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Results for "

AIDs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (7) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (2) CDK (1) CMV (4) DNA/RNA Synthesis (4) Drug Metabolite (1) Endogenous Metabolite (3) Epigenetic Reader Domain (2) HIV (46) HIV Integrase (4) HIV Protease (10) Isotope-Labeled Compounds (5) Liposome (2) NF-κB (1) Orthopoxvirus (2) Parasite (2) Progesterone Receptor (1) Reactive Oxygen Species (1) Reverse Transcriptase (7) SARS-CoV (5)
By Research Areas:	Cancer (15) Endocrinology (1) Infection (55) Inflammation/Immunology (10) Metabolic Disease (3) Neurological Disease (4)

By Targets:

Antibiotic (1)

Apoptosis (7)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (1)

Calcium Channel (2)

CDK (1)

CMV (4)

DNA/RNA Synthesis (4)

Drug Metabolite (1)

Endogenous Metabolite (3)

Epigenetic Reader Domain (2)

HIV (46)

HIV Integrase (4)

HIV Protease (10)

Isotope-Labeled Compounds (5)

Liposome (2)

NF-κB (1)

Orthopoxvirus (2)

Parasite (2)

Progesterone Receptor (1)

Reactive Oxygen Species (1)

Reverse Transcriptase (7)

SARS-CoV (5)

By Research Areas:

Cancer (15)

Endocrinology (1)

Infection (55)

Inflammation/Immunology (10)

Metabolic Disease (3)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10570S

Nevirapine-d4	Isotope-Labeled Compounds HIV Reverse Transcriptase	Neurological Disease
Nevirapine-d₄ is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

HY-120880

SKF107457

HIV Protease Infection

SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research .
HY-146088

HIV-1 inhibitor-31

HIV Infection

HIV-1 inhibitor-31 (compound 4) is a potent HIV-1 inhibitor. HIV-1 inhibitor-31 can be used for researching AIDS .
HY-151197

HIV protease-IN-1

HIV Protease Infection

HIV protease-IN-1 (compound 1·succinate) is a potent HIV protease non-peptidic inhibitor, can be used to research AIDS .

SKF107457	HIV Protease	Infection
SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research .

HIV-1 inhibitor-31	HIV	Infection
HIV-1 inhibitor-31 (compound 4) is a potent HIV-1 inhibitor. HIV-1 inhibitor-31 can be used for researching AIDS .

HIV protease-IN-1	HIV Protease	Infection
HIV protease-IN-1 (compound 1·succinate) is a potent HIV protease non-peptidic inhibitor, can be used to research AIDS .

HY-146089

HIV-1 inhibitor-32	HIV	Infection
HIV-1 inhibitor-32 (compound 3c) is a potent HIV-1 inhibitor with an IC₅₀ value of 34 nM for WT HIV-1. HIV-1 inhibitor-32 can be used for researching AIDS .

HY-147370

HIV-1 inhibitor-46	HIV	Infection
HIV-1 inhibitor-46 (compound 13d) is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor with an EC₅₀ value of 1.425 μM. HIV-1 inhibitor-46 can be used for the research of AIDS .

HY-146091

HIV-1 inhibitor-34	HIV	Infection
HIV-1 inhibitor-34 (compound 5q) is a potent and selective HIV-1 inhibitor with an EC₅₀ of 6.4 nM for HIV-1 and a CC₅₀ of 16 μM in MT-4 cells. HIV-1 inhibitor-34 can be used for researching AIDS .

HY-146090

HIV-1 inhibitor-33	HIV	Infection
HIV-1 inhibitor-33 (compound 5n) is a potent and selective HIV-1 inhibitor with an EC₅₀ of 8.6 nM for HIV-1 and a CC₅₀ of 18 μM in MT-4 cells. HIV-1 inhibitor-33 can be used for researching AIDS .

HY-160634

BRD4 Inhibitor-31	Epigenetic Reader Domain	Infection Inflammation/Immunology Cancer
BRD4 Inhibitor-31 (Example 136) is a BRD4 inhibitor (K_is: 0.234 μM and 0.295 μM for BRD4 BD1 and BRD4 BD2 respectively). BRD4 Inhibitor-31 can be used for research of inflammatory diseases, cancer, and AIDS .

HY-162253

HIV-1 inhibitor-64	HIV	Infection
HIV-1 inhibitor-64 (Compound 7c) is a wild-type HIV-1 inhibitor that effectively suppresses the activity of HIV-1 mutants E138K/Q148K and G140S/Q148R with EC₅₀ values of 62.5 nM and 11.3 nM, respectively. HIV-1 inhibitor-64 exhibits antiviral activity and can be used in the research of AIDS .

