspase Apoptosis Metabolic Disease
    Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .
    Ac-DEVD-CMK TFA
  • HY-120019
    Ac-YVAD-CHO

    L-709049

    		 Interleukin Related Apoptosis Caspase Inflammation/Immunology
    Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .
    Ac-YVAD-CHO
  • HY-120019A
    Ac-YVAD-CHO acetate

    L-709049 acetate

    		 Interleukin Related Caspase Apoptosis Inflammation/Immunology
    Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ .
    Ac-YVAD-CHO acetate
  • HY-P10201
    Ac-GpYLPQTV-NH2

    		STAT Cancer
    Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity .
    Ac-GpYLPQTV-NH2
  • HY-100396
    SQ22536
    20+ Cited Publications

    		 Adenylate Cyclase Metabolic Disease
    SQ22536 is an effective adenylate cyclase (AC) inhibitor.
    SQ22536
  • HY-101801
    Ac-Gly-BoroPro
    3 Publications Verification

    		 FAP Cancer
    Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
    Ac-Gly-BoroPro
  • HY-16990
    Ac-YVAD-cmk
    5+ Cited Publications

    Caspase-1 Inhibitor II

    		 Caspase Inflammation/Immunology
    Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .
    Ac-YVAD-cmk
  • HY-104032
    Ac-CoA Synthase Inhibitor1
    3 Publications Verification

    		 RSV Infection Metabolic Disease
    Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 µM . Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV) .
    Ac-CoA Synthase Inhibitor1
  • HY-153614
    Ac-VLPE-FMK

    Ac-Val-Leu-Pro-Glu(OMe)-CH2F

    		 Cathepsin Cancer
    Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness .
    Ac-VLPE-FMK
  • HY-147286A
    Ac-Lys-Val-Cit-PABC-MMAE formic

    		Drug-Linker Conjugates for ADC Cancer
    Ac-Lys-Val-Cit-PABC-MMAE (formic) is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor Monomethyl auristatin E (HY-15162) .
    Ac-Lys-Val-Cit-PABC-MMAE formic
  • HY-P4846
    Ac-Pro-Gly-Pro-OH

    		CXCR Inflammation/Immunology
    Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
    Ac-Pro-Gly-Pro-OH
  • HY-W048674
    Fmoc-Ser(Ac)-OH

    Fmoc-O-acetyl-L-serine

    		 Amino Acid Derivatives Infection
    Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor .
    Fmoc-Ser(Ac)-OH
  • HY-136733
    Ac-DNLD-CHO

    Ac-Asp-Asn-Leu-Asp-CHO

    		 Caspase Infection Neurological Disease
    Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Ki app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .
    Ac-DNLD-CHO
  • HY-P3234
    Ac-ESMD-CHO

    		Casein Kinase Others
    Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .
    Ac-ESMD-CHO
  • HY-P10162
    Ac-DMQD-AMC

    		Caspase Cancer
    Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
    Ac-DMQD-AMC
  • HY-122051
    AC1903
    1 Publications Verification

    		 TRP Channel Metabolic Disease
    AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model .
    AC1903
  • HY-16450
    SB 204990
    10+ Cited Publications

    		 ATP Citrate Lyase Metabolic Disease
    SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
    SB 204990
  • HY-P5956
    Ac-AAVALLPAVLLALLAP-LEHD-CHO

    		Caspase Cancer
    Ac-AAVALLPAVLLALLAP-LEHD-CHO is an inhibitor of caspases 4, 5 and 9. Ac-AAVALLPAVLLALLAP-LEHD-CHO shows protective effects upon Neocarzinostatin (HY-111183)-treated MCF-7 cells .
    Ac-AAVALLPAVLLALLAP-LEHD-CHO
  • HY-RI01635
    hsa-miR-548ac inhibitor

    		MicroRNA
    hsa-miR-548ac inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-548ac inhibitor
    hsa-miR-548ac inhibitor
  • HY-P1001
    Ac-DEVD-CHO
    Maximum Cited Publications
    27 Publications Verification

    		 Caspase Cancer
    Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM.
    Ac-DEVD-CHO
  • HY-136728
    Ac-YVAD-AOM

    		Caspase Cancer
    Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity .
    Ac-YVAD-AOM
  • HY-112942A
    CMP-Sialic acid sodium salt

    CMP-Neu5Ac sodium salt

    		 Endogenous Metabolite Metabolic Disease
    CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
    CMP-Sialic acid sodium salt
  • HY-112942
    CMP-Sialic acid

    CMP-Neu5Ac

    		 Endogenous Metabolite Metabolic Disease
    CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
    CMP-Sialic acid
  • HY-134567
    Ac-VDVAD-CHO

    		Casein Kinase Others
    Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM) .
    Ac-VDVAD-CHO

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