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ADP-ribosylation

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By Targets:	PARP (5) Adenylate Cyclase (2) DNA/RNA Synthesis (2) Enterovirus (1) Fluorescent Dye (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (2)

15

Inhibitors & Agonists

1

Biochemical Assay Reagents

6

Recombinant Proteins

2

Antibodies

Targets Recommended: Poly(ADP-ribose) Glycohydrolase (PARG) PARP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Fluorescein-NAD+	PARP	Others
Fluorescein-NAD+ is an alternative to radiolabeled NAD and a substrate for ADP-ribosylation. Fluorescein-NAD+ can be used in PARP assays by fluorescence microscopy. Extinction Coefficient: 262 nm.

RBN-3143	PARP	Inflammation/Immunology
RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC₅₀ value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation .

QS11 1 Publications Verification	Others	Cancer
QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC₅₀ of 1.5 µM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells .

K-756	PARP	Cancer
K-756 is a direct and selective tankyrase (TNKS) inhibitor, which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 with IC₅₀s of 31 and 36 nM, respectively.

Guanylyl Imidodiphosphate trisodium Guanosine 5'-[β,γ-imido]triphosphate trisodium	Adenylate Cyclase	Endocrinology
Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies .

Golgicide A 3 Publications Verification GCA
Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 . Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .

(Rac)-Golgicide A (Rac)-GCA	Enterovirus	Infection
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 .Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .

Cholera toxin Maximum Cited Publications 9 Publications Verification Choleragen	Adenylate Cyclase	Inflammation/Immunology
Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER) . Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein .

Nicotinamide 1,N6-ethenoadenine dinucleotide ε-NAD	Fluorescent Dye	Others
Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) , a fluorescent analogue of NAD, is able to serve as a substrate for the bacterial toxincatalyzed G-ADP ribosylation of signal-transducing G-proteins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the studies of the ADP ribosylation reaction .

2-Azido-NAD Nicotinamide 2-azidoadenine dinucleotide	Others	Others
2-Azido-NAD is a NAD ⁺ analog that can be used for visualization of intracellular Poly(ADP ribos)ylation (PARylation) processes .

Iobenguane sulfate MIBG sulfate	Others	Cancer
Iobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation) .

AV-153	DNA/RNA Synthesis	Cancer
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

HY-121719

TIQ-A

PARP Cardiovascular Disease Cancer

TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC₅₀ of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent .

PARP11 inhibitor ITK7 ITK7	PARP	Cancer
PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC₅₀ value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization . PARP11 inhibitor ITK7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Species:	Human (6)
Tag:	His (4) Myc (1) GST (2) Fc (1)
Source:	HEK293 (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

	ARF3 Protein, Human (His) ADP-ribosylation factor 3; ARF3	Human	E. coli
	ARF3 protein, a GTP-binding allosteric activator of cholera toxin, plays a role in protein trafficking and vesicle dynamics in the Golgi apparatus. Beyond toxin activation, ARF3 interacts with PRKCABP, participating in diverse cellular processes. It also associates with PI4KB and NCS1/FREQ at the Golgi complex, emphasizing its role in crucial molecular interactions for cellular functions. ARF3 Protein, Human (His) is the recombinant human-derived ARF3 protein, expressed by E. coli , with N-His labeled tag. The total length of ARF3 Protein, Human (His) is 181 a.a., with molecular weight of ~23 kDa.

	ARF1 Protein, Human (His-GST, Myc) ADP ribosylation Factor 1; ADP-ribosylation factor 1; ARF 1; ARF1; ARF1_HUMAN	Human	E. coli
	ARF1 is a small GTPase responsible for coordinating protein transport within the Golgi complex. In its GTP-bound state, ARF1 critically regulates Golgi vesicle budding and uncoating by recruiting coat proteins. ARF1 Protein, Human (His-GST, Myc) is the recombinant human-derived ARF1 protein, expressed by E. coli , with N-10*His, C-Myc, GST labeled tag. The total length of ARF1 Protein, Human (His-GST, Myc) is 180 a.a., with molecular weight of ~55 kDa.

HY-P76730

ARL6IP6 Protein, Human (HEK293, Fc)

ADP-ribosylation factor-like protein 6-interacting protein 6; Aip-6; PFAAP1
Human HEK293
HY-P75502

ARF5 Protein, Human (His)

ADP-ribosylation factor 5; ARF5
Human E. coli

	ARL2BP Protein, Human (GST) ADP ribosylation factor like 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein; ARL2BP protein; BART; BART1; Binder of ARF2 protein 1	Human	E. coli
	The ARL2BP protein cooperates with ARL2 to play a crucial role in the nuclear translocation, retention, and transcriptional activity of STAT3, highlighting its cellular involvement. As a potential effector of ARL2, ARL2BP forms a complex with ARL2, SLC25A6, and ARL3. ARL2BP Protein, Human (GST) is the recombinant human-derived ARL2BP protein, expressed by E. coli , with N-GST labeled tag. The total length of ARL2BP Protein, Human (GST) is 163 a.a., with molecular weight of ~45.8 kDa.

	ARL2BP Protein, Human (His) ADP ribosylation factor like 2 binding protein; BART; BART1; Binder of ARF2 protein 1	Human	E. coli
	The ARL2BP protein cooperates with ARL2 to play a crucial role in the nuclear translocation, retention, and transcriptional activity of STAT3, highlighting its cellular involvement. As a potential effector of ARL2, ARL2BP forms a complex with ARL2, SLC25A6, and ARL3. ARL2BP Protein, Human (His) is the recombinant human-derived ARL2BP protein, expressed by E. coli , with N-6*His labeled tag. The total length of ARL2BP Protein, Human (His) is 163 a.a., with molecular weight of ~21 KDa.

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