HY-146308

HIV-1 inhibitor-26	HIV	Infection
HIV-1 inhibitor-26 (compound 9a) is a potent HIV-1 reverse transcriptase (RT) inhibitor with an IC₅₀ value of 1.4 μM. HIV-1 inhibitor-26 has low cytotoxicity with a CC₅₀ of 1486 μM in PBMCs. HIV-1 inhibitor-26 can be used for researching AIDS .

HY-109528

Fomivirsen sodium ISIS-2922	CMV	Infection
Fomivirsen (ISIS-2922) sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen sodium is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation .

HY-112958

Fomivirsen ISIS-2922 free base	CMV	Infection
Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used CMV research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation .

HY-150769

ZLM-66	HIV	Inflammation/Immunology
ZLM-66 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTIs) with an IC₅₀ of 41 nM for wild-type (WT) HIV-1 reverse transcriptase and an EC₅₀ value of 13 nM for wild-type HIV-1. ZLM-66 is a Doravirine (HY-16767) analogs. ZLM-66 can be used for the research of AIDS .

HY-15592A

Cabotegravir sodium 5 Publications Verification GSK-1265744 sodium; S/GSK1265744 sodium	HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS .

HY-10571

Delavirdine U 90152; BHAP-U 90152	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-10571A

Delavirdine mesylate 3 Publications Verification U 90152 mesylate; BHAP-U 90152 mesylate	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-137697B

ddCTP trilithium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trilithium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trilithium is a nucleoside analog that targets the reverse trsanscriptase of human immunodeficiency virus (HIV). ddCTP trilithium can be used for AIDS research .

HY-146353

HIV-1 inhibitor-29	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC₅₀ of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC₅₀ = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC₅₀ = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS .

HY-15592

Cabotegravir 5 Publications Verification GSK-1265744; S/GSK1265744	HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-146352

HIV-1 inhibitor-28	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC₅₀ of 58 nM for WT HIV-1 strain and an IC₅₀ of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC₅₀ = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS .

HY-P1075

CALP3 1 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-P1075A

CALP3 TFA	Calcium Channel	Neurological Disease Cancer
CALP3 TFA, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-146339

HIV-1 inhibitor-27	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-27 (compound 5) is a potent HIV-1 inhibitor with IC₅₀s of 16 μM, 0.5 μM and 0.39 μM for HIV-1 YU2, NL4-3 and 89.6 strain, respectively. HIV-1 inhibitor-27 has low cytotoxicity with a CC₅₀ of 128 μM in TZM-bl cells. HIV-1 inhibitor-27 can be used for researching AIDS .

HY-N2840S

Allitol-13C Allodulcitol-¹³C	Isotope-Labeled Compounds	Metabolic Disease Cancer
Allitol- ¹³C is the ¹³C labeled Allitol. Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS[1]

HY-146365

HIV-1 inhibitor-30	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC₅₀ value of 40 nM and an IC₅₀ value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC₅₀s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS .

HY-15815

Bromosporine 3 Publications Verification	Epigenetic Reader Domain Apoptosis CDK HIV	Cancer
Bromosporine is a potent BET inhibitor with an IC₅₀ value of 2.1 μM for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-FU (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in HIV-1 latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS .

HY-145569

Fipravirimat

GSK3640254
HIV Infection

Fipravirimat is a potent HIV-1 inhibitor. Fipravirimat has the potential for HIV and AIDS research .

Fipravirimat GSK3640254	HIV	Infection
Fipravirimat is a potent HIV-1 inhibitor. Fipravirimat has the potential for HIV and AIDS research .

HY-145569A

Fipravirimat dihydrochloride GSK3640254 dihydrochloride	HIV	Infection
Fipravirimat dihydrochloride is a potent HIV-1 inhibitor. Fipravirimat dihydrochloride has the potential for HIV and AIDS research .

HY-127135

B07

HIV Infection

B07 is a HIV inhibitor. B07 also has spermicides activity (EC₅₀: 1.5 mg/mL) .
HY-137565

Hydroxy ritonavir

Drug Metabolite Others

Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS .

B07	HIV	Infection
B07 is a HIV inhibitor. B07 also has spermicides activity (EC₅₀: 1.5 mg/mL) .

Hydroxy ritonavir	Drug Metabolite	Others
Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS .

HY-N6929

Angelic acid	Others	Neurological Disease
Angelic Acid is a substance found in Angelica sinensis, and it exists in an ester form. Angelic acid aids in wound healing and exhibits psychotropic properties .

HY-10570

Nevirapine 4 Publications Verification BI-RG 587; NSC 641530; NVP	HIV Reverse Transcriptase Parasite	Infection Cancer
Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-N2840

Allitol Allodulcitol	Others	Metabolic Disease Cancer
Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS .

HY-90001

Ritonavir Maximum Cited Publications 21 Publications Verification ABT 538; RTV	HIV Protease HIV SARS-CoV Apoptosis	Infection Cancer
Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM.

HY-17041

Darunavir Ethanolate 5+ Cited Publications TMC114 Ethanolate	HIV HIV Protease	Infection
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a K_i of 1 nM for wild type HIV-1 protease.

HY-119210

ZINC04177596	HIV	Infection
ZINC04177596 is a potent HIV-negative factor (HIV-Nef) protein inhibitor. Nef is an accessory gene product of HIV and has an imperative role in viral replication and AIDS pathogenesis .

HY-15592S2

Cabotegravir-d3-1 GSK-1265744-d₃-1; S/GSK1265744-d₃-1	Isotope-Labeled Compounds HIV Integrase	Infection
Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research

HY-B1046S

Clofazimine-d7	Bacterial Antibiotic	Inflammation/Immunology
Clofazimine-d₇ is deuterium labeled Clofazimine. Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial agents to treat AIDS and Crohn's disease.

HY-136548B

Tenofovir diphosphate disodium 1 Publications Verification TFV-DP disodium	HIV	Infection Inflammation/Immunology
Tenofovir diphosphate disodium is an antiretroviral agent and an inhibitor of DNA polymerases. Tenofovir diphosphate disodium is a substrate of HIV-1 reverse transcriptase (RT). Tenofovir diphosphate disodium can be used for the research of Aids .

HY-10570R

Nevirapine (Standard) BI-RG 587 (Standard); NSC 641530 (Standard); NVP (Standard)	HIV Reverse Transcriptase Parasite	Infection Cancer
Nevirapine (Standard) is the analytical standard of Nevirapine. This product is intended for research and analytical applications. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-146019A

HIV-1 inhibitor-25	HIV	Infection
HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC₅₀ value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC₅₀ of 13.6 nM, and exhibits relatively low cytotoxicity with a CC₅₀ of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC₅₀ of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS .

HY-10570S1

Nevirapine-d3	Isotope-Labeled Compounds HIV Reverse Transcriptase	Infection Cancer
Nevirapine-d₃ (BI-RG 587-d3) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM[1].

HY-90001S

Ritonavir-d6 ABT 538-d₆; RTV-d₆	HIV Protease HIV SARS-CoV Apoptosis	Infection
Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].

HY-90001R

Ritonavir (Standard) ABT 538 (Standard); RTV (Standard)	HIV Protease HIV SARS-CoV Apoptosis	Infection Cancer
Ritonavir (Standard) is the analytical standard of Ritonavir. This product is intended for research and analytical applications. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM.

HY-90001S1

Ritonavir-13C,d3 ABT 538-¹³C,d₃; RTV-¹³C,d₃	HIV Protease HIV SARS-CoV Apoptosis	Infection
Ritonavir- ¹³C,d₃ is the ¹³C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.

HY-N0685

Pseudohypericin	HIV	Infection
Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity .

HY-N12082

HIV-IN-8

HIV Infection

HIV-IN-8 (Compound 9) is a HIV inhibitor. HIV-IN-8 inhibits HIV replication with an EC₅₀ of 13 μg/mL .

HY-137697D

ddCTP trisodium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium is a nucleoside analog that targets the reverse transcriptase of human immunodeficiency virus (HIV). ddCTP trisodium can be used for AIDS research .

HY-17438

Cidofovir 2 Publications Verification GS 0504; HPMPC; (S)-HPMPC	CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite	Infection Cancer
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .

Cat. No.	Product Name

HY-L057

Phenols Library

1183 compounds

Phenolic compounds are usually referred to as a diverse group of naturally occurring compounds with multiple medical properties, such as antioxidants, antimicrobial properties. Those compounds are commonly found in food and plants. They have high synthetic, medicinal and industrial values. Polyphenols are compounds with multiple phenolic functionalities. Naturally occurring polyphenols are known to have biological activities for use as drugs, for example, in diseases like AIDS, heart ailments, ulcer formation, bacterial infection, mutagenesis and neural disorders.

MCE offers a unique collection of 1183 natural phenol compounds which is a useful tool for drug discovery as an important source of lead compounds.

HY-L132

Chemokine Compound Library

146 compounds

Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.

The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases.

MCE supplies a unique collection of 146 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.

Cat. No.	Product Name	Target	Research Area